Reconstitution and functional control of the female reproductive tract through spatiotemporal intervention into the tissue-specific stem cells

• Project/Area Number: 23249076
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Obstetrics and gynecology
• Research Institution: Keio University
• Principal Investigator: YOSHIMURA Yasunori 慶應義塾大学, 医学部, 教授 (10129736)
• Co-Investigator(Kenkyū-buntansha): MARUYAMA Tetsuo 慶應義塾大学, 医学部, 講師 (10209702) ; UCHIDA Hiroshi 慶應義塾大学, 医学部, 講師 (90286534) ; YAMASAKI Akiko 慶應義塾大学, 医学部, 研究員 (60528777) ; MASUDA Hirotaka 慶應義塾大学, 医学部, 助教 (80317198)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥50,050,000 (Direct Cost: ¥38,500,000、Indirect Cost: ¥11,550,000); Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000); Fiscal Year 2011: ¥42,770,000 (Direct Cost: ¥32,900,000、Indirect Cost: ¥9,870,000)
• Keywords: 幹細胞 / 子宮内膜 / 子宮平滑筋 / 子宮内膜症 / 子宮筋腫 / 再生医学 / 脱細胞化 / 子宮 / 疾患モデル

Research Abstract

The aim of this study was to reconstitute normal and abnormal uterus in vivo through spatiotemporal intervention on uterine stem cells. First, we have developed a novel in vivo endometrial stem cell assay using a cell tracking method in combination with an endometrial reconstitution system, which reveals that endometrial side population (ESP) cells are the most likely candidate for endometrial stem cells. The stem cell-like properties of ESP cells suggest their involvement in the pathogenesis of endometriosis. Second, we uncovered a paracrine role of the WNT/beta - Catenin pathway that enables mature myometrial or leiomyoma cells to send mitogenic signals to neighboring tissue stem cells in response to estrogen and progesterone,leading to the growth of uterine leiomyomas. Finally, we have developed decellularization and recellularization techniques for the rat uterus, generating structural and functional uterus in vitro and in vivo.

Research Products

• [Journal Article] System amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts. (2014)
  • Author(s): Nishimura T, Yagi R, Usuda M, Oda K, Yamazaki M, Suda S, Takahashi Y, Okazaki F, Sai Y, Higuchi, K, Maruyama T, Tomi M, Nakashima E
  • Journal Title: Biochim Biophys Acta. Volume: VOL. 1838 Issue: 5 Pages: 1306-12
  • DOI: 10.1016/j.bbamem.2014.01.004
  • Peer Reviewed
• [Journal Article] Paracrine activation of WNT/β-catenin pathway in uterine leiomyoma stem cells promotes tumor growth (2013)
  • Author(s): Ono M, Yin P, Navarro A, Moravek MB, Coon JS 5th, Druschitz SA, Serna VA, Qoang W, Brooks DC, Malpani SS, Ma J, Ercan CM, Mittal N, Monsivais D, Dyson MT, Yemelyanov A, Maruyama T, Chkravarti D, Kimm JJ, Kurita T, Gottardi CJ, Bulun SE
  • Journal Title: Proc Natl Acad Sci USA Volume: 110(42) Issue: 42 Pages: 17053-8
  • DOI: 10.1073/pnas.1313650110
  • Peer Reviewed
• [Journal Article] Possible involvement of nerve growth factor in dysmenorrhea and dyspareunia associated with endometriosis (2013)
  • Author(s): Kajitani T, Maruyama T, Asada H, Uchida H, Oda H, Nishikawa-Uchida S, Miyazaki K, Arase T, Ono M, Yoshimura Y
  • Journal Title: Endocr J Volume: 60(10) Pages: 1155-64
  • NAID: 130004770386
  • URL: https://www.jstage.jst.go.jp/article/endocrj/60/10/60_EJ13-0027/_article
  • Peer Reviewed
• [Journal Article] The nose knows tubal function? (2013)
  • Author(s): Maruyama T
  • Journal Title: Fertil Steril Volume: 100(2) Issue: 2 Pages: 353-354
