Structural Basis for the chromatin remodeling by nuclear receptors
| Project/Area Number |
23247016
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Structural biochemistry
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| Research Institution | International Institute for Advanced Studies |
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Principal Investigator |
MORIKAWA Kosuke 公益財団法人国際高等研究所, チーフリサーチフェロー (80012665)
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| Co-Investigator(Renkei-kenkyūsha) |
TSUNAKA Yasuo 京都大学, 物質-細胞統合システム拠点, 特任講師 (40551552)
FUKAGAWA Tatsuo 国立遺伝学研究所, 分子遺伝研究系, 教授 (60321600)
ANDO Toshio 金沢大学, 数物科学系, 教授 (50184320)
MAYANAGI Kota 九州大学, 生体防御医学研究所, 助教 (50418571)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥48,490,000 (Direct Cost: ¥37,300,000、Indirect Cost: ¥11,190,000)
Fiscal Year 2013: ¥15,340,000 (Direct Cost: ¥11,800,000、Indirect Cost: ¥3,540,000)
Fiscal Year 2012: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2011: ¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
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| Keywords | 核内受容体 / クロマチン / 構造生物学 / 発現制御 |
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| Research Abstract |
Nuclear receptors belong to a class of transcription factors that function at the initial stage of gene regulation mechanisms, in response to environmental changes. We studied the interaction of nuclear receptors with in-vitro reconstituted nucleosomes by biochemical experiments. We found that the nucleosome functions as a barrier and prevents the specific binding of nuclear receptors to DNA. These results suggest that the chromatin remodeling should be the prerequisite for the docking of nuclear receptors onto the target DNA sequence in the genome.
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Report
(4 results)
Research Products
(24 results)
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[Journal Article] Architectures of archaeal GINS complexes, essential DNA replication initiation factors2011
Author(s)
Takuji Oyama, Sonoko Ishino, Seiji Fujino, Hiromi Ogino, Tsuyoshi Shirai, Kouta Mayanagi, Mihoko Saito, Naoko Nagasawa, Yoshizumi Ishino, & Kosuke Morikawa
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Journal Title
BMC Biol.
Volume: 9
Issue: 1
Pages: 1-17
DOI
Related Report
Peer Reviewed
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[Presentation] Structural basis for the activation of the nuclear receptor, PPARgamma, by fatty acid-and serotonin metabolites.
Author(s)
Waku, T., Shiraki, T., Oyama, T., Shionyu, C. & Morikawa, K.
Organizer
第85回日本生化学会大会
Place of Presentation
福岡国際会議場・マリンメッセ福岡、福岡
Related Report
Invited
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[Presentation] The Synergistic Stimulation of the MCM Activity by Cdc6/Orc1 and GINS Homotetramer from the Archaeon,Thermoplasma Acidophilum.
Author(s)
2. Ogino, H., Ishino, S., Mayanagi, K., Oyama, T., Shiraki, T., Morikawa, K., Haugland, G. T., Birkeland, N-K. & Ishino, Y.
Organizer
第35回日本分子生物学会年会
Place of Presentation
福岡国際会議場・マリンメッセ福岡、福岡
Related Report
