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Micro communicator - Bio-semiconductor interface devices with ultra-low invasiveness

Research Project

Project/Area Number 23246068
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Electron device/Electronic equipment
Research InstitutionNara Institute of Science and Technology

Principal Investigator

OHTA JUN  奈良先端科学技術大学院大学, 物質創成科学研究科, 教授 (80304161)

Co-Investigator(Kenkyū-buntansha) SHIOSAKA Sadao  奈良先端科学技術大学院大学, バイオサイエンス研究科, 教授 (90127233)
ZHANG Bing  独立行政法人情報通信研究機構, 新世代ワイヤレス研究センター, 主任研究員 (90358888)
LI Karen  独立行政法人情報通信研究機構, 新世代ワイヤレス研究センター, 主任研究員 (30359062)
Co-Investigator(Renkei-kenkyūsha) TOKUDA Takashi  奈良先端科学技術大学院大学, 物質創成科学研究科, 准教授 (50314539)
SASAGAWA Kiyotaka  奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (50392725)
NODA Toshihiko  奈良先端科学技術大学院大学, 物質創成科学研究科, 助教 (20464159)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥49,270,000 (Direct Cost: ¥37,900,000、Indirect Cost: ¥11,370,000)
Fiscal Year 2013: ¥15,210,000 (Direct Cost: ¥11,700,000、Indirect Cost: ¥3,510,000)
Fiscal Year 2012: ¥16,250,000 (Direct Cost: ¥12,500,000、Indirect Cost: ¥3,750,000)
Fiscal Year 2011: ¥17,810,000 (Direct Cost: ¥13,700,000、Indirect Cost: ¥4,110,000)
Keywordsバイオデバイス / 体内埋植 / 生体内伝導通信 / 2次元通信 / CMOS / イメージセンサ / 埋植 / 蛍光 / 分散埋植 / 低侵襲 / マイクロコミュニケータ
Research Abstract

We proposed and demonstrated a u-COM network which enables a bio-semiconductor fusion system, and succeeded in the following results; (1) image transmission experiments through a brain as a transmission medium, (2) proposal and demonstration of an ultra-small imaging device with daisy-chain architecture to reduce wiring, and (3) demonstration of 2-dimensional communication experiments using a brain phantom. These results show a possibility for a bio-semiconductor fusion system by a u-COM brain network system.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (49 results)

All 2014 2013 2012 2011 Other

All Journal Article (9 results) (of which Peer Reviewed: 9 results) Presentation (34 results) (of which Invited: 21 results) Book (5 results) Remarks (1 results)

  • [Journal Article] Functional brain fluorescence plurimetry in rat by implantable concatenated CMOS imaging system2013

    • Author(s)
      T.Kobayashi, H.Masuda, C.Kitsumoto, M.Haruta, M.Motoyama, Y.Ohta, T.Noda, K.Sasagawa, T.Tokuda, S.Shiosaka, J.Ohta
    • Journal Title

      Biosensors and Bioelectronics

      Volume: 53 Pages: 31-36

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Image sensor pixel with on-chip high extinction ratio polarizer based on 65-nm standard CMOS technology2013

    • Author(s)
      K.Sasagawa, S.Shishido, K.Ando, H.Matsuoka, T.Noda, T.Tokuda, K.Kakiuchi, J.Ohta
    • Journal Title

      Optics Express

      Volume: 21(9) Pages: 11132-11140

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A CMOS optoelectronic neural interface device based on an image sensor with on-chip light stimulation and extracellular neural signal recording for Optogenetics2013

    • Author(s)
      Y.Sawadsaringkarn, T.Miyatani, T.Noda, K.Sasagawa, T.Tokuda, J.Ohta
    • Journal Title

      ITE Trans. Media Tech. and Applications

      Volume: 1(2) Pages: 184-189

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Novel implantable imaging system for enabling simultaneous multiplanar and multipoint analysis for fluorescence potentiometry in the visual cortex2012

    • Author(s)
      T.Kobayashi, M.Motoyama, H.Masuda, Y.Ohta, M.Haruta, T.Noda, K.Sasagawa, T.Tokuda, H.Tamura,, Y.Ishikawa, S.Shiosaka, J.Ohta
    • Journal Title

