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Basic and translational research for protection of neurodegeneration.

Research Project

Project/Area Number 23249079
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section一般
Research Field Emergency medicine
Research InstitutionHoshi University (2015)
Showa University

Principal Investigator

SHIODA SEIJI  星薬科大学, 付置研究所, 教授 (80102375)

Co-Investigator(Kenkyū-buntansha) Dohi Kenji  東京慈恵会医科大学, 医学部, 准教授 (20301509)
Nakamachi Tomoya  富山大学, 理工学研究部, 助教 (30433840)
Miyata Atsurou  鹿児島大学, 医学部, 教授 (60183969)
RAKWAL RANDEEP  筑波大学, 体育系, 教授 (70590850)
Hirokazu Otaki  昭和大学, 医学部, 講師 (20349062)
Satoshi Ikeda  鹿児島大学, 医学部, 講師 (00343369)
Project Period (FY) 2011-04-01 – 2016-03-31
Project Status Completed (Fiscal Year 2015)
Budget Amount *help
¥46,410,000 (Direct Cost: ¥35,700,000、Indirect Cost: ¥10,710,000)
Fiscal Year 2015: ¥12,870,000 (Direct Cost: ¥9,900,000、Indirect Cost: ¥2,970,000)
Fiscal Year 2014: ¥13,000,000 (Direct Cost: ¥10,000,000、Indirect Cost: ¥3,000,000)
Fiscal Year 2013: ¥13,130,000 (Direct Cost: ¥10,100,000、Indirect Cost: ¥3,030,000)
Fiscal Year 2012: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2011: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
KeywordsPACAP / 神経細胞死防御 / ヒト骨髄間葉系幹細胞 / 神経損傷の防御 / トランスレーショナルリサーチ / トランスレーショナルリサーチ / 神経細胞死抑制
Outline of Final Research Achievements

PACAP is expressed in neural tissues and is known to exert pleiotropic effects on the nervous system. Although its mechanisms of action are slowly being unraveled. This research was tried to demonstrate the neuroprotective effects, mechanisms, and therapeutic potential of PACAP using stroke and spinal injury model in mice. It appeared that PACAP inhibited delayed neuronal cells in brain and spinal cord and we found that PACAP affected on brain and spinal injury not only to inhibit neuronal cell death through MAPK signaling pathway but also it stimulated to activate and synthesize protein named CRMP2 which has been already reported to activate axonal cell growth in rodents utilizing high-throughout omics approaches. Moreover, we tried to make clear the functional significance of PACAP in primate, so we used common marmoset and we built up stroke model in them and we are now trying to test whether PACAP inhibits neural degeneration in humans in future.

Report

(6 results)
  • 2015 Annual Research Report   Final Research Report ( PDF )
  • 2014 Annual Research Report
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (98 results)

All 2016 2015 2014 2013 2012 2011

All Journal Article (43 results) (of which Int'l Joint Research: 3 results,  Peer Reviewed: 43 results,  Open Access: 11 results,  Acknowledgement Compliant: 3 results) Presentation (53 results) (of which Int'l Joint Research: 6 results) Book (2 results)

  • [Journal Article] Narcolepsy-like sleep disturbance in orexin knockout mice are normalized by the 5-HT1A receptor agonist 8-OH-DPAT.2016

    • Author(s)
      Mori T, Uzawa N, Iwase Y, Masukawa D, Rahmadi M, Hirayama S, Hokazono M, Higashiyama K, Shioda S, Suzuki T
    • Journal Title

      Psychopharmacology(Berl)

      Volume: Epub ahead of print Pages: 1-11

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) contributes to the proliferation of hematopoietic progenitor cells in murine bone marrow via PACAP-specific receptor.2016

    • Author(s)
      Xu Z, Ohtaki H, Watanabe J, Miyamoto K, Murai N, Sasaki S, Matsumoto M, Hashimoto H, Hiraizumi Y, Numazawa S, Shioda S.
    • Journal Title

      Sci Rep

      Volume: 6 Issue: 1 Pages: 22373-22373

    • DOI

      10.1038/srep22373

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research
  • [Journal Article] Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) Is Involved in Adult Mouse Hippocampal Neurogenesis After Stroke.2016

    • Author(s)
      Matsumoto M, Nakamachi T, Watanabe J, Sugiyama K, Ohtaki H, Murai N, Sasaki S, Xu Z, Hashimoto H, Seki T, Miyazaki A, Shioda S
    • Journal Title

      J Mol Neurosci

      Volume: 6 Pages: 1-10

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Opioid systems in the lateral hypothalamus regulate feeding behavior through orexin and GABA neurons.2016

    • Author(s)
      Ardianto C, Yonemochi N, Yamamoto S, Yang L, Takenoya F, Shioda S, Nagase H, Ikeda H, Kamei J.
    • Journal Title

      Neuroscience.

