Viral RNA factory formation and activation of antiviral innate immunity
| Project/Area Number |
23249023
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Virology
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| Research Institution | Kyoto University |
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Principal Investigator |
FUJITA Takashi 京都大学, ウイルス研究所, 教授 (10156870)
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| Co-Investigator(Renkei-kenkyūsha) |
KATO Hiroki 京都大学, ウイルス研究所, 准教授 (10597173)
TAKAHASI Kiyohiro 京都大学, ウイルス研究所, 助教 (90399965)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥49,530,000 (Direct Cost: ¥38,100,000、Indirect Cost: ¥11,430,000)
Fiscal Year 2013: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2012: ¥9,360,000 (Direct Cost: ¥7,200,000、Indirect Cost: ¥2,160,000)
Fiscal Year 2011: ¥30,810,000 (Direct Cost: ¥23,700,000、Indirect Cost: ¥7,110,000)
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| Keywords | ストレス / 感染症 / 免疫学 / ウイルス / インターフェロン / 自然免疫 |
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| Research Abstract |
Invading viral RNA is sensed by RIG-I-like receptor (RLR) in the cytoplasm and antiviral innate immunity, including production of interferon, is induced. It was unclear where RLR senses viral RNA. We found that viral infection induces RNA-protein aggregates, in which RLR is recruited and acts as a platform for viral RNS sensing. We termed this aggregate as antiviral stress granule (avSG). We also found that several viruses actively inhibit avSG to facilitate their replication. Our findings also include that the double-stranded RNA sensors, PKR and DHX36 play critical roles in the formation of avSG.
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Report
(4 results)
Research Products
(52 results)
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[Journal Article] DHX36 Enhances RIG-I Signaling by Facilitating PKR-Mediated Antiviral Stress Granule Formation2014
Author(s)
Yoo, J-S., Takahasi, K., Ng, CS., Ouda, R., Onomoto, K., Yoneyama, M., Lai, J-C., Lattmann, S., Nagamine, Y., Matsui, T., Iwabuchi, K., Kato, H. Fujita, T.
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Journal Title
PLoS Pathog
Volume: 10(3)
Issue: 3
Pages: 1-18
DOI
NAID
Related Report
Peer Reviewed / Open Access
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[Journal Article] Autoimmune Disorders Associated with Gain of Function of the Intracellular Sensor MDA52014
Author(s)
Funabiki M, Kato H, Miyachi M, Toki H, Motegi H, Inoue M, Minowa O, Yoshida A, Deguchi K, Sato H, Ito S, Shiroishi T, Takeyasu K, Noda T and Fujita T
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Journal Title
Immunity
Volume: 40
Pages: 199-212
Related Report
Peer Reviewed
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-
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[Journal Article] Production of a Dominant-Negative Fragment Due to G3BP1 Cleavage Contributes to the Disruption of Mitochondria-Associated Protective Stress Granules during CVB3 Infection2013
Author(s)
Fung G, Ng C-S, Zhang J, Shi J, Wong J, Piesik P, Han L, Chu F, Jagdeo J, Jan E, Fujita T, Luo H
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Journal Title
PLoS ONE
Volume: 8(11)
Issue: 11
Pages: 1-15
DOI
Related Report
Peer Reviewed
-
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[Journal Article] Critical Role of an Antiviral Stress Granule Containing RIG-I and PKR in Viral Detection and Innate Immunity2012
Author(s)
Onomoto K, Jogi M, Yoo J-S, Narita R, Morimoto S, Takemura A, Sambhara S, Kawaguchi A, Osari S, Nagata K, Matsumiya T, Namiki H, Yoneyama M, Fujita T
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Journal Title
PLoS One
Volume: 7
Issue: 8
Pages: 1-15
DOI
Related Report
Peer Reviewed
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[Journal Article] Retinoic Acid-inducible Gene I-inducible miR-23b Inhibits Infections by Minor Group Rhinoviruses through Downregulation of the Very Low Density Lipoprotein Receptor2011
Author(s)
Ouda, R., Onomoto, K., Takahasi, K., Edwards, M.R., Kato, H., Yoneyama, M. and Fujita, T.
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Journal Title
J. Biol. Chem.
Volume: 286
Pages: 26210-219
Related Report
Peer Reviewed
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