Development of fundamental technologies to establish the system of tooth regeneration

• Project/Area Number: 23249085
• Research Category: Grant-in-Aid for Scientific Research (A)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Orthodontic/Pediatric dentistry
• Research Institution: Tohoku University
• Principal Investigator: TAKANO-YAMAMOTO Teruko 東北大学, 歯学研究科(研究院), 教授 (00127250)
• Co-Investigator(Kenkyū-buntansha): TAKESHITA Nobuo 東北大学, 大学院・歯学研究科, 助教 (50431515) ; IKEDA Etsuko 東北大学, 大学院・歯学研究科, 大学院非常勤講師 (20509012)
• Project Period (FY): 2011-11-18 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥23,920,000 (Direct Cost: ¥18,400,000、Indirect Cost: ¥5,520,000); Fiscal Year 2013: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000); Fiscal Year 2012: ¥12,740,000 (Direct Cost: ¥9,800,000、Indirect Cost: ¥2,940,000)
• Keywords: iPS細胞 / 器官原基法 / 再生医学 / 歯科 / 歯性上皮細胞 / 歯性間葉細胞 / 再生歯胚

Research Abstract

In the present study, we have developed fundamental technologies to establish the system of tooth regeneration. Neural crest-like cells (NCLCs) were induced from murine iPS cells, and they were three-dimensionally constructed with epithelial tissues isolated from tooth germs. Development of regenerative teeth was observed in organ culture system. We examined induction of tooth germ cells from murine iPS cells and NCLCs. Moreover, we analyzed mechanisms that IGF-1 enlarge size of regenerative teeth. IGF-1 induced proliferation and odontoblast differentiation of mesenchymal cells isolated from tooth germs. In addition, to obtain basic notions directing the application of mechanical stresses for tooth regeneration, we examined the responses of osteocytes and cranial sutures to mechanicals stresses.

Research Products

• [Journal Article] Compressive Force-Produced CCN2 Induces Osteocyte Apoptosis Through ERK1/2 Pathway (2014)
  • Author(s): Hoshi K, Kawaki H, Takahashi I, Takeshita N, Seiryu M, Murshid SA, Masuda T, Anada T, Kato R, Kitaura H, Suzuki O, Takano-Yamamoto T
  • Journal Title: J Bone Miner Res Volume: 29 Pages: 1244-1257
  • NAID: 130004695790
  • Peer Reviewed
• [Journal Article] An anti-c-Fms antibody inhibits osteoclastogenesis in a mouse periodontitis model (2014)
  • Author(s): Kimura K, Kitaura H, Fujii T, Ishida M, Hakami Z, Takano-Yamamoto T
  • Journal Title: Oral Diseases. Volume: 20(3) (in press) Issue: 3 Pages: 319-24
  • DOI: 10.1111/odi.12117
  • Peer Reviewed
• [Journal Article] Osteocyte function under compressive mechanical force (2014)
  • Author(s): Takano-Yamamoto T
  • Journal Title: Japanese Dental Science Review Volume: 50(2) Issue: 2 Pages: 29-39
  • DOI: 10.1016/j.jdsr.2013.10.004
  • Peer Reviewed
• [Journal Article] Effect of cytokines on osteoclast formation and bone resorption during mechanical force loading of the periodontal membrane (2014)
  • Author(s): Kitaura H, Kimura K, Ishida M, Sugisawa H, Kohara H, Yoshimatsu M, Takano-Yamamoto T
  • Journal Title: Scientific World Journal Volume: 19 Pages: 1-7
  • DOI: 10.1155/2014/617032
  • Peer Reviewed / Open Access
• [Journal Article] Compressive force-produced CCN2 induces osteocyte apoptosis through ERK1/2 pathway (2014)
  • Author(s): K Hoshi, H Kawaki, I Takahashi, N Takeshita, M Seiryu, S A Murshid, T Masuda, T Anada, R Kato, H Kitaura, O Suzuki, T Takano-Yamamoto
  • Journal Title: J Bone Miner Res Volume: 29 Issue: 5 Pages: 1244-1257
  • DOI: 10.1002/jbmr.2115
  • NAID: 130004695790
  • Peer Reviewed / Open Access / Acknowledgement Compliant
• [Journal Article] Immunological Expression of Pituitary Adenylate Cyclase-Activating Peptide (PACAP) and PAC1 in the Periodontal Ligament After Tooth Luxation (2013)
  • Author(s): Nonaka S, Kitaura H, Kimura K, Ishida M, Takano-Yamamoto T
  • Journal Title: Cell Mol Neurobiol Volume: 33(7) Issue: 7 Pages: 885-92
  • DOI: 10.1007/s10571-013-9953-4
  • Peer Reviewed
• [Journal Article] Lectin histochemistry of palatine glands in the developing rat (2013)
  • Author(s): Hakami ZW., Kitaura, H., Honma, S., Wakisaka, S., Takano-Yamamoto T
  • Journal Title: Acta Histochemica Volume: (in press) Issue: 4 Pages: 596-605
  • DOI: 10.1016/j.acthis.2013.11.002
  • Peer Reviewed
• [Journal Article] N-Myristoylation is essential for protein phosphatases PPM1A and PPM1B to dephosphorylate their physiological substrates in cells (2013)
  • Author(s): Chida, T.
  • Journal Title: Biochem J Volume: 449 Issue: 3 Pages: 741-749
  • DOI: 10.1042/bj20121201
  • Peer Reviewed
• [Journal Article] Gap junction-mediated communication in human periodontal ligament cells (2013)
  • Author(s): Kato R, Ishihara Y, Kawanabe N, Sumiyoshi K, Yoshikawa Y, Nakamura M, Imai Y, Yanagita T, Fukushima H, Kamioka H, Takano-Yamamoto T and Yamashiro T
  • Journal Title: JDR Volume: 92(7) Issue: 7 Pages: 635-40
  • DOI: 10.1177/0022034513489992
  • Peer Reviewed
• [Journal Article] Methionine adenosyltransferase II-dependent histone H3K9 methylation at the COX-2 gene locus. (2013)
  • Author(s): Kera, Y., Katoh, Y., Ohta, M., Matsumoto, M., Takano-Yamamoto, T. and Igarashi, K.
