| Project/Area Number |
23247010
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Morphology/Structure
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| Research Institution | The University of Tokyo |
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Principal Investigator |
TAKEI Yoshio 東京大学, 大気海洋研究所, 教授 (10129249)
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| Co-Investigator(Kenkyū-buntansha) |
KUSAKABE Makoto 東京大学, 大気海洋研究所, 助教 (40451893)
MUKUDA Takao 鳥取大学, 医学部, 講師(現職) (60346335)
安藤 正昭 東京大学, 大気海洋研究所, 研究員 (10100976)
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| Co-Investigator(Renkei-kenkyūsha) |
NOBATA Shigenori 東京大学, 大気海洋研究所, 特任研究員 (00522690)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥48,750,000 (Direct Cost: ¥37,500,000、Indirect Cost: ¥11,250,000)
Fiscal Year 2013: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2012: ¥14,430,000 (Direct Cost: ¥11,100,000、Indirect Cost: ¥3,330,000)
Fiscal Year 2011: ¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
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| Keywords | 浸透圧調節 / 海水適応 / 飲水行動 / 腸による吸収 / 比較内分泌 / 水・電解質代謝 / ウナギ / トランスポーター / トランスクリプトーム解析 / 上皮輸送 / レニン・アンジオテンシン / ナトリウム利尿ペプチド / グアニリン / 脳ホルモン / 消化管ホルモン / イオン輸送体 / 腎作用 |
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| Research Abstract |
Marine teleosts drink copiously and absorb 90% of ingested seawater by the intestine to cope with osmotic dehydration. Thus, drinking and subsequent absorption of water by the intestine is essential to survive in hyperosmotic marine environment. The transcriptome analyses showed that the brain (regulatory site for drinking) and the gut (regulatory site for absorption) express several hormone genes and their expression is upregulated after transfer of eels to seawater. Furthermore, the brain and the gut interact with each other by regulating drinking and intestinal absorption through blood stream or via innervated nerves. We are currently performing tissue-specific knockdown of such important genes in medaka to evaluate their roles in seawater adaptation. This is the first study that demonstrate interactions between brain and gut via hormones for seawater adaptation.
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