      Volume: 320 Pages: 183-193

    • DOI

      10.1016/j.neuroscience.2016.02.002

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Int'l Joint Research / Acknowledgement Compliant
  • [Journal Article] A new Xist allele driven by a constitutively active promoter is dominated by Xist locus environment and exhibits the parent-of-origin effects.2015

    • Author(s)
      Amakawa Y, Sakata Y, Hoki Y, Arata S, Shioda S, Fukagawa T, Sasaki H, Sado T.
    • Journal Title

      Development.

      Volume: 142 Pages: 4299-4308

    • DOI

      10.1242/dev.128819

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Two-color dye-swap DNA microarray approach toward confident gene expression profiling in PMCAO mouse model for ischemia-related and PACAP38-influenced genes.2015

    • Author(s)
      Hori M, Shibato J, Nakamachi T, Rakwal R, Ogawa T, Shioda S, and Numazawa S.
    • Journal Title

      Genomics Data

      Volume: 3 Pages: 148-154

    • DOI

      10.1016/j.gdata.2015.01.007

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PACAP as a neuroprotective factor in ischemic neuronal injuries.2015

    • Author(s)
      Shioda S, Nakamachi T
    • Journal Title

      Peptides

      Volume: 72 Pages: 202-207

    • DOI

      10.1016/j.peptides.2015.08.006

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unraveling the Rat Intestine, Spleen and Liver Genome-Wide Transcriptome after the Oral Administration of Lavender Oil by a Two-Color Dye-Swap DNA Microarray Approach.2015

    • Author(s)
      Kubo H, Shibato J, Saito T, Ogawa T, Rakwal R, Shioda S
    • Journal Title

      PLoS One

      Volume: 10 Issue: 7 Pages: e0129951-e0129951

    • DOI

      10.1371/journal.pone.0129951

    • NAID

      120007136329

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Distinct effects of the serotonin-noradrenaline reuptake inhibitors milnacipran and venlafaxine on rat pineal monoamines.2015

    • Author(s)
      Muneoka K, Kuwagata M, Ogawa T, Shioda S
    • Journal Title

      Neuroreport.

      Volume: 26 Issue: 9 Pages: 510-514

    • DOI

      10.1097/wnr.0000000000000379

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Attenuation of inflammatory and neuropathic pain behaviors in mice through activation of free fatty acid receptor GPR40.2015

    • Author(s)
      Karki P, Kurihara T, Nakamachi T, Watanabe J, Asada T, Oyoshi T, Shioda S, Yoshimura M, Arita K, Miyata A.
    • Journal Title

      Mol Pain.

      Volume: 11(1) Pages: 6-6

    • DOI

      10.1186/s12990-015-0003-8

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Neuropeptide W-Induced Hypophagia is Mediated Through Corticotropin-Releasing Hormone-Containing Neurons.2015

    • Author(s)
      Takenoya F, Wang L, Kageyama H, Hirako S, Wada N, Hashimoto H, Ueta Y, Sakagami J, Nonaka N, Shioda S.
    • Journal Title

      J Mol Neurosci

      Volume: 57 Issue: 4 Pages: 789-798

    • DOI

      10.1007/s12031-015-0501-1

    • Related Report
      2015 Annual Research Report
    • Peer Reviewed / Open Access / Acknowledgement Compliant
  • [Journal Article] Mother/offspring co-administration of the traditional herbal remedy yokukansan during the nursing period influences grooming and cerebellar serotonin levels in a rat model of neurodevelopmental disorders.2015

    • Author(s)
      Muneoka K, Kuwagata M, Ogawa T, Shioda S.
    • Journal Title

      Cerebellum.

      Volume: 14(2) Issue: 2 Pages: 86-96

    • DOI

      10.1007/s12311-014-0611-2

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ghrelin suppresses proliferation of fetal neural progenitor cells, and induces their differentiation into neurons.2015

    • Author(s)
      Watanabe J, Matsumoto M, Kageyama H, Murai N, Sasaki S, Hirako S, Wada N, Arata S, Shioda S.
    • Journal Title

      Peptides.

      Volume: 69 Pages: 40-46

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Human mesenchymal stem/stromal cells suppress spinal inflammation in mice with contribution of pituitary adenylate cyclase-activating polypeptide (PACAP).2015

    • Author(s)
      Tsumuraya T, Ohtaki H, Song D, Sato A, Watanabe J, Hiraizumi Y, Nakamachi T, Xu Z, Dohi K, Hashimoto H, Atsumi T, Shioda S.
    • Journal Title

      J Neuroinflammation.

      Volume: 12(1) Issue: 1 Pages: 35-35

    • DOI

      10.1186/s12974-015-0252-5

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Comprehensive analysis of neonatal versus adult unilateral decortication in a mouse model using behavioral, neuroanatomical, and DNA microarray approaches.2014

    • Author(s)
      Yoshikawa A, Nakamachi T, Shibato J, Rakwal R, Shioda S.
    • Journal Title

      Int J Mol Sci.