      Biosensors and Bioelectronics

      Volume: 38(1) Pages: 321-330

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] CMOS image sensor integrated with micro-LED and multielectrode arrays for the patterned photostimulation and multichannel recording of neuronal tissue2012

    • Author(s)
      A.Nakajima, H.Kimura, Y.Sawadsaringkarn, Y.Maezawa, T.Kobayashi, T.Noda, K.Sasagawa, T.Tokuda, Y.Ishikawa, S.Shiosaka, J.Ohta
    • Journal Title

      Opt. Express

      Volume: 20(6) Pages: 6097-6108

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] 最先端半導体技術応用バイオメディカルデバイス2012

    • Author(s)
      太田 淳, 小林 琢磨, 野田 俊彦, 笹川 清隆, 徳田 崇
    • Journal Title

      電気学会論文誌E

      Volume: 131 Pages: 404-408

    • NAID

      10030533195

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CMOS Imaging Devices for Biomedical Applications2011

    • Author(s)
      J.Ohta, T.Kobayashi, T.Noda, K.Sasagawa, T.Tokuda
    • Journal Title

      IEICE Trans. Commun

      Volume: E94-B(9) Pages: 2454-2460

    • NAID

      10030187425

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Implantable Distributed Biomedical Photonic Devices2011

    • Author(s)
      J.Ohta, A.Tagawa, T.Kobayashi, T.Noda, K.Sasagawa, T.Tokuda
    • Journal Title

      Sensors and Materials

      Volume: 23(7) Pages: 369-379

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Planar Multielectrode Array Coupled Complementary Metal Oxide Semiconductor Image Sensor for in vitro Electrophysiology2011

    • Author(s)
      A.Nakajima, T.Noda, K.Sasagawa, T.Tokuda, Y.Ishikawa, S.Shiosaka, J.Ohta
    • Journal Title

      Jpn. J. Appl. Phys

      Volume: 50(4)

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Presentation] Implantable micro CMOS imaging devices for biomedical applications2013

    • Author(s)
      J.Ohta, T.Noda, K.Sasagawa, T.Tokuda
    • Organizer
      IEEE Optical MEMS and Nanophotonics
    • Place of Presentation
      Kanazawa
    • Year and Date
      2013-08-19
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Implantable CMOS Imaging Devices2013

    • Author(s)
      J.Ohta
    • Organizer
      Int'l Neurotechnology Consortium Workshop
    • Place of Presentation
      Osaka
    • Year and Date
      2013-07-05
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Implantable CMOS Image Sensors for Biomedical Applications2013

    • Author(s)
      J.Ohta
    • Organizer
      Int'l Symp. Photoelectronic Detection and Imaging
    • Place of Presentation
      Beijing (Plenary Talk)
    • Year and Date
      2013-06-26
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Implantable CMOS Devices for Biomedical Applications2013

    • Author(s)
      J.Ohta
    • Organizer
      Int'l Conf. Electron. & Packaging
    • Place of Presentation
      Osaka
    • Year and Date
      2013-04-12
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] CMOS Imaging Devices for Biomedical Applications2012

    • Author(s)
      J.Ohta
    • Organizer
      Int'l Conf. BioElectornics, BioSensors, Biomedical Devices, BioMEMS/NEMS and Applications
    • Place of Presentation
      Singapore (Keynote)
    • Year and Date
      2012-11-20
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Implantable CMOS Image Sensors for Biomedical Applications2012

    • Author(s)
      J.Ohta
    • Organizer
      IEEE EMB/CAS/SMC Workshop Brain-Machine-Body Interfaces
    • Place of Presentation
      San Diego, USA
    • Year and Date
      2012-08-27
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Biomedical CMOS Image Sensors2012

    • Author(s)
      J.Ohta
    • Organizer
      VAIL Computer Elements Workshop
    • Place of Presentation
      Vail, CO, USA
    • Year and Date
      2012-06-26
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] Implantable CMOS Biomedical Devices2012

