Integrative elucidation of molecular mechanisms for leukemogenesis: Identification and analyses of mutations with novel categories.

• Project/Area Number: 23249051
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Hematology
• Research Institution: The University of Tokyo
• Principal Investigator: KITAMURA Toshio 東京大学, 医科学研究所, 教授 (20282527)
• Co-Investigator(Kenkyū-buntansha): KITAURA Jiro 東京大学, 医科学研究所, 准教授 (30282651) ; NAKAHARA Fumio 東京大学, 医科学研究所, 助教 (80581181)
• Project Period (FY): 2011-05-31 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥47,970,000 (Direct Cost: ¥36,900,000、Indirect Cost: ¥11,070,000); Fiscal Year 2013: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2012: ¥14,820,000 (Direct Cost: ¥11,400,000、Indirect Cost: ¥3,420,000); Fiscal Year 2011: ¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
• Keywords: 血液腫瘍学 / 癌 / シグナル伝達 / 発現制御 / 内科 / 遺伝子 / 白血病 / 骨随意形成症候群 / エピジェネティクス / miRNA / ASXL1 / EZH2 / マウス骨髄移植モデル

Research Abstract

Mutations in a variety of epigenetic factors have been recently identified in various hematological malignancies. We have demonstrated that the mutations in TET2, EZH2 or ASXL1 induce myelodysplastic syndromes (MDS)-like in mouse bone marrow transplant (BMT) model and that derepression of HoxA9 and miR125a induced by ASXL1 mutants via EZH2/PRC2 repression plays critical roles in inducing MDS-like disease.
We previously reported that Hes1 plays critical roles in CML-BC. We here demonstrate that MMP9 expression induced by Hes1 via NFkB activation plays some roles in the progression of CML-BC. In addition, we also demonstrated that Hes1 collaborated with FIP1L1-PDGFR in inducing AML in mouse BMT model and that Hes1 overexpression was observed in 2 of 5 patients with eosinophilic leukemia harboring FIP1L1-PDGFR. These results indicate that Hes1 contribute to leukemogenesis in suppressing myeloid differentiation.

Research Products

• [Journal Article] Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells. (2014)
  • Author(s): Nakahara F, Kitaura J, Uchida T, Nishida C, Togami K, Inoue D, Matsukawa T, Kagiyama Y, Enomoto Y, Kawabata KC, Chen-Yi L, Komeno Y, Izawa K, Oki T, Nagae G, Harada Y, Harada H, Otsu M, Aburatani H, Heissig B, Hattori K, Kitamura T.
  • Journal Title: Blood Volume: 123(25) Issue: 25 Pages: 3932-42
  • DOI: 10.1182/blood-2013-01-476747
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Ezh2 loss promotes development of myelodysplastic syndrome but attenuates its predisposition to leukemic transformation (2014)
  • Author(s): Sashida, G., Harada, H., Matsui, H., Oshima, M., Yui, M., Harada, Y., Tanaka, S., Mochizuki-Kashio, M., Wang, C., Saraya, A., Muto, T., Hayasi, Y., Suzuki, K., Nakajima, H., Inaba, T., Koseki, H., Huang, G., Kitamura, T. and Iwama, A
  • Journal Title: Nature Commun Volume: (in press)
  • URL: http://www.nature.com/ncomms/index.html
• [Journal Article] Nov/ccn3 regulates long-term repopulating activity of murine hematopoietic stem cells via integrin αvβ3 (2014)
  • Author(s): J. Ishihara, et al
  • Journal Title: International Journal of Hematology Volume: (印刷中) Issue: 4 Pages: 393-406
  • DOI: 10.1007/s12185-014-1534-x
  • Peer Reviewed
• [Journal Article] Hes1 up-regulation contributes to the development of FIP1L1-PDGFRA-positive leukemia in blast crisis. (2014)
  • Author(s): Uchida T, Kawabata KC, Kitamura T., et al.