  • DOI: 10.1016/j.fertnstert.2013.04.026
  • Peer Reviewed
• [Journal Article] Human uterine stem/ progenitor cells : Implications for uterine physiology and pathology (2013)
  • Author(s): Maruyama T, Miyazaki K, Masuda H, Ono M, Uchida H, Yoshimura Y
  • Journal Title: Placenta Volume: 27 Pages: 77-81
  • DOI: 10.1016/j.placenta.2012.12.010
  • Peer Reviewed
• [Journal Article] Somatic stem cells in the myometrium and in myomas (2013)
  • Author(s): Maruyama T, Ono M, Yoshimura Y
  • Journal Title: Semin Reprod Med Volume: 31(1) Issue: 01 Pages: 77-81
  • DOI: 10.1055/s-0032-1331801
  • Peer Reviewed
• [Journal Article] β-Catenin signaling regulates Foxa2 expression during endometrial hyperplasia formation (2013)
  • Author(s): Villacorte M, Suzuki K, Hirasawa A, Ohkawa Y, Suyama M, Maruyama T, Aoki D, Ogino Y, Miyagawa S, Terabayashi T, Tomooka Y, Nakagata N, Yamada G
  • Journal Title: Oncogene Volume: 32 Issue: 29 Pages: 3477-3482
  • DOI: 10.1038/onc.2012.376
  • Peer Reviewed
• [Journal Article] ヒト子宮内膜再構成システムを用いたin vivo幹細胞アッセイの開発と内膜幹細胞の同定 (2013)
  • Author(s): 宮崎 薫,丸山哲夫, 升田博隆, 小田英之, 内田明花, 内田浩, 吉村泰典
  • Journal Title: 日本生殖内分泌雑誌 Volume: 18 Pages: 21-25
  • URL: http://www.seishoku.org/13_18kan/9-frontier1.pdf
  • Peer Reviewed
• [Journal Article] Molecular analysis of a mutated FSH receptor detected in a patient with spontaneous ovarian hyperstimulation syndrome. (2013)
  • Author(s): Uchida S, Uchida H, Maruyama T, Kajitani T, Oda H, Miyazaki K, Maki Kagami, Yoshimura Y
  • Journal Title: PLoS One. Volume: VOL. 8 Issue: 9 Pages: e75478-e75478
  • DOI: 10.1371/journal.pone.0075478
  • Peer Reviewed
• [Journal Article] Possible involvement of nerve growth factor in dysmenorrhea and dyspareunia associated with endometriosis. (2013)
  • Author(s): Kajitani T, Maruyama T, Asada H, Uchida H, Oda H, Nishikawa-Uchida S, Miyazaki K, Arase T, Ono M, Yoshimura Y
  • Journal Title: Endocr J. Volume: VOL. 60 Pages: 1155-64
  • NAID: 130004770386
  • Peer Reviewed
• [Journal Article] Achievement of pregnancies in women with primary ovarian insufficiency using close monitoring of follicle development: case reports. (2013)
  • Author(s): Maruyama T, Miyazaki K, Uchida H, Uchida S, Masuda H, Yoshimura Y
  • Journal Title: Endocr J. Volume: VOL. 60 Pages: 791-7
  • NAID: 10031184548
  • Peer Reviewed
• [Journal Article] ［平成24年度学術奨励賞受賞］ヒト子宮内膜再構成システムを用いたin vivo幹細胞アッセイの開発と内膜幹細胞の同定． (2013)
  • Author(s): 宮崎 薫，丸山哲夫，升田博隆，小田英之，内田明花，内田 浩，吉村泰典
  • Journal Title: 日本生殖内分泌雑誌 Volume: 18巻 Pages: 21-5
• [Journal Article] Achievement of pregnancies in women with primary ovarian insufficiency using close monitoring of follicle development: case reports. (2013)
  • Author(s): Maruyama T, Miyazaki K, Uchida H, Uchida S, Masuda H, Yoshimura Y
  • Journal Title: Endocrine Journal. Volume: -
  • NAID: 10031184548
  • Peer Reviewed
• [Journal Article] 目で見る生殖幹細胞 (2013)
  • Author(s): 升田博隆，丸山哲夫，吉村泰典
  • Journal Title: HORMONE FONTIER IN GYNECOLOGY Volume: 20 Pages: 6-9
• [Journal Article] 特集 生殖と自然免疫 子宮内膜の粘膜免疫機構 (2013)
  • Author(s): 荒瀬 透，丸山哲夫，宮崎 薫，柴田璃香，升田博隆，内田 浩，吉村泰典
  • Journal Title: HORMONE FONTIER IN GYNECOLOGY Volume: 20 Pages: 39-44
• [Journal Article] Stem cell-like differentiation potentials of endometrial side population cells as revealed by a newly developed in vivo endometrial stem cell assay (2012)
