A role for noncoding RNA in recognition of homologous chromosomes
| Project/Area Number |
23247003
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Genetics/Genome dynamics
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| Research Institution | Osaka University |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
ASAKAWA Haruhiko 大阪大学, 大学院生命機能研究科, 助教 (70399533)
CHIKASHIGE Yuji (独)情報通信研究機構, 未来ICT 研究所, 主任研究員 (60359081)
DING Da-qiao (独)情報通信研究機構, 未来ICT 研究所, 主任研究員 (50359080)
OBUSE Chikashi 北海道大学, 先端生命科学研究院, 教授 (00273855)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥48,490,000 (Direct Cost: ¥37,300,000、Indirect Cost: ¥11,190,000)
Fiscal Year 2013: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2012: ¥15,990,000 (Direct Cost: ¥12,300,000、Indirect Cost: ¥3,690,000)
Fiscal Year 2011: ¥16,510,000 (Direct Cost: ¥12,700,000、Indirect Cost: ¥3,810,000)
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| Keywords | 染色体 / 非コードRNA / 減数分裂 |
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| Research Abstract |
Meiosis is an essential process for sexually-reproducing organisms. During meiosis, homologous chromosomes pair with each other and undergo homologous recombination, which is crucial for proper segregation of chromosomes. In the fission yeast Schizosaccharomyces pombe, clustering of telomeres promotes homologous chromosome pairing. However, the mechanisms by which chromosomes recognize their homologous partners remain unclear. We demonstrate that the sme2 gene encodes a meiosis-specific noncoding RNA that mediates homologous recognition in S. pombe. The sme2 RNA transcripts accumulate at their respective gene loci, and greatly enhances pairing of homologous loci: deletion of the sme2 sequence eliminates this robust pairing while transposition to other chromosomal sites confers the robust pairing at those sites. Results indicate that RNA transcripts retained on the chromosome play a role in recognition of homologous chromosomes in S. pombe.
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Report
(4 results)
Research Products
(91 results)
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[Journal Article] Microtubule -organizing center formation at telomeres induces meiotic telomere clustering2013
Author(s)
Yoshida M, Katsuyama S, Tateho K, Nakamura H, Miyoshi J, Ohba T, Matsuhara H, Miki F, Okazaki K, Haraguchi T, Niwa O, Hiraoka Y, Yamamoto A
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Journal Title
J. Cell Biol
Volume: 200
Issue: 4
Pages: 385-395
DOI
Related Report
Peer Reviewed
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[Journal Article] The CCR4-NOT Complex Is Implicated in the Viability of Aneuploid Yeasts2012
Author(s)
Tange Y, Kurabayashi A, Goto B, Hoe K-L, Kim D-U, Park H-O, Hayles J, Chikashige Y, Tsutumi C, Hiraoka Y, Yamao F, Nurse P, Niwa O
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Journal Title
PLoS Genetics
Volume: 8
Issue: 6
Pages: e1002776-e1002776
DOI
Related Report
Peer Reviewed
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[Presentation] The Nuclear Envelope in Meiosis2012
Author(s)
Hiraoka Y
Organizer
The 20th Jerusalem School in Life Sciences"Nuclear Organization, Dynamics and Activity"
Place of Presentation
Israel Institute for Advanced Studiesat the Hebrew University, Israel
Year and Date
2012-07-23
Related Report
Invited
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[Presentation] 3D imaging2011
Author(s)
平岡泰
Organizer
第17回細胞生物学ワークショップ
Place of Presentation
情報通信研究機構、兵庫県(招待講演)
Year and Date
2011-08-09
Related Report
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[Presentation] 蛍光顕微鏡の基礎2011
Author(s)
平岡泰
Organizer
第17回細胞生物学ワークショップ
Place of Presentation
情報通信研究機構、兵庫県(招待講演)
Year and Date
2011-08-08
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[Presentation] The Nuclear Envelope in Meiosis
Author(s)
Hiraoka Y.
Organizer
The 20th Jerusalem School in Life Sciences“Nuclear Organization, Dynamics and Activity”
Place of Presentation
Israel Institute for Advanced Studies at the Hebrew University ( Israel)
Related Report
Invited
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