Research Project
Grant-in-Aid for Scientific Research (A)
To identify the cellular population responsible for the phenotype of girdin KO mice, newly generated girdin flox mice were crossed with nestin-promoter driven Cre-transgenic mice to obtain girdin conditional knockout mice.Our findings suggested that girdin expression in nestin cell lineage is responsible for the phenotype of girdin KO mice.We used a mouse model of pathological ocular neovascularization: oxygen-induced retinopathy.Pathological neovascularization was decreased in S1416A knockin mice. The results demonstrate that girdin and its phosphorylation play an important role in neonatal vascular development and in pathological neovascularization in the retina.We also found that depletion of girdin attenuated venous smooth muscle cells migration and proliferation in vitro and intimal hyperplasia in vein grafts in vivo.Moreover, we demonstrated that a girdin family protein, Dishevelled-associating protein Daple, controls the non-canonical Wnt/Rac pathway and cell motility
All 2014 2013 2012 2011 Other
All Journal Article (22 results) (of which Peer Reviewed: 22 results, Acknowledgement Compliant: 3 results, Open Access: 1 results) Presentation (17 results) (of which Invited: 7 results) Remarks (1 results)
Breast Cancer
Volume: (in press)
J. Vasc. Surg.
Journal of Vascular Surgery
Volume: 60 Issue: 2 Pages: 479-489
10.1016/j.jvs.2013.06.080
Biochem. Biophys. Res. Commun.
Volume: 442 Pages: 16-21
Am. J. Pathol.
Volume: 182 Pages: 586-596
American Journal of Pathology
Volume: 182 Issue: 2 Pages: 586-596
10.1016/j.ajpath.2012.10.012
Volume: 442 Issue: 1-2 Pages: 16-21
10.1016/j.bbrc.2013.10.126
Volume: - Issue: 5 Pages: 445-451
10.1007/s12282-013-0501-3
Cancer Sci.
Volume: 103 Pages: 1780-1787
Volume: 426 Pages: 533-538
Nature Commun.
Volume: May 29 3 Pages: 859-859
PLoS One
Volume: 7
Oncogene
Volume: 31 Pages: 2715-2724
Volume: 7 Issue: 5 Pages: e36681-e36681
10.1371/journal.pone.0036681
Nat Commun
Volume: 3 Issue: 1 Pages: 859-859
10.1038/ncomms1861
Volume: 426 Issue: 4 Pages: 533-538
10.1016/j.bbrc.2012.08.122
Cancer Science
Volume: 103 Issue: 10 Pages: 1780-1787
10.1111/j.1349-7006.2012.02378.x
Neurobiol Aging
Volume: 33 Issue: 3 Pages: 626.e25-626.e34
10.1016/j.neurobiolaging.2011.04.002
J. Neurosci.
Volume: 31 Pages: 8109-8122
Circ. Res.
Volume: 108 Pages: 1170-1179
Circulation Research
Volume: 108 Issue: 10 Pages: 1170-1179
10.1161/circresaha.110.236174
Journal of Neuroscience
http://www.med.nagoya-u.ac.jp/patho2/