      Volume: 15(12) Issue: 12 Pages: 22492-22517

    • DOI

      10.3390/ijms151222492

    • NAID

      120007136490

    • Related Report
      2015 Annual Research Report 2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] PACAP38 suppresses cortical damage in mice with traumatic brain injury by enhancing antioxidant activity.2014

    • Author(s)
      Miyamoto K, Tsumuraya T, Ohtaki H, Dohi K, Satoh K, Xu Z, Tanaka S, Murai N, Watanabe J, Sugiyama K, Aruga T, Shioda S.
    • Journal Title

      J Mol Neurosci.

      Volume: 54(3) Issue: 3 Pages: 370-379

    • DOI

      10.1007/s12031-014-0309-4

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PACAP stimulates functional recovery after spinal cord injury through axonal regeneration.2014

    • Author(s)
      Tsuchida M, Nakamachi T, Sugiyama K, Tsuchikawa D, Watanabe J, Hori M, Yoshikawa A, Imai N, Kagami N, Matkovits A, Atsumi T, Shioda S.
    • Journal Title

      J Mol Neurosci.

      Volume: 54(3) Issue: 3 Pages: 380-387

    • DOI

      10.1007/s12031-014-0338-z

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Comparison of expression and proliferative effect of pituitary adenylate cyclase-activating polypeptide (PACAP) and its receptors on human astrocytoma cell lines.2014

    • Author(s)
      Nakamachi T, Sugiyama K, Watanabe J, Imai N, Kagami N, Hori M, Arata S, Shioda S.
    • Journal Title

      J Mol Neurosci.

      Volume: 54(3) Issue: 3 Pages: 388-394

    • DOI

      10.1007/s12031-014-0362-z

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PACAP38 differentially effects genes and CRMP2 protein expression in ischemic core and penumbra regions of permanent middle cerebral artery occlusion model mice brain.2014

    • Author(s)
      Hori M, Nakamachi T, Shibato J, Rakwal R, Tsuchida M, Shioda S, Numazawa S.
    • Journal Title

      Int J Mol Sci.

      Volume: 15(9) Issue: 9 Pages: 17014-17034

    • DOI

      10.3390/ijms150917014

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Status of Systemic Oxidative Stress during Therapeutic Hypothermia in Patients with Post-Cardiac Arrest Syndrome.2013

    • Author(s)
      Dohi K, Miyamoto K, Fukuda K, Nakamura S, Hayashi M, Ohtaki H, Shioda S, Aruga T
    • Journal Title

      Oxid Med Cell Longev.

      Volume: 2013 Pages: 562429-562429

    • DOI

      10.1155/2013/562429

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Establishment and Characterization of Primary Adult Microglial Culture in Mice2013

    • Author(s)
      Ohtaki H, Tsumuraya T, Song D, Sato A, Ohara K, Miyamoto K, Nakano H, Kiriyama K, Dohi K, Hiraizumi H, Matsunaga M, Shioda S
    • Journal Title

      Acta Neurochir Suppl

      Volume: 118 Pages: 49-54

    • DOI

      10.1007/978-3-7091-1434-6_8

    • ISBN
      9783709114339, 9783709114346
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Pituitary adenylate cyclase-activating polypeptide (PACAP) receptor expression in reactive astrocytes induced by global brain ischemia in mice.2013

    • Author(s)
      Nakamachi T, Jozsef F, Kagami N, Wada Y, Hori M, Tsuchikawa D, Tsuchida M, Yoshikawa A, imai N, Hata A, Atrata S, Shioda S
    • Journal Title

      Acta Neurochir Suppl

      Volume: 118 Pages: 55-59

    • DOI

      10.1007/978-3-7091-1434-6_9

    • ISBN
      9783709114339, 9783709114346
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The anti-inflammatory property of human bone marrow-derived mesenchymal stem/stromal cells is preserved in late-passage cultures.2013

    • Author(s)
      Song D, Ohtaki H, Tsumuraya T, Miyamoto K, Shibato J, Rakwal R, Xu Z, Hiraizumi Y, Inoue T, Shioda S
    • Journal Title

      J Neuroimmunol.

      Volume: 263(1-2) Issue: 1-2 Pages: 55-63

    • DOI

      10.1016/j.jneuroim.2013.07.018

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Edaravone Increases Regional Cerebral Blood Flow After Traumatic Brain Injury in Mice2013

    • Author(s)
      Miyamoto K, Ohtaki H, Dohi K, Tsumuraya T, Nakano H, Kiriyama K, Song D, Aruga T, Shioda S
    • Journal Title

      Acta Neurochir Suppl

      Volume: 118 Pages: 103-9

    • DOI

      10.1007/978-3-7091-1434-6_18

    • ISBN
      9783709114339, 9783709114346
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] PACAP Attenuates NMDA-Induced Retinal Damage in Association with Modulation of the Microglia/Macrophage Status into an Acquired Deactivation Subtype.2013

    • Author(s)
      Wada Y, Nakamachi T, Endo K, Seki T, Ohtaki H, Tsuchikawa D, Hori M, Tsuchida M, Yoshikawa A, Matkovits A, Kagami N, Imai N, Fujisaka S, Usui I, Tobe K, Koide R, Takahashi H, Shioda S
    • Journal Title

      J Mol Neurosci.