  • Journal Title: Exp Hematol. Volume: S0301-472X(14) Issue: 5 Pages: 56-3
  • DOI: 10.1016/j.exphem.2014.01.009
  • Peer Reviewed / Open Access
• [Journal Article] Nov/CCN regulates long term repopulation activity of murine hematopietic stem cells via integrin αvβ3. (2014)
  • Author(s): Ishihara, J
  • Journal Title: Int. J. Hematol. Volume: in press
  • Peer Reviewed
• [Journal Article] Hes1 promotes blast crisis in chronic myelogenous leukemia through MMP-9 upregulation in leukemic cells (2014)
  • Author(s): Nakahara, F
  • Journal Title: Blood Volume: in press
  • Peer Reviewed
• [Journal Article] Hes1 up-regulation contributes to the development of FIP1L1-PDGFRA-positive leukemia in blast crisis. (2014)
  • Author(s): Uchida, T
  • Journal Title: Exp. Hematol. Volume: in press
  • Peer Reviewed
• [Journal Article] Myelodysplastic syndromes are induced by histone methylation-altering ASXL1 mutations. (2013)
  • Author(s): Inoue, D
  • Journal Title: J. Clin. Invest. Volume: 123 Issue: 11 Pages: 4627-4640
  • DOI: 10.1172/jci70739
  • Peer Reviewed
• [Journal Article] The shortest isoform of C/EBPβ, Liver inhibitory protein (LIP) , collaborates with Evi1 to induce AML in a mouse BMT model (2013)
  • Author(s): Okochi, N., Yoshimi, A., Sato, T., Ikeda, T., Kumano, K., Taoka, K., Sato, Y., Shinohara, A., Tsuruta, A., Masuda, A., Yokota, H., Yatomi, Y., Takahashi, K., Kitaura, J., Kitamura, T. and Kurokawa, M
  • Journal Title: Blood Volume: 121 Issue: 20 Pages: 4142-4155
  • DOI: 10.1182/blood-2011-07-368654
  • NAID: 10031196292
  • Peer Reviewed
• [Journal Article] RUNX1/AML1 mutant collaborates with BMI1 overexpression in tnedevelopment of human and murine myelodysplastic syndromes. (2013)
  • Author(s): 原田結花、井上大地, 他
  • Journal Title: Blood Volume: 128(3) Issue: 17 Pages: 3434-3446
  • DOI: 10.1182/blood-2012-06-434423
  • Peer Reviewed
• [Journal Article] Human CD300C delivers an Fc receptor-ν-dependent activating signal in mast cells and monocytes and differs from CD300A in ligand recognition. (2013)
  • Author(s): Takahashi M, Izawa K, Kashiwakura JI, Yamanishi Y, Enomoto Y, Kaitani A, Maehara A, Isobe M, Ito S, Matsukawa T, Nakahara F, Oki T, Kajikawa M, Ra C, Okayama Y, Kitamura T, Kitaura J.
  • Journal Title: J Biol Chem. Volume: 288(11) Issue: 11 Pages: 7662-75
  • DOI: 10.1074/jbc.m112.434746
  • Peer Reviewed
• [Journal Article] MicroRNA-125b-1 accelerates a C-terminal mutant of C/EBPa (C/EBPa-C(m)) -induced myeloid leukemia (2012)
  • Author(s): Enomoto, Y., Kitaura, J., Shimanuki, M., Kato, N., Nishimura, K., Takahashi, M., Nakamura, H., Kitamura, T., and Sonoki T
  • Journal Title: Int. J. Hematol Volume: 96 Issue: 3 Pages: 334-341
  • DOI: 10.1007/s12185-012-1143-5
• [Journal Article] Aberrant expression of RasGRP1 cooperates with gain-of-function NOTCH1 mutations in T-cell leukemogenesis (2012)
  • Author(s): Oki T, Kitaura J, Watanabe-Okochi N, Nishimura K, Maehara A, Uchida T, Komeno Y, Nakahara F, Harada Y, Sonoki T, Harada H, Kitamura T
  • Journal Title: Leukemia Volume: (in press) Issue: 5 Pages: 1038-1045
  • DOI: 10.1038/leu.2011.328
  • Peer Reviewed
• [Journal Article] Upregulation of CD200R1 in lineage-negative leukemic cells is characteristic of AML1-ETO-positive leukemia in mice. (2012)
  • Author(s): Kagiyama Y, Kitaura J, Togami K, Uchida T, Inoue D, Matsukawa T, Izawa K, Kawabata KC, Komeno Y, Oki T, Nakahara F, Sato K, Aburatani H, Kitamura T.
