Origin of autophagic membrane: study on organelle biogenesis

• Project/Area Number: 23247034
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Cell biology
• Research Institution: Osaka University
• Principal Investigator: YOSHIMORI Tamotsu 大阪大学, 生命機能研究科, 教授 (60191649)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥48,490,000 (Direct Cost: ¥37,300,000、Indirect Cost: ¥11,190,000); Fiscal Year 2013: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000); Fiscal Year 2012: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000); Fiscal Year 2011: ¥15,470,000 (Direct Cost: ¥11,900,000、Indirect Cost: ¥3,570,000)
• Keywords: たんぱく質分解 / オートファゴソーム / ミトコンドリア / 小胞体 / 発がん / 神経変性疾患 / 感染症 / オルガネラ / 再循環エンドソーム / 膜の起源 / Atg9 / ゴルジ体 / Atg14L / 小胞体-ミトコンドリア接触点 / Syntaxin17 / 小胞体・ミトコンドリア接触サイト / 電子線トモグラフィー / SNARE

Research Abstract

Autophagy is an intracellular degradation system having multiple functions from development and differentiation to suppression of tumorigenesis, neurodegeneration, infectious diseases, etc. The membrane-bound compartment, atuophagosome executes autophagy. Where autophagosome is formed has been a target of the long-standing debate. In this project we demonstrated that is is formed the contact sites between mitochondria and the endoplasmic reticulum. Our finding resolved the enigma and provided useful information for developing autophagy regulating therapy.

Research Products

• [Journal Article] Structural Basis of the Autophagy-Related LC3/Atg13 LIR Complex : Recognition and Interaction Mechanism (2014)
  • Author(s): Suzuki H, Tabata K, Morita E, Kawasaki M, Kato R, Dobson RC, Yoshimori T, Wakatsuki S
  • Journal Title: Structure. Volume: 22 Issue: 1 Pages: 47-58
  • DOI: 10.1016/j.str.2013.09.023
  • Peer Reviewed / Open Access
• [Journal Article] Recruitment of the autophagic machinery to endosomes during infection is mediated by ubiquitin (2013)
  • Author(s): Naonobu Fujita et al.
  • Journal Title: J. Cell Biol. Volume: 203 Issue: 1 Pages: 115-128
  • DOI: 10.1083/jcb.201304188
  • Peer Reviewed / Open Access
• [Journal Article] Autophagy Induced by HIF1α Overexpression Supports Trophoblast Invasion by Supplying Cellular Energy (2013)
  • Author(s): Yamanaka-Tatematsu M, Nakashima A, Fujita N, Shima T, Yoshimori T, Saito S
  • Journal Title: PLoS One. Volume: 8 Issue: 10 Pages: e76605-e76605
  • DOI: 10.1371/journal.pone.0076605
  • Peer Reviewed / Open Access
• [Journal Article] Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy. (2013)
  • Author(s): Ichimura, Y., Waguri, S., Sou, Y., Kageyama, S., Hasegawa, J., Ishimura, R., Saito, T., Yang, Y., Kouno, T., Fukutomi, T., Hoshii, T., Atsushi, H., Takagi, K., Mizushima, T., Motohashi, H., Lee, M-S., Yoshimori, T., Tanaka, K., Yamamoto, M., and Komatsu, K.