      Volume: 51(2) Issue: 2 Pages: 493-502

    • DOI

      10.1007/s12031-013-0017-5

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Impaired response to hypoxia in the respiratory center is a main cause of neonatal death of the PACAP knockout mouse2013

    • Author(s)
      Arata Satoru, Nakamachi, Tomoya,Onimaru Hiroshi, Hashimoto Hitoshi and Shioda Seiji
    • Journal Title

      European Journal of Neuroscience

      Volume: 37 Issue: 3 Pages: 407-416

    • DOI

      10.1111/ejn.12054

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Therapeutic time window for edaravone treatment of traumatic brain injury in mice.2013

    • Author(s)
      Miyamoto K, Ohtaki H, Dohi K, Tsumuraya T, Song D, Kiriyama K, Satoh K, Shimizu A, Aruga T, Shioda S
    • Journal Title

      Biomed Res Int.

      Volume: 2013 Pages: 379206-379206

    • DOI

      10.1155/2013/379206

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IL-6 and PACAP receptor expression and localization after global brain ischemia in mice.2012

    • Author(s)
      Nakamachi Tomoya
    • Journal Title

      J Mol Neurosci

      Volume: 48 Pages: 518-525

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuroprotective effect of endogenous pituitary adenylate cyclase-activating polypeptide on spinal cord injury.2012

    • Author(s)
      Tsuchikawa Daisuke
    • Journal Title

      J Mol Neurosci

      Volume: 48 Pages: 508-517

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intranasal administration of PACAP: uptake by brain and regional brain targeting with cyclodextrins.2012

    • Author(s)
      Nonaka Naoko
    • Journal Title

      Peptides

      Volume: 36 Issue: 2 Pages: 168-175

    • DOI

      10.1016/j.peptides.2012.05.021

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcriptomics and proteomics analyses of the PACAP38 influenced ischemic brain in permanent middle cerebral artery occlusion model mice2012

    • Author(s)
      Hori M, Nakamachi T, Rakwal R, Shibato J, Ogawa T, Aiuchi T, Tsuruyama T, Tamaki K, Shioda S
    • Journal Title

      J Neuroinflammation

      Volume: 9 Issue: 1 Pages: 256-256

    • DOI

      10.1186/1742-2094-9-256

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution and protective function of pituitary adenylate cyclase-activating polypeptide in the retina.2012

    • Author(s)
      Nakamachi Tomoya
    • Journal Title

      Front Endocrinol (Lausanne)

      Volume: 3 Pages: 145-145

    • DOI

      10.3389/fendo.2012.00145

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Interleukin-1 participates in the classical and alternative activation of microglia/macrophages after spinal cord injury2012

    • Author(s)
      Sato A, et al
    • Journal Title

      J Neuroinflammation

      Volume: 9 Pages: 65-65

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Unraveling the ischemic brain transcriptome in a permanent middle cerebral artery occlusion mouse model by DNA microarray analysis2012

    • Author(s)
      Hori M, et al
    • Journal Title

      Dis Model Mech

      Volume: 5 Pages: 270-283

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche2011

    • Author(s)
      Yamazaki S, et al
    • Journal Title

      Cell

      Volume: 147 Pages: 1146-1158

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Hyperactivity induced by prenatal BrdU exposure across several experimental conditions2011

    • Author(s)
      Kuwagata M, et al
    • Journal Title

      Congenit Anom (Kyoto)

      Volume: 51 Pages: 177-182

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Auranofin protects against cocaine-induced hepatic injury through induction of heme oxygenase-12011

    • Author(s)
      Ashino T, et al
    • Journal Title

      J Toxicol Sci

      Volume: 36 Pages: 635-643

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Time-lapse imaging reveals symmetric neurogenic cell division of GFAP-expressing progenitors for expansion of postnatal dentate granule neurons2011

    • Author(s)
      Namba T, et al
    • Journal Title

      PLoS One

      Volume: 6

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Seeking gene candidates responsible for developmental origins of health and disease2011

    • Author(s)
      Ogawa T, et al
    • Journal Title

      Congenit Anom (Kyoto)

      Volume: 51 Pages: 110-125

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Role of PACAP in neural stem/progenitor cell and astrocyte--from neural development to neural repair2011

    • Author(s)
      Nakamachi T, et al
    • Journal Title

      Curr Pharm Des

      Volume: 17 Pages: 973-984

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] VIP and PACAP : novel approaches to brain functions and neuroprotection2011

    • Author(s)
      Shioda S, Gozes I
    • Journal Title

      Curr Pharm Des

      Volume: 17 Pages: 961-961

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Involvement of interleukin-1 in lipopolysaccaride-induced microglial activation and learning and memory deficits2011

    • Author(s)
      Tanaka S, et al
    • Journal Title

      J Neurosci Res

      Volume: 89 Pages: 506-514

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution of the longevity gene product, SIRT1, in developing mouse organs2011