  • Journal Title: Int J Hematol. Volume: 96(5) Issue: 5 Pages: 638-48
  • DOI: 10.1007/s12185-012-1207-6
  • Peer Reviewed
• [Journal Article] The receptor LMIR3 negatively regulates mast cell activation and allergic responses by binding to extracellular ceramide. (2012)
  • Author(s): Izawa K, Yamanishi Y, Maehara A, Takahashi M, Isobe M, Ito S, Kaitani A, Matsukawa T, Matsuoka T, Nakahara F, Oki T, Kiyonari H, Abe T, 0kumura K, Kitamura T, Kitaura J.
  • Journal Title: Immunity Volume: 16;37(5) Issue: 5 Pages: 827-39
  • DOI: 10.1016/j.immuni.2012.08.018
  • Peer Reviewed
• [Journal Article] A soluble form of LMIR5/CD300b amplifies lipopolysaccharide-induced lethal inflammation in sepsis. (2012)
  • Author(s): Yoshinori Yamanishi
  • Journal Title: Journal of Immunology Volume: 189 Issue: 4 Pages: 1773-1779
  • DOI: 10.4049/jimmunol.1201139
  • Peer Reviewed
• [Journal Article] HDACI-induced thrombocytopenia is caused by its unexpected target. (2012)
  • Author(s): 北村俊雄、井上大地
  • Journal Title: Experimental hematology Volume: 40(9) Issue: 9 Pages: 695-697
  • DOI: 10.1016/j.exphem.2012.07.001
  • Peer Reviewed
• [Journal Article] Fyn is not essential for Bcr-Ab1-induced leukemogenesis in mouse bone marrow transplantation models (2012)
  • Author(s): Doki N, Kitaura J, Inoue D, Kato N, Kagiyama Y, Uchida T, Togami K, Isobe M, Ito S, Maehara A, Izawa K, Oki T, Harada Y, Nakahara F, Harada H, Kitamura T
  • Journal Title: Int J Hematol Volume: 95(2) Issue: 2 Pages: 167-175
  • DOI: 10.1007/s12185-011-0994-5
  • Peer Reviewed
• [Journal Article] TSC-22 is a negative-feedback regulator of Ras/Raf signaling: Implications for tumorigenesis. (2012)
  • Author(s): Nakamura, M
  • Journal Title: Cancer Science Volume: 103 Issue: 1 Pages: 26-33
  • DOI: 10.1111/j.1349-7006.2011.02108.x
  • Peer Reviewed
• [Journal Article] TANK-binding kinase 1 (TBK1) controls cell survival through PAI-2/serpinB2 and transglutaminase 2. (2012)
  • Author(s): Delhase, M
  • Journal Title: Proc Natl Acad Sci Volume: 109 Issue: 11 Pages: 177-86
  • DOI: 10.1073/pnas.1201576109
  • Peer Reviewed
• [Journal Article] Development and Function of Invariant Natural Killer T cells Producing TH2- and TH17-cytokines (2012)
  • Author(s): Watarai H, Sekine-Kondo E, Shigeura T, Motomura Y, Yasuda T, Satoh R, Yoshida H, Kubo M, Kawamoto H, Koseki H, Taniguchi M
  • Journal Title: PLoS Biol Volume: 10 Issue: 2 Pages: e1001255-e1001255
  • DOI: 10.1371/journal.pbio.1001255
  • Peer Reviewed
• [Journal Article] Survival and death signals can predict tumor response to therapy after oncogene inactivation (2012)
  • Author(s): Tran, P.T
  • Journal Title: Science Translational Medicine Volume: (in press) Issue: 103
  • DOI: 10.1126/scitranslmed.3002018
  • Peer Reviewed
• [Journal Article] IKAROS isoform 6 enhances BCR-ABL1-mediated proliferation of human CD34+ hematopoietic cells on stromal cells (2012)
  • Author(s): Suzuki K, et al
  • Journal Title: Int J Oncol Volume: 40 Pages: 53-62