  • Journal Title: Mol Cell Volume: 51 Issue: 5 Pages: 618-631
  • DOI: 10.1016/j.molcel.2013.08.003
  • Peer Reviewed / Open Access
• [Journal Article] TRAPPIII is responsible for the vesicular transport from early endosomes to the Golgi apparatus that facilitates Atg9 cycling in autophagy (2013)
  • Author(s): Shirahama-Noda K, Kira S, Yoshimori T, Noda T
  • Journal Title: J Cell Sci. Volume: 126 Pages: 4963-73
  • DOI: 10.1242/jcs.131318
  • Peer Reviewed / Open Access
• [Journal Article] Autophagy sequesters damaged lysosomes to control lysosomal biogenesis and kidney injury (2013)
  • Author(s): Maejima I, Takahashi A, Omori H, Kimura T, Takabatake Y, Saitoh T, Yamamoto A, Hamasaki M, Noda T, Isaka Y, Yoshimori T
  • Journal Title: EMBO J. Volume: 32 Issue: 17 Pages: 2336-47
  • DOI: 10.1038/emboj.2013.171
  • Peer Reviewed / Open Access
• [Journal Article] Autophagy Has a Significant Role in Determining Skin Color by Regulating Melanosome Degradation in Keratinocytes (2013)
  • Author(s): Murase D, Hachiya A, Takano K, Hicks R, Visscher MO, Kitahara T, Hase T, Takema Y, Yoshimori T
  • Journal Title: J Invest Dermatol. Volume: 133 Issue: 10 Pages: 2416-24
  • DOI: 10.1038/jid.2013.165
  • Peer Reviewed / Open Access
• [Journal Article] Autophagosomes form at ER.mitochondria contact sites (2013)
  • Author(s): Hamasaki M, Furuta N, Matsuda A, Nezu A, Yamamoto A, Fujita N, Oomori H, Noda T, Haraguchi T, Hiraoka Y, Amano A, Yoshimori T
  • Journal Title: Nature Volume: 495 Issue: 7441 Pages: 389-93
  • DOI: 10.1038/nature11910
  • Peer Reviewed
• [Journal Article] Vacuolating Cytotoxin and Variants in Atg16L1 That Disrupt Autophagy Promote Helicobacter pylori Infection in Humans (2012)
  • Author(s): Raju D, Hussey S, Ang M, Terebiznik MR, Sibony M, Galindo-Mata E, Gupta V, Blanke SR, Delgado A, Romero-Gallo J, Ramjeet MS, Mascarenhas H, Peek RM, Correa P, Streutker C, Hold G, Kunstmann E, Yoshimori T, Silverberg MS, Girardin SE, Philpott DJ, El Omar E, Jones NL
  • Journal Title: Gastroenterology. Volume: 142 Issue: 5 Pages: 1160-71
  • DOI: 10.1053/j.gastro.2012.01.043
  • Peer Reviewed
• [Journal Article] Autophagy guards against cisplatin-induced acute kidney injury (2012)
  • Author(s): 高橋篤史,松阪泰二、新村文男, 他
  • Journal Title: Am J Pathol Volume: 180 Issue: 2 Pages: 517-525
  • DOI: 10.1016/j.ajpath.2011.11.001
  • Peer Reviewed
• [Journal Article] Autophagy guards against Cisplatin-induced acute kidney injury (2012)
  • Author(s): Takahashi A, Kimura T, Takabatake Y, Namba T, Kaimori J, Kitamura H, Matsui I, Niimura F, Matsusaka T, Fujita N, Yoshimori T, Isaka Y, Rakugi H
  • Journal Title: Am J Pathol Volume: 180 Pages: 517-25
  • Peer Reviewed
• [Journal Article] Inhibition of autophagy potentiates the antitumor effect of the multikinase inhibitor sorafenib in hepatocellular carcinoma (2011)
  • Author(s): Shimizu S, Takehara T, Hikita H, Kodama T, Tsunematsu H, Miyagi T, Hosui A, Ishida H, Tatsumi T, Kanto T, Hiramatsu N, Fujita N, Yoshimori T, Hayashi N
  • Journal Title: Int.J.Cancer Volume: 131 Issue: 3 Pages: 548-57
  • DOI: 10.1002/ijc.26374
  • Peer Reviewed
• [Journal Article] Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12-5-16L2 complex (2011)
  • Author(s): Ishibashi K, Fujita N, Kanno E, Omori H, Yoshimori T, Itoh T, Fukuda M
  • Journal Title: Autophagy. Volume: 7 Pages: 1500-13
  • URL: http://www.ncbi.nlm.nih.gov/pubmed/22082872
  • Peer Reviewed
• [Journal Article] Dysfunction of autophagy participates in vacuole formation and cell death in cells replicating hepatitis C virus (2011)
  • Author(s): Taguwa S., Kambara H., Fujita N., Noda T., Yoshimori T., Koike K., Moriishi K., and Matsuura Y.