  • Author(s): Miyazaki K, Maruyama T, Masuda H, Yamasaki A, Uchida S, Oda H, Uchida H, Yoshimura Y
  • Journal Title: PLoS One Volume: 7(12) Issue: 12 Pages: e50749-e50749
  • DOI: 10.1371/journal.pone.0050749
  • Peer Reviewed
• [Journal Article] Involvement of epithelial mesenchymal transition of human endometrial epithelial cells in human embryo implantation : evidence from studies using in vitro model (2012)
  • Author(s): H.Uchida, T.Maruyama, S.Nishikawa-Uchida, H.Oda, K.Miyazaki, A.Yamasaki, Y.Yoshimura
  • Journal Title: Journal of Biological Chemistry Volume: 287 Issue: 7 Pages: 4441-4450
  • DOI: 10.1074/jbc.m111.286138
  • Peer Reviewed
• [Journal Article] Stem cell theory for the pathogenesis of endometriosis (2012)
  • Author(s): Maruyama T, Yoshimura Y
  • Journal Title: Front Biosci Volume: 4 Pages: 2854-2863
  • URL: http://www.bioscience.org/2012/V4e/af/589/fulltext.htm
  • Peer Reviewed
• [Journal Article] Psychological adjustment and psychosocial stress among Japanese couples with a history of recurrent pregnancy loss (2012)
  • Author(s): M.Kagami, T.Maruyama, T.Koizumi, K.Miyazaki, S.Nishikawa-Uchida, H.Oda, H.Uchida, D.Fujisawa, N.Ozawa, L.Schmidt, Y.Yoshimura
  • Journal Title: Human Reproduction Volume: 27 Issue: 3 Pages: 787-794
  • DOI: 10.1093/humrep/der441
  • Peer Reviewed
• [Journal Article] Stem cell theory for the pathogenesis of endometriosis. (2012)
  • Author(s): Maruyama T, Yoshimura Y
  • Journal Title: Front Biosci. Volume: 4 Pages: 2754-2763
  • Peer Reviewed
• [Journal Article] Establishment of an immortalized human endometrial stromal cell line with functional responses to ovarian stimuli (2011)
  • Author(s): Yuhki M, Kajitani T, Mizuno T, Aoki Y, Maruyama T
  • Journal Title: Reprod Biol Endocrinol Volume: 9 Issue: 1 Pages: 104-104
  • DOI: 10.1186/1477-7827-9-104
  • Peer Reviewed
• [Journal Article] 子宮内膜幹細胞と子宮内膜症 (2011)
  • Author(s): 丸山哲夫
  • Journal Title: Prog.Med. Volume: 31 Pages: 621-628
• [Presentation] 幹細胞から見た子宮内膜症の発生・病態メカニズムと治療戦略 (2014)
  • Author(s): 丸山哲夫
  • Organizer: 第35回日本エンドメ トリオーシス学会
  • Place of Presentation: 鹿児島県鹿児島市・城山観光ホテル
• [Presentation] 希少部位子宮内膜症発生モデルマウスの開発の試み (2014)
  • Author(s): 小田英之, 丸山哲夫,山崎彰子, 宮崎薫, 荒瀬透, 内田浩, 升田博隆, 吉村泰典
  • Organizer: 第35回日本エンドメトリオーシス学会
  • Place of Presentation: 鹿児島県鹿児島市・城山観光ホテル
• [Presentation] 幹細胞から見た子宮内膜症の発生・病態メカニズムと治療戦略． (2014)
  • Author(s): 丸山哲夫
  • Organizer: 第35回日本エンドメトリオーシス学会［教育講演］
  • Place of Presentation: 城山観光ホテル（鹿児島県鹿児島市）
  • Invited
• [Presentation] 希少部位子宮内膜症発生モデルマウスの開発の試み． (2014)
  • Author(s): 小田英之，丸山哲夫，山崎彰子，宮崎 薫，荒瀬 透，内田 浩，升田博隆，吉村泰典
  • Organizer: 第35回日本エンドメトリオーシス学会［日本エンドメトリオーシス学会演題発表賞（基礎部門）］
  • Place of Presentation: 城山観光ホテル（鹿児島県鹿児島）
• [Presentation] Regeneration and reconstruction of the uterus as a future infertility treatment (2013)
  • Author(s): Tetsuo Maruyama
  • Organizer: International Federation of Fertility Societies (IFFS) Regional Meeting 2014
  • Place of Presentation: Boston, USA
  • Year and Date: 2013-10-14
  • Invited
• [Presentation] Differential management of patients with explained and unexplained recurrent pregnancy loss (2013)
  • Author(s): Tetsuo Maruyama
  • Organizer: The 13th Korea-Japan Joint Conference of Obstetrics and Gynecology
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2013-09-27
  • Invited
• [Presentation] Human endometrial stem cells; implications for endometrial physiology and pathology (2013)
  • Author(s): Tetsuo Maruyama