    • Author(s)
      J.Ohta
    • Organizer
      IEEE Int'l Mtg. Future of Electron Dev., Kansai
    • Place of Presentation
      Osaka
    • Year and Date
      2012-05-10
    • Related Report
      2013 Final Research Report
    • Invited
  • [Presentation] 脳内埋植型イメージセンサ信号送信のための電圧制御発振器の試作2012

    • Author(s)
      横田昇吾, 笹川清隆, 野田俊彦, 徳田崇, 太田淳
    • Organizer
      応用物理学関係連合講演会
    • Place of Presentation
      早稲田大学
    • Year and Date
      2012-03-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] 生体内埋植マイクロコミュニケータ~超低侵襲生体・半導体インターフェイスデバイスを目指して~2011

    • Author(s)
      太田淳, 笹川清隆, 小林琢磨, 野田俊彦, 徳田崇, 塩坂貞夫, デイビスピーター, 松田隆志, 張兵, 李可人
    • Organizer
      映像情報メディア学会情報センシング研究会
    • Place of Presentation
      機械振興会館
    • Year and Date
      2011-09-30
    • Related Report
      2011 Annual Research Report
  • [Presentation] Wireless Intra-Brain Communication for Image Transmission through Mouse Brain2011

    • Author(s)
      K.Sasagawa, T.Matsuda, P.Davis, Z.Bing, K.Li, T.Kobayashi, T.Noda, T.Tokuda, J.Ohta
    • Organizer
      IEEE EMBC
    • Place of Presentation
      Boston, USA
    • Year and Date
      2011-09-01
    • Related Report
      2011 Annual Research Report
  • [Presentation] 無線脳内通信によるマウス脳内画像伝送2011

    • Author(s)
      笹川清隆, 松田隆志, ピーターデイビス, 張兵, 李可人, 小林琢磨, 野田俊彦, 徳田崇, 太田淳
    • Organizer
      2011年映像情報メディア学会年次大会
    • Place of Presentation
      成蹊大学
    • Year and Date
      2011-08-26
    • Related Report
      2011 Annual Research Report
  • [Presentation] Implantable CMOS imaging device with absorption filters for green fluorescence imaging

    • Author(s)
      Yoshinori Sunaga, Makito Haruta, Hironari Takehara, Mayumi Motoyama, Yasumi Ohta, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
    • Organizer
      Photonics West
    • Place of Presentation
      The Moscone Center San Francisco, California, United States
    • Related Report
      2013 Annual Research Report
  • [Presentation] CMOS-based Bio-Implantable Neural Observation and Stimulation Device

    • Author(s)
      Takashi Tokuda
    • Organizer
      International Workshop on Biomedical Engineering Translational Research
    • Place of Presentation
      National Chiao Tung University, Hsinchu City, Taiwan
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Implantable device for intrinsic signals imaging in cortices of freely moving rats

    • Author(s)
      Makito Haruta, Chikara Kitsumoto, Yoshinori Sunaga, Hironari Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
    • Organizer
      Neuroscience2013
    • Place of Presentation
      San Diego Convention Center, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Integrated Microphotonic Devices for Biomedical Applications

    • Author(s)
      Jun Ohta
    • Organizer
      International Conference on BioSensors, BioElectronics, BioMedical Devices, BioMEMS/NEMS and Applications 2013 (Bio4Apps 2013)
    • Place of Presentation
      東京医科歯科大学,東京都文京区
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] CMOS-Based Implantable Brain Imaging Technology

    • Author(s)
      Takashi Tokuda, Makito Haruta, Yasumi Ohta, Mayumi Motoyama, Toshihiko Noda, Kiyotaka Sasagawa, Yasuyuki Ishikawa, Sadao Shiosaka, Jun Ohta
    • Organizer
      2013 International Conferences on Active Media Technology / Brain and Health Informatics (AMT-BHI 2013)
    • Place of Presentation
      前橋テルサ,群馬県前橋市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Functional brain imaging under freely moving experiments by an implantable CMOS imaging device

