Regulatory mechanisms in oral tissue-specific immune responses and tolerance

• Project/Area Number: 23249082
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Pathobiological dentistry/Dental radiology
• Research Institution: Tokyo Medical and Dental University
• Principal Investigator: AZUMA Miyuki 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (90255654)
• Co-Investigator(Kenkyū-buntansha): OHNO Tatsukuni 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (80435635)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥47,710,000 (Direct Cost: ¥36,700,000、Indirect Cost: ¥11,010,000); Fiscal Year 2013: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000); Fiscal Year 2012: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000); Fiscal Year 2011: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
• Keywords: 免疫学 / 歯学 / 樹状細胞 / 口腔粘膜 / 歯髄 / 歯肉 / 免疫制御 / 舌下免疫療法 / 歯周病 / 歯髄炎

Research Abstract

We investigated oral immune responses induced by oral mucosal or dental pulpal DCs and epithelial cells, and found following new observations; 1) The density of oral mucosal DCs was clearly lower. 2) The density of sublingual DCs was markedly lower than those of buccal mucosa and dorsal surface of the tongue. 3) A comparable recruitment of submucosal DCs (smDCs) in the sublingual mucosa (SLM) was induced at an early phase after an initial hapten painting. 4) Repeated antigen painting onto SLM induced exhaustion of smDCs and conversion of macrophage-like smDC that possess less dendrites and round morphology with high levels of CD11b and CD206. 5) Dental pulp DCs migrated into regional lymph nodes after cusp trimming and possess mature phenotype. 6) Prickle cells in gingiva and dorsal surface of tongue constitutively expressed an immune regulatory molecule B7-H1. 7) B7-H1 that was overexpressed in gingival keratinocytes inhibited P.g-induced gingival inflammation and alveolar bone loss.

Research Products

• [Journal Article] Dental pulp dendritic cells migrate to regional lymph nodes (2014)
  • Author(s): Bhingare AC, Ohno T, Tomura M, Zhang C, Aramaki O, Otsuki M, Tagami J, Azuma M
  • Journal Title: J Dental Res Volume: 93 Issue: 3 Pages: 288-293
  • DOI: 10.1177/0022034513518223
  • Peer Reviewed
• [Journal Article] HPV1 6 E2 protein promotes innate immunity by modulating immunosuppressive status (2014)
  • Author(s): Sunthamala N, Pientong C, Ohno T, Zhang C. Bhingare A, Kondo Y, Azuma M, Ekalaksananan T
  • Journal Title: BiochemBiophys Res Commun Volume: 446 Issue: 4 Pages: 977-82
  • DOI: 10.1016/j.bbrc.2014.03.042
  • Peer Reviewed
• [Journal Article] Intact B7-H3 signaling promotes allograft proliferation through preferential suppression of Th1 effector responses (2013)
  • Author(s): Ueno T, Yeung MY, McGrath M, Yang S, Zaman N, Snawder B, Padera RF, Magee CN, Gorbatov R, Hashiguchi M, Azuma M, Freeman GJ, Sayegh MH, Najafian N
  • Journal Title: Eur J Immunol Volume: 42 Pages: 2343-53
• [Journal Article] Th2 cell-intrinsic hypo-responsiveness determines susceptibility to helminth infection (2013)
  • Author(s): Van der Werf N, redpath SA, Azuma M, Yaguita H, Taylor MD
  • Journal Title: PLOS Pathogens Volume: 62 Pages: 2859-60
• [Journal Article] PD-1 , but not PD-L1 , expressed by islet-reactive CD4+ T cells suppresses infiltration of the pancreas during type 1 diabetes (2013)
  • Author(s): Pauken KE, Jenkins MK, Azuma M. Fife BT
  • Journal Title: Diabetes Volume: 62 Issue: 8 Pages: 2859-60
  • DOI: 10.2337/db12-1475
• [Journal Article] Host programmed death ligand-1 is dominant over programmed death ligand-2 expression in regulating graft-versus-host disease lethality (2013)
  • Author(s): Saha A, Aoyama K, Taylor PA, Koehn BH, Veestra RG, Panoskaltsis-Mortari A, Munn DH, Murphy WJ, Azuma M, Yagita H, Fife BT, Sayegh MH, Najafian N, Ahme R, Freeman GJ, Sharpe AH, Blazar BR.