  • Organizer: The 99th Annual Congress of Korean Society of Obstetrics and Gynecology (KSOG)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2013-09-27
  • Invited
• [Presentation] Application of decellularzed rat uterus as a three-dimensional scaffold to in vitro and in vivo uterine tissue engineering (2013)
  • Author(s): Kaoru Miyazaki, Tetsuo Maruyama, Hirotaka Masuda, Naoko Hida, Hiroshi Uchida, Yasunori Yoshimura
  • Organizer: 69th American Society for Reproductive Medicine (ASRM) Annual Meeting
  • Place of Presentation: Boston, USA
• [Presentation] Role of stem cells in the pathogenesis of endometriosis : implications for prevention and therapy of endometriosis targeting stem cells (2013)
  • Author(s): Tetsuo Maruyama
  • Organizer: 23th International Conference of Russian Association of Human Reproduction (RAHR)
  • Place of Presentation: Volgograd, Russia
  • Invited
• [Presentation] Development of in vivo human endometrial stem cell assay (2013)
  • Author(s): Kaoru Miyazaki, Tetsuo Maruyama, Hirotaka Masuda, Akiko Yamasaki, Sayaka Uchida, Hideyuki Oda, Hiroshi Uchida, and Yasunori Yoshimura
  • Organizer: 60th Annual Meeting of the Society for Gynecologic Investigation(SGI)
  • Place of Presentation: Orlando, FL, USA
• [Presentation] ベンチサイドから : ヒト子宮幹細胞研究のこれまでと未来予想図 (2013)
  • Author(s): 丸山哲夫
  • Organizer: 第126回関東連合産科婦人科学会
  • Place of Presentation: 静岡県浜松市・アクトシティ浜松
• [Presentation] 脱細胞化マトリックスを用いた子宮の再構築 (2013)
  • Author(s): 宮崎薫, 丸山哲夫, 升田博隆, 内田浩, 吉村泰典
  • Organizer: 第86回日本内分泌学会
  • Place of Presentation: 宮城県仙台市・仙台国際センター
• [Presentation] 習慣流産において25(OH)ビタミンDは末梢血NK細胞を抑制する． (2013)
  • Author(s): 太田邦明，丸山哲夫，森田峰人，Joanne Kwak-Kim，吉村泰典
  • Organizer: 第28回日本生殖免疫学会［学会賞］
  • Place of Presentation: 平成記念会館（兵庫県西宮市）
• [Presentation] ベンチサイドから：ヒト子宮幹細胞研究のこれまでと未来予想図． (2013)
  • Author(s): 丸山哲夫
  • Organizer: 第126回関東連合産科婦人科学会［ワークショップ］
  • Place of Presentation: アクトシティ浜松（静岡県浜松市）
  • Invited
• [Presentation] Application of decellularzed rat uterus as a three-dimensional scaffold to in vitro and in vivo uterine tissue engineering. (2013)
  • Author(s): Kaoru Miyazaki, Tetsuo Maruyama, Hirotaka Masuda, Naoko Hida, Hiroshi Uchida, Yasunori Yoshimura
  • Organizer: 69th American Society for Reproductive Medicine (ASRM) Annual Meeting.［Society of Reproductive Biologists and Technologists (SRBT) BASIC SCIENCE AWARD］
  • Place of Presentation: Boston, USA.
• [Presentation] Role of stem cells in the pathogenesis of endometriosis: implications for prevention and therapy of endometriosis targeting stem cells. (2013)
  • Author(s): Tetsuo Maruyama
  • Organizer: 23th International Conference of Russian Association of Human Reproduction (RAHR).
  • Place of Presentation: Volgograd, Russia.
  • Invited
• [Presentation] 着床におけるエピジェネティクスと上皮間葉転換(epithelial-to-mesenchymal transition, EMT). (2013)
  • Author(s): 丸山哲夫，内田 浩
  • Organizer: 第31回日本受精着床学会[ワークショップ］
  • Place of Presentation: 別府国際コンベンションセンター(大分県別府市)
  • Invited
• [Presentation] Novel decellularization and recellularization techniques for reconstruction and regeneration of the uterus in rat. (2013)
  • Author(s): Kaoru Miyazaki, Tetsuo Maruyama, Hirotaka Masuda, Hideyuki Oda, Naoko Hida, Hiroshi Uchida, Yasunori Yoshimura
  • Organizer: 29th Annual Meeting of the European Society of Human Reprodution and Embryology(ESHRE).
  • Place of Presentation: London, United Kingdom.