  • Journal Title: The Journal of Biological Chemistry Volume: 288 Issue: 19 Pages: 12592-13601
  • DOI: 10.1074/jbc.m112.429738
  • Peer Reviewed
• [Journal Article] Immunological reaction in TNF- α-mediated osteoclast formation and bone resorption in vitro and in vivo (2013)
  • Author(s): Kitaura H, Kimura K, Ishida M, Kohara H, Yoshimatsu M, Takano-Yamamoto T
  • Journal Title: Clin Dev Immunol Volume: 2013 Pages: 1-8
  • DOI: 10.1155/2013/181849
  • Peer Reviewed
• [Journal Article] Anti-c-Fms antibody inhibits lipopolysaccharide-induced osteoclastogenesis in vivo (2012)
  • Author(s): Kimura K, Kitaura H, Fujii T, Hakami ZW, Takano-Yamamoto T
  • Journal Title: FEMS Immunol Med Microbiol Volume: 64 Issue: 2 Pages: 219-227
  • DOI: 10.1111/j.1574-695x.2011.00888.x
  • Peer Reviewed
• [Journal Article] Increase of CGRP-Containing Nerve Fibers in the Rat Periodontal Ligament After Luxation (2012)
  • Author(s): Nagayama T, Seiryu M, Deguchi T, Kano M, Suzuki T, Takano-Yamamoto T, Ichikawa H
  • Journal Title: Cell Mol Neurobiol Volume: 32(3) Issue: 3 Pages: 391-397
  • DOI: 10.1007/s10571-011-9767-1
  • Peer Reviewed
• [Journal Article] IL-4 inhibits TNF- α-mediated osteoclast formation by inhibition of RANKL expression in TNF- α-activated stromal cells and direct inhibition of TNF- α-activated osteoclast precursors via a T-cell-independent mechanism in vivo (2012)
  • Author(s): Fujii T, Kitaura H, Kimura K, Hakami ZW, Takano-Yamamoto T
  • Journal Title: bone Volume: 51(4) Pages: 771-780
  • Peer Reviewed
• [Journal Article] Promotion of Ccn2 expression and osteoblastic differentiation by actin polymerization, which is induced by laminar fluid flow stress (2012)
  • Author(s): Honjo T, Kubota S, Kamioka H, Sugawara Y, Ishihara Y, Yamashiro T, Takigawa M, Takano-Yamamoto T
  • Journal Title: J Cell Commun Signal Volume: 6(4) Issue: 4 Pages: 225-32
  • DOI: 10.1007/s12079-012-0177-z
  • Peer Reviewed
• [Journal Article] Analgesic effects of the non-nitrogen-containing bisphosphonates etidronate and clodronate, independent of anti-resorptive effects on bone (2012)
  • Author(s): Kim S, Seiryu M, Okada S, Kuroishi T, Takano-Yamamoto T, Sugawara S, Endo Y
  • Journal Title: Eur J Pharmacol Volume: 699(1 -3) Issue: 1-3 Pages: 14-22
  • DOI: 10.1016/j.ejphar.2012.11.031
  • Peer Reviewed
• [Journal Article] IL-4 inhibits TNF-α-mediated osteoclast formation by inhibition of RANKL expression in TNF-α- activated stromal cells and direct inhibition of TNF-α-activated osteoclast precursors via a T-cell- independent mechanism in vivo (2012)
  • Author(s): Fujii T, Kitaura H, Kimura K, Hakami ZW, Takano-Yamamoto
  • Journal Title: Bone Volume: 51 Issue: 4 Pages: 771-780
  • DOI: 10.1016/j.bone.2012.06.024
  • Peer Reviewed
• [Journal Article] IL-12- and IL-18-mediated, nitric oxide-induced apoptosis in TNF-α-mediated osteoclastogenesis of bone marrow cells (2011)
  • Author(s): Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Morita Y, Aonuma T, Fukumoto E, Masuyama R, Yoshida N, Takano-Yamamoto T
  • Journal Title: Calcif Tissue Int Volume: 89 Issue: 1 Pages: 65-73
  • DOI: 10.1007/s00223-011-9494-0
  • Peer Reviewed
• [Journal Article] Differential roles of CCN family proteis during osteoblast differentiation : involvement of Smad and MAPK signaling pathways (2011)
  • Author(s): Kawaki, H., et al
  • Journal Title: Bone Volume: 49 Issue: 5 Pages: 975-989
  • DOI: 10.1016/j.bone.2011.06.033
  • Peer Reviewed
• [Journal Article] Functional tooth regeneration using a bioengineered tooth unit as a mature organ replacement regenerative therapy (2011)
  • Author(s): M.Oshima, et al
  • Journal Title: PLoS ONE Volume: 6(7) Issue: 7 Pages: 10590-10601
  • DOI: 10.1371/journal.pone.0021531
  • Peer Reviewed
• [Journal Article] Allergy-inducing nickel concentration is lowered by lipopolysaccharide at both the sensitization and elicitation steps in a murine model (2011)
  • Author(s): Kinbara M, Sato N, Kuroishi T, Takano-Yamamoto T, Sugawara S, Endo Y