    • Author(s)
      Makito Haruta, Chikara Kitsumoto, Yoshinori Sunaga,  Hironari Takehara, Toshihiko Noda, Kiyotaka Sasagawa,  Takashi Tokuda, Jun Ohta
    • Organizer
      Asian Symposium on Advanced Image Sensors and Imaging Systems
    • Place of Presentation
      静岡大学,静岡県浜松市
    • Related Report
      2013 Annual Research Report
  • [Presentation] An implantable CMOS device for functional brain imaging under freely moving experiments of rat

    • Author(s)
      Makito Haruta, Chikara Kitsumoto, Yoshinori Sunaga, Hironari Takehara, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda, Jun Ohta
    • Organizer
      2013 International Conference on Solid State Devices and Materials (SSDM)
    • Place of Presentation
      ヒルトン福岡シーホーク, 福岡県福岡市中央区
    • Related Report
      2013 Annual Research Report
  • [Presentation] Implantable micro CMOS imaging devices for biomedical applications

    • Author(s)
      Jun Ohta, Toshihiko Noda, Kiyotaka Sasagawa, Takashi Tokuda
    • Organizer
      Optical MEMS and Nanophotonics 2013
    • Place of Presentation
      金沢文化ホール,石川県金沢市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Implantable Biomedical Devices Based on Microelectronics Technology

    • Author(s)
      Jun Ohta
    • Organizer
      2013 Tsukuba Nanotechnology Symposium (TNS’13)
    • Place of Presentation
      AIST Tsukuba West, 茨城県つくば市
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Needle Type CMOS Imaging Device for Fluorescence Imaging of Deep Brain Activities

    • Author(s)
      Yoshinori Sunaga, Chikara Kitsumoto, Mayumi Motoyama, Yasumi Ohta, Toshihiko Noda, Kiyotaka Sasagawa, Yasuyuki Ishikawa, Takashi Tokuda, Sadao Shiosaka, Jun Ohta
    • Organizer
      The 10th Conference on Lasers and Electro-Optics Pacific Rim(CLEO-PR 2013)
    • Place of Presentation
      国立京都国際会館,京都府京都市左京区
    • Related Report
      2013 Annual Research Report
  • [Presentation] Integrated Bio-Circuits for in Vivo and in Vitro Monitoring and Control of Biological Systems –Introduction and Bio-Circuits in Vivo – (I)

    • Author(s)
      Jun Ohta
    • Organizer
      IEEE Engineering in Medicine and Biology Society (EMBC2013)
    • Place of Presentation
      大阪国際会議場,大阪府大阪市北区
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Implantable Image Sensor Based on Intra-Brain Image Transmission

    • Author(s)
      Kiyotaka Sasagawa, Yoshiaki Ishii, Shogo Yokota, Takashi Matsuda, Peter Davis, Bing Zhang, Keren Li, Toshihiko Noda, Takashi Tokuda, Jun Ohta
    • Organizer
      IEEE Engineering in Medicine and Biology Society (EMBC2013)
    • Place of Presentation
      大阪国際会議場,大阪府大阪市北区
    • Related Report
      2013 Annual Research Report
  • [Presentation] Implantable CMOS Imaging Devices

    • Author(s)
      Jun Ohta
    • Organizer
      IEEE Engineering in Medicine and Biology Society (EMBC2013)
    • Place of Presentation
      大阪国際会議場,大阪府大阪市北区
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Optoelectronics Devices for Biomedical Applications

    • Author(s)
      Takashi Tokuda
    • Organizer
      The 10th Conference on Lasers and Electro-Optics Pacific Rim(CLEO-PR 2013)
    • Place of Presentation
      国立京都国際会館,京都府京都市左京区
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Implantable CMOS Image Sensors for Biomedical Applications

    • Author(s)
      Jun Ohta
    • Organizer
      International Symposium on Photoelectronic Detection and Imaging 2013 (ISPDI 2013)
    • Place of Presentation
      China National Convention Center, Beijing, CHINA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] A Low-Invasive Micro Imaging Device for Measuring Neural Activities Implanted in the Mouse Deep Brain

