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Epidemiology and pathlogy of leishmaniasis in Old world.

Research Project

Project/Area Number 23256001
Research Category

Grant-in-Aid for Scientific Research (A)

Allocation TypeSingle-year Grants
Section海外学術
Research Field Parasitology (including Sanitary zoology)
Research InstitutionThe University of Tokyo

Principal Investigator

MATSUMOTO Yoshitsugu  東京大学, 農学生命科学研究科, 教授 (00173922)

Co-Investigator(Renkei-kenkyūsha) MATSUMOTO Yasunobu  東京大学, 農学生命科学研究科, 准教授 (90251420)
SANJOBA Chizu  東京大学, 農学生命科学研究科, 助教 (70549667)
GOTO Yasuyuki  東京大学, 農学生命科学研究科, 准教授 (50553434)
Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥45,500,000 (Direct Cost: ¥35,000,000、Indirect Cost: ¥10,500,000)
Fiscal Year 2014: ¥10,660,000 (Direct Cost: ¥8,200,000、Indirect Cost: ¥2,460,000)
Fiscal Year 2013: ¥10,400,000 (Direct Cost: ¥8,000,000、Indirect Cost: ¥2,400,000)
Fiscal Year 2012: ¥10,270,000 (Direct Cost: ¥7,900,000、Indirect Cost: ¥2,370,000)
Fiscal Year 2011: ¥14,170,000 (Direct Cost: ¥10,900,000、Indirect Cost: ¥3,270,000)
Keywordsリーシュマニア症 / 人獣共通感染症 / 原虫 / 媒介昆虫 / 保虫宿主 / 内蔵型 / モンゴル / 内蔵型リーシュマニア症 / L. donovani
Outline of Final Research Achievements

The comparative studies of leishmaniasis from different foci: visceral leishmaniasis, post kala-azar dermal leishmaniasis, cutaneous leishmaniasis including the parasites, vector insects, patients, reservoir animals were attempted to understand the epidemiology and pathology of leishmaniasis in Old world. Based on these studies, a new therapeutic drug candidate for visceral leishmaniasis had been obtained and the diagnosis regent for cutaneous leishmaniasis is under development. The sustainable and functioning vector control method concerning with the geographic matter, host-parasite interaction, and the vector behavior was proposed on endemic area of leishmaniasis in Turkey and Bangladesh.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (44 results)

All 2015 2014 2013 2012 2011 Other

All Journal Article (10 results) (of which Peer Reviewed: 6 results,  Acknowledgement Compliant: 1 results,  Open Access: 1 results) Presentation (31 results) (of which Invited: 3 results) Book (1 results) Patent(Industrial Property Rights) (2 results)

  • [Journal Article] Elevation of serum B-cell activating factor levels during visceral leishmaniasis2014

    • Author(s)
      Goto Y, Omachi S, Sanjoba C, Matsumoto Y.
    • Journal Title

      The American Journal of Tropical Medicine and Hygiene

      Volume: 91 Pages: 912-914

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Acknowledgement Compliant
  • [Journal Article] Protective epitopes of the Plasmodium falciparum SERA5 malaria vaccine reside in intrinsically unstructured N-terminal repetitive sequences.2014

    • Author(s)
      Yagi M, Bang G, Tougan T, Palacpac NM, Arisue N, Aoshi T, Matsumoto Y, Ishii KJ, Egwang TG, Druilhe P, Horii T.
    • Journal Title

      PLoS One

      Volume: 9 Issue: 6 Pages: e98460-e98460

    • DOI

      10.1371/journal.pone.0098460

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] The accumulation of macrophages expressing myeloid-related protein 8 (MRP8) and MRP14 in the spleen of BALB/cA mice during infection with Plasmodium berghei.2014

    • Author(s)
      Mizobuchi H, Yamakoshi S, Omachi S, Osada Y, Sanjoba C, Goto Y, Matsumoto Y.
    • Journal Title

