• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

The investigation of genes related to refractory respiratory diseases and development of novel therapeutics

Research Project

Project/Area Number 23249045
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Respiratory organ internal medicine
Research InstitutionThe University of Tokyo

Principal Investigator

NAGASE TAKAHIDE  東京大学, 医学部附属病院, 教授 (40208004)

Co-Investigator(Renkei-kenkyūsha) SHIMIZU TAKAO  東京大学, 大学院医学系研究科, 特任教授 (80127092)
Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥46,800,000 (Direct Cost: ¥36,000,000、Indirect Cost: ¥10,800,000)
Fiscal Year 2015: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
Fiscal Year 2014: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2013: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2012: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2011: ¥12,220,000 (Direct Cost: ¥9,400,000、Indirect Cost: ¥2,820,000)
KeywordsCOPD / 肺線維症 / ARDS / 呼吸器内科学 / 呼吸器内科 / 肺炎症 / 転写コアクチベーター / siRNA / エイコサノイド
Outline of Final Research Achievements

In respiratory diseases, there are several refractory disorders such as COPD, ARDS and pulmonary fibrosis, to which no pharmaceutical agents are currently available or effective. However, their mechanisms still remain to be elucidated. The purpose of this project is to investigate the roles of lipid mediators and TAZ in these disorders using genetically-engineered mice. We found that lipid mediators and TAZ were involved in the pathogenesis of these lung disorders. Our results suggest that these mediators might provide a novel therapeutic approach to these diseases.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (34 results)

All 2015 2014 2013 2012 2011

All Journal Article (29 results) (of which Peer Reviewed: 29 results,  Open Access: 10 results,  Acknowledgement Compliant: 7 results) Presentation (5 results) (of which Int'l Joint Research: 1 results,  Invited: 4 results)

  • [Journal Article] Interleukin-17A and Toll-Like Receptor 3 Ligand Poly(I:C) Synergistically Induced Neutrophil Chemoattractant Production by Bronchial Epithelial Cells.2015

    • Author(s)
      MatsuzakiH, Mikami Y, Yamauchi Y ,et al.
    • Journal Title

      PLoS One

      Volume: 10 Issue: 10 Pages: 10-10

    • DOI

      10.1371/journal.pone.0141746

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Hippo and TGF-β interplay in the lung field2015

    • Author(s)
      Saito A, Nagase T
    • Journal Title

      Am J Physiol Lung Cell Mol Physiol

      Volume: 309(8) Issue: 8 Pages: L756-L767

    • DOI

      10.1152/ajplung.00238.2015

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Histone methylation-mediated silencing of miR-139 enhances invasion of non-small-cell lung cancer2015

    • Author(s)
      Kousuke Watanabe, Yosuke Amano, Rie Ishikawa, Mitsuhiro Sunohara, Hidenori Kage, Junji Ichinose, Atsushi Sano, Jun Nakajima, Masashi Fukayama, Yutaka Yatomi, Takahide Nagase, Nobuya Ohishi and Daiya Takai
    • Journal Title

      Cancer Medicine

      Volume: 4 Issue: 10 Pages: 1573-82

    • DOI

      10.1002/cam4.505

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of clinical characteristics and outcomes between aspiration pneumonia and community-acquired pneumonia in patients with chronic obstructive pulmonary disease.2015

    • Author(s)
      Yamauchi Y, Yasunaga H, Matsui H, et al.
    • Journal Title

      BMC Pulm Med

      Volume: 15 Issue: 1 Pages: 69-69

    • DOI

      10.1186/s12890-015-0064-5

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Oncogenic activity of BIRC2 and BIRC3 mutants independent of nuclear factor-κB-activating potential.2015

    • Author(s)
      Yamato A, Soda M, Ueno T, Kojima S, Sonehara K, Kawazu M, Sai E, Yamashita Y, Nagase T, Mano H.
    • Journal Title

      Cancer Sci.