  • DOI: 10.3892/ijo.2011.1192
  • Peer Reviewed
• [Journal Article] Identification of RHOXF2 (PEPP2) as a cancer-promoting gene by expression cloning (2012)
  • Author(s): Shibata-Minoshima, F
  • Journal Title: Int J Oncology Volume: 40 Pages: 93-98
  • DOI: 10.3892/ijo.2011.1173
  • Peer Reviewed
• [Journal Article] Plasma membrane-associated sialidase (NEU3) regulates progression of prostate cancer to androgen-independent growth through modulation of androgen receptor signaling (2012)
  • Author(s): Kawamura, S., et al
  • Journal Title: Cell Death Differ Volume: 19 Issue: 1 Pages: 170-179
  • DOI: 10.1038/cdd.2011.83
  • Peer Reviewed
• [Journal Article] Em/miR-125b transgenic mice develop lethal B-cell malignancies (2011)
  • Author(s): Enomoto, Y
  • Journal Title: Leukemia Volume: 25 Issue: 12 Pages: 1849-1856
  • DOI: 10.1038/leu.2011.166
  • Peer Reviewed
• [Journal Article] Two types of C/EBPa mutations play distinct roles in leukemogenesis : Lessons from clinical data and BMT models (2011)
  • Author(s): Kato, N
  • Journal Title: Blood Volume: 117 Issue: 1 Pages: 221-233
  • DOI: 10.1182/blood-2010-02-270181
  • Peer Reviewed
• [Journal Article] Evi1 represses PTEN expression and activates PI3K/AKT/mTOR via interactions with polycomb proteins (2011)
  • Author(s): Yoshimi Akihide
  • Journal Title: Blood Volume: 117 Issue: 13 Pages: 3617-28
  • DOI: 10.1182/blood-2009-12-261602
  • Peer Reviewed
• [Presentation] C-terminal-truncating ASXL1 mutations induce MDS via repression of PRC2 function (2013)
  • Author(s): 井上大地, 北村俊雄
  • Organizer: The 55th American Society of Hematology annual meeting
  • Place of Presentation: ニューオーリンズ
  • Year and Date: 2013-12-09
• [Presentation] Hes1 promotes blast crisis of chronic myelogenous leukemia through MMP-9 up-regulation (2013)
  • Author(s): 北村俊雄
  • Organizer: 分子生物学会ワークショップ
  • Place of Presentation: 神戸
  • Year and Date: 2013-12-04
• [Presentation] ASXL1 mutations induces an MDS-like disease in mice via derepression of HoxA9 and miR125a (2013)
  • Author(s): 北村俊雄
  • Organizer: 日仏がん会議(French Japanese Cancer Meeting)
  • Place of Presentation: トゥールーズ
  • Year and Date: 2013-11-21
  • Invited
• [Presentation] ASXL1 mutations induces an MDS-like disease in mice via derepression of HoxA9 and miR125a (2013)
  • Author(s): 北村俊雄
  • Organizer: 日仏がん会議（French Japanese Cancer Meeting）
  • Place of Presentation: フランス・トゥールーズ
  • Invited
• [Presentation] Leukemogenesis induced by C-terminal mutations in the basic leucine zipper domain of C/EBPα (2012)
  • Author(s): 戸上勝仁, 北浦次郎, 井上大地, 鍵山侑希, 内田智之, 西村耕太郎, 土岐典子, 加藤菜穂子, 中原史雄, 沖俊彦, 原田結花, 原田浩徳, 北村俊雄
  • Organizer: 第74回日本血液学会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2012-10-20
• [Presentation] Molecular Mechanisms of blast crisis in chronic myelogenous leukemia caused by upregulation of Hes1 (2012)
  • Author(s): 中原史雄, 北浦次郎, 川畑公人, 内田智之,鍵山侑希, 井上大地, 戸上勝仁, 沖俊彦, 原田結花 , 原田浩徳 , 北村俊雄
  • Organizer: 第74回日本血液学会
  • Place of Presentation: 京都国際会館
