New development of diagnostic and therapeutic modality for ischemia/reperfusion injury by intelligent DDS
| Project/Area Number |
23249005
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Physical pharmacy
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| Research Institution | University of Shizuoka |
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Principal Investigator |
OKU Naoto 静岡県立大学, 薬学部, 教授 (10167322)
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| Co-Investigator(Kenkyū-buntansha) |
SHIMIZU Kosuke 静岡県立大学, 薬学部, 講師 (30423841)
TAKEDA Atsushi 静岡県立大学, 薬学部, 教授 (90145714)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥47,970,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥11,070,000)
Fiscal Year 2014: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Fiscal Year 2013: ¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2012: ¥10,530,000 (Direct Cost: ¥8,100,000、Indirect Cost: ¥2,430,000)
Fiscal Year 2011: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
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| Keywords | 脳梗塞 / 虚血再灌流障害 / 薬物送達システム / ＤＤＳ / リポソーム / 脳保護薬 / ナノ粒子 / 運動機能 / ＰＥＴ / アシアロエリスロポエチン / ファスジル / タクロリムス / 虚血性疾患 / 薬物送達 / DDS / エリスロポエチン / 細胞保護効果 / 行動薬理 |
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| Outline of Final Research Achievements |
Cerebrovascular disease, stroke, is the fourth leading cause of death in Japan, and the first position of the number of people certiflied for long-term care. Cerebral infarction occupies about 60% of the disease. This study aimed to create a new drug by use of drug delivery system which delivers the drug to the ischemic site. Although transport of materials from bloodstream to brain tissue is strictly regulated in normal brain, this barrier (blood-brain barrier) is degenerated in cerebral infarction. We observed that 100 nm-sized liposome, a lipid-based microcapsule, could enter the ischemic brain tissues. We modified a certain protein having neuro protective effect on the liposomal surface or incorporated some neuro protective drugs in liposomes. These liposomes protected the brain cell death by infarction, and suppressed the decrease in motor function, an indicator of the aftereffect by brain infarction.
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Report
(5 results)
Research Products
(36 results)
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[Journal Article] Real-time trafficking of PEGylated liposomes in the rodent focal brain ischemia analyzed by positron emission tomography2014
Author(s)
Fukuta T, Ishii T, Asai T, Nakamura G, Takeuchi Y, Sato A, Agato Y, Shimizu K, Asai S, Fukumoto D, Harada N, Tsukada H, Kawaguchi AT, Oku N
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Journal Title
Artificial organs
Volume: 38
Issue: 8
Pages: 662-6
DOI
Related Report
Peer Reviewed / Open Access / Acknowledgement Compliant
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[Journal Article] Neuroprotective effect of nobiletin on cerebral ischemia-reperfusion injury in transient middle cerebral artery-occluded rats.2014
Author(s)
Yasuda N, Ishii T, Oyama D, Fukuta T, Agato Y, Sato A, Shimizu K, Asai T, Asakawa T, Kan T, Yamada S, Ohizumi Y, Oku N.
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Journal Title
Brain Res.
Volume: 1559
Pages: 46-54
DOI
Related Report
Peer Reviewed / Acknowledgement Compliant
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[Presentation] Neuroprotective Effect of PEGylated Liposomes Encapsulating FK506 on Cerebral Ischemia-reperfusion Injury.
Author(s)
Yurika Agato, Takayuki Ishii, Dai Oyama, Nodoka Yasuda, Tatsuya Fukuta, Akihiko Sato, Kosuke Shimizu, Tomohiro Asai, Tetsuo Minamino, Naoto Oku:
Organizer
40th Annual Meeting & Exposition of the Controlled Release Society
Place of Presentation
Honolulu, Hawaii, USA
Related Report
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