    • Author(s)
      Ogawa T, et al
    • Journal Title

      Congenit Anom (Kyoto)

      Volume: 51 Pages: 70-79

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Intranasal administration of GALP suppressed the lipid accumulation in the liver.2016

    • Author(s)
      Hirako S, Kageyama H, Takaenoya F, Wada N, Okabe M, Shioda S.
    • Organizer
      13th International Congress on Obesity
    • Place of Presentation
      バンクーバー、カナダ
    • Year and Date
      2016-05-01
    • Related Report
      2015 Annual Research Report
  • [Presentation] マウスにおけるPACAPの唾液分泌促進作用2016

    • Author(s)
      中町智哉, 渡邊 潤, 塩田清二
    • Organizer
      第121回日本解剖学会総会全国学術集会
    • Place of Presentation
      郡山
    • Year and Date
      2016-03-28
    • Related Report
      2015 Annual Research Report
  • [Presentation] Impairment of memory and learning and hippocampal oxidative damage in aged PACAP deficient mouse.2015

    • Author(s)
      Nakamachi, T., Matsuda, K., and Shioda, S.
    • Organizer
      CompBiol 2015
    • Place of Presentation
      広島
    • Year and Date
      2015-12-11
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effects of PACAP on the secretions of tear and saliva in mouse.2015

    • Author(s)
      Nakamachi, T., Watanabe, J., Seki, T., Ohtaki, H., and Shioda, S.,
    • Organizer
      Neuropeptide 2015
    • Place of Presentation
      アバディーン、イギリス
    • Year and Date
      2015-09-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Crucial role of PACAP in neural progenitor cells during development and after degeneration.2015

    • Author(s)
      Watanabe, J., Ohtaki, H., Nakamachi, T., Matsumoto, M., Sasaki, S., Murai, N., Arata, S., and Shioda, S.,
    • Organizer
      Neuropeptide 2015
    • Place of Presentation
      アバディーン、イギリス
    • Year and Date
      2015-09-28
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PACAP attenuates retinal damage in association with modulation of the microglia/macrophage status and cytokines expression.2015

    • Author(s)
      Nakamachi, T., Wada, Y., Endo, K., Seki, T., and Shioda, S.
    • Organizer
      12th international symposium on VIP/PACAP and related peptides
    • Place of Presentation
      カッパドキア、トルコ
    • Year and Date
      2015-09-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Neuroprotective effect of PACAP on spinal cord injury through CRMP2 protein.2015

    • Author(s)
      Shioda, S., Takenoya, F., Hori, M., Shibato, J., Nakamachi, T., and Rakwal, R
    • Organizer
      12th international symposium on VIP/PACAP and related peptides
    • Place of Presentation
      カッパドキア、トルコ
    • Year and Date
      2015-09-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] Involvement of PACAP in differentiation of neural progenitor cells via radial glia.2015

    • Author(s)
      Watanabe, J., Ohtaki, H., Nakamachi, T., Sasaki, S., Matsumoto, M., Murai, N., Seki, T., Arata, S., and Shioda, S.
    • Organizer
      12th international symposium on VIP/PACAP and related peptides,
    • Place of Presentation
      カッパドキア、トルコ
    • Year and Date
      2015-09-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PACAP contributes proliferation of hippocampal neural stem/progenitor cells after global ischemia in mice.2015

    • Author(s)
      Nakamachi, T., Ohtaki, H., Watanabe, J., and Shioda, S.
    • Organizer
      12th international symposium on VIP/PACAP and related peptides
    • Place of Presentation
      カッパドキア、トルコ
    • Year and Date
      2015-09-21
    • Related Report
      2015 Annual Research Report
    • Int'l Joint Research
  • [Presentation] PACAP 遺伝子欠損マウスにおける加齢に伴う学習記憶障害2015

    • Author(s)
      中町智哉, 松田恒平, 塩田清二
    • Organizer
      日本動物学会第86回大会
    • Place of Presentation
      新潟
    • Year and Date
      2015-05-17
    • Related Report
      2015 Annual Research Report
  • [Presentation] GALPによる自律神経系を介した脂質代謝調節機構2015

    • Author(s)
      平子哲史、竹ノ谷文子、和田亘弘、塩田清二
    • Organizer
      第12回GPCR研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] PACAPの唾液および汗分泌促進作用2015

    • Author(s)
      中町智哉、渡邊 潤、佐々木駿、塩田清二
    • Organizer
      第12回GPCR研究会
    • Place of Presentation
      東京
    • Year and Date
      2015-05-15
    • Related Report
      2015 Annual Research Report
  • [Presentation] Effect of intranasal GALP on obesity and hepatic lipid metabolism in obese mice.2015

    • Author(s)
      Hirako S, Kageyama H, Takaenoya F, Wada N, Okabe M, Shioda S
    • Organizer
      12th Asian Congress of Nutrition.
    • Place of Presentation
      横浜
    • Year and Date
      2015-05-14
    • Related Report
      2015 Annual Research Report
  • [Presentation] PACAP is involved in hippocampal neurogenesis after global ischemia.2015

