Formation process of self-organized nano-pore arrays on metal substrates and their applications to metallic biomaterials

• Project/Area Number: 23246128
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Material processing/treatments
• Research Institution: Osaka University
• Principal Investigator: FUJIMOTO SHINJI 大阪大学, 工学(系)研究科(研究院), 教授 (70199371)
• Co-Investigator(Kenkyū-buntansha): TSUCHIYA Hiroaki 大阪大学, 大学院工学研究科, 准教授 (50432513) ; MIYABE Sayaka 大阪大学, 大学院工学研究科, 助教 (50584132)
• Co-Investigator(Renkei-kenkyūsha): HIROMOTO Sachiko 独立行政法人物質・材料研究機構 (00343880)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥47,450,000 (Direct Cost: ¥36,500,000、Indirect Cost: ¥10,950,000); Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000); Fiscal Year 2012: ¥24,830,000 (Direct Cost: ¥19,100,000、Indirect Cost: ¥5,730,000); Fiscal Year 2011: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
• Keywords: ナノホールアレイ / 自己組織化 / 生体材料 / 生体適合性 / 腐食防食 / 電気化学 / 表面機能化 / ステンレス鋼 / 生体親和性 / ナノポーラス / 電気化学プロセス / チタン・チタン合金 / コバルト・クロム合金

Research Abstract

The present work examined the electrochemical formation of self-organized nano-porous structures on metallic biomaterials and evaluates their biocompatibility. Self-organized nano-porous structures were formed on stainless steels, titanium and cobalt-chromium alloy although optimized condition for the pore formation was different depending on the substrates. Cell proliferation was enhanced on porous Type316L stainless steel surfaces compared to a flat stainless steel surface. Repassivation that is one of the most essential factors to suppress metal dissolution induced by deformation was facilitated by the presence of nano-porous structures on stainless steel surface. These findings demonstrated that the formation of self-organized nano-porous structure on stainless steel surface can improve the biocompatibility as well as corrosion resistance during the deformation of stainless steel.