• [Presentation] 脱細胞化マトリックスを用いた子宮の再構築． (2013)
  • Author(s): 宮崎 薫，丸山哲夫，升田博隆，内田 浩，吉村泰典
  • Organizer: 第86回日本内分泌学会[若手研究奨励賞（YIA）]
  • Place of Presentation: 仙台国際センター(宮城県仙台市)
• [Presentation] [25 SGI President’s Presenter Awards受賞 ]Development of in vivo human endometrial stem cell assay. (2013)
  • Author(s): Kaoru Miyazaki, Tetsuo Maruyama, Hirotaka Masuda, Akiko Yamasaki, Sayaka Uchida, Hideyuki Oda, Hiroshi Uchida, and Yasunori Yoshimura
  • Organizer: 60th Annual Meeting of Society for Gynecologic Investigation(SGI).
  • Place of Presentation: Orlando, FL, USA.
• [Presentation] 子宮内膜症動物実験モデル (2013)
  • Author(s): 升田博隆，丸山哲夫，松崎有未，岡野栄之，吉村泰典
  • Organizer: 第34回日本エンドメトリオーシス学会
  • Place of Presentation: 栃木総合文化センター（栃木県）
• [Presentation] ヒト子宮内膜幹細胞の分化能を明らかにするin vivo解析システムの開発 (2013)
  • Author(s): 宮崎 薫，丸山哲夫，升田博隆，小田英之，内田明花，内田 浩，吉村泰典
  • Organizer: 第34回日本エンドメトリオーシス学会
  • Place of Presentation: 栃木総合文化センター（栃木県）
• [Presentation] ヒト子宮内膜再構成システムを用いたin vivo幹細胞アッセイの開発と内膜幹細胞の同定 (2012)
  • Author(s): 宮崎薫, 丸山哲夫, 升田博隆, 小田英之, 内田明花, 内田浩, 吉村泰典
  • Organizer: 第17回日本生殖内分泌学会
  • Place of Presentation: 東京都千代田区・サピアタワー
  • Year and Date: 2012-12-08
• [Presentation] Isolation and characterization of human myometrial stem/progenitor cells : implications for pregnancy-induced myometrial remodeling (2012)
  • Author(s): Tetsuo Maruyama, Masanori Ono, Takashi Kajitani, Hiroshi Uchida, Hideyuki Oda, Sayaka Uchida, Kaoru Miyazaki, Toru Arase, Takashi Nagashima, Hirotaka Masuda, Hideyuki Okano, Yumi Matsuzaki, Yasunori Yoshimura
  • Organizer: 63rd The Korean Society for Reproductive for Reproductive Medicine Meeting(KSRM)
  • Place of Presentation: Seoul, Korea
  • Year and Date: 2012-12-01
  • Invited
• [Presentation] 成体幹細胞を用いた雌性生殖器官の再生・再建と疾患モデルの構築 (2012)
  • Author(s): 丸山哲夫
  • Organizer: 第14回神澤医学研究振興財団講演会
  • Place of Presentation: 東京都港区・ホテルオークラ
  • Year and Date: 2012-06-01
  • Invited
• [Presentation] ヒト子宮幹細胞と臨床医学へのトランスレーション-子宮再生・再建医療への挑戦- (2012)
  • Author(s): 丸山哲夫
  • Organizer: 熊本大学授業科目 : 名医に学ぶセミナー
  • Place of Presentation: 熊本県熊本市・熊本大学
  • Year and Date: 2012-02-01
  • Invited
• [Presentation] ヒト子宮幹細胞と臨床医学へのトランスレーション-子宮再生・再建医療への挑戦- (2012)
  • Author(s): 丸山哲夫
  • Organizer: 熊本大学授業科目:名医に学ぶセミナー
  • Place of Presentation: 熊本県熊本市・熊本大学(招待講演)(セミナー)
  • Year and Date: 2012-02-01
• [Presentation] Human uterine stem/progenitor cells : implications for uterine physiology and pathology (2012)
  • Author(s): Tetsuo Maruyama
  • Organizer: 18th International Federation of Placenta Association Meeting(IFPA)
  • Place of Presentation: Hiroshima, Japan
  • Invited
• [Presentation] Combined treatment with estrogen and progesterone promotes ectopic survival of intravenously injected human endometrial cells in immunodeficient mice (2012)
  • Author(s): Tetsuo Maruyama, Akiko Yamasaki, Kaoru Miyazaki, Toru Arase, Hiroshi Uchida, Yasunori Yoshimura
  • Organizer: 28th Annual Meeting of European Society of Human Reproduction and Embryology(ESHRE)
  • Place of Presentation: Istanbul, Turkey
• [Presentation] Human uterine stem/ progenitor cells (2012)
  • Author(s): Tetsuo Maruyama
  • Organizer: 2nd The State Key Laboratory of Reproductive Biology Symposia in Reproductive Biology(SKLRB)
  • Place of Presentation: Beijing ,China
  • Invited
• [Presentation] ヒト子宮由来幹細胞-何が分かって何ができるか- (2012)
  • Author(s): 丸山哲夫
  • Organizer: 第30回日本受精着床学会
  • Place of Presentation: 大阪府大阪市・大阪国際会議場
  • Invited
• [Presentation] [平成24年度学術奨励賞受賞]ヒト子宮内膜再構成システムを用いたin vivo幹細胞アッセイの開発と内膜幹細胞の同定 (2012)
  • Author(s): 宮崎 薫，丸山哲夫，升田博隆，小田英之，内田明花，内田 浩，吉村泰典
  • Organizer: 第17回日本生殖内分泌学会
  • Place of Presentation: サピアタワー（東京都）
• [Presentation] Isolation and characterization of human myometrial stem/progenitor cells: implications for pregnancy-induced myometrial remodeling. (2012)
  • Author(s): Tetsuo Maruyama, Hiroshi Uchida, Hirotaka Masuda, Yasunori Yoshimura, et al.