  • Journal Title: Br J Dermatol Volume: 164(2) Issue: 2 Pages: 356-362
  • DOI: 10.1111/j.1365-2133.2010.10016.x
  • Peer Reviewed
• [Presentation] Activity of parietal somatosensory neurons during sequential tongue moter task : with special reference to the temporal structure of spike trains. Innovate Research for Biosis-Abiosis Intelligent Interface Symposium (2014)
  • Author(s): Kitaura H, Kimura K, Ishida M, Hakami ZW, Saeed J, Sugisawa H, Kohara H, Ypshimastu M, Takano-Yamamoto T
  • Organizer: The 5th International Symposium for Interface Oral Health Science
  • Place of Presentation: Sendai, Miyagi, Japan
• [Presentation] M-CSF receptor c-Fms antibody inhibits pathological osteoclast formation in vivo. Innovate Research for Biosis-Abiosis Intelligent Interface Symposium (2014)
  • Author(s): Kimura K, Kitaura H, Ishida M, Hakami ZW, Saeed J, Sugisawa H, Takano-Yamamoto T
  • Organizer: The 5th International Symposium for Interface Oral Health Science
  • Place of Presentation: Sendai, Miyagi, Japan
• [Presentation] Gap-junction-mediated communication in human periodontal ligament cells. Innovate Research for Biosis-Abiosis Intelligent Interface Symposium (2014)
  • Author(s): Kato R, Ishihara Y, Kawanabe N, Sumiyoshi K, Yoshikawa Y, Nakamura M, Imai Y, Yanagita T, Fukushima H, Kamioka H, Takano-Yamamoto T, Yamashiro T
  • Organizer: The 5th International Symposium for Interface Oral Health Science
  • Place of Presentation: Sendai, Miyagi, Japan
• [Presentation] Glycohistochemical observation of the developing rat paratine glands: heterogenous distribution between anterior and posterior side glands of adult soft palate (2014)
  • Author(s): Hakami ZW, Kitaura H, Honma S, Wakisawa S, Takano-Yamamoto T
  • Organizer: Innovate Research for Biosis-Abiosis Intelligent Interface Symposium, The 5th International Symposium for Interface Oral Health Science
  • Place of Presentation: Sendai, Japan
• [Presentation] Activity of parietal somatosensory neurons during sequential tongue moter task: with special reference to the temporal structure of spike trains (2014)
  • Author(s): Kitaura H, Kimura K, Ishida M, Hakami ZW, Saeed J, Sugisawa H, Kohara H, Ypshimastu M, Takano-Yamamoto T
  • Organizer: Innovate Research for Biosis-Abiosis Intelligent Interface Symposium, The 5th International Symposium for Interface Oral Health Science
  • Place of Presentation: Sendai, Japan
• [Presentation] M-CSF receptor c-Fms antibody inhibits pathological osteoclast formation in vivo (2014)
  • Author(s): Kimura K, Kitaura H, Ishida M, Hakami ZW, Saeed J, Sugisawa H, Takano-Yamamoto T
  • Organizer: Innovate Research for Biosis-Abiosis Intelligent Interface Symposium, The 5th International Symposium for Interface Oral Health Science
  • Place of Presentation: Sendai, Japan
• [Presentation] Gap-junction-mediated communication in human periodontal ligament cells. Innovate Research for Biosis-Abiosis (2014)
  • Author(s): Kato R, Ishihara Y, Kawanabe N, Sumiyoshi K, Yoshikawa Y, Nakamura M, Imai Y, Yanagita T, Fukushima H, Kamioka H, Takano-Yamamoto T, Yamashiro T
  • Organizer: Intelligent Interface Symposium, The 5th International Symposium for Interface Oral Health Science
  • Place of Presentation: Sendai, Japan
• [Presentation] Osteocyte function under mechanical compressive force (2013)
  • Author(s): Takano-Yamamoto T
  • Organizer: NIDCR-Tohoku University Graduate School of Dentistry Symposium
  • Place of Presentation: 仙台
  • Year and Date: 2013-05-10
  • Invited
• [Presentation] Gap junction-mediated Cell-cell Communication in Human Periodontal ligament Cells (2013)
  • Author(s): Kato R, Yoshirhiro I, Kawanabe N, Sumiyoshi K, Yoshikawa Y, Nakamura M, Imai Y, Yanagita T, Fukushima H, Kamioka H, Takano-Yamamoto T, Yamashiro T
  • Organizer: NIDCR-Tohoku University Graduate School of Dentistry Symposium
  • Place of Presentation: 仙台
  • Year and Date: 2013-05-10
• [Presentation] Neutralization of Macrophage Colony-Stimulating Factor Inhibits Pathological Osteoclatstogenesis in vitro and in vivo (2013)