      Experimental Parasitology

      Volume: 138 Pages: 1-8

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Medical Entomology in former times2014

    • Author(s)
      Kurihara T, Sanjoba C
    • Journal Title

      Proc Res Grp Pestology

      Volume: 11 Pages: 11-25

    • NAID

      40020157286

    • Related Report
      2014 Annual Research Report
  • [Journal Article] 犬のリーシュマニア症2013

    • Author(s)
      松本芳嗣ら
    • Journal Title

      日本獣医師会雑誌

      Volume: 66 Pages: 5-7

    • NAID

      10031168941

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
  • [Journal Article] Studies on Phlebotomine sand flies in Japan.2012

    • Author(s)
      Sanjoba, C.
    • Journal Title

      Proc Res Grp Pestology

      Volume: 9 Pages: 129-140

    • NAID

      40019748951

    • Related Report
      2012 Annual Research Report
  • [Journal Article] The development of Leishmania turanica in sand flies and competition with L. major.2012

    • Author(s)
      Chajbullinova, A., et al.
    • Journal Title

      Parasit Vector

      Volume: 5 Pages: 219-219

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] リーシュマニア症に対するワクチン開発の展望2012

    • Author(s)
      後藤康之
    • Journal Title

      獣医寄生虫学雑誌

      Volume: 11 Pages: 1-7

    • Related Report
      2012 Annual Research Report
  • [Journal Article] Recent collections of Sergentomyia squamirostris (Newstead) (Diptera: Psychodidae) in Japan, with descriptions and illustrations.2011

    • Author(s)
      Sanjoba, C., et al.
    • Journal Title

      Med Entomol Zool

      Volume: 62 Pages: 71-77

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Distribution and Ecological Aspects of Sand Fly (Diptera: Psychodidae) Species in Sri Lanka.2011

    • Author(s)
      Ozbel, Y., et al.
    • Journal Title

      Journal of Vector Ecology

      Volume: 36 Pages: 77-86

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Myeloid-related protein(MRP)によるローデントマラリア脾腫の増悪2015

    • Author(s)
      溝渕 悠代
    • Organizer
      第84回日本寄生虫学会大会
    • Place of Presentation
      杏林大学 (東京都三鷹市)
    • Year and Date
      2015-03-22
    • Related Report
      2014 Annual Research Report
  • [Presentation] 内臓型リーシュマニア症における血中B-cell activating factor(BAFF)濃度の増加2015

    • Author(s)
      大間知聡子
    • Organizer
      第84回日本寄生虫学会大会
    • Place of Presentation
      杏林大学 (東京都三鷹市)
    • Year and Date
      2015-03-21
    • Related Report
      2014 Annual Research Report
  • [Presentation] In silico identification of novel vaccine candidates against Leishmania major.2014

    • Author(s)
      Goto Yasuyuki
    • Organizer
      18th Japanese-German Cooperative Symposium on Protozoan Diseases.
    • Place of Presentation
      Dresden (Germany)
    • Year and Date
      2014-10-02
    • Related Report
      2014 Annual Research Report
  • [Presentation] 内臓型リーシュマニア症患者における血清B-cell activating factor(BAFF)濃度の増加2014

    • Author(s)
      大間知聡子
    • Organizer
      第74回日本寄生虫学会東日本支部大会
    • Place of Presentation
      自治医科大学(栃木県下野市)
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] Peroxiredoxin as one major antigen of IgE antibody during Leishmania major infection2014

    • Author(s)
      Sun Jamei
    • Organizer
      第74回日本寄生虫学会東日本支部大会
    • Place of Presentation
      自治医科大学(栃木県下野市)
    • Year and Date
      2014-09-27
    • Related Report
      2014 Annual Research Report
  • [Presentation] In silico identification of novel vaccine candidates against Leishmania major.2014