    • Author(s)
      Matsumoto M, Sugiyama K, Watanabe J, Nakamachi T, Sasaki S, Murai N, Ohtaki H, Shioda S
    • Organizer
      第120回 日本解剖学会総会・全国学術集会・第92回 日本生理学会大会合同大会 (神
    • Place of Presentation
      神戸国際会議場・展示場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] The distribution of PACAP receptor on the sweat glands.2015

    • Author(s)
      Sasaki S, Ohtaki H, Watanabe J, Xu Z, Murai N, Matsumoto M, Shioda S.
    • Organizer
      第120回 日本解剖学会総会・全国学術集会・第92回 日本生理学会大会合同大会 (神
    • Place of Presentation
      神戸国際会議場・展示場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Role of neuropeptide PACAP in hematopoiesis via its specific receptor PAC1R.2015

    • Author(s)
      Xu Z, Ohtaki H, Watanabe J, Hiraizumi Y, Numazawa S, Shioda S
    • Organizer
      第120回 日本解剖学会総会・全国学術集会・第92回 日本生理学会大会合同大会
    • Place of Presentation
      神戸国際会議場・展示場
    • Year and Date
      2015-03-21 – 2015-03-23
    • Related Report
      2014 Annual Research Report
  • [Presentation] Implantation of human mesenchymal stem/progenitor cells (hMSCs) from bone marrow suppresses spinal cord injury mediated by pituitary adenylate cyclase activating polypeptide (PACAP).2014

    • Author(s)
      Ohtaki H, Tsumuraya T, Sato A, Xu Z, Watanabe J, Matsumoto M, Murai N, Nakamachi T, Hiraizumi Y, Hashimoto H, Shioda S.
    • Organizer
      44th Annual meeting Society for Neuroscience
    • Place of Presentation
      Washington, DC,
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] PACAP receptor expression of hematopoietic stem/progenitor cells in mouse bone marrow with special reference to sympathetic innervation.2014

    • Author(s)
      Xu Z, Tanaka S, Ohtaki H, Wwatanabe J, Hirazumi Y, Numazawa S, Shioda S
    • Organizer
      44th Annual meeting Society for Neuroscience
    • Place of Presentation
      Washington, DC,
    • Year and Date
      2014-11-15 – 2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Suppression of spinal cord injury on human mesenchymal stem/progenitor cells (MSCs) mediated by pituitary adenylate cyclase activating polypeptide (PACAP).2014

    • Author(s)
      Ohtaki H, Tsumuraya T, Sato A, Xu Z, Miyamoto K, Watanabe J, Nakamachi T, Hashimoto H, Shioda S.
    • Organizer
      12th International Congress of Neuroimmunology.
    • Place of Presentation
      Mainz, Germany,
    • Year and Date
      2014-11-09 – 2014-11-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] The role of neuropeptide PACAP in the crosstalk between central nervous system and hematopoiesis.2014

    • Author(s)
      Xu Z, Ohtaki H, Watanabe J, Nakamachi T, Dohi K, Shioda S
    • Organizer
      The 11th China-Japan Joint Seminar Histochemistry and Cytochemistry
    • Place of Presentation
      長野県松本市中央公民館(松本)
    • Year and Date
      2014-09-28 – 2014-09-29
    • Related Report
      2014 Annual Research Report
  • [Presentation] マウスの涙液分泌調節機構におけるPACAPの役割.2014

    • Author(s)
      中町智哉・大滝博和・渡邊潤・関保・塩田清二
    • Organizer
      日本動物学会第85回大会
    • Place of Presentation
      東北大学川内北キャンパス(宮城)
    • Year and Date
      2014-09-11 – 2014-09-13
    • Related Report
      2014 Annual Research Report
  • [Presentation] PACAP stimulates tear seretion through AQP5 signal in mouse.2014

    • Author(s)
      Nakamachi T, Ohtaki H, Watanabe J, Seki T, Shioda S.
    • Organizer
      20th International Symposium on Regulatory Peptides (REGPEP2014)
    • Place of Presentation
      Kyoto Garden Palace (Kyoto)
    • Year and Date
      2014-09-07 – 2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] PACAP type 1 receptor expression in hematopoietic stem/progenitor cells of mouse bone marrow with special reference to sympathetic innervation.2014

    • Author(s)
      Xu Z, Ohtaki H, Watanabe J, Hiraizumi Y, Numazawa S, Shioda.
    • Organizer
      20th International Symposium on Regulatory Peptides
    • Place of Presentation
      Kyoto Garden Palace (Kyoto)
    • Year and Date
      2014-09-07 – 2014-09-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Expression and localization of PACAP specific receptor (PAC1R) in bone marrow of mice.2014

    • Author(s)
      徐枝芳、大滝博和、渡邊潤、宮本和幸、村井謙允、中町智哉、平泉裕、沼澤聡、塩田清二
    • Organizer
      第35回日本炎症・再生医学会
    • Place of Presentation
      万国津梁館(沖縄)
    • Year and Date
      2014-07-02 – 2014-07-05
    • Related Report
      2014 Annual Research Report
  • [Presentation] PACAPの抗酸化誘導作用と加齢に伴う神経変性との関連2014

