• Search Research Projects
  • Search Researchers
  • How to Use
  1. Back to previous page

Establishment of new diagnostic imaging system for hepatocellular carcinoma and its application to cancer therapy

Research Project

Project/Area Number 23249067
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Digestive surgery
Research InstitutionThe University of Tokyo

Principal Investigator

KOKUDO Norihiro  東京大学, 医学部附属病院, 教授 (00205361)

Co-Investigator(Kenkyū-buntansha) KARAKO Takashi  東京大学, 医学部附属病院, 助教 (00313213)
CHEN Yu  東京大学, 新領域創成科学研究科, 准教授 (00272394)
ISHIZAWA Takeaki  公益財団法人がん研究会, 有明病院・消化器外科, 副医長 (10422312)
URANO Yasuteru  東京大学, 薬学系研究科, 教授 (20292956)
AKIMITSU Nobuyoshi  東京大学, アイソトープ総合センター, 教授 (40294962)
Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥46,800,000 (Direct Cost: ¥36,000,000、Indirect Cost: ¥10,800,000)
Fiscal Year 2015: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2014: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2013: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2012: ¥10,010,000 (Direct Cost: ¥7,700,000、Indirect Cost: ¥2,310,000)
Fiscal Year 2011: ¥10,920,000 (Direct Cost: ¥8,400,000、Indirect Cost: ¥2,520,000)
Keywords肝細胞癌 / バイオマーカー / 画像診断 / 治療
Outline of Final Research Achievements

The most effective treatment for hepatocellular carcinoma (HCC) is surgery, but the frequent recurrence of HCC after surgery is a clinical issue. Resolving the problem requires the development of sensitive diagnostic methods and efficacious post-operative therapies. We found that the fluorescent substance indocyanine green (ICG) accumulated in HCC tissue over a period of 1 week. Given this property of ICG, we examined its fluorescence during surgery and we developed an intraoperative diagnostic technique to detect sites of HCC that visual inspection and existing diagnostic images had failed to detect. Moreover, we developed a form of photodynamic therapy that illuminates HCC tissue where ICG has accumulated with near-infrared light to selectively destroy HCC cells. These approaches can help to prevent the recurrence of HCC.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (43 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (23 results) (of which Peer Reviewed: 21 results,  Open Access: 5 results,  Acknowledgement Compliant: 5 results) Presentation (18 results) (of which Int'l Joint Research: 2 results,  Invited: 2 results) Book (2 results)

  • [Journal Article] Evaluation of hepatic perfusion in the liver graft using fluorescence imaging with indocyanine green.2015

    • Author(s)
      Kawaguchi Y, Akamatsu N, Ishizawa T, Kaneko J, Arita J, Sakamoto Y, Hasegawa K, Kokudo N.
    • Journal Title

      Int J Surg Case Rep

      Volume: 14 Pages: 149-151

    • DOI

      10.1016/j.ijscr.2015.07.031

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Reappraisal of a Dye-Staining Technique for Anatomic Hepatectomy by the Concomitant Use of Indocyanine Green Fluorescence Imaging.2015

    • Author(s)
      Miyata A, Ishizawa T, Tani K, Shimizu A, Kaneko J, Aoki T, Sakamoto Y, Sugawara Y, Hasegawa K, Kokudo N.
    • Journal Title

      J Am Coll Surg

      Volume: 221 Issue: 2 Pages: e27-e36

    • DOI

      10.1016/j.jamcollsurg.2015.05.005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Advances in Assessment and Planning for Surgical Treatment of Hepatocellular Carcinoma.2015

    • Author(s)
      Kawaguchi Y, Hasegawa K, Tanaka N, Ishizawa T, Kaneko J, Sakamoto Y, Aoki T, Sugawara Y, Kokudo N.
    • Journal Title

      Dig Dis

      Volume: 33 Issue: 5 Pages: 683-690

    • DOI

      10.1159/000438498

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Techniques of Fluorescence Cholangiography During Laparoscopic Cholecystectomy for Better Delineation of the Bile Duct Anatomy.2015