  • Organizer: 63rd The Korean Society for Reproductive fo Reproductive Medicine Meeting(KSRM).
  • Place of Presentation: Seoul, Korea.
  • Invited
• [Presentation] 単一の新規マーカーにより分離されたヒト子宮内膜間葉系幹細胞の機能解析 (2012)
  • Author(s): 升田博隆，丸山哲夫，吉村泰典，Caroline Gargett
  • Organizer: 第57回日本生殖医学会
  • Place of Presentation: ブリックホール（長崎県）
• [Presentation] ヒト子宮内膜幹細胞の in vivo 解析・同定システムの開発 (2012)
  • Author(s): 宮崎 薫，丸山哲夫，升田博隆，小田英之，内田明花，内田 浩，吉村泰典
  • Organizer: 第57回日本生殖医学会
  • Place of Presentation: ブリックホール（長崎県）
• [Presentation] [第20回日本胎盤学会相馬賞受賞]Characterization of sodium dependent betaine uptake in human placental brush-border membranes. (2012)
  • Author(s): Hiromi Eguchi, Masatoshi Tomi, Tomohiro Nishimura, Kenji Oda, Mai Yamazaki, Risa Yagi, Mariko Usuda, Kei Higuchi, Tetsuo Maruyama, Emi Nakashima
  • Organizer: 18th International Federation of Placenta Association Meeting(IFPA).
  • Place of Presentation: Hiroshima, Japan.
• [Presentation] Examining the role of SLC10A3 in the placenta. (2012)
  • Author(s): Tomohiro Tawara, Tomohiro Nishimura, Masatoshi Tomi, Mai Yamazaki, Rina Matsushita, Kei Higuchi, Tetsuo Maruyama, Emi Nakashima
  • Organizer: 18th International Federation of Placenta Association Meeting(IFPA).
  • Place of Presentation: Hiroshima, Japan.
• [Presentation] Human uterine stem/progenitor cells: implications for uterine physiology and pathology. (2012)
  • Author(s): Tetsuo Maruyama
  • Organizer: 18th International Federation of Placenta Association Meeting(IFPA).
  • Place of Presentation: Hiroshima, Japan.
  • Invited
• [Presentation] ヒト子宮由来幹細胞-何が分かって何ができるか- (2012)
  • Author(s): 丸山哲夫
  • Organizer: 第30回日本受精着床学会
  • Place of Presentation: 大阪国際会議場（大阪府）
• [Presentation] Thioredoxin, a small redox protein, in ovarian follicles of women undergoing IVF-ET. (2012)
  • Author(s): Ikuko Kishi, Tetsuo Maruyama, Miho Ohishi, Yasuo Akiba, Hironori Asada, Yasuhiro Konishi, Masao Nakano, Kiyoshi Kamei, Yasunori Yoshimra
  • Organizer: 28th Annual Meeting of European Society of Human Reproduction and Embryology(ESHRE).
  • Place of Presentation: Istanbul, Turkey.
• [Presentation] Combined treatment with estrogen and progesterone promotes ectopic survival of intravenously injected human endometrial cells in immunodeficient mice. (2012)
  • Author(s): Tetsuo Maruyama, Akiko Yamasaki, Kaoru Miyazaki, Toru Arase, Hiroshi Uchida, Yasunori Yoshimura
  • Organizer: 28th Annual Meeting of European Society of Human Reproduction and Embryology(ESHRE).
