| Project/Area Number |
23247035
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Cell biology
|
|---|
| Research Institution | Aichi Cancer Center Research Institute |
|---|
Principal Investigator |
INAGAKI Masaki 愛知県がんセンター(研究所), 腫瘍医化学部, 部長 (30183007)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
IZAWA Ichiro 愛知県がんセンター(研究所), 腫瘍医化学部, 室長 (20311441)
GOTO Hidemasa 愛知県がんセンター(研究所), 腫瘍医化学部, 室長 (20393126)
KASAHARA Kousuke 愛知県がんセンター(研究所), 腫瘍医化学部, 研究員 (90455535)
|
|---|
| Project Period (FY) |
2011-11-18 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥29,380,000 (Direct Cost: ¥22,600,000、Indirect Cost: ¥6,780,000)
Fiscal Year 2013: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
Fiscal Year 2012: ¥14,690,000 (Direct Cost: ¥11,300,000、Indirect Cost: ¥3,390,000)
|
|---|
| Keywords | 中間径フィラメント / 増殖 / 分化 / ケラチン / 細胞骨格 / 中心体 |
|---|
| Research Abstract |
To uncover roles of intermediate filaments in proliferation and differentiation, we studied the functions of trichoplein, a keratin-binding protein, and trichoplein-related proteins. We found that trichoplein-Aurora-A pathway is required for G1 progression through a key role in the continuous suppression of primary cilia assembly. On the other hand, we revealed that knock-in mice expressing phosphodeficient vimentin variants developed binucleation and aneuploidy in lens epithelial cells, which promoted lens cataract, an aging phenotype.
|