  • Journal Title: Blood Volume: 122 Issue: 17 Pages: 3062-73
  • DOI: 10.1182/blood-2013-05-500801
  • Peer Reviewed
• [Journal Article] Intact B7-H3 signaling promotes allograft proliferation through preferential suppression of Th1 effector responses. (2013)
  • Author(s): Ueno T
  • Journal Title: Eur J Immunol Volume: 42 Pages: 2343-53
  • Peer Reviewed
• [Journal Article] RANKL expression, function and therapeutic targeting in multiple myeloma and chronic lymphocytic leukemia. (2013)
  • Author(s): Schmiedel BJ
  • Journal Title: Cancer Res Volume: 73 Issue: 2 Pages: 683-694
  • DOI: 10.1158/0008-5472.can-12-2280
  • Peer Reviewed
• [Journal Article] Receptor activator for NF-kB ligand in acute myeloid leukemia: expression, function and modulation of NK cell immunosurveillance. (2013)
  • Author(s): Schmiedel BJ
  • Journal Title: J Immunol Volume: 190 Pages: 821-31
  • Peer Reviewed
• [Journal Article] Human B7-H3 binds to Triggering receptor expressed on myeloid cell-like transcript 2(TLT-2) and enhances T cell responses. Open J (2012)
  • Author(s): M. Hashiguchi, Y. Inamochi, S. Nagai, S., N. Otsuki, P. Jinhua, H. Kobori, Y. Kanno, T. Kobata, M. Azuma
  • Journal Title: Immunol. Peer-reviewed Volume: 2 Issue: 01 Pages: 9-16
  • DOI: 10.4236/oji.2012.21002
  • Peer Reviewed
• [Journal Article] Programmed cell death-1 forms negative costimulatorymicroclusters that directly inhibit T cell receptor signaling by recruiting phosphatase SHP2 (2012)
  • Author(s): Yokosuka T, Takamatsu M, Kobayashi-Imanishi W, Hashimoto-Tani A, Azuma M, Saito T
  • Journal Title: J Exp Med Volume: 209 Issue: 6 Pages: 935-945
  • DOI: 10.1084/jem.20112741
  • Peer Reviewed
• [Journal Article] Antibodies against B7-DC with differential binding properties exert opposite effects (2012)
  • Author(s): Ritprajak P, Hashiguchi M, Akiba H, Yagita H, Okumura K, Azuma M
  • Journal Title: Hybridoma Volume: 31 Issue: 1 Pages: 40-47
  • DOI: 10.1089/hyb.2011.0087
  • Peer Reviewed
• [Journal Article] Antibodies against B7-DC with differential binding properties exert opposite effects. (2012)
  • Author(s): Ritprajak P
  • Journal Title: Hybridoma Volume: 31 Pages: 40-47
  • Peer Reviewed
• [Journal Article] B7-H1 overexpression regulates epithelial-mesenchymal transition and accelerates carcinogenesis in skin (2011)
  • Author(s): Cao Y, Zhang L, Kamimura Y, Ritprajak P, Hashiguchi M, Hirose S, Azuma M
  • Journal Title: Cancer Res Volume: 71 Issue: 4 Pages: 1235-43
  • DOI: 10.1158/0008-5472.can-10-2217
  • Peer Reviewed
• [Journal Article] Immunoregulatory molecules B7-H1 (CD274) contributes to skin carcinogenesis (2011)
  • Author(s): Cao Y, Zhang L, Ritprajak P, Tsushima F, Youngnak-Piboonratanakit P, Kamimura Y, Hashiguchi M, Azuma M
  • Journal Title: Cancer Res Volume: 71 Issue: 14 Pages: 4737-4741
  • DOI: 10.1158/0008-5472.can-11-0527
  • Peer Reviewed
• [Journal Article] Blockade of B7-H1 (programmed death ligand 1) enhances humoral immunity by positively regulating the generation of T follicular helper cells (2011)
  • Author(s): Hams E, McCarron ML, Amu S, Yagita H, Azuma M, Chen L, Fallon PG
  • Journal Title: J Immunol Volume: 186 (10) Issue: 10 Pages: 5648-55
  • DOI: 10.4049/jimmunol.1003161
