INVESTIGATION OF THE BIOLOGICAL MOLECULES RESPONDING TO ENVIROMENTAL SIGNALS

• Project/Area Number: 23247045
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Applied anthropology
• Research Institution: Osaka City University
• Principal Investigator: SAEKI Shigeru 大阪市立大学, 大学院生活科学研究科, 教授 (60211926)
• Co-Investigator(Kenkyū-buntansha): NISHIKAWA Yoshikazu 大阪市立大学, 大学院生活科学研究科, 教授 (60183539) ; HABU Daiki 大阪市立大学, 大学院生活科学研究科, 教授 (40301428) ; YOSHITA Katsushi 大阪市立大学, 大学院生活科学研究科, 教授 (60299245) ; SONE Yoshiaki 美作大学, 生活科学部, 教授 (60145802)
• Project Period (FY): 2011-04-01 – 2016-03-31
• Project Status: Completed (Fiscal Year 2015)
• Budget Amount: ¥19,110,000 (Direct Cost: ¥14,700,000、Indirect Cost: ¥4,410,000); Fiscal Year 2014: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2013: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000); Fiscal Year 2012: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: 環境シグナル / 生体センサー / サーカディアンリズム / 体内時計

Outline of Final Research Achievements

The present studies were undertaken to explore the biological molecules in rats with metabolic syndrome whose responses to light and darkness cycle or cold temperature are different from those in normal rats. Some biological molecules of the suprachiasmatic nucleus of the hypothalamus and the liver showed abnormal circadian rhythms in rats with metabolic syndrome. Furthermore, cold exposure failed to produce the increase in the expression of the thrifty gene in brown adipose tissue in rats with metabolic syndrome.