  • Journal Title: J. Virol Volume: 85 Issue: 24 Pages: 13185-13194
  • DOI: 10.1128/jvi.06099-11
  • Peer Reviewed
• [Journal Article] Proteome of ubiquitin/MVB pathway : possible involvement of iron-induced ubiquitylation of transferrin receptor in lysosomal degradation (2011)
  • Author(s): Tachiyama R, Ishikawa D, Matsumoto M, Nakayama KI, Yoshimori T, Yokota S, Himeno M, Tanaka Y, Fujita H
  • Journal Title: Genes Cells Volume: 16 Issue: 4 Pages: 448-66
  • DOI: 10.1111/j.1365-2443.2011.01499.x
  • Peer Reviewed
• [Journal Article] A Sensitive and Quantitative Technique for Detecting Autophagic Events Based on Lysosomal Delivery (2011)
  • Author(s): Katayama, et al
  • Journal Title: Chemistry & Biology Volume: 18 Issue: 8 Pages: 1042-1052
  • DOI: 10.1016/j.chembiol.2011.05.013
  • Peer Reviewed
• [Journal Article] The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella (2011)
  • Author(s): Kageyama S, Omori H, Saitoh T, Sone T, Guan JL, Akira S, Imamoto F, Noda T, Yoshimori T
  • Journal Title: Mol Biol Cell. Volume: 22 Issue: 13 Pages: 2290-300
  • DOI: 10.1091/mbc.e10-11-0893
  • Peer Reviewed
• [Journal Article] The LC3 recruitment mechanism is separate from Atg9L1-dependent membrane formation in the autophagic response against Salmonella (2011)
  • Author(s): Kageyama S, Omori H, Saitoh T, Sone T, Guan JL, Akira S, Imamoto F, Noda T, Yoshimori T
  • Journal Title: Mol Biol Cell Volume: 22 Pages: 2290-300
  • Peer Reviewed
• [Journal Article] A sensitive and quantitative technique for detecting autophagic events based on lysosomal delivery (2011)
  • Author(s): Katayama H, Kogure T, Mizushima N, Yoshimori T, Miyawaki A
  • Journal Title: Chem Biol Volume: 18 Pages: 1042-52
  • Peer Reviewed
• [Journal Article] Dysfunction of autophagy participates in vacuole formation and cell death in cells replicating hepatitis C virus (2011)
  • Author(s): Taguwa S, Kambara H, Fujita N, Noda T, Yoshimori T, Koike K, Moriishi K, Matsuura Y
  • Journal Title: J Virol Volume: 85 Pages: 13185-94
  • Peer Reviewed
• [Journal Article] Atg16L2, a novel isoform of mammalian Atg16L that is not essential for canonical autophagy despite forming an Atg12-5-16L2 complex (2011)
  • Author(s): Ishibashi K, Fujita N, Kanno E, Omori H, Yoshimori T, Itoh T, Fukuda M
  • Journal Title: Autophagy Volume: 7(Epub ahead of print)
  • Peer Reviewed
• [Presentation] New insights into membrane dynamics in autophagy (2014)
  • Author(s): Tamotsu Yoshimori
  • Organizer: APOCB Congress and ASCB Workshops
  • Place of Presentation: Biopolis, Singapore
  • Year and Date: 2014-02-25
• [Presentation] New insights into autophagosome formation (2014)
  • Author(s): Tamotsu Yoshimori
  • Organizer: 9th International EMBO-Annaberg Conference on Protein and lipid function in secretion and endocytosis
  • Place of Presentation: Goldegg am See, Austria
  • Year and Date: 2014-01-18
• [Presentation] New insights into autophagosome formation (2014)
  • Author(s): Tamotsu Yoshimori
  • Organizer: 9th International EMBO-Annaberg Conference on Protein and lipid function in secretion and endocytosis
