| Project/Area Number |
23249034
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Hygiene
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| Research Institution | Hyogo Medical University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
SAWAI Hideaki 兵庫医科大学, 医学部, 教授 (80215904)
TANIZAWA Takakuni 兵庫医科大学, 医学部, 教授 (10126534)
KOMORI Shinji 兵庫医科大学, 医学部, 教授 (60195865)
AKATANI Akiko 兵庫医科大学, 医学部, 講師 (50212402)
UCHIDA Kyoko 兵庫医科大学, 医学部, 助教 (00418964)
OTANI Naruhito 兵庫医科大学, 医学部, 助教 (10561772)
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| Co-Investigator(Renkei-kenkyūsha) |
TAMURA Kenji 国立環境研究所, 環境健康研究センター, フェロー (10179898)
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| Research Collaborator |
YODA Yoshiko 兵庫医科大学, 医学部, 助教 (80748434)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥48,230,000 (Direct Cost: ¥37,100,000、Indirect Cost: ¥11,130,000)
Fiscal Year 2014: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
Fiscal Year 2013: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2012: ¥11,700,000 (Direct Cost: ¥9,000,000、Indirect Cost: ¥2,700,000)
Fiscal Year 2011: ¥16,380,000 (Direct Cost: ¥12,600,000、Indirect Cost: ¥3,780,000)
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| Keywords | 大気汚染 / 妊娠 / 出生コーホート研究 / 窒素酸化物 / オゾン / 粒子状物質 / 出生時体重 / アレルギー / 気道炎症 / 微小粒子状物質 / 環境 / コーホート研究 / 曝露評価 |
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| Outline of Final Research Achievements |
Effects of air pollution exposure during pregnancy on health of pregnant women and birth outcomes were evaluated on the basis of a birth cohort study. The concentrations of air pollutants inside and outside of the house of pregnant women were measured. The concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), and ozone (O3) outside of the house were correlated with the concentrations at a monitoring station in the city. The concentration of inside PM2.5 was also correlated with that. The levels of serum high-sensitivity C-reactive protein (hs-CRP) and TARC during early pregnancy were affected by smoking habit and BMI. PM2.5 and O3 exposure prior to blood sampling were associated with increased TARC levels, but not hs-CRP. This study show no association between air pollution exposure and low birth weight.
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