  • Place of Presentation: 大阪国際会議場（大阪府）
• [Presentation] [第14回神澤医学賞受賞講演]子成体幹細胞を用いた雌性生殖器官の再生・再建と疾患モデルの構築 (2012)
  • Author(s): 丸山哲夫
  • Organizer: 第14回神澤医学研究振興財団講演会
  • Place of Presentation: ホテルオークラ（東京都）
  • Invited
• [Presentation] Human Uterine Stem/ Progenitor Cells. (2012)
  • Author(s): Tetsuo Maruyama
  • Organizer: 2nd The State Key Laboratory of Reproductive Biology Symposia in Reproductive Biology(SKLRB)
  • Place of Presentation: Beijing ,Chaina.
  • Invited
• [Presentation] 子宮内膜症の遺伝的関与-Keynote Lecture- (2012)
  • Author(s): 丸山哲夫
  • Organizer: 第33回日本エンドメトリオーシス学会
  • Place of Presentation: 長崎県長崎市・長崎大学(ワークショップ)(招待講演)
• [Presentation] Human uterine stem/progenitor cells : implications for uterine physiology and pathology (2011)
  • Author(s): Tetsuo Maruyama
  • Organizer: Monash Health Translation Precinct (MHTP)
  • Place of Presentation: Melbourne, Australia
  • Year and Date: 2011-10-06
  • Invited
• [Presentation] Human uterine stem/progenitor cells : implications for uterine physiology and pathology (2011)
  • Author(s): Tetsuo Maruyama
  • Organizer: Monash Health Translation Precinct (MHTP) Seminars 2011
  • Place of Presentation: Melbourne, Australia(招待講演)(セミナー)
  • Year and Date: 2011-10-06
• [Presentation] Stem/progenitor cells in the human uterus ; implication for uterine diseases (2011)
  • Author(s): Tetsuo Maruyama
  • Organizer: CHU Clermont-Ferrand
  • Place of Presentation: Clermont-Ferrand, France(招待講演)(セミナー)
  • Year and Date: 2011-09-08
• [Presentation] Contribution of myometrial stem/progenitor cells to pregnancy-induced uterine remodelling (2011)
  • Author(s): Masanori Ono, Tetsuo Maruyama, Takashi Kajitani, Hiroshi Uchida, Hideyuki Oda, Sayaka Uchida, Toru Arase, Akiko Yamasaki, Takashi Nagashima, Hirotaka Masuda, Yasunori Yoshimura
  • Organizer: 2nd World Congress on Reproductive Biology(WCRB)
  • Place of Presentation: Cairns, Australia
• [Presentation] Stem cell theory for the pathogenesis of endometriosis (2011)
  • Author(s): Tetsuo Maruyama
  • Organizer: 22nd Asian and Oceanic Congress of Obstetrics and Gynecology(AOCOG)
  • Place of Presentation: Taipei, Taiwan
• [Presentation] Contribution of myometrial stem/progentior cells to pregnancy-induced uterine remodeling (2011)
  • Author(s): Masanori Ono, Tetsuo Maruyama, Takashi Kajitani, Hiroshi Uchida, Hideyuki Oda, Sayaka Uchida, Toru Arase, Akiko Yamasaki, Takashi Nagashima, Hirotaka Masuda, Yasunori Yoshimura
  • Organizer: 2nd World Congress on Reproductive Biology(WCRB)
  • Place of Presentation: Cairns, Australia
• [Presentation] Possible evidence for epithelial-mesenchymal transition mediating displacement of endometrial cells away from the site of embryo implantation (2011)
  • Author(s): Hiroshi Uchida, Tetsuo Maruyama, Sayaka Uchida-Nishikawa, Yasunori Yoshimura
  • Organizer: 2nd World Congress on Reproductive Biology (WCRB)
  • Place of Presentation: Cairns, Australia
• [Presentation] Stem cells theory for the pathogenesis of endometriosis (2011)
  • Author(s): Tetsuo Maruyama
  • Organizer: 22th Asian and Oceanic Congress of Obstetrics and Gynecology (AOCOG)
  • Place of Presentation: Taipei, Taiwan(招待講演)(シンポジウム)
• [Presentation] Identification of a novel endometrial gene associated with menstruation, endometriosis and adenomyosis (2011)