  • Place of Presentation: Goldegg am See, Austria
  • Invited
• [Presentation] Mechanistic insights into membrane dynamics in autophagy (2013)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 2013 Cold Spring Harbor Asia Conference
  • Place of Presentation: Suzhou Dushu Lake Conference Center, China
  • Year and Date: 2013-11-19
• [Presentation] オートファジー : 疾患に対抗する細胞内自己分解システム (2013)
  • Author(s): 吉森保
  • Organizer: 第25回日本色素細胞学会学術大会
  • Place of Presentation: 大阪大学
  • Year and Date: 2013-11-16
• [Presentation] Mammalian autophagy : its machinery, membrane dynamics, and role in diseases (2013)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Argentine Society for Biochemistry and Molecular Biology scientific meeting (SAIB 2013)
  • Place of Presentation: the Fundacion Leloir,Buenos Aires, Argentina
  • Year and Date: 2013-11-07
• [Presentation] オートファジーの膜動態制御機構 (2013)
  • Author(s): 吉森保
  • Organizer: 第72回日本癌学会学術総会・シンポジウム S10"がんとオートファジー"
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2013-10-03
• [Presentation] Lysosome homeostasis : damaged lysosomes are selectivelyeliminated by autophagy (2013)
  • Author(s): 吉森保
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: パシフィコ横浜
  • Year and Date: 2013-09-11
• [Presentation] オートファゴソームはどこから来るのか (2013)
  • Author(s): 吉森保
  • Organizer: 第65回日本細胞生物学会大会
  • Place of Presentation: 愛知県産業労働センター、名古屋
  • Year and Date: 2013-06-19
• [Presentation] 50 Years of Autophagy : towards Understanding The Intracellular Self-Degradation System Sustaining Life (2013)
  • Author(s): Tamotsu Yoshimori
  • Organizer: 2013 The 28th Joint Annual Conference of Biomedical Sciences
  • Place of Presentation: National Defense Medical Center, Taipei, Taiwan
  • Year and Date: 2013-03-23
• [Presentation] オートファジー：疾患に対抗する細胞内自己分解システム (2013)
  • Author(s): 吉森 保
  • Organizer: 第25回日本色素細胞学会学術大会
  • Place of Presentation: 大阪大学
  • Invited
• [Presentation] Mammalian autophagy: its machinery, membrane dynamics, and role in diseases (2013)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Argentine Society for Biochemistry and Molecular Biology scientific meeting (SAIB 2013)
  • Place of Presentation: the Fundacion Leloir, Buenos Aires, Argentina
  • Invited
• [Presentation] Insights into membrane dynamics in mammalian autophagy (2013)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Buenos Aires Conference 2013
  • Place of Presentation: University of Buenos Aires, Argentina
  • Invited
• [Presentation] New Insights into Selective Autophagy (2013)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 3rd Sino-Japan Symposium on Autophagy
  • Place of Presentation: The Dunhuang International Hotel, China
  • Invited
• [Presentation] オートファジーと疾患 (2013)
  • Author(s): 吉森 保
  • Organizer: 第24回近畿リウマチ病研究会
  • Place of Presentation: 大阪グランフロント
  • Invited
• [Presentation] オートファジーの膜動態制御機構 (2013)
  • Author(s): 吉森 保
  • Organizer: 第72回日本癌学会学術総会・シンポジウムS10“がんとオートファジー”
  • Place of Presentation: パシフィコ横浜
  • Invited
• [Presentation] Lysosome homeostasis: damaged lysosomes are selectively eliminated by autophagy (2013)