• [Journal Article] Differential expression of co-signal molecules and migratory properties in four distinct subsets of migratory dendritic cells from the oral mucosa (2011)
  • Author(s): Aramaki O, Chalermsarp N, Otsuki M, Tagami J, Azuma M
  • Journal Title: BiochemBiophys Res Commun Volume: 413 Issue: 3 Pages: 407-413
  • DOI: 10.1016/j.bbrc.2011.08.099
• [Journal Article] Essential role of B7-H1 in double-stranded RNA-induced augmentation of an asthma phenotype in mice (2011)
  • Author(s): 松元幸一郎, 井上博雅, 他
  • Journal Title: Am J Respir Cell Mol Biol Volume: 45 Issue: 1 Pages: 31-39
  • DOI: 10.1165/rcmb.2009-0450oc
  • Peer Reviewed
• [Journal Article] The link between the PDL1 costimulatory pathway and TH1 7 in fetomaternal tolerance (2011)
  • Author(s): D'Addio F, Riella LV, Mfarrej BG, Chabtini L, Adams LT, Yeung M, Yagita H, Azuma M, Sayegh MH, Guleria I
  • Journal Title: J Immunol Volume: 187(9) Issue: 9 Pages: 4530-41
  • DOI: 10.4049/jimmunol.1002031
• [Journal Article] Increased prevalence of interleukin-17-producing CD4^+ tumor infiltrating lymphocytes in human oral squamous cell carcinoma (2011)
  • Author(s): Lee J, Chang Y, Lai W, Ko Z, Kuo MY, Chiang C, Azuma M, Chen CW, Chia J
  • Journal Title: Head and Neck Volume: 33(9) Issue: 9 Pages: 1301-8
  • DOI: 10.1002/hed.21607
  • Peer Reviewed
• [Journal Article] Th2 responses to helminth parasites can be therapeutically enhanced by, but are not dependent upon, GITR-GITRL co-stimulation in vivo (2011)
  • Author(s): Van der Werf N, Redpath SA, Phythian-Adams AT, Azuma M, Allen JE, Maizels RM, Macdonald AS, Taylor MD
  • Journal Title: J Immunol Volume: 187(3) Issue: 3 Pages: 1411-20
  • DOI: 10.4049/jimmunol.1100834
  • Peer Reviewed
• [Journal Article] Differentoal expression of co-signal molecules and migratory properties in four distinct subsets of migratory dendritic cells from the oral mucosa (2011)
  • Author(s): Aramaki O, Chalermsarp N, Otsuki M, Tagami J, Azuma M
  • Journal Title: Biochem Biophys Res Commun Volume: 413 Pages: 407-413
  • Peer Reviewed
• [Presentation] Determination of migratory dental pulp dendritic cells in regional lymph nodes using" Kaede" transgenic mice (2013)
  • Author(s): Bhingare A, Ohno T, Zhang C, Tomura M, Azuma M
  • Organizer: 第42回日本免疫学会
  • Place of Presentation: 幕張
• [Presentation] cell-dependent and -independent regulatory roles of a new inhibitory molecule VISTA (2013)
  • Author(s): Ohno T, Zhang C, Azuma M. T
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 幕張
• [Presentation] Unique features of sublingual mucosal dendritic cells (2013)
  • Author(s): Zhang C, Kang S, Ohno T, Azuma M
  • Organizer: 第42回日本免疫学会
  • Place of Presentation: 幕張
• [Presentation] 抗原塗布後における舌下粘膜樹状細胞の特徴 (2013)
  • Author(s): 張晨陽, 大野建州, 東みゆき
  • Organizer: 第55回歯科基礎医学会
  • Place of Presentation: 岡山
• [Presentation] Kaedeトランスジェニックマウスを利用した歯髄から所属リンパ節に遊走する樹状細胞の同定 (2013)
  • Author(s): Bhingare A, 大野建州, 張晨陽, 東みゆき
  • Organizer: 第55回歯科基礎医学会
  • Place of Presentation: 岡山
• [Presentation] Establishment of a simple method for Japanese cedar pollinosis and sublingual immunotherapy in mice (2013)
  • Author(s): Zhang C, Yagishita S, Tomoda T, Kang S, Azuma M
  • Organizer: 15th ICI
  • Place of Presentation: Milan, Italy