  • Year and Date: 2012-10-20
• [Presentation] T細胞白血化におけるNOTCH1の新しい共同因子,RasGRP1 (2012)
  • Author(s): 沖俊彦
  • Organizer: 第16回造血器腫瘍研究会
  • Place of Presentation: 東京 国立がんセンター研究所
  • Year and Date: 2012-01-28
• [Presentation] Molecular aspects of leukemic transformation of myelodysplastic syndromes (MDS) and myeloproliferative neoplasm (MPN) (2012)
  • Author(s): Toshio Kitamura
  • Organizer: 日仏がんワークショップ
  • Place of Presentation: 徳島グランドエクシブ鳴門
  • Invited
• [Presentation] Two types of C/EBPa mutations collaborate in inducing leukemia in a mouse BMT model. (2012)
  • Author(s): Toshio Kitamura
  • Organizer: 9th International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia
  • Place of Presentation: Cincinnati,USA
• [Presentation] Two forms of C/EBPa mutants collaborate in leukemogenesis. (2012)
  • Author(s): Toshio Kitamura
  • Organizer: 9th International Workshop on Molecular Aspects of Myeloid Stem Cell Development and Leukemia
  • Place of Presentation: Cincinnati,USA
• [Presentation] RUNX1/AML1 Mutants collaborate with BMI1 in the development of myelodysplastic syndromes. (2012)
  • Author(s): Hironori Harada
  • Organizer: ISEH 41st Annual Scientific Meeting/Experimental Hematology
  • Place of Presentation: Amsterdam, Netherlands
• [Presentation] 細胞周期制御因子MgcRacGAPの新規発現調節機構 (2011)
  • Author(s): 西村耕太郎
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 神奈川 パシフィコ横浜
  • Year and Date: 2011-12-15
• [Presentation] Nov/CCN3 Enhances Long-Term Repopulating Activity of-Mouse Hematopoietic Stem Cells Via Intergin β3 Signaling Collaborating with Thrombopoietin (2011)
  • Author(s): Jun Ishihara
  • Organizer: American Society of Hematology Fifty-third annual meeting
  • Place of Presentation: San Diego, California, USA
  • Year and Date: 2011-12-10
• [Presentation] Dual Inhibition of the STAT3 and Src Pathways by N-018,a JAK2 and Src-Family Kinase Inhibitor, Reduces Myeloma Cell Proliferation and Adhesion and Suppresses Osteoclast Formation (2011)
  • Author(s): Ayumi Kodama
  • Organizer: American Society of Hematology Fifty-third annual meeting
  • Place of Presentation: San Diego, California, USA
  • Year and Date: 2011-12-10
• [Presentation] LMIR3ノックアウトマウスにおけるアレルギー反応の亢進 (2011)
  • Author(s): 伊沢久未
  • Organizer: 日本免疫学会
  • Place of Presentation: 千葉 幕張メッセ
  • Year and Date: 2011-11-29
• [Presentation] CD300/LMIRファミリーとマスト細胞 (2011)
  • Author(s): 北浦次郎
  • Organizer: 第61回日本アレルギー学会秋季学術大会
  • Place of Presentation: 東京 グランドプリンスホテル新高輪
  • Year and Date: 2011-11-11
• [Presentation] Molecular basis of leukemia, MPN and MDS (2011)
  • Author(s): 北村俊雄
  • Organizer: 第70回 日本癌学会学術総会
  • Place of Presentation: 愛知 名古屋国際会議場
  • Year and Date: 2011-10-03
• [Presentation] Molecular mechanisms of blast crisis in chronic myelogenous leukemia (2011)
  • Author(s): 中原史雄
  • Organizer: 第70回 日本癌学会学術総会
  • Place of Presentation: 愛知 名古屋国際会議場
  • Year and Date: 2011-10-03
• [Presentation] LMIR5/CD300bのリガンド(TIM1)同定と(腎虚血における)機能解析 (2011)
  • Author(s): 北浦次郎