    • Author(s)
      中町智哉・大滝博和・渡邊潤・松田恒平・塩田清二
    • Organizer
      第11回GPCR研究会
    • Place of Presentation
      日本科学未来館(東京)
    • Year and Date
      2014-05-09 – 2014-05-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] Expression and localization of PACAP specific receptor PAC1R in mouse bone marrow.2014

    • Author(s)
      徐枝芳・大滝博和・渡邊潤・宮本和幸・村井謙允・中町智哉・平泉裕・沼澤聡・塩田清二
    • Organizer
      第11回GPCR研究会
    • Place of Presentation
      日本科学未来館(東京)
    • Year and Date
      2014-05-09 – 2014-05-10
    • Related Report
      2014 Annual Research Report
  • [Presentation] PACAPの抗酸化誘導作用と加齢性神経変性との関連2014

    • Author(s)
      中町智哉・大滝博和・渡邊 潤・吉川 輝・土田将史・杉山公一・加賀美信幸・今井ノリ・塩田清二
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] 脳虚血刺激によるヒト骨髄間葉系幹細胞の応答2014

    • Author(s)
      大滝博和・谷口紗季・徐 枝芳・渡邊 潤・宗 丹丹・宮本和幸・塩田清二
    • Organizer
      第119回日本解剖学会総会・全国学術集会
    • Place of Presentation
      自治医科大学キャンパス
    • Related Report
      2013 Annual Research Report
  • [Presentation] 緑内障モデルマウスを用いたPACAPの網膜保護機構の検討~マイクログリア/マクロファージの関与~.2013

    • Author(s)
      中町智哉・和田悦洋・関保・加賀美信幸・今井ノリ・荒田悟・塩田清二
    • Organizer
      第60回日本実験動物学会総会
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] Human stem/progenitor cells from bone marrow improve spinal cord injury via communicating with PACAP.2013

    • Author(s)
      Ohtaki H, Tsumuraya T, Song D, Sato A, Xu Z, Miyamoto K, Hiraizumi Y, Nakamachi T, Hashimoto H, Shintani N, Shioda S
    • Organizer
      The 11th International Symposium on VIP, PACAP and Related Peptides
    • Place of Presentation
      Pecs, Hungary
    • Related Report
      2013 Annual Research Report
  • [Presentation] PACAP stimulates the corneal healing via lacrimal-mediating and direct pathways in mouse.2013

    • Author(s)
      Nakamachi T, Seki T, Wada Y, Ohtaki H, Kagami N, Imai N, Arata S, Hashimoto H, Shintani N, Farkas J, Matkovits A, Reglodi D, Shioda S
    • Organizer
      The 11th International Symposium on VIP, PACAP and Related Peptides
    • Place of Presentation
      Pecs, Hungary
    • Related Report
      2013 Annual Research Report
  • [Presentation] PACAP stimulates functional recovery after spinal cord injury through axonal regeneration.2013

    • Author(s)
      Tsuchida M, Nakamachi T, Sugiyama K, Tsuchikawa D, Hori M, Yoshikawa A, Imai N, Kagami N, Matkovits A, Atsumi T, Shioda
    • Organizer
      The 11th International Symposium on VIP, PACAP and Related Peptides
    • Place of Presentation
      Pecs, Hungary
    • Related Report
      2013 Annual Research Report
  • [Presentation] Proteomics of the PACAP38 influenced ischemic brain in permanent middle cerebral artery occlusion model mice.2013

    • Author(s)
      Hori M, Nakamachi T, Rakwal R, Shibato J, Tsuchida M, Yoshikawa A, Sugiyama K, Shioda
    • Organizer
      The 11th International Symposium on VIP, PACAP and Related Peptides
    • Place of Presentation
      Pecs, Hungary
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス硝子体内へのPACAP投与による網膜保護効果と局所免疫環境変化についての検討2013

    • Author(s)
      中町智哉・和田悦洋・関保・堀元英・吉川輝・土田将史・杉山公一・加賀美信幸・今井ノリ・荒田悟・塩田清二
    • Organizer
      第38回日本比較内分泌学会
    • Place of Presentation
      宮崎
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neuropeptides and stem cell therapeutics: spinal cord injury and stroke.2013

    • Author(s)
      Shioda S
    • Organizer
      The 43th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, CA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Human bone marrow-derived mesenchymal stem cells suppressed classical activation of microglial cells.2013

    • Author(s)
      Song D, Ohtaki H, Xu Z, Miyamoto K, Shibato J, Rakwal R, Dohi K, Hiraizumi Y, Shioda S
    • Organizer
      The 43th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, CA
    • Related Report
      2013 Annual Research Report
  • [Presentation] Expression and localization of IL-6 and PACAP receptor in mouse brain after global ischemia.2013