• [Presentation] Co-stimulatory effects of PD-1 in sublingual mucosa-mediated CD4+ T cell responses (2013)
  • Author(s): Ohno T, Zhang C, Yagita H, Azuma M
  • Organizer: 15th ICI
  • Place of Presentation: Milan, Italy
• [Presentation] Unique features of sublingual mucosal dendritic cells after antigen application (2013)
  • Author(s): Zhang C, Ohno T, Azuma M
  • Organizer: 15th International Congress of Immunology (ICI)
  • Place of Presentation: Milan, Italy
• [Presentation] Protective roles of co-inhibitory molecule B7-H1 in gingival inflammation (2013)
  • Author(s): Maekawa S, Ohno T, Kobayashi H, Nakagawa I, Izumi Y, Azuma M
  • Organizer: 2nd Meeting of the International Association of Dental Research-Asia Pacific Region (IADR-APR)
  • Place of Presentation: Bangkok, Thailand
• [Presentation] Unique features of sublingual mucosal dendritic cells after antigen application (2013)
  • Author(s): Azuma M, Zhang C, Ohno T
  • Organizer: 2nd Meeting of the International Association of Dental Research-Asia Pacific Region (IADR-APR)
  • Place of Presentation: Bangkok, Thailand
• [Presentation] 急性および慢性歯肉炎症における免疫抑制分子B7-H1の関与 (2013)
  • Author(s): 前川祥吾, 大野建州, 小林宏明. 中川一路, 和泉雄一, 東みゆき
  • Organizer: 第56回日本歯周病学会(春季)東京
  • Place of Presentation: 東京
• [Presentation] Dual function of PD-1 in CD4+ T cell responses by sublingual mucosa-mediated antigen application (2013)
  • Author(s): Ohno T, Zhang C, Yagita H, Azuma M
  • Organizer: Immunology2013
  • Place of Presentation: Honolulu, USA.
• [Presentation] Effects of sublingual immunotherapy on a murine model of Japanese cedar pollinosis (2013)
  • Author(s): Azuma M, Zhang C, Yanagisawa S, Tomoda T, Kang S, Ohno T
  • Organizer: Immunology2013
  • Place of Presentation: Honolulu, USA
• [Presentation] Effects of sublingual immunotherapy on a murine model of Japanese cedar pollinosis. (2013)
  • Author(s): Azuma M, Zhang C, Yanagisawa S, Tomoda T, Kang S, Ohno T
  • Organizer: Immunology 2013 (AAI)
  • Place of Presentation: Honolulu, USA
• [Presentation] Dual function of PD-1 in CD4+ T cell responses by sublingual mucosa-mediated antigen application (2013)
  • Author(s): Ohno T, Zhang C, Yagita H, Azuma M
  • Organizer: Immunology 2013 (AAI)
  • Place of Presentation: Honolulu, USA
• [Presentation] Dual roles interleukin-33 in LPS-induced gingival inflammation (2013)
  • Author(s): Ohno T, Zhang C, Maekawa S, Azuma M
  • Organizer: 2nd Meeting of the International Association of Dental Research-Asia Pacific Region (IADR-APR)
  • Place of Presentation: Bangkok, Thailand
• [Presentation] 'Protective roles of co-inhibitory molecule B7-H1 in gingival inflammation' (2013)
  • Author(s): Maekawa S, Ohno T, Kobayashi H, Nakagawa I, Izumi Y, Azuma M
  • Organizer: 2nd Meeting of the International Association of Dental Research-Asia Pacific Region (IADR-APR)
  • Place of Presentation: Bangkok, Thailand
• [Presentation] Unique features of sublingual mucosal dendritic cells after antigen application (2013)
  • Author(s): Zhang C, Ohno T, Azuma M
  • Organizer: 15th International Congress of Immunology (ICI2013)
  • Place of Presentation: Milan, Italy
• [Presentation] Co-stimulatory effects of PD-1 in sublingual mucosa-mediated CD4+ T cell responses (2013)
  • Author(s): Ohno T, Zhang C, Yagita H, Azuma M.