  • Author(s): Kimura K, Kitaura H, Zaki Weil-Hakami, Ishida M, Sugisawa H, Takano-Yamamoto T
  • Organizer: NIDCR-Tohoku University Graduate School of Dentistry Symposium
  • Place of Presentation: 仙台
  • Year and Date: 2013-05-10
• [Presentation] IL-4 Inhibits TNF-a-mediated Osteoclast Formation via a T-cell-independent Mechanism in vitro and in vivo (2013)
  • Author(s): Kitaura H,Kimura K, Zaki Weil-Hakami, Ishida M, Sugisawa H, Takano-Yamamoto T
  • Organizer: NIDCR-Tohoku University Graduate School of Dentistry Symposium
  • Place of Presentation: 仙台
  • Year and Date: 2013-05-10
• [Presentation] Tensile Force Induces Vascular Formation in Cranial Sutures Via CTGF Signaling (2013)
  • Author(s): Takeshita N, Hasegawa M, Sasaki K, Seki D, Miyashita S, Takano I, Fukuno S, Takano-Yamamoto T
  • Organizer: NIDCR-Tohoku University Graduate School of Dentistry Symposium
  • Place of Presentation: 仙台
  • Year and Date: 2013-05-10
• [Presentation] 矯正的歯の移動モデルを用いた歯根膜幹細胞ニッチの解析 (2013)
  • Author(s): 山本照子
  • Organizer: 再生医科学研究所「再生医学・再生医療の先端融合的共同研究拠点」
  • Place of Presentation: 京都
  • Year and Date: 2013-03-15
  • Invited
• [Presentation] 牽引力はCTGFシグナルを介して頭蓋縫合における血管形成を促進する (2013)
  • Author(s): 竹下信郎,長谷川正和,佐々木紀代,関大輔,宮下俊郎,高野郁子,宮島悠旗,福野佐知子, 山本照子
  • Organizer: 第72回日本矯正歯科学会大会
  • Place of Presentation: 松本
• [Presentation] Forkhead protein FoxC1 regulates chondrogenic genes expression by modulating Ihh/Gli2 signaling (2013)
  • Author(s): Yoshida M, Hata K, Takashima R, Iseki S, Takano-Yamamoto T, Nishimura R, Yoneda T
  • Organizer: The American Society for Bone and Mineral Research 2013 35th Annual Meeting
  • Place of Presentation: Baltimore, Maryland, USA
• [Presentation] 圧縮力による骨細胞のアポトーシスに対するCTGF/CCN2の役割 (2013)
  • Author(s): 山本照子
  • Organizer: 第55回歯科基礎医学会学術大会
  • Place of Presentation: 岡山
• [Presentation] IFN- γ inhibits TNF- α-mediated osteoclast formation in vitro and in vivo and induces apoptosis by Fas/Fas ligand interactions (2013)
  • Author(s): Kitaura H, Kimura K, Ishida M, Sugisawa H, Saeed J, Hakami ZW, Takano-Yamamoto T
  • Organizer: 8th International Workshop on Biomaterials in Interface Science. Innovative Research for Biosis-Abiosis Intelligent Interface Summer Seminar 2013
  • Place of Presentation: Zao, Miyagi, Japan
• [Presentation] The transcription factor FoxC1 up-regulates PTHrP expression together with Gli2 in chondrocytes (2013)
  • Author(s): Yoshida M, Hata K, Takashima R, Iseki S, Takano-Yamamoto T, Nishimura R, Yoneda T
  • Organizer: The 2nd Joint Meeting of the International Bone and Mineral Society and The Japanese Society for Bone and Mineral Research
  • Place of Presentation: Kobe, Japan
• [Presentation] Early response of cranial sutures to in vivo tensile force loading (2013)
  • Author(s): Takeshita N, Hasegawa M, Sasaki K, Seki D, Miyashita S, Takano I, Takano-Yamamoto T
  • Organizer: The 2nd Joint Meeting of the International Bone and Mineral Society and The Japanese Society for Bone and Mineral Research
  • Place of Presentation: Kobe, Japan
• [Presentation] Tensile force induces vascular formation in cranial sutures via CTGF signaling (2013)
  • Author(s): Takeshita N, Hasegawa M, Sasaki K, Seki D, Miyashita S, Takano I, Fukuno S, Takano-Yamamoto T
  • Organizer: NIH-Tohoku University-JPSP Symposium
  • Place of Presentation: Sendai, Japan
• [Presentation] The transcription factor FoxC1 regulates chondrogenesis together with Gli2 through induction of PTHrP (2013)
  • Author(s): Yoshida M, Hata K, Takashima R, Iseki S, Takano-Yamamoto T, Nishimura R, Yoneda T
  • Organizer: 第7回Bone Research Seminar
  • Place of Presentation: 東京
• [Presentation] Osteocyte function under mechanical compressive force (2013)
  • Author(s): Takano-Yamamoto T
  • Organizer: NIDCR-Tohoku University Graduate School of Dentistry Symposium
  • Place of Presentation: Sendai, Japan
  • Invited
• [Presentation] 圧縮力による骨細胞のアポトーシスに対するCTGF／CCN2の役割 (2013)
  • Author(s): 山本照子
  • Organizer: 第55回歯科基礎医学会学術大会