    • Author(s)
      Kono Y, Ishizawa T, Tani K, Harada N, Kaneko J, Saiura A, Bandai Y, Kokudo N.
    • Journal Title

      Medicine

      Volume: 94 Issue: 25 Pages: e1005-e1005

    • DOI

      10.1097/md.0000000000001005

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Mechanistic background and clinical applications of indocyanine green fluorescence imaging of hepatocellular carcinoma.2014

    • Author(s)
      Ishizawa T, Masuda K, Urano Y, Kawaguchi Y, Satou S, Kaneko J, Hasegawa K, Shibahara J, Fukayama M, Tsuji S, Midorikawa Y, Aburatani H, Kokudo N.
    • Journal Title

      Ann Surg Oncol.

      Volume: 21 Issue: 2 Pages: 440-8

    • DOI

      10.1245/s10434-013-3360-4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Can gamma-glutamyl transferase levels contribute to a better prognosis for patients with hepatocellular carcinoma?2014

    • Author(s)
      Wang Z, Song P, Xia J, Inagaki Y, Tang W, Kokudo N.
    • Journal Title

      Drug Discoveries & Therapeutics

      Volume: 8 Issue: 3 Pages: 134-138

    • DOI

      10.5582/ddt.2014.01025

    • NAID

      130005054786

    • ISSN
      1881-7831, 1881-784X
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Clinical utility of simultaneous measurement of alpha-fetoprotein and des-γ-carboxy prothrombin for diagnosis of patients with hepatocellular carcinoma in China: A multi-center case-controlled study of 1,153 subjects2014

    • Author(s)
      Song P, Feng X, Inagaki Y, Song T, Zhang K, Wang Z, Zheng S, Ma K, Li Q, Kong D, Wu Q, Zhang T, Zhao X, Hasegawa K, Sugawara Y, Kokudo N, Tang W.
    • Journal Title

      BioScience Trends

      Volume: 8 Issue: 5 Pages: 266-273

    • DOI

      10.5582/bst.2014.01116

    • NAID

      130004708161

    • ISSN
      1881-7815, 1881-7823
    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Photodynamic therapy for human hepatoma-cell-line tumors utilizing biliary excretion properties of indocyanine green.2014

    • Author(s)
      Kaneko J, Inagaki Y, Ishizawa T, Gao J, Tang W, Aoki T, Sakamoto Y, Hasegawa K, Sugawara Y, Kokudo N.
    • Journal Title

      J Gastroenterol.

      Volume: 49 Issue: 1 Pages: 110-116

    • DOI

      10.1007/s00535-013-0775-4

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Perspectives on using des-γ-carboxyprothrombin (DCP) as a serum biomarker: facilitating early detection of hepatocellular carcinoma in China.2013

    • Author(s)
      Song P, Feng X, Zhang K, Song T, Ma K, Kokudo N, Dong J, Tang W.
    • Journal Title

      Hepatobiliary Surg Nutr.

      Volume: 2 Pages: 227-231

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Biomarkers: Evaluation of Screening for and Early Diagnosis of Hepatocellular Carcinoma in Japan and China.2013

    • Author(s)
      Song P, Gao J, Inagaki Y, Kokudo N, Hasegawa K, Sugawara Y, Tang W.
    • Journal Title

      Liver Cancer.

