Realization of High Performance Real Time Arteriosclerosis Diagnosis System by Soft Computing

• Project/Area Number: 23300086
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Sensitivity informatics/Soft computing
• Research Institution: Yamaguchi University
• Principal Investigator: UCHINO Eiji 山口大学, 理工学研究科, 教授 (30168710)
• Co-Investigator(Kenkyū-buntansha): SUETAKE Noriaki 山口大学, 大学院・理工学研究科, 准教授 (80334051) ; HIRO Takafumi 日本大学, 医学部, 准教授 (10294638)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000); Fiscal Year 2013: ¥6,630,000 (Direct Cost: ¥5,100,000、Indirect Cost: ¥1,530,000); Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000); Fiscal Year 2011: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: 血管内超音波法 / 動脈硬化 / 心筋梗塞 / プラーク / 組織性状判別 / ソフトコンピューティング / 実用化 / 学習 / 動脈硬化診断 / プラーク組織性状判別

Research Abstract

Rupture of plaque piled up in the coronary artery causes acute coronary syndromes (ACS) including arteriosclerosis which results in myocardial infarction leading to death in the worst case. Plaque is classified into stable plaque (easy to rupture) and unstable plaque according to the structure of plaque. Therefore for the early detection and diagnosis of ACS, tissue characterization of coronary plaque with high accuracy is essential. In this research, soft computing based signal analysis imitating the information processing scheme in the human brain is applied for the tissue characterization of coronary plaque. It enabled the high performance diagnosis system giving 2D and/or 3D imaging of characterized plaque on the bed side.

