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Novel Approach for Treatment of Glomeruloclerosis

Research Project

Project/Area Number 23249047
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Kidney internal medicine
Research InstitutionTokai University

Principal Investigator

ICHIKAWA Iekuni  東海大学, 医学部, 客員教授 (80317768)

Co-Investigator(Kenkyū-buntansha) MATSUSAKA Taiji  東海大学, 医学部・内科, 准教授 (50317749)
MOTOJIMA Masaru  東海大学, 医学部・薬理学, 講師 (80468636)
Research Collaborator Pastan Ira  National Institutes of Health, Laboratory of Molecular Biology, Center for Cancer Research, National Cancer Institute, Professor
Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥47,060,000 (Direct Cost: ¥36,200,000、Indirect Cost: ¥10,860,000)
Fiscal Year 2015: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2014: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2013: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2012: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
Fiscal Year 2011: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Keywordsポドサイト傷害 / 慢性腎不全 / 糸球体硬化症 / タンパク尿 / ポドサイト / アンジオテンシン / 慢性腎臓病 / トランスジェニックマウス / コラーゲン / 性差 / CAKUT
Outline of Final Research Achievements

Kidney diseases are major national health problems. Various causes including nephritis and diabetes leads to injury in “podocytes” in the kidney, which leads to loss of the whole kidney function. Damage in a subpopulation of podocytes secondarily propagates injury to the neighboring podocytes. In this project, we have established a mouse model in which injury to a fraction of the podocyte population can be induced, analyzed how the podocyte injury spreads and identified several key molecules potentially involved in the propagation of injury. It is expected that drugs targeting these molecules would forestall the progression of kidney diseases.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (31 results)

All 2016 2015 2014 2013 2012 2011 Other

All Journal Article (18 results) (of which Int'l Joint Research: 8 results,  Peer Reviewed: 18 results,  Open Access: 11 results,  Acknowledgement Compliant: 9 results) Presentation (13 results) (of which Int'l Joint Research: 2 results)

  • [Journal Article] Time-dependent dysregulation of autophagy: implications in aging and mitochondrial homeostasis in the kidney proximal tubule. Autophagy.2016

    • Author(s)
      Yamamoto T, Takabatake Y, Kimura T, Takahashi A, Namba T, Matsuda J, Minami S, Kaimori JY, Matsui I, Kitamura H, Matsusaka T, Niimura F, Yanagita M, Isaka Y, Rakugi H.
    • Journal Title

      -

      Volume: -

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Possible role for nephron-derived angiotensinogen in angiotensin-II dependent hypertension.2016

    • Author(s)
      Ramkumar N, Stuart D, Calquin M, Wang S, Niimura F, Matsusaka T, Kohan DE.
    • Journal Title

      Physiol Rep.

      Volume: 4・1 Issue: 1 Pages: e12675-e12675

    • DOI

      10.14814/phy2.12675

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Mammalian autophagy is essential for hepatic and renal ketogenesis during starvation.2016

    • Author(s)
      Takagi A, Kume S, Kondo M, Nakazawa J, Chin-Kanasaki M, Araki H, Araki S, Koya D, Haneda M, Chano T, Matsusaka T, Nagao K, Adachi Y, Chan L, Maegawa H, Uzu T.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 18944-18944

    • DOI

      10.1038/srep18944

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Conditional knockout of Foxc2 gene in kidney: efficient generation of conditional alleles of single-exon gene by double-selection system2016

    • Author(s)
      Motojima, Masaru; Ogiwara, Sanae; Matsusaka, Taiji; Kim, Sang Yong; Sagawa, Nobuho; Abe, Koichiro; Ohtsuka, Masato
    • Journal Title

      Mamm Genome

      Volume: 27 Issue: 1-2 Pages: 62-69

    • DOI

      10.1007/s00335-015-9610-y

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Genome-wide association study of IgA nephropathy using 23 465 microsatellite markers in a Japanese population.2015

    • Author(s)
      Saka S, Hirawa N, Oka A, Yatsu K, Hirukawa T, Yamamoto R, Matsusaka T, Imai E, Narita I, Endoh M, Ichikawa I, Umemura S, Inoko H.
    • Journal Title

      J Hum Genet.