    • Author(s)
      Jun Ohta, Chiakra Kitsumoto, Makito Haruta, Yoshinori Sunaga, Toshihiko Noda, Kiyotaka Sasagawa,Takashi Tokuda, Mayumi Motoyama, Yasumi Ohta
    • Organizer
      2013 International Image Sensor Workshop(IISW2013)
    • Place of Presentation
      Snowbird Ski & Summer Resort, Utah, USA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Implantable CMOS Devices for Biomedical Applications

    • Author(s)
      Jun Ohta
    • Organizer
      International Conference on Electronics Packaging (ICEP2013)
    • Place of Presentation
      大阪国際会議場,大阪府大阪市北区
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Image Signal Transmission Through Brain by an Implantable Micro-Imager

    • Author(s)
      Kiyotaka Sasagawa, Shogo Yokota, Chikara Kitsumoto, Takashi Matsuda, Peter Davis, Bing Zhang, Keren Li, Toshihiko Noda, Takashi Tokuda, Jun Ohta
    • Organizer
      IEEE Biomedical Circuits and Systems Conference
    • Place of Presentation
      Hsinchu, Taiwan
    • Related Report
      2012 Annual Research Report
  • [Presentation] CMOS Imaging Devices for Biomedical Applications

    • Author(s)
      Jun Ohta
    • Organizer
      "International Conference on BioElectornics, BioSensors, Biomedical Devices, BioMEMS/NEMS and Applications 2012 (Bio4Apps 2012)"
    • Place of Presentation
      Singaphore
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Baseband Signal Transmission Experiment for Intra-Brain Communication with Implantable Image Sensor

    • Author(s)
      Kiyotaka Sasagawa, Shogo Yokota, Takashi Matsuda, Peter Davis, Bing Zhang, Keren Li, Takuma Kobayashi, Toshihiko Noda, Takashi Tokuda, Jun Ohta
    • Organizer
      Annual International IEEE EMBS Conference
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Implantable CMOS Image Sensors for Biomedical Applications

    • Author(s)
      Jun Ohta
    • Organizer
      IEEE EMB/CAS/SMC Workshop on Brain-Machine-Body Interfaces
    • Place of Presentation
      San Diego, USA
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Implantable CMOS Biomedical Devices

    • Author(s)
      Jun Ohta
    • Organizer
      IEEE International Meeting for Future of Electron Devices, Kansai  (IMFEDK 2012)
    • Place of Presentation
      Suita, Osaka, Japan
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Book] Implantable CMOS imaging devices in Evgeny Katz, Ed., Implantable Bioelectronics -Devices, Materials and Applications-2014

    • Author(s)
      J.Ohta (分担執筆)
    • Publisher
      Wiley-VCH
    • Related Report
      2013 Final Research Report
  • [Book] 「第3章人工視覚-生体埋植用イメージセンサ-」,スマート・ヒューマンセンシング~健康ビッグデータ時代のためのセンサ・情報・エネルギー技術~(三林浩二監修)2014

    • Author(s)
      太田 淳
    • Total Pages
      265
    • Publisher
      シーエムシー出版
    • Related Report
      2013 Annual Research Report
  • [Book] "Chap.10 Implantable CMOS Imaging Devices" in Implantable Bioelectronics (Evgeny Katz ed.)2014

    • Author(s)
      Jun Ohta
    • Total Pages
      472
    • Publisher
      WILEY-VCH
    • Related Report
      2013 Annual Research Report
  • [Book] オペアンプの応用(I),アナログ電子回路(永田真編著)2013

    • Author(s)
      太田 淳 (分担執筆)
    • Publisher
      オーム社
    • Related Report
      2013 Final Research Report
  • [Book] 高機能イメージセンサの概要, 映像情報メディア学会編 CMOS イメージセンサ (相澤清晴,浜本隆之編著)2012

    • Author(s)
      太田 淳 (分担執筆)
    • Publisher
      コロナ社
    • Related Report
      2013 Final Research Report
  • [Remarks]

    • URL

      http://mswebs.naist.jp/LABs/pdslab/index-j.html

    • Related Report
      2013 Final Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

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