      Volume: 2 Issue: 1 Pages: 31-39

    • DOI

      10.1159/000346220

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intermittent clamping is superior to ischemic preconditioning and its effect is more marked with shorter clamping cycles in the rat liver.2013

    • Author(s)
      Seyama Y et al.
    • Journal Title

      J Gastroenterol

      Volume: 48(1) Issue: 1 Pages: 115-124

    • DOI

      10.1007/s00535-012-0613-0

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Des-γ-carboxy prothrombin and c-Met were concurrently and extensively expressed in hepatocellular carcinoma and associated with tumor recurrence2012

    • Author(s)
      Gao J et al.
    • Journal Title

      BioScience Trends

      Volume: 6 Issue: 4 Pages: 153-159

    • DOI

      10.5582/bst.2012.v6.4.153

    • NAID

      130004572572

    • ISSN
      1881-7815, 1881-7823
    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting c-Met as a promising strategy for the treatment of hepatocellular carcinoma2012

    • Author(s)
      Gao J, Inagaki Y, Song P, Qu X, Kokudo N, Tang W
    • Journal Title

      Pharmacol Res

      Volume: 65(1) Pages: 23-30

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] ICG蛍光法を用いた術中胆道造影:現況と将来展望2012

    • Author(s)
      石沢武彰, 河口義邦, 國土典宏
    • Journal Title

      胆道

      Volume: 26 Pages: 34-100

    • NAID

      130004838852

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Des-gamma-carboxyprothrombin in patients with hepatocellular carcinoma and liver cirrhosis2011

    • Author(s)
      Inagaki Y, Xu HL, Hasegawa K, Aoki T, Beck Y, Sugawara Y, Tang W, Kokudo N
    • Journal Title

      J Dig Dis

      Volume: 12(6) Issue: 6 Pages: 481-488

    • DOI

      10.1111/j.1751-2980.2011.00521.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Clinical and molecular insights into the hepatocellular carcinoma tumour marker des-Y-carboxyprothrombin2011

    • Author(s)
      Inagaki Y, Tang W, Makuuchi M, Hasegawa K, Sugawara Y, Kokudo N
    • Journal Title

      Liver Int.

      Volume: Jan ; 31(1) Pages: 22-35

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Application of fluorescent cholangiography to single-incision laparoscopic cholecystectomy2011

    • Author(s)
      Ishizawa T, Kaneko J, Inoue Y, Takemura N, SeyamaY, Aoki T, Beck Y, Sugawara Y, Hasegawa K, Harada N, Ijichi M, Kusaka K, Shibasaki M, Bandai Y, Kokudo N
    • Journal Title

      Sure Endosc.

      Volume: Aug ; 25(8) Pages: 2631-6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hepatobiliary surgery guided by a novel fluorescent imaging technique for visualizing hepatic arteries, bile ducts, and liver cancers on color images2011

    • Author(s)
      Kawaguchi Y, Ishizawa T, Masuda K, Sato S, Kaneko J, Aoki T, Beck Y, Sugawara Y, Hasegawa K, Kokudo N
    • Journal Title

      J Am Coll Surg.

      Volume: Jun ; 212(6)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 転移性肝癌の肝切除治療2011

    • Author(s)
      石沢武彰、長谷川潔、國土典宏
    • Journal Title

      臨床消化器内科

      Volume: 26(4) Pages: 391-396

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 胆嚢造影法2011

    • Author(s)
      石沢武彰、長谷川潔、國土典宏
    • Journal Title

      外科

      Volume: 73(5) Pages: 496-500

    • Related Report
      2011 Annual Research Report
  • [Journal Article] 蛍光胆道造影を利用して単孔式腹腔鏡下胆摘術を施工した右側肝円索の1例2011

    • Author(s)
      廣吉淳子、石沢武彰、進藤潤一、金子順一、長谷川潔、國土典宏
    • Journal Title

      日本臨床外科

      Volume: 72(6) Pages: 153-156

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Positive and negative staining of hepatic segment by fluorescent imaging technique during laparoscopic hepatectomy

    • Author(s)
      Ishizawa T, et al.
    • Journal Title

      Archives of Surgery

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Laparoscopic segmentectomy of the liver : from segment I to VIII

    • Author(s)
      Ishizawa T
    • Journal Title

      Annals of Surgery

      Volume: (In press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Loss of e-cadherin portal vein tumor thrombosis of hepatocellular carcinoma can be reversed by c-metinhibitor2015