  • Author(s): Tetsuo Maruyama, Takashi Kajitani, Hideyuki Oda, Kaoru Miyazaki, Sayaka Uchida, Akiko Yamasaki, Hironori Asada, Hiroshi Uchida, Yasunori Yoshimura
  • Organizer: 11th World Congress on Endometriosis (WCE)
  • Place of Presentation: Montpellier, France
• [Presentation] Possible involvement of UDP-glucose and its recepter P2RY14 in embryo implantation (2011)
  • Author(s): Toru Arase, Tetsuo Maruyama, Hiroshi Uchida, Kaoru Miyazaki, Hideyuki Oda, Sayaka Uchida-Nishikawa, Maki Kagami, Akiko Yamasaki, Kayoko Tamaki, Yasunori Yoshimura
  • Organizer: 27th European Society of Human Reproduction & Embryolosy (ESHRE)
  • Place of Presentation: Stockholm, Sweden
• [Presentation] CD93 and CD31 as possible candidate markers for human endometrial stem/progenitor cells (2011)
  • Author(s): Kaoru Miyazaki, Takashi Kajitani, Hirotaka Masuda, Toshio Hamatani, Hideyuki Oda, Akiko Yamasaki, Sayaka Nishikawa-Uchida, Hiroshi Uchida, Yasunori Yoshimura, Tetsuo Maruyama
  • Organizer: 9th International Society for Stem Cell Research (ISSCR)
  • Place of Presentation: Tronto, Ontario Canada
• [Presentation] BMP type II receptor(BMPR2)は着床後の妊娠維持に必須である．
  • Author(s): 長島 隆，Martin M. Matzuk，丸山哲夫，吉村泰典
  • Organizer: 第18回日本生殖内分泌学会［学術奨励賞］
  • Place of Presentation: シェーンバッハ・サボー（東京都千代田区）
• [Presentation] 成人期：早発卵巣不全・早発閉経に関する諸問題．
  • Author(s): 丸山哲夫
  • Organizer: 第18回日本生殖内分泌学会［シンポジウム］
  • Place of Presentation: シェーンバッハ・サボー（東京都千代田区）
  • Invited
• [Presentation] 自然発症OHSS患者に見いだされた変異FSH受容体の解析．
  • Author(s): 内田明花，内田 浩，丸山哲夫，梶谷 宇，小田英之，宮崎 薫、各務真紀，吉村泰典
  • Organizer: 第18回日本生殖内分泌学会
  • Place of Presentation: シェーンバッハ・サボー（東京都千代田区）
• [Presentation] 子宮・胎盤の炎症とdanger signal．
  • Author(s): 丸山哲夫
  • Organizer: 第21回日本胎盤学会［ランチョンセミナー］
  • Place of Presentation: ウィンク愛知（愛知県名古屋市）
  • Invited
• [Presentation] Regeneration and reconstruction of the uterus as a future infertility treatment.
  • Author(s): Tetsuo Maruyama
  • Organizer: International Federation of Fertility Societies (IFFS) Regional Meeting 2014.
  • Place of Presentation: Boston, USA.
  • Invited
• [Presentation] Differential management of patients with explained and unexplained recurrent pregnancy loss.
  • Author(s): Tetsuo Maruyama
  • Organizer: The 13th Korea-Japan Joint Conference of Obstetrics and Gynecology.
  • Place of Presentation: Seoul, Korea.
  • Invited
• [Presentation] Human endometrial stem cells; implications for endometrial physiology and pathology.
  • Author(s): Tetsuo Maruyama
  • Organizer: The 99th Annual Congress of Korean Society of Obstetrics and Gynecology (KSOG).
  • Place of Presentation: Seoul, Korea.
  • Invited
• [Remarks] テレビ東京「話題の医学 : ヒト子宮内膜の再生と幹細胞」2012年12月30日午前5～5時15分放映
• [Remarks] 毎日新聞「部分切除の子宮再生」2014年3月6日
• [Patent(Industrial Property Rights)] 動物モデルとその作成方法 (2013)
  • Inventor(s): 丸山哲夫, 升田博隆, 吉村泰典, 岡野栄之, 岡野ジェイムス洋尚, 松崎有美
  • Industrial Property Rights Holder: 学校法人慶應義塾, 公益財団法人実験動物中央研究所
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-06-14
• [Patent(Industrial Property Rights)] 平滑筋幹細胞の単離方法 (2009)
  • Inventor(s): 丸山哲夫, 小野政徳
  • Industrial Property Rights Holder: 学校法人慶應義塾
  • Industrial Property Rights Type: 特許
  • Filing Date: 2009-04-13
  • Overseas
• [Patent(Industrial Property Rights)] 平滑筋幹細胞の単離方法 (2009)
  • Inventor(s): 丸山哲夫, 小野政徳
  • Industrial Property Rights Holder: 学校法人慶應義塾
  • Industrial Property Rights Type: 特許
  • Filing Date: 2009-04-13
  • Overseas