  • Organizer: 第84回日本生化学会大会
  • Place of Presentation: 京都 国立京都国際会館
  • Year and Date: 2011-09-21
• [Presentation] Two types of C/EBPa mutations collaborate in inducing leukemia in a mouse BMT model (2011)
  • Author(s): 北村俊雄
  • Organizer: 第25回IACRLRD
  • Place of Presentation: 東京大学本郷キャンパス(招待講演)
  • Year and Date: 2011-09-15
• [Presentation] The Roles of RasGRPs in Hematological Malignancies (2011)
  • Author(s): Toshihiko Oki
  • Organizer: 40th Annual Scientific Meeting of International Society of Experimental Hematology
  • Place of Presentation: Westin Bavshore Hotel, Vancouber, Canada
  • Year and Date: 2011-08-25
• [Presentation] Lessons from mouse models for myelodysplastic syndromes/overt leukemia and chronic myelogeneous leukemia in blast crisis : Insertional mutagenesis induced Evi-1 expression but not Hes1 expression (2011)
  • Author(s): 北村俊雄
  • Organizer: 日本学術振興会二国間交流事業セミナー
  • Place of Presentation: 九州大学百年講堂
  • Year and Date: 2011-07-14
• [Presentation] Animal models for AML (2011)
  • Author(s): 北村俊雄
  • Organizer: MDS and MPN 日本遺伝子治療学会教育講演
  • Place of Presentation: 九州大学百年講堂
  • Year and Date: 2011-07-14
• [Presentation] Animal models for AML, MDS and MPN (2011)
  • Author(s): 北村俊雄
  • Organizer: 日本遺伝子治療学会
  • Place of Presentation: 九州大学 百年講堂
  • Year and Date: 2011-07-14
• [Presentation] Lessons from mouse models for myelodysplastic syndromes/overt leukemia and chronic myelogeneous leukemia in blast crisis : Insertional mutagenesis induced Evi-1 expression but not Hes1 expression (2011)
  • Author(s): 北村俊雄
  • Organizer: 二国間交流事業セミナー
  • Place of Presentation: 九州大学 百年講堂(招待講演)
  • Year and Date: 2011-07-14
• [Presentation] Two types of C/EBPa mutations collaborate in inducing leukemia in a mouse BMT model (2011)
  • Author(s): 北村俊雄
  • Organizer: 第25回IACRLRD
  • Place of Presentation: 東京大学本郷キャンパス
• [Presentation] Molecular basis of leukemia, MPN and MDS (2011)
  • Author(s): 北村俊雄
  • Organizer: 第70回日本癌学会学術総会シンポジウム
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Mouse models for MDS/overt leukemia and CML-BC (2011)
  • Author(s): 北村俊雄
  • Organizer: 第73回日本血液学会学術集会シンポジウム
  • Place of Presentation: 名古屋国際会議場
• [Presentation] Two types of C/EBPa mutations play distinct roles and collaborate in inducing leukemia (2011)
  • Author(s): 北村俊雄
  • Organizer: International Scientific Coordination Network (ISCN) "FRANCE-JAPAN-CANCER"
  • Place of Presentation: フランス モンペリエ(招待講演)
• [Presentation] C-terminal-truncating ASXL1 mutations induce MDS via repression of PRC2 function
  • Author(s): 井上大地
  • Organizer: 20th East Asia Joint Symposium
  • Place of Presentation: 日本・東京
• [Presentation] Molecular basis of hematological malignancies
  • Author(s): 北村俊雄
  • Organizer: 20th East Asia Joint Symposium
  • Place of Presentation: 日本・東京
• [Presentation] C-terminal-truncating ASXL1 mutations induce MDS via repression of PRC2 function
  • Author(s): 井上大地
  • Organizer: The 55th American Society of Hematology annual meeting
  • Place of Presentation: アメリカ・ニューオーリンズ