    • Author(s)
      Goto Yasuyuki
    • Organizer
      13th International Congress of Parasitology (ICOPA).
    • Place of Presentation
      Mexico City (Mexico)
    • Year and Date
      2014-08-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 実験的内臓型リーシュマニア症における治療後の再感染抵抗性2014

    • Author(s)
      長田康孝ら
    • Organizer
      第83回日本寄生虫学会大会
    • Place of Presentation
      愛媛大学(愛媛)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 実験的内臓型リーシュマニア症における血中IgGの異常亢進2014

    • Author(s)
      大間知聡子ら
    • Organizer
      第83回日本寄生虫学会大会
    • Place of Presentation
      愛媛大学(愛媛)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Anti-Leishmania IgE antibodies: a bio-maker for characterization of cutaneous leishmaniasis.2014

    • Author(s)
      孫家梅ら
    • Organizer
      第83回日本寄生虫学会大会
    • Place of Presentation
      愛媛大学(愛媛)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Susceptibility and resistance correlates with differential expansion of helper T cell subsets in experimental murine visceral leishmaniasis.2013

    • Author(s)
      Osada,Y. et al.
    • Organizer
      Worldleish5
    • Place of Presentation
      Porto de Galinhas(ブラジル)
    • Related Report
      2013 Annual Research Report
  • [Presentation] The infection site of Leishmania major parasites influences the performance of Leish-111f intranasal immunization.2013

    • Author(s)
      Matsumoto,Y. et al.
    • Organizer
      Worldleish5
    • Place of Presentation
      Porto de Galinhas(ブラジル)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Tandem repeat proteins for serological diagnosis of visceral leishmaniasis.2013

    • Author(s)
      Goto,Y. et al.
    • Organizer
      Worldleish5
    • Place of Presentation
      Porto de Galinhas(ブラジル)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Kala Azar in South Asia – current status and challenges ahead: vector surveillance studies in Bangladesh; hints and hopes.2013

    • Author(s)
      Ozbel,Y. et al.
    • Organizer
      Worldleish5
    • Place of Presentation
      Porto de Galinhas(ブラジル)
    • Related Report
      2013 Annual Research Report
  • [Presentation] In silico identification of vaccine antigens for leishmaniasis.2013

    • Author(s)
      Goto,Y. et al.
    • Organizer
      Worldleish5
    • Place of Presentation
      Porto de Galinhas(ブラジル)
    • Related Report
      2013 Annual Research Report
  • [Presentation] バングラデシュにおけるサシチョウバエに対する長期残効型蚊帳の効力試験2013

    • Author(s)
      三條場千寿ら
    • Organizer
      第65回日本衛生動物学会東日本支部大会
    • Place of Presentation
      川口総合文化センター(埼玉)
    • Related Report
      2013 Annual Research Report
  • [Presentation] Involvement of IgE responses in experimental cutaneous leishmaniasis.2013

    • Author(s)
      Jiamei Sun et al.
    • Organizer
      第73回日本寄生虫学会東日本支部大会
    • Place of Presentation
      国立科学博物館(東京)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 薬剤標的としてのトリパノソーマ科原虫ミトコンドリア呼吸鎖複合体II2013

    • Author(s)
      二橋望ら
    • Organizer
      第86回日本生化学会大会
    • Place of Presentation
      パシフィコ横浜(神奈川)
    • Related Report
      2013 Annual Research Report
  • [Presentation] 海藻類Sargassum yamadaeより単離したキノンテルペノイドの抗リーシュマニア症活性

    • Author(s)
      長田康孝
    • Organizer
      第82回日本寄生虫学会大会
    • Place of Presentation
      東京医科歯科大学(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Reverse vaccinologyによるリーシュマニア症ワクチン抗原の探索

    • Author(s)
      後藤康之
    • Organizer
      第82回日本寄生虫学会大会
    • Place of Presentation
      東京医科歯科大学(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] マウス実験的内臓型リーシュマニア症におけるTh1、Th2の感受性、抵抗性への関与

    • Author(s)
      長田康孝
    • Organizer
      第155回日本獣医学会学術集会
    • Place of Presentation
      東京大学(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] カラ・アザールとPKDL

    • Author(s)
      松本芳嗣
    • Organizer
      第53回日本熱帯医学会大会
    • Place of Presentation
      とかちプラザ(帯広)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Efficacy of Long-Lasting Insecticidal Net against Sand Flies.

