|Budget Amount *help
¥47,970,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥11,070,000)
Fiscal Year 2014: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2013: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2012: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2011: ¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
|Outline of Final Research Achievements
In this study, we elucidated molecular mechanisms of hormone actions in aging and geriatric diseases at whole body, tissue, and cell levels based on next generation sequencing and revealed novel hormone signaling and cross-talk pathways including the functions of novel target molecules, interacting factors, and modification factors. In particular, we elucidated action mechanisms of androgen-responsive long noncoding RNA CTBP1-AS and microRNAs, an androgen target gene APP, androgen receptor-collaborating factors Oct1 and CtBP2, estrogen target genes COX7RP and Efp, and vitamin K action modulators GGCX and SXR. We also clarified their relevance in the anti-aging medicine as molecular targets for prevention, diagnosis, and therapy of age-related and geriatric diseases.