      Volume: 106 Issue: 9 Pages: 1137-42

    • DOI

      10.1111/cas.12726

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Role of α1 and α2 chains of type IV collagen in early fibrotic lesions of idiopathic interstitial pneumonias and migration of lung fibroblasts.2015

    • Author(s)
      Urushiyama H, Terasaki Y, Nagasaka S, Terasaki M, Kunugi S, Nagase T, Fukuda Y, Shimizu A.
    • Journal Title

      Lab Invest

      Volume: 95 Issue: 8 Pages: 872-885

    • DOI

      10.1038/labinvest.2015.66

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comparison of in-hospital mortality in patients with COPD, asthma and asthma-COPD overlap exacerbations.2015

    • Author(s)
      Yamauchi Y, Yasunaga H, Matsui H, et al.
    • Journal Title

      Respirology

      Volume: 20 Issue: 6 Pages: 940-946

    • DOI

      10.1111/resp.12556

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ovary-dependent emphysema augmentation and osteopontin induction in adult female mice.2015

    • Author(s)
      Niikura Y, Ishii T, Hosoki K, Nagase T, Yamashita N.
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 461 Issue: 4 Pages: 642-7

    • DOI

      10.1016/j.bbrc.2015.04.081

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Factors that predict in-hospital mortality in eosinophilic granulomatosis with polyangiitis.2015

    • Author(s)
      Hasegawa W, Yamauchi Y, Yasunaga H, Sunohara M, Jo T, Matsui H, Fushimi K, Takami K, Nagase T
    • Journal Title

      Allergy.

      Volume: 70 Issue: 5 Pages: 585-90

    • DOI

      10.1111/all.12597

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Oncogenic TPM3-ALK activation requires dimerization through the coiled-coil structure of TPM32015

    • Author(s)
      Amano Y, Ishikawa R, Sakatani T, Ichinose J, Sunohara M, Watanabe K, Kage H, Nakajima J, Nagase T, Ohishi N, Takai D
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 13 Issue: 3 Pages: 457-60

    • DOI

      10.1016/j.bbrc.2015.01.014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Lymphotoxin β receptor signaling induces IL-8 production in human bronchial epithelial cells.2014

    • Author(s)
      Mikami Y, Matsuzaki H, Horie M, Noguchi S, Jo T, Narumoto O, Kohyama T, Takizawa H, Nagase T, Yamauchi Y.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 12 Pages: 1-21

    • DOI

      10.1371/journal.pone.0114791

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Alternative polyadenylation is associated with lower expression of PABPN1 and poor prognosis in non-small cell lung cancer.2014

    • Author(s)
      Ichinose J, Watanabe K, Sano A, Nagase T, Nakajima J, Fukayama M, Yatomi Y, Ohishi N, Takai D.
    • Journal Title

      Cancer Sci

      Volume: 105 Issue: 9 Pages: 1135-1141

    • DOI

      10.1111/cas.12472

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Novel swine model of transfusion-related acute lung injury.2014

    • Author(s)
      Okazaki H, Ishikawa O, Iijima T, Kohira T, Teranishi M, Kawasaki S, Saito A, Mikami Y, Sugiura A, Hashimoto S, Shimada E, Uchikawa M, Matsuhashi M, Tsuno NH, Tanaka M, Kiyokawa N, Fujimoto J, Nagase T, Tadokoro K, Takahashi K.
    • Journal Title

      Transfusion.

      Volume: 54 Issue: 12 Pages: 3097-3107

    • DOI

      10.1111/trf.12766

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An integrative analysis of the tumorigenic role of TAZ in human non-small cell lung cancer.2014

    • Author(s)
      3.Noguchi S, Saito A, Horie M, Mikami Y, Suzuki HI, Morishita Y, Ohshima M, Abiko Y, Mattsson JS, König H, Lohr M, Edlund K, Botling J, Micke P, Nagase T
    • Journal Title

      Clin Cancer Res.