• [Presentation] Leukemogenesis induced by C-terminal mutations in the basic leucine zipper domain of C/EBPα
  • Author(s): 戸上勝仁
  • Organizer: 42nd ISEH Annual Scientific Meeting
  • Place of Presentation: オーストリア・ウィーン
• [Presentation] C-terminal-truncated ASXL1 induced MDS-like symptoms in mice via derepression of miR-125a and reduced expression of Clec5a/Mdl1
  • Author(s): 井上大地
  • Organizer: The 11th Stem Cell Research Symposium
  • Place of Presentation: 日本・東京
• [Presentation] C-terminal-truncating ASXL1 mutations induce MDS via repression of PRC2 function
  • Author(s): 井上大地
  • Organizer: 第75回日本血液学会学術集会
  • Place of Presentation: 日本・札幌
• [Presentation] 細胞周期制御因子MgcRacGAPの新規発現調節機構
  • Author(s): 西村耕太郎
  • Organizer: 第12回東京大学生命科学シンポジウム
  • Place of Presentation: 東京大学山上会館（東京）
• [Presentation] LMIR3/CD300f negatively regulates mast cell-dependent allergic responses.
  • Author(s): 伊沢久未
  • Organizer: The International Symposium Allergy and Inflammation
  • Place of Presentation: 韓国、ソウル
  • Invited
• [Presentation] An active mutant of c-Kit collaborates with AML1-ETO in inducing AML in a mouse BMT model.
  • Author(s): 鍵山侑希
  • Organizer: 第74回日本血液学会
  • Place of Presentation: 京都国際会館（京都）
• [Presentation] The roles of Hes1 in the myeloid leukemogenesis.
  • Author(s): 内田智之
  • Organizer: 第74回日本血液学会
  • Place of Presentation: 京都国際会館（京都）
• [Presentation] MLL fusion genes transform hematopoietic stem cells through an aberrant self-renewal program by Plzf.
  • Author(s): Ryoichi Ono
  • Organizer: 第74回日本血液学会
  • Place of Presentation: 京都国際会館（京都）
• [Presentation] NS-018 Suppresses myeloma cell growthand osteoclast formation by inhibiting JAK2 and Src pathways.
  • Author(s): Ayumi Kodama
  • Organizer: 第74回日本血液学会
  • Place of Presentation: 京都国際会館（京都）
• [Presentation] RasGRP1 and its roles in T-ALL.
  • Author(s): 沖俊彦
  • Organizer: 第74回日本血液学会
  • Place of Presentation: 京都国際会館（京都）
• [Presentation] Leukemogenesis induced by C-terminal mutations in the basic leucine zipper domain of C/EBPα.
  • Author(s): 戸上勝仁
  • Organizer: 第74回日本血液学会
  • Place of Presentation: 京都国際会館
• [Presentation] Molecular Mechanisms of blast crisis in chronic myelogenous leukemia caused by upregulation of Hes1.
  • Author(s): 中原史雄
  • Organizer: 第74回日本血液学会
  • Place of Presentation: 京都国際会館（京都）
• [Presentation] Phosphatidylethanolamine is a possible ligand for human CD300c which delivers an FcRg-dependent activating signal in mast cells and monocytes.
  • Author(s): 高橋まり子
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際展示場（神戸）
• [Presentation] Extracellular ceramide is a ligand for LMIR3 which negatively regulates mast-cell-dependent allergic responses.
  • Author(s): 伊沢久未
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸国際展示場（神戸）
• [Presentation] Elucidating the control mechanisms of Microcap expression
  • Author(s): 西村耕太郎
  • Organizer: 第３５回日本分子生物学会年会
  • Place of Presentation: マリンメッセ福岡（福岡）
• [Remarks]
  • URL: http://www.ims.u-tokyo.ac.jp/clinical_oncol/