  • Author(s): 吉森 保
  • Organizer: 第86回日本生化学会大会
  • Place of Presentation: パシフィコ横浜
  • Invited
• [Presentation] New Insights into Membrane Biogenesis and Selectivity in Autophagy (2013)
  • Author(s): 吉森 保
  • Organizer: 第5回都医学研国際シンポジウム
  • Place of Presentation: 東京都医学総合研究所
  • Invited
• [Presentation] 16 years of autophagy: towards understanding the intracellular self-degradation system sustaining life (2013)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Viikki Biocenter Monday Lectures Fall 2013
  • Place of Presentation: Universty of Helsinki, Finland
  • Invited
• [Presentation] 細胞の守護者オートファジー：分子機構、膜動態、疾患との関わり (2013)
  • Author(s): 吉森 保
  • Organizer: 第60回毒素シンポジウム
  • Place of Presentation: 楓香荘、宍粟市、兵庫県
  • Invited
• [Presentation] オートファジー：分子機構と疾患における役割 (2013)
  • Author(s): 吉森 保
  • Organizer: 第8回大阪消化器フォーラム
  • Place of Presentation: リーガロイヤルホテル大阪
  • Invited
• [Presentation] Insights into membrane dynamics in autophagy (2013)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Ubiquitin and Autophagy 2013
  • Place of Presentation: De Rode Hoed, Amsterdam, The Netherlands
  • Invited
• [Presentation] オートファゴソームはどこから来るのか (2013)
  • Author(s): 吉森 保
  • Organizer: 第65回日本細胞生物学会大会
  • Place of Presentation: ウィンクあいち(愛知県産業労働センター）、名古屋市
  • Invited
• [Presentation] 細胞の守護者オートファジー：分子機構と疾患における役割 (2013)
  • Author(s): 吉森 保
  • Organizer: 第77回日本生化学会中部支部例会・シンポジウム
  • Place of Presentation: 名古屋大学理学南館 坂田・平田ホール
  • Invited
• [Presentation] 50 Years of Autophagy: towards Understanding The Intracellular Self-Degradation System Sustaining Life (2013)
  • Author(s): Tamotsu Yoshimori
  • Organizer: 2013 The 28th Joint Annual Conference of Biomedical Sciences
  • Place of Presentation: National Defense Medical Center(Taipei,Taiwan)
  • Invited
• [Presentation] Insights into MembraneDynamics in Mammalian Autophagy (2012)
  • Author(s): 吉森保
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡
  • Year and Date: 2012-12-15
• [Presentation] オートファジー : 発見から半世紀を経て (2012)
  • Author(s): 吉森保
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場
  • Year and Date: 2012-12-05
• [Presentation] Autophagy : Molecular Machinery and Role in Diseases (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 12th International Symposium on Dendritic Cells
  • Place of Presentation: Convention Center EXCO,Daegu, Korea
  • Year and Date: 2012-10-08
• [Presentation] Mechanistic Insights into Autophagy against Bacteria Invading Host Cells (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Cambridge Immunology Forum 2012 (Roche Distinguished Lecturer)
  • Place of Presentation: Peterhouse in Cambridge University, UK
  • Year and Date: 2012-09-20
• [Presentation] New insights into selective autophagy (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Beatson International Cancer Conference
  • Place of Presentation: Glasgow University, Scotland
  • Year and Date: 2012-07-02
• [Presentation] Mechanistic insights into membrane dynamics in autophagy (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: ASBMB 2012 Annual Meeting
  • Place of Presentation: San Diego Convention Center, U.S.A.
