Protective effect of granular leukocytes on host defense against intestinal nematode infection
| Project/Area Number |
23249022
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (A)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Parasitology (including Sanitary zoology)
|
|---|
| Research Institution | Hyogo Medical University |
|---|
Principal Investigator |
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
YASUDA Koubun 兵庫医科大学, 医学部, 講師 (50333539)
MATSUMOTO Makoto 兵庫医科大学, 医学部, 講師 (40380521)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥48,620,000 (Direct Cost: ¥37,400,000、Indirect Cost: ¥11,220,000)
Fiscal Year 2013: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2012: ¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2011: ¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
|
|---|
| Keywords | 腸管寄生虫感染 / 好酸球性肺炎 / 腸管肥満細胞性炎症 / Th2細胞 / ILC2 / IgE / IgG1 / IgG / IgE抗体 / AID欠損マウス / 受身免疫 / FcγRIII / FCεR1 / Th2応答 / IgG抗体 / 肥満細胞 / S Venezuelensis / 寄生虫の排除 / 寄生虫感染 / IL-33 / II型肺胞上皮細胞(ATII) / キチン / ナチュラルヘルパー細胞 |
|---|
| Research Abstract |
In this study, we demonstrated the relevant roles of group 2 innate lymphoid cells (ILC2s) for induction of pulmonary eosinophilia. Infection with Strongyloides venezuelensis (Sv) induces IL-33 production by increasing the number of Type II alveolar epithelial cells, which express IL-33 in their nucleus. Then, IL-33 induces ILC2s to proliferate and produce IL-5 and IL-13, which in combination induce lung eosinophilic inflammation, aiding to expel infected worms in the lungs. We also showed that AID-/- mice, lacking the capacity to switch from IgM to other isotypes, normally develop Th2 cells and intestinal mastocytosis after infection with Sv.However, they failed to rapidly expel Sv and need adoptive transfers of IgE and IgG from Sv-infected mice to obtain the capacity to promptly expel Sv. Thus, both innate and acquired immunity are required for rapid expulsion of intestinal nematode.
|
Report
(4 results)
Research Products
(59 results)
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Journal Article] A critical role of IL-33 in experimental allergic rhinitis2012
Author(s)
Haenuki Y, Matsushita K, Futatsugi-Yumikura S, Ishii KJ, Kawagoe T, Imoto Y, Fujieda S, Yasuda M, Hisa Y, Akira S, Nakanishi K, Yoshimoto T
-
Journal Title
J Allergy Clin Immunol
Volume: (in press)
Issue: 1
Pages: 184-194
DOI
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
[Presentation] Contribution of IL-33-acivated type II innate lymphoid cells to pulmonary eosinophilia in intestinal nematode-infected mice.2012
Author(s)
Yasuda K, Muto T, Kawagoe T, Matsumoto M, Sasaki Y, Matushita K, Taki Y, Futatsugi-Yumikura S, Tsutsui H, Ishi KJ, Yoshimoto T, Akira S, Nakanishi K.
Organizer
第77回日本インターフェロン・サイトカイン学会学術集会
Place of Presentation
神戸商工会議所
Related Report
Invited
-
-
-
-
-
[Presentation] Chitin induces lung eosinophilia dependently on IL-332012
Author(s)
Muto T, Yasuda K, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, Futatsugi-Yumikura S, Tsutsui H, Ishii KJ, Yoshimoto T, Akira S, Nakanishi K.
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸国際会議場
Related Report
-
[Presentation] Contribution of IL-33-activated type II innate lymphoid cells to pulmonary eosinophilia in Strongyloides venezuelensis-infected mice.2012
Author(s)
Yasuda K, Muto T, Kawagoe T, Matsumoto M, Sasaki Y, Matsushita K, Futatsugi-Yumikura S, Tsutsui H, Ishi KJ, Yoshimoto T, Akira S, Nakanishi K.
Organizer
第41回日本免疫学会学術集会
Place of Presentation
神戸国際会議場
Related Report
-
-
-
-
-
-
-
-
-
-