    • Author(s)
      Nakamachi T, Kagami N, Hori M, Yoshikawa A, Sugiyama K, Imai N, Seki T, Arata A, Shioda S
    • Organizer
      The 43th Annual Meeting of the Society for Neuroscience
    • Place of Presentation
      San Diego, CA
    • Related Report
      2013 Annual Research Report
  • [Presentation] 骨髄間葉系幹細胞の神経損傷抑制機構に関わる神経ペプチドPACAP2013

    • Author(s)
      大滝博和
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川県
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス頭部外傷モデルにおけるエダラボンの脳血流への影響についての検討2013

    • Author(s)
      大滝博和
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川県
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウスにおけるPACAPの角膜傷害治癒効果の検討2013

    • Author(s)
      中町智哉
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川県
    • Related Report
      2012 Annual Research Report
  • [Presentation] 脳虚血後のマウス海馬におけるIL-6とPACAP受容体の発現動態2013

    • Author(s)
      中町智哉
    • Organizer
      第118回日本解剖学会総会・全国学術集会
    • Place of Presentation
      香川県
    • Related Report
      2012 Annual Research Report
  • [Presentation] STEM CELL CHARACTERISTICS OF HUMAN MSCS IN DIFFERENT PASSAGES.2012

    • Author(s)
      Song Dan Dan
    • Organizer
      10th International Society for Stem Cell Research (ISSCR)
    • Place of Presentation
      Yokohama
    • Related Report
      2012 Annual Research Report
  • [Presentation] 神経損傷モデルにおける骨髄幹細胞による神経再生2012

    • Author(s)
      大滝博和
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      甲府、山梨県(シンポジスト)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 誘導性の涙液分泌におけるアクアポリン5の役割2012

    • Author(s)
      中町智哉, 他
    • Organizer
      第117回日本解剖学会総会・全国学術集会
    • Place of Presentation
      甲府、山梨県
    • Related Report
      2011 Annual Research Report
  • [Presentation] Functional significance of PACAP on learning and memory in aged animals2011

    • Author(s)
      塩田清二, 他
    • Organizer
      Summer Neuropeptide Conference and The European Neuropeptide Club Meeting
    • Place of Presentation
      Boston, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] 涙液分泌機能低下を示すPACAP欠損マウスを用いた涙液分泌機構の解析2011

    • Author(s)
      中町智哉, 他
    • Organizer
      第58回日本実験動物学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] Anti-inflammatory effect of human MSCs on global ischemia2011

    • Author(s)
      大滝博和, 他
    • Organizer
      The XVth International Symposium of Brain Edema and Cellular Injury (Brain Edema 2011)
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] Expression of pituitary adenylate cyclase-activating polypeptide (PACAP) receptor expression on reactive astrocyte after brain ischemia in mice2011

    • Author(s)
      中町智哉, 他
    • Organizer
      The XVth International Symposium of Brain Edema and Cellular Injury (Brain Edema 2011)
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] PACAPによる涙液分泌促進作用機序の解析2011

    • Author(s)
      中町智哉, 他
    • Organizer
      第36回日本比較内分泌学会
    • Place of Presentation
      東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] Interleukin-1 gene deficient mice modulate microglial activation after spinal cord injury2011

    • Author(s)
      大滝博和, 他
    • Organizer
      41st Annual meeting Society for Neuroscience
    • Place of Presentation
      Washington DC, USA
    • Related Report
      2011 Annual Research Report
  • [Presentation] PACAP receptor expression and its function in mouse reactive astrocytes2011

    • Author(s)
      中町智哉, 他
    • Organizer
      Symposium of the 20th Annual Meeting of The Israel Society for Neuroscience~Basic and Clinical Research of GPCRs~
    • Place of Presentation
      Eilat, Israel
    • Related Report
      2011 Annual Research Report
  • [Presentation] Suppression of Oxidative Stress on PACAP Might Involve in the Neuroprotection2011

    • Author(s)
      大滝博和, 他
    • Organizer
      Symposium of the 20th Annual Meeting of The Israel Society for Neuroscience~Basic and Clinical Research of GPCRs~
    • Place of Presentation
      Eilat, Israel
    • Related Report
      2011 Annual Research Report
  • [Presentation] PACAP stimulates the lacrimation via aquaporin 5 translocatoin in mouse2011

    • Author(s)
      中町智哉, 他
    • Organizer
      The 10th international Symposium on VIP, PACAP and Related Peptides
    • Place of Presentation
      Eilat, Israel
    • Related Report
      2011 Annual Research Report
  • [Book] 特集 未病・健康ー病気にならないための衣・食・住そしてココロ2016

    • Author(s)
      塩田清二、竹ノ谷文子、亀井淳三 他
    • Total Pages
      83
    • Publisher
      Biophilia
    • Related Report
      2015 Annual Research Report
  • [Book] アンチエイジング医学の基礎と臨床2015

    • Author(s)
      藤英胤(編集)、塩田清二、竹ノ谷文子 他
    • Total Pages
      447
    • Publisher
      メジカルビュー社
    • Related Report
      2015 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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