| Project/Area Number |
23249086
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| Research Category |
Grant-in-Aid for Scientific Research (A)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Periodontal dentistry
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| Research Institution | Osaka University |
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Principal Investigator |
MURAKAMI Shinya 大阪大学, 歯学研究科(研究院), 教授 (70239490)
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| Co-Investigator(Kenkyū-buntansha) |
KITAMURA Masahiro 大阪大学, 大学院歯学研究科, 准教授 (10243247)
YAMADA Satoru 大阪大学, 歯学部附属病院, 講師 (40359849)
YAMASHITA Motozo 大阪大学, 歯学部附属病院, 助教 (90524984)
KITAGAKI Jirouta 大阪大学, 歯学部附属病院, 助教 (90570292)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEBE Kazunori 大阪大学, 大学院歯学研究科, 准教授 (70273696)
KAMIDE Kei 大阪大学, 大学院医学系研究科, 講師 (80393239)
GONDO Yasuyuki 大阪大学, 大学院人間科学研究科, 准教授 (40250196)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥42,120,000 (Direct Cost: ¥32,400,000、Indirect Cost: ¥9,720,000)
Fiscal Year 2014: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2013: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2012: ¥9,490,000 (Direct Cost: ¥7,300,000、Indirect Cost: ¥2,190,000)
Fiscal Year 2011: ¥13,650,000 (Direct Cost: ¥10,500,000、Indirect Cost: ¥3,150,000)
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| Keywords | 歯周病 / 侵襲性歯周炎 / 分子疫学 / 疾患関連遺伝子 / バイオインフォマティクス |
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| Outline of Final Research Achievements |
In this study, we investigated the genes responsible for progression of periodontal disease based on the information of molecular epidemiological studies of over 70-year-old adult, aged twins and aggressive periodontitis patients. Moreover, we analyzed the expression and function of the various candidate genes. As a result, we confirmed that genetic factor is associated with the progression of periodontal disease and found that cathepsin A might be a responsible gene for aggressive periodontitis as assessed by the epidemiological database. We also revealed that CD73, PLAP-1, ferritin, and periostin are deeply involved in the cytodifferentiation and mineralization of periodontal ligament cells which play crucial roles in periodontal tissue homeostasis.
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