  • Year and Date: 2012-04-23
• [Presentation] Autophagy : molecular machinery and role in diseases (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: BSCB-BSDB-JSDB Joint Spring Meeting
  • Place of Presentation: University of Warwick, Coventry, UK
  • Year and Date: 2012-04-18
• [Presentation] オートファジー:生命を護る細胞内大規模分解システム (2012)
  • Author(s): 吉森保
  • Organizer: 第24回気道病態研究会
  • Place of Presentation: 東京ステーションコンファレンス、東京(招待講演)
  • Year and Date: 2012-03-03
• [Presentation] Insights into Membrane Dynamics in Selective and Non-Selective Autophagy (2012)
  • Author(s): 吉森保
  • Organizer: 2012 Senri Life Science Int.Symposium on 'Cutting-edge of Autophagy Study'
  • Place of Presentation: 千里ライフサイエンスセンタービル、大阪(招待講演)
  • Year and Date: 2012-01-20
• [Presentation] Autophagy : Molecular Machinery, Membrane Dynamics, and Role in Diseases (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: ASIシンポジウム'Frontier in Cell Biology Research'
  • Place of Presentation: The Chinese University of Hong Kong, China(招待講演)
  • Year and Date: 2012-01-04
• [Presentation] Insights into Membrane Dynamics in Mammalian Autophagy (2012)
  • Author(s): 吉森 保
  • Organizer: 第85回日本生化学会大会
  • Place of Presentation: 福岡国際会議場・マリンメッセ福岡（福岡）
  • Invited
• [Presentation] オートファジー：発見から半世紀を経て (2012)
  • Author(s): 吉森 保
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際会議場（神戸）
  • Invited
• [Presentation] 哺乳類オートファジーの膜動態と疾患との関わり (2012)
  • Author(s): 吉森 保
  • Organizer: 第28回京都賞記念ワークショップ基礎科学部門
  • Place of Presentation: 国立京都国際会館（京都）
  • Invited
• [Presentation] Autophagy : Molecular Machinery and Role in Diseases (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 12th International Symposium on Dendritic Cellｓ
  • Place of Presentation: Convention Center EXCO(Daegu,Korea)
  • Invited
• [Presentation] Mechanistic Insights into Autophagy against Bacteria Invading Host Cells (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Cambridge Immunology Forum 2012
  • Place of Presentation: Peterhouse in Cambridge University(Cambridge,UK)
  • Invited
• [Presentation] New insights into selective autophagy (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Beatson International Cancer Conference
  • Place of Presentation: Glasgow University(Glasgow,Scotland)
  • Invited
• [Presentation] 生体防御システムとしてのオートファジー (2012)
  • Author(s): 吉森 保
  • Organizer: 第17回東京肝臓シンポジウム
  • Place of Presentation: 経団連会館（東京）
  • Invited
• [Presentation] 15 Years of Autophagy: Towards Understanding The Intracellular Self-Degradation System Sustaining Life (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Frontiers of Biological Sciences Seminar Series in Tsinghua University
  • Place of Presentation: 精華大学（北京、中国）
  • Invited
• [Presentation] Mechanistic insights into membrane dynamics in autophagy (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: ASBMB 2012 Annual Meeting
  • Place of Presentation: San Diego Convention Center(San Diego ,USA)
  • Invited
• [Presentation] Autophagy : molecular machinery and role in diseases (2012)
  • Author(s): Tamotsu Yoshimori
  • Organizer: BSCB- BSDB- JSDB Joint Spring Meeting
  • Place of Presentation: University of Warwick(Coventry, UK)
  • Invited
• [Presentation] New Insights into Selective Autophagy (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Zing Conference on Autophagy 2011
  • Place of Presentation: Occidental Grand Xcaret, Mexico
  • Year and Date: 2011-12-09
• [Presentation] New Insights into Selective Autophagy (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Zing Conference on Autophagy 2011
  • Place of Presentation: Occidental Grand Xcaret, Mexico(招待講演)
  • Year and Date: 2011-12-09
