| Budget Amount *help |
¥47,970,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥11,070,000)
Fiscal Year 2014: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2013: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2012: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2011: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
|
|---|
| Outline of Final Research Achievements |
Cerebrovascular disease, stroke, is the fourth leading cause of death in Japan, and the first position of the number of people certiflied for long-term care. Cerebral infarction occupies about 60% of the disease. This study aimed to create a new drug by use of drug delivery system which delivers the drug to the ischemic site. Although transport of materials from bloodstream to brain tissue is strictly regulated in normal brain, this barrier (blood-brain barrier) is degenerated in cerebral infarction. We observed that 100 nm-sized liposome, a lipid-based microcapsule, could enter the ischemic brain tissues. We modified a certain protein having neuro protective effect on the liposomal surface or incorporated some neuro protective drugs in liposomes. These liposomes protected the brain cell death by infarction, and suppressed the decrease in motor function, an indicator of the aftereffect by brain infarction.
|
