Regulatory mechanisms in oral tissue-specific immune responses and tolerance
| Project/Area Number |
23249082
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Pathobiological dentistry/Dental radiology
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
AZUMA Miyuki 東京医科歯科大学, 医歯(薬)学総合研究科, 教授 (90255654)
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| Co-Investigator(Kenkyū-buntansha) |
OHNO Tatsukuni 東京医科歯科大学, 大学院・医歯学総合研究科, 助教 (80435635)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥47,710,000 (Direct Cost: ¥36,700,000、Indirect Cost: ¥11,010,000)
Fiscal Year 2013: ¥13,390,000 (Direct Cost: ¥10,300,000、Indirect Cost: ¥3,090,000)
Fiscal Year 2012: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Fiscal Year 2011: ¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
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| Keywords | 免疫学 / 歯学 / 樹状細胞 / 口腔粘膜 / 歯髄 / 歯肉 / 免疫制御 / 舌下免疫療法 / 歯周病 / 歯髄炎 |
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| Research Abstract |
We investigated oral immune responses induced by oral mucosal or dental pulpal DCs and epithelial cells, and found following new observations; 1) The density of oral mucosal DCs was clearly lower. 2) The density of sublingual DCs was markedly lower than those of buccal mucosa and dorsal surface of the tongue. 3) A comparable recruitment of submucosal DCs (smDCs) in the sublingual mucosa (SLM) was induced at an early phase after an initial hapten painting. 4) Repeated antigen painting onto SLM induced exhaustion of smDCs and conversion of macrophage-like smDC that possess less dendrites and round morphology with high levels of CD11b and CD206. 5) Dental pulp DCs migrated into regional lymph nodes after cusp trimming and possess mature phenotype. 6) Prickle cells in gingiva and dorsal surface of tongue constitutively expressed an immune regulatory molecule B7-H1. 7) B7-H1 that was overexpressed in gingival keratinocytes inhibited P.g-induced gingival inflammation and alveolar bone loss.
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Report
(4 results)
Research Products
(73 results)
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[Journal Article] Intact B7-H3 signaling promotes allograft proliferation through preferential suppression of Th1 effector responses2013
Author(s)
Ueno T, Yeung MY, McGrath M, Yang S, Zaman N, Snawder B, Padera RF, Magee CN, Gorbatov R, Hashiguchi M, Azuma M, Freeman GJ, Sayegh MH, Najafian N
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Journal Title
Eur J Immunol
Volume: 42
Pages: 2343-53
Related Report
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[Journal Article] Host programmed death ligand-1 is dominant over programmed death ligand-2 expression in regulating graft-versus-host disease lethality2013
Author(s)
Saha A, Aoyama K, Taylor PA, Koehn BH, Veestra RG, Panoskaltsis-Mortari A, Munn DH, Murphy WJ, Azuma M, Yagita H, Fife BT, Sayegh MH, Najafian N, Ahme R, Freeman GJ, Sharpe AH, Blazar BR.
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Journal Title
Blood
Volume: 122
Issue: 17
Pages: 3062-73
DOI
Related Report
Peer Reviewed
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