Research Products

• [Journal Article] Hybrid Boundary Detection Method for Image with Application to Coronary Plaque (2014)
  • Author(s): S. Anam, E. Uchino, and N. Suetake
  • Journal Title: Int. J. Digital Information and Wireless Communications Volume: Vol.4,No.4
  • Peer Reviewed
• [Journal Article] Combining PSO and Fuzzy Inference for the Calculation of Coronary Plaque Boundary in IVUS Image (2014)
  • Author(s): S. Anam, E. Uchino, Misawa and N. Suetake
  • Journal Title: Int. J. of Biomedical Soft Computing and Human Sciences Volume: Vol.19,No.1
  • Peer Reviewed
• [Journal Article] Characterization of Coronary Plaque by Using 2D Frequency Histogram of RF Signal (2014)
  • Author(s): S. Nakao, K. Tokunaga, N. Suetakea n d E. Uchino
  • Journal Title: Soft Computing in Industrial Applications,Advances in Intelligent Systems and Computing Volume: Vol.223 Pages: 187-196
  • Peer Reviewed
• [Journal Article] Combining PSO and Fuzzy Inference for the Calculation of Coronary Plaque Boundary in IVUS Image (2014)
  • Author(s): S. Anam, E. Uchino, Misawa and N. Suetake
  • Journal Title: International Journal of Biomedical Soft Computing and Human Sciences Volume: 19
  • Peer Reviewed
• [Journal Article] Tissue Characterization of Coronary Plaque by kNN Classifier with Fractal-based Features of IVUS RF-signal (2013)
  • Author(s): E. Uchino, T. Koga, H. Misawa and N. Suetake
  • Journal Title: J. of Intelligent Manufacturing Volume: (published online) Issue: 5 Pages: 973-982
  • DOI: 10.1007/s10845-013-0793-3
  • Peer Reviewed
• [Journal Article] Plaque Stabilization by Intensive LDL-Cholesterol Lowering Therapy with Atorvastatin is Delayed in Type 2 Diabetic Patients with Coronary Artery Disease-Serial Angioscopic and Intravascular Ultrasound Analysis (2013)
  • Author(s): T. Takayama, T. Hiro, Y. Ueda, J. Honye, S. Komatsu, O. Yamaguchi, Y. Li, J. Yajima, K. Takazawa, S. Nanto, S. Saito, A. Hirayama and K. Kodama
  • Journal Title: J. Cardiol Volume: Vol.61,No.6 Pages: 381-386
  • Peer Reviewed
• [Journal Article] Three Stars of the Constellation of Color Intravascular Ultrasound in the Space of Tissue Characterization of Coronary Plaque (2013)
  • Author(s): T. Hiro
  • Journal Title: J. Cardiol Volume: Vol.61,No.2 Pages: 186-187
  • Peer Reviewed
• [Journal Article] Plaque stabilization by intensive LDL-cholesterol lowering therapy with atorvastatin is delayed in type 2 diabetic patients with coronary artery disease-Serial angioscopic and intravascular ultrasound analysis (2013)
  • Author(s): T. Takayama, T. Hiro, Y. Ueda, J. Honye, S. Komatsu, O. Yamaguchi, Y. Li, J. Yajima, K. Takazawa, S. Nanto, S. Saito , A. Hirayama and K. Kodama
  • Journal Title: J. Cardiol Volume: 61 Issue: 6 Pages: 381-386
  • DOI: 10.1016/j.jjcc.2013.01.010
  • Peer Reviewed
• [Journal Article] IVUS-Based Coronary Plaque Tissue Characterization Using Weighted Multiple k-Nearest Neighbor (2012)
  • Author(s): E. Uchino, K. Tokunaga, H. Tanaka and N. Suetake
  • Journal Title: Engineering Letters Volume: Vol.20,No.3 Pages: 211-216
  • Peer Reviewed
• [Journal Article] IVUS-Based Coronary Plaque Tissue Characterization Using Weighted Multiple k-Nearest Neighbor (2012)
  • Author(s): Eiji Uchino
  • Journal Title: Engineering Letters Volume: 20 Pages: 211-216
  • Peer Reviewed
• [Journal Article] High-Speed Calculation for Tissue Characterization of Coronary Plaque by Employing Parallel Computing Techniques (2011)
  • Author(s): T. Koga, S. Furukawa, E. Uchinoand N. Suetake
  • Journal Title: Int. J. of Circuits, Systems and Signal Processing Volume: Vol.5,No.4 Pages: 435-442
  • Peer Reviewed
• [Journal Article] High-Speed Calculation for Tissue Characterization of Coronary Plaque by Employing Parallel Computing Techniques (2011)
  • Author(s): Takanori Koga
  • Journal Title: Int.J.of Circuits, Systems and Signal Processing Volume: Vol.5 Pages: 435-442
  • Peer Reviewed
• [Presentation] Tissue Characterization of Coronary Plaque by Subspace Method with Consideration to Neighborhood Information of Target Tissue (2014)
  • Author(s): S. Furukawa, E. Uchino, S. Miwa, and N. Suetake
  • Organizer: Proc. of the 2014 Int. Conf. on Artificial Intelligence and Applications (ICAIA 2014)
