|Budget Amount *help
¥47,320,000 (Direct Cost: ¥36,400,000、Indirect Cost: ¥10,920,000)
Fiscal Year 2014: ¥9,750,000 (Direct Cost: ¥7,500,000、Indirect Cost: ¥2,250,000)
Fiscal Year 2013: ¥9,620,000 (Direct Cost: ¥7,400,000、Indirect Cost: ¥2,220,000)
Fiscal Year 2012: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2011: ¥18,850,000 (Direct Cost: ¥14,500,000、Indirect Cost: ¥4,350,000)
|Outline of Final Research Achievements
In the present study, we aimed to reveal the neural and molecular mechanisms induced by the early weaning and new methods to improve the developmental period are challenged. In the first experiment, we found that excessive glucocorticoid secretion after early weaning, and this glucocorticoid is the key to induce the higher anxiety in the early-weaned mouse. In the prefrontal cortex of the early-weaned mice, FKBP5 increased and the expression level of FKBP5 was negatively correlated with the anxiety level. The pups staying with the dam showed higher oxytocin secretion in the anterior cingulate cortex, and this oxytocin concentration was positively associated with the duration time of physical contact with the dam. Finally, we introduced a alloparental female, which was not the biological mother but showed the similar maternal behavior toward the pups, and observed the adult phenotypes of the early-weaned mouse. Some parameters were partially recovered by the alloparenting in male mice.