  • Place of Presentation: 岡山
  • Invited
• [Presentation] Gap junction-mediated Cell-cell Communication in Human Periodontal ligament Cells (2013)
  • Author(s): Kato R, Yoshirhiro I, Kawanabe N, Sumiyoshi K, Yoshikawa Y, Nakamura M, Imai Y, Yanagita T, Fukushima H, Kamioka H, Takano-Yamamoto T, Yamashiro T
  • Organizer: NIDCR-Tohoku University Graduate School of Dentistry Symposium
  • Place of Presentation: Sendai, Japan
• [Presentation] Neutralization of Macrophage Colony-Stimulating Factor Inhibits Pathological Osteoclatstogenesis in vitro and in vivo (2013)
  • Author(s): Kimura K, Kitaura H, Zaki Weil-Hakami, Ishida M, Sugisawa H, Takano-Yamamoto T
  • Organizer: NIDCR-Tohoku University Graduate School of Dentistry Symposium
  • Place of Presentation: Sendai, Japan
• [Presentation] IL-4 Inhibits TNF-a-mediated Osteoclast Formation via a T-cell-independent Mechanism in vitro and in vivo. (2013)
  • Author(s): Kitaura H,Kimura K, Zaki Weil-Hakami, Ishida M, Sugisawa H, Takano-Yamamoto T
  • Organizer: NIDCR-Tohoku University Graduate School of Dentistry Symposium
  • Place of Presentation: Sendai, Japan
• [Presentation] Heterogeneous lectin binding pattern between anterior and posterior portions of the palatine glands of adult rat (2013)
  • Author(s): Hakami ZW, Kitaura H, Honma S, Wakisaka S, Takano-Yamamoto T
  • Organizer: NIH Tohoku University JSPS Symposium
  • Place of Presentation: Sendai, Japan
• [Presentation] Tensile Force Induces Vascular Formation in Cranial Sutures Via CTGF Signaling (2013)
  • Author(s): Takeshita N, Hasegawa M, Sasaki K, Seki D, Miyashita S, Takano I, Fukuno S, Takano-Yamamoto T
  • Organizer: NIDCR-Tohoku University Graduate School of Dentistry Symposium
  • Place of Presentation: Sendai, Japan
• [Presentation] Histochemical evaluation of glycoproteins in the developing rat palatine glands (2013)
  • Author(s): Hakami ZW, Kitaura H, Honma S, Wakisaka S, Takano-Yamamoto T
  • Organizer: The 2nd Meeting of the International Association for Dental Research-Asia Pacific Region 2013
  • Place of Presentation: Bangkok, Thailand
• [Presentation] Forkhead protein FoxC1 regulates chondrogenic genes expression by modulating Ihh/Gli2 signaling (2013)
  • Author(s): Yoshida M, Hata K, Takashima R, Iseki S, Takano-Yamamoto T, Nishimura R, Yoneda T
  • Organizer: The American Society for Bone and Mineral Research 2013 35th Annual Meeting
  • Place of Presentation: Baltimore, USA
• [Presentation] Treatment of Class III malocclusion case by distal mandibular molar movement with orthodontic anchored screws (2013)
  • Author(s): Jafari S, Aonuma Tomo, Kitaura H, Oikawa H, Hashimoto T, Takano－Yamamoto T
  • Organizer: 第72回日本矯正歯科学会
  • Place of Presentation: 松本
• [Presentation] Developmental glycoproteins modification and distribution in rat palatine glands (2013)
  • Author(s): Hakami Zaki Weli, Kitaura H, Honma S, Wakisaka S, Takano-Yamamoto T
  • Organizer: 第72回日本矯正歯科学会
  • Place of Presentation: 松本
• [Presentation] IFN-γ inhibits TNF-α-mediated osteoclast formation in vitro and in vivo and induces apoptosis by Fas/Fas ligand interactions (2013)
  • Author(s): Kitaura H, Kimura K, Ishida M, Sugisawa H, Saeed J, Hakami ZW, Takano-Yamamoto T
  • Organizer: 8th International Workshop on Biomaterials in Interface Science. Innovative Research for Biosis-Abiosis Intelligent Interface Summer Seminar 2013
  • Place of Presentation: Zao, Japan
• [Presentation] ヒト歯根膜細胞間ギャップ結合の機能性および調節機構は低酸素環境下において抑制的に調節される (2013)
  • Author(s): 加藤 龍史、石原 嘉人、川邉 紀章、上岡 寛、山本 照子、山城 隆
  • Organizer: 第31回 日本骨代謝学会 (IBMS-JSBMR 2013)
  • Place of Presentation: 神戸
• [Presentation] LPSの破骨細胞形成に対するMDPの作用の検討 (2013)
  • Author(s): 石田匡彦、北浦英樹、木村桂介、高田春比古、山本照子
  • Organizer: 第56回歯科基礎医学学会・総会
  • Place of Presentation: 岡山
• [Presentation] ヒト歯根膜細胞におけるギャップ結合を介した細胞間コミュニケーションの骨代謝へ及ぼす影響 (2013)
  • Author(s): 加藤 龍史、石原 嘉人、川邉 紀章、住吉 久美、吉川 祐介、中村 政裕、 今井 裕一、柳田 剛志、福島 宏明、上岡 寛、山本 照子、山城 隆
  • Organizer: 第72回 日本矯正歯科学会大会
  • Place of Presentation: 松本
• [Presentation] 侵襲刺激後の神経ぺプタイドpituitary adenylate cyclase activating polypeptide(PACAP)の歯根膜での発現 (2013)