  • Organizer: 15th International Congress of Immunology (ICI2013)
  • Place of Presentation: Milan, Italy
• [Presentation] Establishment of a simple method for Japanese cedar pollinosis and sublingual immunotherapy in mice (2013)
  • Author(s): Zhang C, Yagishita S, Tomoda T, Kang S, Azuma M
  • Organizer: 15th International Congress of Immunology (ICI2013)
  • Place of Presentation: Milan, Italy
• [Presentation] 急性および慢性歯肉炎症における免疫抑制分子B7-H1の関与 (2013)
  • Author(s): 前川祥吾、大野建州、小林宏明、中川一路、和泉雄一、東みゆき
  • Organizer: 第56回日本歯周病学会(春季)
  • Place of Presentation: 東京
• [Presentation] Kaedeトランスジェニックマウスを利用した歯髄から所属リンパ節に遊走する樹状細胞の同定 (2013)
  • Author(s): Bhingare A、大野建州、張晨陽、東みゆき
  • Organizer: 第55回歯科基礎医学会学術大会
  • Place of Presentation: 岡山
• [Presentation] 抗原塗布後における舌下粘膜樹状細胞の特徴 (2013)
  • Author(s): 張晨陽、大野建州、東みゆき
  • Organizer: 第55回歯科基礎医学会学術大会
  • Place of Presentation: 岡山
• [Presentation] Unique features of sublingual mucosal dendritic cells (2013)
  • Author(s): Zhang C, Kang S, Ohno T, Azuma M
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 千葉・幕張
• [Presentation] T cell-dependent and -independent regulatory roles of a new inhibitory molecule VISTA (2013)
  • Author(s): Ohno T, Zhang C, Azuma M
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 千葉・幕張
• [Presentation] Involvement of PD-1 and B7-H1 in a Japanese ceder pollinosis. (2013)
  • Author(s): Kang S, Zhang C, Ohno T, Yanagisawa S, Yagita H , Azuma M.
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 千葉・幕張
• [Presentation] Determination of Migratory Dental Pulp Dendritic Cells in Regional Lymph Nodes using (2013)
  • Author(s): Bhingare A, Ohno T, Zhang C, Tomura M, Azuma M
  • Organizer: 第42回日本免疫学会学術集会
  • Place of Presentation: 千葉・幕張
• [Presentation] Involvement of PD-1 and B7-H1 in acute and chronic inflammation in periodontal disease (2012)
  • Author(s): Maekawa S, Ohno T, Kobayashi H, Nakagawa I, Izumi Y, Azuma M
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸
• [Presentation] Characterization of migrating dental pulp dendritic cells in regional lymph nodes after cusp treatment (2012)
  • Author(s): Bhingare A, Aramaki O, Ohno T, Zhang C, Azuma M
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸
• [Presentation] Establishment of a murine model for Japanese cedar pollinosis that manifests various symptoms like rhinitis, dermatitis, and asthma (2012)
  • Author(s): Yanagisawa S, Zhang C, Tomoda T, Azuma M
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸
• [Presentation] Dynamics of oral mucosal dendritic cells after antigen application (2012)
  • Author(s): Zhang C, Ohno T, Azuma M
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸
• [Presentation] Dual functions of PD-1 in CD4+ T cell responses by sublingual mucosa-mediated antigen application (2012)
  • Author(s): Ohno T, Zhang C, Yagita H, Azuma M
  • Organizer: 第41回日本免疫学会
  • Place of Presentation: 神戸
• [Presentation] 舌下粘膜樹状細胞は抗原刺激により急激に枯渇する (2012)
  • Author(s): 張晨陽, 大野建州, 東みゆき
  • Organizer: 第77回口腔病学会
  • Place of Presentation: 東京