• [Presentation] Autophagy : Molecular Machinery and Role in Diseases (2011)
  • Author(s): 吉森保
  • Organizer: 第27回熊本医学・生物科学シンポジウム
  • Place of Presentation: 熊本大学山崎記念館、熊本(招待講演)
  • Year and Date: 2011-11-23
• [Presentation] Autophagy : New Insights into Its Membrane Dynamics (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 2^<nd> Int. Symposium on Ubiquitin and Ubiquitin-Like Modifications
  • Place of Presentation: Sinicaアカデミア生物医科学研究所、台北、台湾(招待講演)
  • Year and Date: 2011-11-11
• [Presentation] Insights into Membrane Dynamics in Autophagy (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: EMBO Conference on Autophagy in Health and Disease
  • Place of Presentation: Ma'ale Hachamisha Hotel, Tel Aviv, Israel
  • Year and Date: 2011-10-31
• [Presentation] Insights into Membrane Dynamics in Autophagy (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: EMBO Conference on Autophagy in Health and Disease
  • Place of Presentation: Ma'ale Hachamisha Hotel, Israel(招待講演)
  • Year and Date: 2011-10-31
• [Presentation] 非選択的および選択的オートファジーにおける膜創成 (2011)
  • Author(s): 吉森保
  • Organizer: 第1回都医学研シンポジウム
  • Place of Presentation: 津田ホール、東京(招待講演)
  • Year and Date: 2011-10-27
• [Presentation] Where Does Autophagosome Come from? : Membrane Biogenesis in Autophagy (2011)
  • Author(s): 吉森保
  • Organizer: 第2回日中オートファジーシンポジウム
  • Place of Presentation: 湘南国際村センター、神奈川(招待講演)
  • Year and Date: 2011-10-06
• [Presentation] Autophagosome Formation : between the ER and Mitochondria (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The Gordon Research Conference on Molecular Membrane Biology
  • Place of Presentation: Proctor Academy, Andover, NH, U.S.A.
  • Year and Date: 2011-07-14
• [Presentation] Autophagosome Formation : between the ER and Mitochondria (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: Gordon Research Conference 'Molecular Membrane Biology'
  • Place of Presentation: Proctor Academy、Andover, NH, U.S.A.(招待講演)
  • Year and Date: 2011-07-14
• [Presentation] Mechanistic Insight into Membrane Dynamics in Autophagy (2011)
  • Author(s): 吉森保
  • Organizer: 第30回内藤コンファレンス
  • Place of Presentation: シャトレーゼガトーキングダムサッポロ、北海道(招待講演)
  • Year and Date: 2011-06-30
• [Presentation] Autophagy, A Guardian of Cells against Infection (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 19th Federation Meeting of Korean Basic Medical Scientists
  • Place of Presentation: Grand Hilton Seoul Convention Center, Korea
  • Year and Date: 2011-05-13
• [Presentation] Autophagy, A Guardian of Cells against Infection (2011)
  • Author(s): Tamotsu Yoshimori
  • Organizer: The 19^<th> Federation Meeting of Korean Basic Medical Scientists
  • Place of Presentation: Grand Hilton Seoul Convention Center, Korea(招待講演)
  • Year and Date: 2011-05-13
• [Book] Morphological Analysis of Autophagy. Cell Imaging Techniques Methods and Protocols Second Edition (2013)
  • Author(s): Keisuke T, Mitsuko H-N, Takeshi N. Akitsugu Y. Yoshimori T
  • Publisher: Humana Press
• [Book] Q&A/哺乳類におけるオートファジー関連因子、オートファジー生命をささえる細胞の自己分解システム、水島昇・吉森保編 (2012)
  • Author(s): 吉森保
  • Publisher: 化学同人C1-10
• [Book] オートファジー 生命をささえる細胞の自己分解システム (2012)
  • Author(s): 吉森 保
  • Publisher: 化学同人
• [Book] Cell Imaging Techniques: Methods and Protocols Second Edition (2012)
  • Author(s): Keisuke T, Mitsuko H-N, Takeshi N, Akitsugu Y,Yoshimori T.
  • Publisher: Humana Press
• [Remarks]
  • URL: http://www.fbs.osaka-u.ac.jp/labs/yoshimori/
• [Remarks] 研究室HP
  • URL: http://www.fbs.osaka-u.ac.jp/labs/yoshimori/
• [Remarks] 研究室ＨＰ
  • URL: http://www.fbs.osaka-u.ac.jp/labs/yoshimori/
• [Remarks]
  • URL: http://www.fbs.osaka-u.ac.jp/labs/yoshimori/jp/achievement/010/