Laser sintering of tissue engineering scaffold for reconstruction of three dimensional, large scale and high metabolic rate organs
Project/Area Number |
23246027
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Research Category |
Grant-in-Aid for Scientific Research (A)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Production engineering/Processing studies
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Research Institution | The University of Tokyo |
Principal Investigator |
NIINO TOSHIKI 東京大学, 生産技術研究所, 教授 (70291929)
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Project Period (FY) |
2011-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥50,180,000 (Direct Cost: ¥38,600,000、Indirect Cost: ¥11,580,000)
Fiscal Year 2013: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
Fiscal Year 2012: ¥9,880,000 (Direct Cost: ¥7,600,000、Indirect Cost: ¥2,280,000)
Fiscal Year 2011: ¥29,120,000 (Direct Cost: ¥22,400,000、Indirect Cost: ¥6,720,000)
|
Keywords | additive manufacturing / tissue engineering / laser sintering / 3D printing / アディティブマニュファクチャリング / 組織工学 / レーザー焼結 / 臓器再構築 / 担体 / 3Dプリンティング / 付加製造 |
Outline of Final Research Achievements |
Tissue engineering is basically composed of the three technologies which are concerning cells, their culture and scaffold. This research is concerning the fabrication of tissue engineering scaffold with laser sintering, one of so-called 3D printer technology. In this research, short wave length of 1.1 microns was selected to reduce the laser spot diameter, while typical commerciall systems employ 11microns, and a prototype scaffold was successfully developed out of typical scaffold material of Polycaprolactone. Fabrication technique that reduces powder bed temperature was developed. Material of porogen powder was switched from sodium chloride to less heat conductive and alkaline soluble plastic. Owing two these developments, precision of scaffold was roughly doubled. Hydrophilicity treatment of PCL scaffold with alkaline solution was established to improve cell adhesion. Resultantly, stability of cell culture of HepG2 cells was improved.
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Report
(4 results)
Research Products
(57 results)
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[Presentation] 付加製造の現状と将来性2014
Author(s)
新野俊樹
Organizer
第81回レーザー加工学会講演会
Place of Presentation
大阪府
Year and Date
2014-05-27 – 2014-05-28
Related Report
Invited
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[Presentation] 付加製造技術の現状と将来性2014
Author(s)
新野俊樹
Organizer
レーザー学会学術講演会第34回年次大会
Place of Presentation
福岡県
Year and Date
2014-01-20 – 2014-01-22
Related Report
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