• [Presentation] Characterization of migrating dental pulp dendritic cells in regional lymph nodes after cusp treatment (2012)
  • Author(s): Bhingare A, Aramaki O, Ohno T, Zhang C, Azuma M
  • Organizer: DC2012
  • Place of Presentation: Daegu, Korea
• [Presentation] Dynamics of oral mucosal dendritic cells after antigen application (2012)
  • Author(s): Zhang C, Ohno T, Azuma M
  • Organizer: DC2012
  • Place of Presentation: Daegu, Korea
• [Presentation] Differential expression of co-signal molecules and migratory properties in four distinct subsets of migratory dendritic cells from the oral mucosa (2012)
  • Author(s): Azuma M, Aramaki O, Bhingare A, Zhang C, Ohno T, Chalermsarp N
  • Organizer: DC2012
  • Place of Presentation: Daegu, Korea
• [Presentation] 咬頭切削後の所属リンパ節における歯髄から遊走する樹状細胞の解析 (2012)
  • Author(s): 荒牧音, Bhingare A, 大野建州, 張晨陽,田上順次, 東みゆき
  • Organizer: 第54回歯科基礎医学会
  • Place of Presentation: 郡山
• [Presentation] 抗原塗布後の舌下粘膜樹状細胞の動態 (2012)
  • Author(s): 張晨陽, 大野建州, 東みゆき
  • Organizer: 第54回歯科基礎医学会
  • Place of Presentation: 郡山
• [Presentation] 抗原塗布後の舌下粘膜樹状細胞の動態 (2012)
  • Author(s): 東みゆき
  • Organizer: 第54回歯科基礎医学会学術大会
  • Place of Presentation: 郡山
• [Presentation] 咬頭切削後の所属リンパ節における歯髄から遊走する樹状細胞の解析 (2012)
  • Author(s): 東みゆき
  • Organizer: 第54回歯科基礎医学会学術大会
  • Place of Presentation: 郡山
• [Presentation] 舌下粘膜樹状細胞は抗原刺激により急激に枯渇する (2012)
  • Author(s): 東みゆき
  • Organizer: 第77回口腔病学会学術大会
  • Place of Presentation: 東京
• [Presentation] Dynamics of oral mucosal dendritic cells after antigen application (2012)
  • Author(s): Azuma M
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Establishment of a murine model for Japanese cedar pollinosis that manifests various symptoms like rhinitis, dermatitis, and asthma (2012)
  • Author(s): Azuma M
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Dual functions of PD-1 in CD4+ T cell responses by sublingual mucosa-mediated antigen application. (2012)
  • Author(s): Azuma M
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Characterization of migrating dental pulp dendritic cells in regional lymph nodes after cusp treatment. (2012)
  • Author(s): Azuma M
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] Involvement of PD-1 and B7-H1 in acute and chronic inflammation in periodontal disease. (2012)
  • Author(s): Azuma M
  • Organizer: 第41回日本免疫学会学術集会
  • Place of Presentation: 神戸
• [Presentation] 抗原投与による口腔粘膜樹状細胞の局所動態に関する免疫組織学的解析 (2011)
  • Author(s): 張晨陽、大野建州、東みゆき
  • Organizer: 第21回日本口腔粘膜学会総会
  • Place of Presentation: 鹿児島
• [Presentation] 口腔粘膜から所属リンパ節に遊走する樹状細胞サブセットにおける遊走特性と共刺激分子発現 (2011)
  • Author(s): 荒牧音、大野建州、張晨陽、東みゆき
  • Organizer: 第21回日本口腔粘膜学会総会
  • Place of Presentation: 鹿児島
• [Presentation] Immunoregulatory molecule CD274 (B7-H1/PD-L1) contributes to skin carcinogenesis (2011)
  • Author(s): 張晨陽、曹寓佳、大野建州、津島文彦、東みゆき
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋
• [Presentation] LPS刺激によるマクロファージからのIL-33産生とパラクライン機構 (2011)
  • Author(s): 大野建州、東みゆき、奥村康、斎藤博久、中江進
  • Organizer: 第40回日本免疫学会学術集会
  • Place of Presentation: 千葉
• [Remarks]
  • URL: http://www.tmd.ac.jp/mim/index.html