    • Author(s)
      Kokudo T, Hasegawa K, Shirata, ,Kaneko J, Akamatu N, Arita J, Sakamoto Y, Kokudo N
    • Organizer
      International Liver Cancer Association 9th Annual Conference ILCA 201
    • Place of Presentation
      パリ、フランス
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Near infrared photodynamic therapy using indocyanine green inhibits tumor growth of human hepatocellular carcinoma2015

    • Author(s)
      Shirata C, Kaneko J, Inagaki Y, Kokudo T,Yamamoto S, Akamatu N, Arita J, Sakamoto Y, Hasegawa K , Kokudo N
    • Organizer
      International Liver Cancer Association 9th Annual Conference ILCA 201
    • Place of Presentation
      パリ、フランス
    • Year and Date
      2015-09-04
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Indocyanine green蛍光肝細胞癌に対する腹腔鏡下ないし開腹下近赤外光レーザー照射による光線力学療法2015

    • Author(s)
      金子順一、稲垣善則、白田 力、國土貴嗣、山本訓史、赤松延久、有田淳一、阪本良弘、唐子 尭、長谷川 潔 國土典宏
    • Organizer
      第69回手術手技研究会
    • Place of Presentation
      高崎、群馬
    • Year and Date
      2015-05-16
    • Related Report
      2015 Annual Research Report
  • [Presentation] The applicatons of ICG fluirescence imaging in liver surgery2014

    • Author(s)
      國土典宏
    • Organizer
      Progress in Management on Hepatocellular Carcinoma
    • Place of Presentation
      中国・武漢
    • Year and Date
      2014-11-14 – 2014-11-16
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ICG蛍光法を活用した肝癌診断と手術法の進歩2014

    • Author(s)
      國土典宏
    • Organizer
      第21回外科ファーラム
    • Place of Presentation
      東京
    • Year and Date
      2014-07-26
    • Related Report
      2014 Annual Research Report
    • Invited
  • [Presentation] ICG蛍光法で検出された早期肝細胞癌の一例2014

    • Author(s)
      工藤宏樹、進藤潤一、赤松延久、金子順一、青木 琢、阪本良弘、菅原寧彦、長谷川 潔 國土典宏
    • Organizer
      第49回日本肝癌症例検討会
    • Place of Presentation
      東京
    • Year and Date
      2014-04-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] ICG蛍光法による肝静脈閉寒域の肝機能評価を応用した拡大左肝切除2013

    • Author(s)
      河口義邦、石沢武彰、田中信孝、三瀨祥弘、田村純人、金子順一、阪本良弘、青木琢、菅原寧彦、長谷川潔、瀬尾明彦、永井元樹、野村幸博、國土典宏
    • Organizer
      第113回日本外科学会学術集会
    • Place of Presentation
      福岡
    • Related Report
      2013 Annual Research Report
  • [Presentation] Clinical Applications of Fluorescence Imaging tohepatobiliary and pancreatic surgery2013

    • Author(s)
      國土典宏、石沢武彰、浦野泰照
    • Organizer
      第8回 日本分子イメージング学会
    • Place of Presentation
      横浜
    • Related Report
      2013 Annual Research Report
  • [Presentation] ICG蛍光法を肝癌および肝動脈・胆管の描出に用いた腹腔鏡下肝切除2013

    • Author(s)
      石沢武彰、谷圭吾、原田庸寛、清水篤志、田村純人、金子順一、青木琢、阪本良弘、菅原寧彦、長谷川潔、國土典宏
    • Organizer
      第25回日本肝胆膵外科学会
    • Place of Presentation
      宇都宮
    • Related Report
      2013 Annual Research Report
  • [Presentation] ICG蛍光法を応用した肝切除・肝移植術中の肝内血流動態の評価2013