      Volume: 60・10 Issue: 10 Pages: 573-80

    • DOI

      10.1038/jhg.2015.88

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Erythropoiesis and Blood Pressure Are Regulated via AT1 Receptor by Distinctive Pathways2015

    • Author(s)
      Kato H, Ishida J, Matsusaka T, Ishimaru T, Tanimoto K, Sugiyama F, Yagami K, Nangaku M, Fukamizu A
    • Journal Title

      PLoS One

      Volume: 10 Issue: 6 Pages: e0129484-e0129484

    • DOI

      10.1371/journal.pone.0129484

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Podocyte injury-driven lipid peroxidation accelerates the infiltration of glomerular foam cells in focal segmental glomerulosclerosis.2015

    • Author(s)
      Hara S, Kobayashi N, Sakamoto K, Ueno T, Manabe S, Takashima Y, Hamada J, Pastan I, Fukamizu A, Matsusaka T, Nagata M.
    • Journal Title

      Am J Pathol

      Volume: 185 Issue: 8 Pages: 2118-31

    • DOI

      10.1016/j.ajpath.2015.04.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Podocyte injury-driven intracapillary plasminogen activator inhibitor type 1 accelerates podocyte loss via uPAR-mediated β1-integrin endocytosis.2015

    • Author(s)
      Kobayashi N, Ueno T, Ohashi K, Yamashita H, Takahashi Y, Sakamoto K, Manabe S, Hara S, Takashima Y, Dan T, Pastan I, Miyata T, Kurihara H, Matsusaka T, Reiser J, Nagata M.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 308・6 Issue: 6 Pages: F614-F626

    • DOI

      10.1152/ajprenal.00616.2014

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Sirtuin1 Maintains Actin Cytoskeleton by Deacetylation of Cortactin in Injured Podocytes.2015

    • Author(s)
      Motonishi S, Nangaku M, Wada T, Ishimoto Y, Ohse T, Matsusaka T, Kubota N, Shimizu A, Kadowaki T, Tobe K, Inagi R.
    • Journal Title

      J Am Soc Nephrol.

      Volume: 26・8 Issue: 8 Pages: 1939-59

    • DOI

      10.1681/asn.2014030289

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] Unilateral ureteral obstruction attenuates intrarenal angiotensin Ⅱgeneration induced by podocyte injury.2015

    • Author(s)
      Okabe M,Miyazaki Y,Niimura F,Pastan I,Nishiyama A,Yokoo T,Ichikawa I,Matsusaka T.
    • Journal Title

      Am J Physiol Renal Physiol

      Volume: 308・8 Issue: 8 Pages: F932-F937

    • DOI

      10.1152/ajprenal.00444.2014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Kidney Diseases Enhance Expression of Tetraspanin-8: A Possible Protective Effect against Tubular Injury.2014

    • Author(s)
      Hirukawa T, Wu Q, Sawada K, Matsusaka T, Saka S, Oka A, Hirawa N, Umemura S, Kakuta T, Endoh M, Inoko H, Ichikawa I, Fukagawa M.
    • Journal Title

      Nephron Extra.

      Volume: 4・1 Issue: 1 Pages: 70-81

    • DOI

      10.1159/000362451

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mice are unable to endogenously regenerate podocytes during the repair of immunotoxin-induced glomerular injury.2013

    • Author(s)
      Y Miyazaki , A Shimizu , I Ichikawa ,T Hosoya , I Pastan ,T Matsusaka.
    • Journal Title

      Nephrology Dial Transplant.

      Volume: -

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Podocyte injury enhances filtration of liver-derived angiotensinogen and renal angiotensinIIgeneration.2013

    • Author(s)
      T Matsusaka,F Niimura,I Pastan ,A Shintani, A Nishiyama , I Ichikawa.
    • Journal Title

      Kidney Int.

      Volume: - Issue: 5 Pages: 1068-1077

    • DOI

      10.1038/ki.2013.453

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Foxc1 gene null mutation causes ectopic budding and kidney hypoplasia but not dysplasia.2013

    • Author(s)
      Komaki F,Miyazaki Y, Niimura F,Mtsusaka T, Ichikawa I,Motojima M .
    • Journal Title

      Cells Tissues Organs.

      Volume: 198・1 Issue: 1 Pages: 22-27

    • DOI

      10.1159/000351291

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Liver angiotensinogen is the primary source of renal angiotensin II.2012

    • Author(s)
      Matsusaka T, Niimura F, Shimizu A, Pastan I, Saito A, Kobori H, Nishiyama A, Ichikawa I.
    • Journal Title

      J Am Soc Nephrol.

