| Budget Amount *help |
¥49,660,000 (Direct Cost: ¥38,200,000、Indirect Cost: ¥11,460,000)
Fiscal Year 2015: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2014: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2012: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000)
Fiscal Year 2011: ¥29,380,000 (Direct Cost: ¥22,600,000、Indirect Cost: ¥6,780,000)
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| Outline of Final Research Achievements |
In order to clarify the mechanisms of shell formation in molluscs, genome sequencing, transcriptome analysis, proteome analysis, functional analysis of gene products using various inhibitory chemicals, and development of transgenic techniques were done using the gastropod Lymnaea stagnalis, Patella vulgata, and Nipponacmea fuscoviridis, the bivalve Pinctada fucata, as well as the cephalopod Nautilus pompilius. As a result, a gene regulatory pathway responsible for the initial development of the shells and proteins responsible for the control of curvature and torsion of shell growth were discovered. Outcomes of this project also include exhaustive identification of shell matrix proteins, elucidation of possible mechanisms and evolutionary processes for those shell matrix proteins, and establishment of an experimental system with which to carry out transgenic studies in molluscs.
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