    • Author(s)
      河口義邦、石沢武彰、永井元樹、野村幸博、田中信孝、阪本良弘、青木琢、菅原寧彦、長谷川潔、國土典宏
    • Organizer
      第68回日本消化器外科学会総会
    • Place of Presentation
      宮崎
    • Related Report
      2013 Annual Research Report
  • [Presentation] ICG-fluorescent imaging during liver surgery for evaluation of portal uptake function in veno-occlusive regions.2013

    • Author(s)
      Kawaguchi Y et al.
    • Organizer
      JCMWDD&T 2013
    • Place of Presentation
      東京、東京大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] KL-6 mucin in hepatobiliary and pancreatic tumors.2013

    • Author(s)
      Inagaki Y et al.
    • Organizer
      JCMWDD&T 2013
    • Place of Presentation
      東京、東京大学
    • Related Report
      2012 Annual Research Report
  • [Presentation] Gayet教授の腹腔鏡下肝切除2011

    • Author(s)
      石沢武彰
    • Organizer
      第5回 肝臓内視鏡外科研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-11-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Clinical application of indocyanine green-fluorescent im Taaging for real-time identification of liver cancers2011

    • Author(s)
      Takeaki Ishizawa
    • Organizer
      第5回 肝臓内視鏡外科研究会
    • Place of Presentation
      Tokyo
    • Year and Date
      2011-11-12
    • Related Report
      2011 Annual Research Report
  • [Presentation] 蛍光ナビゲーション肝胆道手術2011

    • Author(s)
      河口義邦、石沢武彰、金子順一、原田庸寛、宮田陽一、山下俊、増田晃一、佐藤彰一、田村純人、阪本良弘、青木琢、菅原寧彦、長谷川潔、國土典宏
    • Organizer
      第4回蛍光Navigation Surgery研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] ICG蛍光法による胆汁うつ隊滞領域の描出 肝切除への応用2011

    • Author(s)
      原田庸寛、石沢武彰、河口義邦、宮田陽一、山下俊、増田晃一、佐藤彰一、田村純人、金子順一、阪本良弘、青木琢、菅原寧彦、長谷川潔、國土典宏、伊地知正賢,日下浩二、柴崎正幸、万代恭嗣
    • Organizer
      第4回蛍光Navigation Surgery研究会
    • Place of Presentation
      東京
    • Year and Date
      2011-10-15
    • Related Report
      2011 Annual Research Report
  • [Presentation] Invited Lecture New diagnostic modalities before and during liver surgery2011

    • Author(s)
      Norihiro Kokudo, Shoichi Sato, Takeaki Ishizawa, Junichi Shindo, Yosuke Inoue, Michiro Takahashi, Junichi Kaneko, Yoshihiro Sakamoto, Taku Aoki, Yasuhiko Sugawara, Kiyoshi Hasegawa
    • Organizer
      IASGO2011
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] Fluorescent Cholangiography : knacks for visualization of bile duct by indocyanine green2011

    • Author(s)
      Yoshikuni Kawaguchi, Takeaki Ishizawa, Koichi Masuda, Shouichi Satoh, Junichi Kaneko, Sumihito Tamura, Yoshihiko Sakamoto, Taku Aiki, Yasuhiko Sugawara, Kiyoshi Hasegawa, Norihiro Kokudo
    • Organizer
      IASGO2011
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Book] Fluorescence Imaging for Surgeons Concepts and Applications2015

    • Author(s)
      Dip, F.D., Ishizawa, T., Kokudo, N., Rosenthal, R.
    • Total Pages
      351
    • Publisher
      Springer
    • Related Report
      2015 Annual Research Report
  • [Book] Fluorescent Imaging Treatment of Hepatobiliary and Pancreatic Diseases2013

    • Author(s)
      Kokudo N, Ishizawa T.
    • Total Pages
      124
    • Publisher
      KARGER
    • Related Report
      2013 Annual Research Report

URL: 

Published: 2011-04-06   Modified: 2019-07-29  

Information User Guide FAQ News Terms of Use Attribution of KAKENHI

Powered by NII kakenhi