      Volume: 23-7 Issue: 7 Pages: 1181-1189

    • DOI

      10.1681/asn.2011121159

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ARB protects podocytes from HIV-1 nephropathy independently of podocyte AT12012

    • Author(s)
      清水昭博、市川家國、松阪泰二, 他
    • Journal Title

      Nephrol Dial Transplant

      Volume: (Epub ahead of print) Issue: 8 Pages: 3169-3175

    • DOI

      10.1093/ndt/gfs033

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Podocyte injury damages other podocytes2011

    • Author(s)
      松阪泰二、市川家國, 他
    • Journal Title

      J Am Soc Nephrol

      Volume: 22 Issue: 7 Pages: 1275-1285

    • DOI

      10.1681/asn.2010090963

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Induction of podocyte-derived VEGF ameliorates podocyte injury and subsequent abnormal glomerular development caused by puromycin aminonucleoside2011

    • Author(s)
      Ma Ji, 松阪泰二、市川家國, 他
    • Journal Title

      Pediatr Res

      Volume: 70 Issue: 1 Pages: 83-89

    • DOI

      10.1203/pdr.0b013e31821bdf1c

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Ribotagマウスを利用したポドサイト特異的ポリソームmRNAの解析2016

    • Author(s)
      岡部匡裕、松阪泰二、市川家國
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2016-06-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] 一部のポドサイトのみに傷害を誘導可能な新しいモデルマウスの解析2016

    • Author(s)
      岡部匡裕、松阪泰二、市川家國
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      名古屋国際会議場(愛知県名古屋市)
    • Year and Date
      2016-06-07
    • Related Report
      2015 Annual Research Report
  • [Presentation] Comprehensive Polysome Analysis in Injured Podocytes .2015

    • Author(s)
      Masahiro Okabe, Yoichi Miyazaki, Takashi Yokoo, Masafumi Fukagawa, Taiji Matsusaka.
    • Organizer
      ASN Kidney Week 2015
    • Place of Presentation
      San Diego Convention Center(USA SanDiego)
    • Year and Date
      2015-11-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Podocyte Injury .2015

    • Author(s)
      Taiji Matsusaka, Fumio Niimura, Akira Nishiyama, Akihiko Saito, Motoko Yanagita, Iekuni Ichikawa.
    • Organizer
      ASN Kidney Week 2015
    • Place of Presentation
      San Diego Convention Center(USA SanDiego)
    • Year and Date
      2015-11-03
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] A New Mosaic Model of Segmetal Potocyte Ablation2014

    • Author(s)
      Okabe M,Matsusaka T,Ichikawa I
    • Organizer
      ASN meeting 2014
    • Place of Presentation
      Pensylvania Convention Center
    • Year and Date
      2014-11-14
    • Related Report
      2014 Annual Research Report
  • [Presentation] 一部のポドサイトのみに限局した傷害を誘導可能な新しいモデルマウス2014

    • Author(s)
      岡部匡裕、松阪泰二、市川家國
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      パシフィコ横浜
    • Year and Date
      2014-07-06
    • Related Report
      2014 Annual Research Report
  • [Presentation] 糸球体硬化症における1型コラーゲン転写の減弱2013

    • Author(s)
      小泉賢洋、住吉秀明、稲垣豊、深川雅史、松阪泰二、市川家國
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report
  • [Presentation] Liver-, but Not Kidney-Specific Angiotensinogen Gene Knockout Abrogates the Enhancement of Renal Angiotensin II Synthesis that Follows Podocyte Injury in Progressive Glomerulosclerosis2012

    • Author(s)
      Taiji Matsusaka, Fumio Niimura, Masafumi Fukagawa, Akira Nishiyama, Iekuni Ichikawa.
    • Organizer
      ASN meeting 2012
    • Place of Presentation
      San Diego コンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] Filtered Angiotensinogen, Not Renal Renin, Determines the Renal Angiotensin II Synthesis when Podocytes Lose Their Molecular Barrier Function.2012

    • Author(s)
      Fumio Niimura, Akira Nishiyama, Iekuni Ichikawa, Taiji Matsusaka.
    • Organizer
      ASN meeting 2012
    • Place of Presentation
      San Diego コンベンションセンター
    • Related Report
      2012 Annual Research Report
  • [Presentation] Keap1抑制による糸球体硬化症の軽減2011

    • Author(s)
      清水昭博、市川家國、松阪泰二他
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      パシフィコ横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] Mechanism of Increased Renal Angiotensin II in Glomerular Disease2011

    • Author(s)
      Matsusaka T, Niimura F, Ichikawa I et al
    • Organizer
      ASN Kidney Week
    • Place of Presentation
      Philadelphiaコンベンションセンター
    • Related Report
      2011 Annual Research Report
  • [Presentation] Angiotensinogen Is Filtered through the Glomerulus and Reabsorbed by the Proximal Tubule in Both Mice and Humans.2011

    • Author(s)
      Niimura F, Matsusaka T, Ichikawa I et al
    • Organizer
      ASN Kidney Week
    • Place of Presentation
      Philadelphiaコンベンションセンター
    • Related Report
      2011 Annual Research Report
  • [Presentation] 腎特異的トランスジェニックマウス作製の新たな方法

    • Author(s)
      小泉賢洋、大塚正人、深川雅史、松阪泰二
    • Organizer
      日本腎臓学会総会
    • Place of Presentation
      東京国際フォーラム
    • Related Report
      2013 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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