      Volume: 20 Issue: 17 Pages: 4660-72

    • DOI

      10.1158/1078-0432.ccr-13-3328

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2.2014

    • Author(s)
      4.Tarui M, Shindou H, Kumagai K, Morimoto R, Harayama T, Hashidate T, Kojima H, Okabe T, Nagano T, Nagase T, Shimizu T.
    • Journal Title

      J Lipid Res.

      Volume: 55 Pages: 1386-96

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Histamine induces human lung fibroblast-mediated collagen gel contraction via histamine H1 receptor.2014

    • Author(s)
      5.Horie M, Saito A, Yamauchi Y, Mikami Y, Sakamoto M, Jo T, Nakajima J, Takizawa H, Nagase T, Kohyama T.
    • Journal Title

      Exp Lung Res.

      Volume: 40 Issue: 5 Pages: 222-36

    • DOI

      10.3109/01902148.2014.900155

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Differential knockdown of TGF-β ligands in a three-dimensional co-culture tumor- stromal interaction model of lung cancer.2014

    • Author(s)
      6.Horie M, Saito A, Noguchi S, Yamaguchi Y, Ohshima M, Morishita Y, Suzuki HI, Kohyama T, Nagase T.
    • Journal Title

      BMC Cancer.

      Volume: 14 Issue: 1 Pages: 580-580

    • DOI

      10.1186/1471-2407-14-580

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] MxA transcripts with distinct first exons and modulation of gene expression levels by single-nucleotide polymorphisms in human bronchial epithelial cells.2013

    • Author(s)
      Noguchi S, Hijikata M, Hamano E, Matsushita I, Ito H, Ohashi J, Nagase T, Keicho N.
    • Journal Title

      Immunogenetics

      Volume: 65 Issue: 2 Pages: 107-114

    • DOI

      10.1007/s00251-012-0663-8

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Differential effects of a common splice site polymorphism on the generation of OAS1 variants in human bronchial epithelial cells.2013

    • Author(s)
      Noguchi S, Hamano E, Matsushita I, Hijikata M, Ito H, Nagase T, Keicho N.
    • Journal Title

      Hum Immunol

      Volume: 74 Issue: 3 Pages: 395-401

    • DOI

      10.1016/j.humimm.2012.11.011

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effect of secreted lymphocyte antigen-6/urokinase-type plasminogen activator receptor-related peptide-1 (SLURP-1) on airway epithelial cells.2013

    • Author(s)
      Narumoto O, Niikura Y, Ishii S, Morihara H, Okashiro S, Nakahari T, Nakano T, Matsumura H, Shimamoto C, Moriwaki Y, Misawa H, Yamashita N, Nagase T, Kawashima K, Yamashita N.
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 438 Issue: 1 Pages: 175-179

    • DOI

      10.1016/j.bbrc.2013.07.048

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] FER overexpression is associated with poor postoperative prognosis and cancer-cell survival in non-small cell lung cancer.2013

    • Author(s)
      Kawakami M, Morita S, Sunohara M, Amano Y, Ishikawa R, Watanabe K, Hamano E, Ohishi N, Nakajima J, Yatomi Y, Nagase T, Fukayama M, Takai D.
    • Journal Title

      Int J Clin Exp Pathol

      Volume: 6 Pages: 598-612

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Detection of novel paraja ring finger 2-fer tyrosine kinase mRNA chimeras is associated with poor postoperative prognosis in non-small cell lung cancer.2013

    • Author(s)
      Kawakami M, Ishikawa R, Amano Y, Sunohara M, Watanabe K, Ohishi N, Yatomi Y, Nakajima J, Fukayama M, Nagase T, Takai D.
    • Journal Title

      Cancer Sci

      Volume: 104 Issue: 11 Pages: 1447-1454

    • DOI

      10.1111/cas.12250

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] An integrated expression profiling reveals target genes of TGF-β and TNF-α possibly mediated by microRNAs in lung cancer cells2013