  • Author(s): 北浦英樹、野中紗弥子、出口徹、木村桂介、石田匡彦、山本照子
  • Organizer: 第72回 日本矯正歯科学会大会
  • Place of Presentation: 松本
• [Presentation] LPS誘導破骨細胞形成および骨吸収に対するMDPの作用の検討 (2013)
  • Author(s): 石田匡彦、北浦英樹、木村桂介、ハカミ ザキ ウェリ、杉澤晴紀、ジャファリ サイード、高田春比古、山本照子
  • Organizer: 第72回 日本矯正歯科学会大会
  • Place of Presentation: 松本
• [Presentation] 三次元scaffoldを用いた加圧刺激による間葉系幹細胞の象牙芽細胞への分化誘導 (2013)
  • Author(s): 宮下俊郎, Nermeen El Motaz, 村上真史, 庵原耕一郎, 山本照子, 中島美砂子
  • Organizer: 第72回 日本矯正歯科学会大会
  • Place of Presentation: 松本
• [Presentation] 牽引力はCTGFシグナルを介して頭蓋縫合における血管形成を促進する (2013)
  • Author(s): 竹下信郎、長谷川正和、佐々木紀代、関大輔、宮下俊郎、高野郁子、宮島悠旗、福野佐知子、山本照子
  • Organizer: 第７２回日本矯正歯科学会大会
  • Place of Presentation: 松本
• [Presentation] 歯根膜細胞における伸展刺激に応答したScleraxis発現調節メカニズムの解析 (2013)
  • Author(s): 川津正慶、宿南知佐、滝本昌、岩崎将也、清流正弘、池田悦子、山本照子
  • Organizer: 第72回日本矯正歯科学会
  • Place of Presentation: 松本
• [Presentation] マウス歯周病モデルを用いた破骨細胞形成および骨吸収に対する抗c-Fms抗体の抑制効果の検討 (2013)
  • Author(s): 木村桂介、北浦英樹、石田匡彦、ハカミ ザキ ウェリ、杉澤晴紀、ジャファリ サイード、山本照子
  • Organizer: 第72回日本矯正歯科学会
  • Place of Presentation: 松本
• [Presentation] 矯正的歯の移動モデルを用いた歯根膜幹細胞ニッチの解析 (2013)
  • Author(s): 山本照子
  • Organizer: 再生医科学研究所「再生医学・再生医療の先端融合的共同研 究拠点」
  • Place of Presentation: 京都
  • Invited
• [Presentation] The transcription factor FoxC1 regulates chondrogenesis together with Gli2 through induction of PTHrP (2013)
  • Author(s): Yoshida M, Hata K, Takashima R, Iseki S, Takano-Yamamoto T, Nishimura R, Yoneda T
  • Organizer: 第7回Bone Research Seminar
  • Place of Presentation: 東京
• [Presentation] リン酸化プルラン開発の進め方―口唇裂・口蓋裂治療に最適化した薬剤コンビネー ション接着性人工骨の開発と実用化への検討 (2013)
  • Author(s): 山本照子
  • Organizer: 厚労省実用化促進事業
  • Place of Presentation: 筑波
  • Invited
• [Presentation] Early response of cranial sutures to in vivo tensile force loading (2013)
  • Author(s): Nobuo Takeshita, Masakazu Hasegawa, Kiyo Sasaki, Daisuke Seki, Shunro Miyashita, Ikuko Takano, Teruko Takano-Yamamoto
  • Organizer: 2nd Joint Meeting of the International Bone and Mineral Society and The Japanese Society for Bone and Mineral Research
  • Place of Presentation: Kobe
• [Presentation] Tensile force induces vascular formation in cranial sutures via CTGF signaling (2013)
  • Author(s): Nobuo Takeshita, Masakazu Hasegawa, Kiyo Sasaki, Daisuke Seki, Shunro Miyashita, Ikuko Takano, Sachiko Fukuno,Teruko Takano-Yamamoto
  • Organizer: NIH-Tohoku University-JSPS Symposium
  • Place of Presentation: Sendai
• [Presentation] The transcription factor FoxC1 regulates chondrogenesis together with Gli2 through induction of PTHrP (2012)
  • Author(s): Yoshida M, Hata K, Takashima R, Iseki S, Takano-Yamamoto T, Nishimura R, Yoneda T
  • Organizer: 第34回American Society for Bone and Mineral Research
  • Place of Presentation: Minneapolis,USA
  • Year and Date: 2012-10-15
• [Presentation] 機械的刺激に対する骨細胞の応答能 (2012)
  • Author(s): 山本照子
  • Organizer: 第121回日本補綴学会
  • Place of Presentation: 横浜
  • Year and Date: 2012-05-25
  • Invited
• [Presentation] 圧縮力負荷による骨細胞のアポトーシスへのCTGFの関与 (2012)
  • Author(s): 星健治, 高橋一郎, 益田泰輔, 鈴木誠, 加藤龍史, 鈴木治, 上岡寛, 山城隆, 山本照子
  • Organizer: 第71回日本矯正歯科学会
  • Place of Presentation: 松本
• [Presentation] The transcription factor FoxC1 regulates chondrogenesis together with Gli2 through induction of PTHrP (2012)
  • Author(s): Yoshida M, Hata K, Takashima R, Iseki S, Takano-Yamamoto T, Nishimura R, Yoneda T
  • Organizer: Australian & New Zealand Bone & Mineral Society 22nd Annual Scientific Meeting in conjunction with 1st Asia-Pacific Bone and Mineral Research Meeting
  • Place of Presentation: Pan Pacific Hotel,Perth, Western Australia
• [Presentation] The transcription factor FoxC1 regulates chondrogenesis together with Gli2 through induction of PTHrP (2012)
  • Author(s): Yoshida M, Hata K, Takashima R, Iseki S, Takano-Yamamoto T, Nishimura R, Yoneda T
  • Organizer: Australian & New Zealand Bone & Mineral Society 22nd Annual Scientific Meeting in conjunction with 1st Asia-Pacific Bone and Mineral Research Meeting
  • Place of Presentation: Perth, Western Australia