Research Products

• [Journal Article] Breakdown of Passive Films and Repassivation of Ti-6Al-4V Alloy with Rapid Elongation in Simulated Body Fluid including Osteoblast-like Cells (2013)
  • Author(s): Kotaro Doi, Sayaka Miyabe, Shinji Fujimoto
  • Journal Title: Journal of the Electrochemical Society Volume: 160 Issue: 11 Pages: C576-C580
  • DOI: 10.1149/2.085311jes
• [Journal Article] Formation of self-organized pores on type 316 stainless steel in organic solvents (2012)
  • Author(s): Hiroaki Tsuchiya
  • Journal Title: Electrochimica Acta Volume: 82 Pages: 333-338
  • DOI: 10.1016/j.electacta.2012.06.048
  • Peer Reviewed
• [Presentation] ステンレス鋼ナノホールアレイを用いた薬剤徐放システムの検討 (2014)
  • Author(s): 藤永悠志、宮部さやか、土谷博昭、藤本慎司
  • Organizer: 日本金属学会
  • Place of Presentation: 東京工業大学
• [Presentation] 模擬体液中で繰返し変形させたTi-6Al-4V合金のき裂発生・進展挙動の電気化学的検討 (2014)
  • Author(s): 土井康太郎、宮部さやか、藤本慎司
  • Organizer: 日本金属学会
  • Place of Presentation: 東京工業大学
• [Presentation] Repassivation on Type 316L Stainless Steel with Cyclic Deformation in Simulated Body Fluid including Cells (2013)
  • Author(s): Kotaro Doi, Sayaka Miyabe, Shinji Fujimoto
  • Organizer: 224th Meeting of the Electrochemical Society
  • Place of Presentation: The Hilton San Francisco Hotel
• [Presentation] 模擬体液中で繰返し応力を付与したSUS316Lステンレス鋼の溶解・再不働態化挙動 (2013)
  • Author(s): 土井康太郎、宮部さやか、藤本慎司
  • Organizer: 日本金属学会
  • Place of Presentation: 金沢大学
• [Presentation] 陰極析出によるSUS316Lステンレス鋼基板へのアパタイト被覆 (2013)
  • Author(s): 中尾拓哉、宮部さやか、土谷博昭、藤本慎司
  • Organizer: 日本金属学会
  • Place of Presentation: 金沢大学
• [Presentation] 自己組織化ナノ細孔を形成したSUS316Lステンレス鋼の薬剤徐放性の検討 (2013)
  • Author(s): 藤永悠志、宮部さやか、土谷博昭、藤本慎司
  • Organizer: 日本金属学会
  • Place of Presentation: 金沢大学
• [Presentation] 細胞培養下のTi-6Al-4V合金の変形に伴う不働態破壊と再不働態化挙動 (2013)
  • Author(s): 土井康太郎、宮部さやか、藤本慎司
  • Organizer: 第60回材料と環境討論会
  • Place of Presentation: コラッセふくしま
• [Presentation] Repassivation on Type 316L Stainless Steel with Cyclic Deformation in (2013)
  • Author(s): Kotaro Doi, Sayaka Miyabe, Shinji Fujimoto
  • Organizer: 224th Meeting of the Electrochemical Society
  • Place of Presentation: The Hilton San Francisco Hotel
• [Presentation] 模擬生体環境におけるSUS316L,Co-Cr合金および純Tiのガルバニック腐食挙動 (2012)
  • Author(s): 志田夏美, 宮部さやか, 藤本慎司
  • Organizer: 電気化学会
  • Place of Presentation: アクトシティ浜松
  • Year and Date: 2012-03-31
• [Presentation] Metal Dissolution and Repassivation Behavior of Ti6Al4V Alloy during Rapid Straining in Simulated Body Fluid (2012)
  • Author(s): Kotaro Doi, Sayaka Miyabe, Shinji Fujimoto
  • Organizer: 222nd Meeting of the Electrochemical Society
  • Place of Presentation: The Hilton San Francisco Hotel
• [Presentation] ナノホール構造を付与した316Lステンレス鋼の生体適合性 (2012)
  • Author(s): 中尾拓哉、末廣隆史、宮部さやか、土谷博昭、藤本慎司
  • Organizer: 日本金属学会
  • Place of Presentation: 愛媛大学
• [Presentation] ナノホール表面を有するSUS316L鋼の急速ひずみに伴う変形・溶解挙動 (2012)
  • Author(s): 土井康太郎、宮部さやか、土谷博昭、藤本慎司
  • Organizer: 日本金属学会
  • Place of Presentation: 愛媛大学
• [Presentation] Passive Films Breakdown of Ti-6Al-4V Alloy with Rapid Deformation in Simulated Body Fluid (2012)
  • Author(s): Shinji Fujimoto
  • Organizer: Gordon Research Conference
  • Place of Presentation: New London, USA
• [Presentation] In Vitro Galvanic Corrosion of Metallic Biomaterials (2012)
  • Author(s): Shinji Fujimoto
  • Organizer: 222nd Meeting of The Electrochemical Society
  • Place of Presentation: Honolulu, Hawaii
• [Presentation] Metal Dissolution and Repassivation Behavior of Ti6Al4V Alloy during Rapid Straining in Simulated Body Fluid (2012)
  • Author(s): Shinji Fujimoto
  • Organizer: 222nd Meeting of The Electrochemical Society
  • Place of Presentation: Honolulu, Hawaii
• [Presentation] ナノホール表面を有するSUS316L鋼の急速ひずみに伴う変形・溶解挙動 (2012)
  • Author(s): 藤本慎司
  • Organizer: 日本金属学会秋期講演大会
  • Place of Presentation: 愛媛大学
• [Presentation] ナノホール構造を付与した316Lステンレス鋼の生体適合性 (2012)
  • Author(s): 藤本慎司
  • Organizer: 日本金属学会秋期講演大会
  • Place of Presentation: 愛媛大学
• [Presentation] 有機溶媒電気化学プロセスによるFe-Cr合金表面のポーラス化 (2011)
  • Author(s): 寺田圭徹, 鈴村貴大, 土谷博昭, 藤本慎司
  • Organizer: 日本鉄鋼協会・日本金属学会関西支部材料化学研究会・鉄鋼プロセス研究会合同研究会
  • Place of Presentation: 大阪大学
  • Year and Date: 2011-12-16
• [Presentation] 模擬体液中で急速ひずみを付与したSUS316L鋼の溶解挙動 (2011)
  • Author(s): 土井康太郎, 宮部さやか, 藤本慎司
  • Organizer: 日本金属学会秋季講演大会
  • Place of Presentation: 沖縄コンベンションセンター
  • Year and Date: 2011-11-07
• [Presentation] 電解処理によるステンレス鋼表面ナノポーラス化に及ぼす電気化学条件の影響 (2011)
  • Author(s): 鈴村貴大, 土谷博昭, 藤本慎司
  • Organizer: 電気化学会
  • Place of Presentation: 朱鷺メッセ
  • Year and Date: 2011-09-09
• [Presentation] 模擬生体環境下における金属系バイオマテリアルのガルバニック腐食挙動 (2011)
  • Author(s): 志田夏美, 宮部さやか, 藤本慎司
  • Organizer: 電気化学会
  • Place of Presentation: 朱鷺メッセ
  • Year and Date: 2011-09-09
• [Presentation] 電解処理によるステンレス鋼表面ナノポーラス化に及ぼす電気化学条件の影響 (2011)
  • Author(s): 鈴村貴大、土谷博昭、藤本慎司
  • Organizer: 電気化学会
  • Place of Presentation: 朱鷲メッセ