    • Author(s)
      Sanjoba, C.
    • Organizer
      Third International Conference on Neglected Tropical Diseases, Bangladesh and Scientific Meeting on Kala-azar and PKDL
    • Place of Presentation
      Filaria and General Hospital(バングラデシュ)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] Antigen Discovery for Serological Diagnosis of Visceral Leishmaniasis.

    • Author(s)
      Goto, Y.
    • Organizer
      Third International Conference on Neglected Tropical Diseases, Bangladesh and Scientific Meeting on Kala-azar and PKDL
    • Place of Presentation
      Filaria and General Hospital(バングラデシュ)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] リーシュマニア症ワクチン抗原の有用性に寄与するパラメータの探索

    • Author(s)
      後藤康之
    • Organizer
      第154回日本獣医学会学術集会
    • Place of Presentation
      岩手大学(岩手)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 実験的内臓型リーシュマニア症におけるMRP8、14陽性細胞の増加

    • Author(s)
      長田康孝
    • Organizer
      第20回分子寄生虫学ワークショップ
    • Place of Presentation
      神戸セミナーハウス(神戸)
    • Related Report
      2012 Annual Research Report
  • [Presentation] リーシュマニア原虫の抗原学

    • Author(s)
      後藤康之
    • Organizer
      第20回分子寄生虫学ワークショップ
    • Place of Presentation
      神戸セミナーハウス(神戸)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Efficacy of Olyset® nets against phlebotomine sand flies

    • Author(s)
      Sanjoba, C.
    • Organizer
      7th International Symposium on Phlebotomine
    • Place of Presentation
      Pine Bay Hotel (トルコ)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Leishmania turanica: development in sand flies and competition with L. major

    • Author(s)
      Chajbullinova, A.
    • Organizer
      7th International Symposium on Phlebotomine
    • Place of Presentation
      Pine Bay Hotel (トルコ)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Leishmania donovani 感染マウスの原虫血症

    • Author(s)
      長田康孝
    • Organizer
      第80回日本寄生虫学会大会
    • Place of Presentation
      東京慈恵会医科大学(東京都)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 内臓型リーシュマニア症in vivoモデルを用いたAmBisomeの抗リーシュマニア症活性

    • Author(s)
      長田康孝
    • Organizer
      第81回日本寄生虫学会大会
    • Place of Presentation
      兵庫医科大学(兵庫県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] 実験的Leishmania donovani感染マウス血液からの原虫分離

    • Author(s)
      長田康孝
    • Organizer
      第153回日本獣医学会学術集会
    • Place of Presentation
      大宮ソニックシティ(埼玉県)
    • Related Report
      2011 Annual Research Report
  • [Book] Kala-azar in South Asia - current status and challenges ahead2011

    • Author(s)
      Matsumoto, Y., et al.
    • Publisher
      Springer verlag
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗リーシュマニア化合物および抗リーシュマニア薬2012

    • Inventor(s)
      松本芳嗣ら
    • Industrial Property Rights Holder
      学校法人青山学院
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-02-07
    • Acquisition Date
      2012-07-20
    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] 抗リーシュマニア薬2012

    • Inventor(s)
      松本芳嗣ら
    • Industrial Property Rights Holder
      学校法人青山学院
    • Industrial Property Rights Type
      特許
    • Filing Date
      2012-02-07
    • Acquisition Date
      2012-07-20
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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