| Budget Amount *help |
¥48,230,000 (Direct Cost: ¥37,100,000、Indirect Cost: ¥11,130,000)
Fiscal Year 2013: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2012: ¥15,600,000 (Direct Cost: ¥12,000,000、Indirect Cost: ¥3,600,000)
Fiscal Year 2011: ¥17,030,000 (Direct Cost: ¥13,100,000、Indirect Cost: ¥3,930,000)
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| Outline of Final Research Achievements |
In order to achieve expressional regulation in response to Fe availability, Fe sensing systems by sensors and signals must exist, but their identity has not been clarified in plants. We proposed that direct Fe binding to expressional regulators is a compelling candidate for the primary Fe sensing in plant cells. IDEF1 is a central transcriptional regulator of graminaceous genes involved in iron uptake and utilization, predominantly during early stages of iron deficiency. IDEF1 directly binds to divalent metals and sense the cellular metal ion balance caused by changes in iron availability. HRZs, novel regulators in rice, and BTS in Arabidopsis bind Fe and Zn, and possess ubiquitination activity. HRZ-knockdown rice plants show Fe efficiency and accumulation, with enhanced expression of Fe utilisation-related genes. HRZs/BTS are E3 ligases and negative regulators of iron deficiency responses in both graminaceous and non-graminaceous plants.
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