• [Presentation] 転写因子FoxC1はPTHrPの発現誘導を介して内軟骨性骨形成を制御する (2012)
  • Author(s): 吉田倫子、波多賢二、高島利加子、井関祥子、山本照子、西村理行、米田俊之
  • Organizer: 第71回日本矯正歯科学会
  • Place of Presentation: 盛岡
• [Presentation] MATIIによるエピジェネティックなCox2遺伝子抑制機構 (2012)
  • Author(s): 解良洋平、加藤恭丈、五十嵐和彦、山本照子
  • Organizer: 第71回日本矯正歯科学会
  • Place of Presentation: 盛岡
• [Presentation] 圧縮力負荷による骨細胞のアポトーシスへのCTGFの関与 (2012)
  • Author(s): 星健治、高橋一郎、益田泰輔、鈴木誠、加藤龍史、鈴木治、上岡寛、山城隆、山本照子
  • Organizer: 第71回日本矯正歯科学会
  • Place of Presentation: 盛岡
• [Presentation] PP2Cδ/ILKAPはAkt-GSK3β回路を介してp53の安定性制御を行う (2012)
  • Author(s): 千田透子、小林考安、田村眞理、山本照子
  • Organizer: 第71回日本矯正歯科学会
  • Place of Presentation: 盛岡
• [Presentation] 再生歯胚のサイズに及ぼすIGF-1の影響 (2012)
  • Author(s): 原真美子、池田悦子、岩崎将也、髙野郁子、大島正光、辻孝、山本照子
  • Organizer: 第71回日本矯正歯科学会
  • Place of Presentation: 盛岡
• [Presentation] TNF-αによる破骨細胞形成におけるIL-4の影響のinvivoでの検討 (2012)
  • Author(s): 北浦英樹、木村桂介、石田匡彦、HakamiZaki、山 本照子
  • Organizer: 第30回日本骨代謝学会学術集会
  • Place of Presentation: 東京
• [Presentation] LPS誘導骨吸収に対する抗c-fms抗体の抑制作用の検討 (2012)
  • Author(s): 木村桂介、北浦英樹、石田匡彦、HakamiZaki、山 本照子
  • Organizer: 第30回日本骨代謝学会学術集会
  • Place of Presentation: 東京
• [Presentation] シリコーン膜を用いた加圧刺激によるヒト歯髄細胞の象牙芽細胞への分化誘導 (2012)
  • Author(s): 宮下俊郎、村上真史、庵原耕一郎、山本照子、中 島美砂子
  • Organizer: 第11回日本再生医療学会
  • Place of Presentation: 横浜
• [Presentation] IL4のTNF-αによるRANKLおよびDC-STAMP発現のin vivoにおける抑制効果について (2012)
  • Author(s): 北浦英樹、藤井俊哉、木村桂介、石田匡彦、ハカ ミ ザキ ウェリ、山本照子
  • Organizer: 第71回日本矯正歯科学会
  • Place of Presentation: 盛岡
• [Presentation] M-CSF作用抑制による病的骨吸収に対する制御の検討 (2012)
  • Author(s): 木村桂介、北浦英樹、藤井俊哉、石田匡彦、ハカ ミ ザキ ウェリ、山本照子
  • Organizer: 第71回日本矯正歯科学会
  • Place of Presentation: 盛岡
• [Presentation] 転写因子FoxC1はPTHrPの発現誘導を介して内軟骨性骨形成を制御する (2012)
  • Author(s): 吉田倫子、波多賢二、高島利加子、井関祥子、山本照子、西村理行、米田俊之
  • Organizer: 第6回瀬戸内フォーラム
  • Place of Presentation: 神戸
• [Presentation] ヒト歯根膜細胞におけるギャップ結合を介した細胞間伝達は低酸素環境下において抑制的に調節される (2012)
  • Author(s): 加藤龍史、石原嘉人、川邉紀章、住吉久美、吉川祐介、今井裕一、福島宏明、タレク バラム、上岡寛、山本照子、山城隆
  • Organizer: 第6回瀬戸内フォーラム
  • Place of Presentation: 神戸
• [Presentation] シリコーン膜を用いた加圧刺激によるヒト歯髄細胞の象牙芽細胞への分化誘導 (2012)
  • Author(s): 宮下俊郎、村上真史、庵原耕一郎、山本照子、中島美砂子
  • Organizer: 第136回日本歯科保存学会
  • Place of Presentation: 沖縄
• [Presentation] 歯科医療におけるZr貴金属ガラスの生体材料としての有用性 (2012)
  • Author(s): 岩崎将也、池田悦子、原真美子、髙野郁子、堤祐介、横山嘉彦、山本照子
  • Organizer: 第71回日本矯正歯科学会
  • Place of Presentation: 盛岡
• [Presentation] 再生歯ユニット移植による歯・歯周組織の機能的再生－多数歯欠損および歯槽骨再生に向けたアプローチ－ (2012)
  • Author(s): 中島啓、大島正充、山崎大道、井上香織、小川美帆、菅原彩香、春日井昇平、山本照子、井上孝、齋藤正寛、辻 孝
  • Organizer: 第10回日本再生歯科医学会総会・学術大会
  • Place of Presentation: 神戸
• [Presentation] 歯周組織を有する次世代型機能性インプラントの開発 (2012)
  • Author(s): 中島啓、大島正充、山崎大道、井上香織、小川美帆、菅原彩香、春日井昇平、山本照子、井上孝、齋藤正寛、辻 孝
  • Organizer: 第10回日本再生歯科医学会総会・学術大会
  • Place of Presentation: 神戸
• [Presentation] 歯周組織を有する新規機能性デンタルインプラントの開発 (2012)
  • Author(s): 大島正充、水野光政、山崎大道、小川美帆、森田梨津子、春日井昇平、山本照子、齋藤正寛、辻孝
  • Organizer: 第11回日本再生医療学会総会
  • Place of Presentation: 横浜
• [Presentation] 再生歯移植による歯科再生治療システムの開発－再生歯ユニット移植による重篤歯科疾患への応用－ (2012)
  • Author(s): 大島正充、水野光政、小川美帆、山崎大道、森田梨津子、山本照子、齋藤正寛、辻 孝
  • Organizer: 第11回日本再生医療学会総会
  • Place of Presentation: 横浜
• [Presentation] 頭蓋縫合におけるメカニカルストレス初期応答としてのCTGFとVEGFの発現 (2012)
  • Author(s): 竹下信郎、長谷川正和、佐々木紀代、関大輔、宮島悠旗、宮下俊郎、 山本照子
  • Organizer: 第13回運動器科学研究会
  • Place of Presentation: 京都
• [Presentation] Interleukin-4 inhibits tumor necrosis factor- α-mediated osteoclast formation in vivo (2011)
  • Author(s): Fujii T, Kitaura H, Kimura K, Hakami Z, Takano-Yamamoto T
  • Organizer: The 4th International Congress and the 70th Annual Meeting of the Japanese Orthodontic Society
  • Place of Presentation: 名古屋
• [Presentation] Anti-c-Fms antibody inhibits lipopolysaccharide-induced osteoclastogenesis in vivo.marrow cells in TNF- α-induced osteoclast formation (2011)
  • Author(s): Kimura K, Kitaura H, Fujii T, Hakami Z, Takano-Yamamoto T
  • Organizer: The 4th International Congress and the 70th Annual Meeting of the Japanese Orthodontic Society
  • Place of Presentation: 名古屋
• [Presentation] IL-12- and IL-18-mediated nitric oxide-induced apoptosis in TNF- α-mediated osteoclastogenesis (2011)