    • Author(s)
      Akira Saito, Hiroshi I Iizuka, Masafumi Horie, Mitsuhiro Ohshima, Yasuyuki Morishita, Yoshimitsu Abiko, Takahide Nagase
    • Journal Title

      PLoS ONE 8

      Volume: 8 Issue: 1 Pages: 158-163

    • DOI

      10.1016/j.bbrc.2012.05.104

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Characterization of human lung cancer-associated fibroblasts in three dimensional in vitro co-culture model2012

    • Author(s)
      Masafumi Horie, Akira Saito, Mitsuhiro Ohshima, Yasuyuki Morishita, Jun Nakajima, Tadashi Kohyama, Takahide Nagase
    • Journal Title

      Biochem Biophys Res Commun

      Volume: 423 Issue: 2 Pages: 158-163

    • DOI

      10.1371/journal.pone.0056587

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Tumor necrosis factor superfamily member LIGHT induces epithelial-mesenchymal transition in A549 human alveolar epithelial cells.2012

    • Author(s)
      Mikami Y
    • Journal Title

      Biochem Biophys Res Commun.

      Volume: 428 Issue: 4 Pages: 451-7

    • DOI

      10.1016/j.bbrc.2012.10.097

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Dynamic change in respiratory resistance during inspiratory and expiratory phases of tidal breathing in patients with chronic obstructive pulmonary disease.2012

    • Author(s)
      Yamauchi Y
    • Journal Title

      Int J Chron Obstruct Pulmon Dis.

      Volume: 7 Pages: 259-69

    • DOI

      10.2147/copd.s30399

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Polymerase reaction without primers throughout for the reconstruction of full-length cDNA from products of rapid amplification of cDNA ends (RACE)2011

    • Author(s)
      Sunohara M, Kawasaki M, Kage H, Watanabe K, Emoto N, Nagase T, Ohishi N, Takai D
    • Journal Title

      Biotechnol Lett

      Volume: 33 Pages: 1301-1307

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Suppression of transforming growth factor β1 in lung alveolar epithelium-decells using adeno-associated virus type 2/5 vectors to carry short hairpin RNA2011

    • Author(s)
      Kage H, Sugimoto K, Sano A, Kitagawa H, Nagase T, Ohishi N, Takai D
    • Journal Title

      Exp Lung Res

      Volume: 37 Pages: 175-185

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Simultaneous stimulation with TGF-β1-and TNF-α induces epithelial mesenchymal transition in bronchial epithelial cells2011

    • Author(s)
      Kamitani S, Yamauchi Y, Kawasaki S, Takami K, Takizawa H, Nagase T, Kohyama T
    • Journal Title

      Int Arch Allergy Immnunol

      Volume: 155 Pages: 119-128

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Recent progress of cellular and molecular biology in respiratory diseases2015

    • Author(s)
      Nagase T
    • Organizer
      APSR 2015
    • Place of Presentation
      クアラルンプール (マレーシア)
    • Year and Date
      2015-12-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research / Invited
  • [Presentation] Hot topics in experimental animal model2014

    • Author(s)
      Nagase T
    • Organizer
      APSR 2014
    • Place of Presentation
      Bali, Indonesia
    • Year and Date
      2014-11-14
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] モデルマウスを用いた呼吸器疾患の病態解明2013

    • Author(s)
      長瀬隆英
    • Organizer
      第53回日本呼吸器学会総会
    • Place of Presentation
      東京(東京国際フォーラム)
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Cellular and molecular models of lung diseases.2012

    • Author(s)
      Nagase T
    • Organizer
      APSR Meeting
    • Place of Presentation
      Hong Kong
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Molecular mechanisms underlying respiratory diseases2011

    • Author(s)
      長瀬隆英
    • Organizer
      16th APSR Meeting
    • Place of Presentation
      上海(中国)(招待講演)
    • Year and Date
      2011-11-06
    • Related Report
      2011 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi