| Project/Area Number |
23249016
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathological medical chemistry
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| Research Institution | Kyoto University |
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Principal Investigator |
KAKIZUKA Akira 京都大学, 生命科学研究科, 教授 (80204329)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEDA Hanako 京都大学, 大学院医学研究科, 助教 (20372162)
IMAMURA Hiromi 京都大学, 白眉センター, 准教授 (20422545)
IEMURA Shun-ichiro 福島県立医科大学, 医療-産業TRセンー, 教授 (90356410)
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| Project Period (FY) |
2011-05-31 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥48,100,000 (Direct Cost: ¥37,000,000、Indirect Cost: ¥11,100,000)
Fiscal Year 2013: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2012: ¥15,860,000 (Direct Cost: ¥12,200,000、Indirect Cost: ¥3,660,000)
Fiscal Year 2011: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
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| Keywords | ATP / ATPase / VCP / ERストレス / 細胞死 / 網膜色素変性症 / 緑内障 / 酵素 / 胞・組織 / ストレス / 蛋白質 / 阻害剤 / 繊維状構造物 / グルコース代謝 / 飢餓 / リン脂質 |
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| Outline of Final Research Achievements |
We analyzed the functions of VCP, a major ATPase in the cell, in physiological and pathological conditions, and revealed the followings: Suppression of VCP ATPase activities could contribute to reduce the consumption of cellular ATP. VCP could form fiver-like structure, which reduced its ATPase activities. Our newly developed chemical compounds, named KUSs, could suppress VCP ATPase activities without suppressing cellular VCP functions, and KUS could suppress the onset and retard the progression of mouse models of retinitis pigmentosa and glaucoma.
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