  • Author(s): Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Morita Y, Aonuma T, Fukumoto E, Yoshida N, Takano-Yamamoto T
  • Organizer: The 4th International Congress and the 70th Annual Meeting of the Japanese Orthodontic Society
  • Place of Presentation: Nagoya, Japan
• [Presentation] Interleukin-4 inhibits tumor necrosis factor-α-mediated osteoclast formation in vivo (2011)
  • Author(s): Fujii T, Kitaura H, Kimura K, Hakami Z, Takano-Yamamoto T
  • Organizer: The 4th International Congress and the 70th Annual Meeting of the Japanese Orthodontic Society
  • Place of Presentation: Nagoya, Japan
• [Presentation] Anti-c-Fms antibody inhibits lipopolysaccharide-induced osteoclastogenesis in vivo.marrow cells in TNF-α-induced osteoclast formation (2011)
  • Author(s): Kimura K, Kitaura H, Fujii T, Hakami Z, Takano-Yamamoto T
  • Organizer: The 4th International Congress and the 70th Annual Meeting of the Japanese Orthodontic Society
  • Place of Presentation: Nagoya, Japan
• [Presentation] Metal-allergy cross-reactions in mice (2011)
  • Author(s): Kinbara M, Sugawara S, Endo Y, Takano-Yamamoto T
  • Organizer: The 4th International Congress and the 70th Annual Meeting of the Japanese Orthodontic Society
  • Place of Presentation: Nagoya, Japan
• [Presentation] IL-12- and IL-18-mediated nitric oxide-induced apoptosis in TNF-α-mediated osteoclastogenesis (2011)
  • Author(s): Kitaura H, Fujimura Y, Yoshimatsu M, Kohara H, Morita Y, Aonuma T, Fukumoto E, Yoshida N, Takano-Yamamoto T
  • Organizer: The 4th International Congress and the 70th Annual Meeting of the Japanese Orthodontic Society
  • Place of Presentation: Nagoya, Japan
• [Presentation] IL-4のTNF-αによる破骨細胞形成に対する抑制効果についてのinvivoでの検討 (2011)
  • Author(s): 藤井俊哉、北浦英樹、木村桂介、山本照子
  • Organizer: 第59回東北大学歯学会
  • Place of Presentation: 仙台
• [Presentation] 骨吸収抑制作用とは関連しないbisphosphonates(BPs)の鎮痛効果 (2011)
  • Author(s): 金始瑛、清流正弘、岡田諭、山本照子、菅原俊二、遠藤康男
  • Organizer: 第59回東北大学歯学会
  • Place of Presentation: 仙台
• [Presentation] S-アデノシルメチオニン合成酵素MATIIによるエピゲノム制御と転写調節 (2011)
  • Author(s): 解良洋平、加藤恭丈、太田嶺人、山本照子、五十嵐和彦
  • Organizer: 第77回日本生化学会東北支部例会
  • Place of Presentation: 仙台
• [Presentation] 骨吸収抑制作用とは関連しないbisphosphonates(BPs)の鎮痛効果 (2011)
  • Author(s): 金始瑛、清流正弘、岡田諭、山本照子、菅原俊二、遠藤康男
  • Organizer: 第53回歯科基礎医学会
  • Place of Presentation: 岐阜
• [Presentation] CCNファミリータンパク質によるMAPK経路を介した骨芽細胞増殖・分化調節 (2011)
  • Author(s): 川木晴美、久保田聡、鈴木誠、高坂久美子、星健治、加藤龍史、高山英次、神谷真子、BernardPerbal、山本照子、近藤信夫
  • Organizer: 第4回日本CCNファミリー研究会
  • Place of Presentation: 岡山
• [Presentation] 骨吸収抑制作用とは関連しないbisphosphonates(BPs)の鎮痛効果 (2011)
  • Author(s): 金始瑛、岡田論、山本照子、遠藤康男
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大坂
• [Presentation] 胎生期下顎形成期におけるFGF10によるメッケル軟骨形態の制御 (2011)
  • Author(s): 寺尾文恵、高橋一郎、三谷英稔、春山直人、笹野泰之、鈴木治、山本照子
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大坂
• [Presentation] マウスにおけるminodronateの骨吸収抑制作用と炎症壊死作用：他のbisphosphonatesとの比較 (2011)
  • Author(s): 坂東加南、山口昇史、金始瑛、岡田論、大泉丈史、山本照子、遠藤康男
  • Organizer: 第29回日本骨代謝学会学術集会
  • Place of Presentation: 大坂
• [Presentation] Methionine adenosyl transferase(MATII)-dependent writing of histoneH3K9 methylation of Cox2 gene (2011)
  • Author(s): 解良洋平、加藤恭丈、太田嶺人、松本光代、山本照子、五十嵐和彦
  • Organizer: 第34回日本分子生物学会年会
  • Place of Presentation: 横浜
• [Patent(Industrial Property Rights)] IGFを含む成長因子による歯, 再生歯および再生歯胚における歯冠および咬頭ならびに歯根の大きさおよび形の制御の方法 (2013)
  • Inventor(s): 山本照子, 池田悦子
  • Industrial Property Rights Holder: 国立大学法人東北大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-08-22
  • Overseas
• [Patent(Industrial Property Rights)] IGFを含む成長因子による歯、再生歯及び再生歯胚における歯冠及び咬頭ならびに歯根の大きさ及び形の制御の方法 (2013)
  • Inventor(s): 山本照子、池田悦子
  • Industrial Property Rights Holder: 国立大学法人東北大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-08-22
  • Overseas
• [Patent(Industrial Property Rights)] IGFを含む成長因子による歯,再生歯および再生歯胚における歯冠および咬頭ならびに歯根の大きさおよび形の制御の方法 (2012)
  • Inventor(s): 山本照子, 池田悦子
  • Industrial Property Rights Holder: 国立大学法人東北大学, 日本ケミカルリサーチ
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-08-23