  • Place of Presentation: The Royal Garden Hotel, Kowloon, Hong Kong, China
  • Year and Date: 2014-03-14
• [Presentation] Application of Bag-of- Keypoints to Tissue Characterization of Coronary Plaque for the Diagnosis of Arteriosclerosis (2014)
  • Author(s): S. Nakao, E. Uchino, S. Furukawa and N. Suetake
  • Organizer: Proc. of 2014 RISP Int. Workshop on Nonlinear Circuits, Communications and Signal Processing (NCSP 2014)
  • Place of Presentation: Waikiki Beach Marriott Resort & Spa, Honolulu, Hawaii, USA
  • Year and Date: 2014-03-03
• [Presentation] Sparse Feature Based Analysis of RF Signal for Coronary Plaque Tissue Classification with Reference to the Neighboring Information of the Target Tissue (2014)
  • Author(s): S. Furukawa, E. Uchino, T. Azetsu, and N. Suetake
  • Organizer: Proc. of the 2014 Int. Conf. on Communications, Signal Processing and Computers (CSCP 2014)
  • Place of Presentation: Lindner Grand Hotel Beau Rivage, Interlaken, Switzerland
  • Year and Date: 2014-02-23
• [Presentation] Classification of Intravascular Ultrasound Signal by Kernel Density Estimation and Bayes Theorem for Identification of Coronary Plaque Tissue (2014)
  • Author(s): H. Tanaka, K. Tokunaga, E. Uchino, and N. Suetake
  • Organizer: Proc. Of the 2014 Int. Conf. on Communications, Signal Processing and Computers (CSCP 2014)
  • Place of Presentation: Lindner Grand Hotel Beau Rivage, Interlaken, Switzerland
  • Year and Date: 2014-02-22
• [Presentation] Classification of Intravascular Ultrasound Signal by Kernel Density Estimation and Bayes Theorem for Identification of Coronary Plaque Tissue (2014)
  • Author(s): H. Tanaka, K. Tokunaga, E. Uchino, and N. Suetake
  • Organizer: 2014 International Conference on Communications, Signal Processing and Computers, Best Paper
  • Place of Presentation: Lindner Grand Hotel Beau Rivage, Interlaken, Switzerland
• [Presentation] Sparse Feature Based Analysis of RF Signal for Coronary Plaque Tissue Classification with Reference to the Neighboring Information of the Target Tissue (2014)
  • Author(s): S. Furukawa, E. Uchino, T. Azetsu, and N. Suetake
  • Organizer: 2014 International Conference on Communications, Signal Processing and Computers
  • Place of Presentation: Lindner Grand Hotel Beau Rivage, Interlaken, Switzerland
• [Presentation] Application of Bag-of-Keypoints to Tissue Characterization of Coronary Plaque for the Diagnosis of Arteriosclerosis (2014)
  • Author(s): S. Nakao, E. Uchino, S. Furukawa and N. Suetake
  • Organizer: 2014 RISP International Workshop on Nonlinear Circuits, Communications and Signal Processing
  • Place of Presentation: Waikiki Beach Marriott Resort & Spa, Honolulu, Hawaii, USA
• [Presentation] Tissue Characterization of Coronary Plaque by Subspace Method with Consideration to Neighborhood Information of Target Tissue (2014)
  • Author(s): S. Furukawa, E. Uchino, S. Miwa, and N. Suetake
  • Organizer: 2014 International Conference on Artificial Intelligence and Applications
  • Place of Presentation: The Royal Garden Hotel, Kowloon, Hong Kong
• [Presentation] Coronary Plaque Boundary Detection in Intravascular Ultrasound Image by Using Hybrid Modified Level Set Method and Fuzzy Inference (2013)
  • Author(s): S. Anam, E. Uchinoand N. Suetake
  • Organizer: Proc. of the Second Int. Conf. on Informatics Engineering & Information Science (ICIEIS 2013)
  • Place of Presentation: Advanced Informatics School, University Technology Malaysia (UTM), Kuala Lumpur, Malaysia
  • Year and Date: 2013-11-12
• [Presentation] Coronary Plaque Boundary Calculation in IVUS Image by Modified PMD Filter and Fuzzy Inference (2013)
  • Author(s): S. Anam, E. Uchinoand N. Suetake
  • Organizer: Proc. of the 20th Int. Conf. on Neural Information Processing (ICONIP 2013)
  • Place of Presentation: EXCO, Daegu, Korea
  • Year and Date: 2013-11-05
• [Presentation] Image Boundary Detection Using the Modified Level Set Method and a Diffusion Filter (2013)
  • Author(s): S. Anam, E. Uchino and N. Suetake
  • Organizer: 17th International Conference on Knowledge-Based and Intelligent Information & Engineering Systems
  • Place of Presentation: Kitakyushu International Conference Center, Kitakyushu, Japan
• [Presentation] Coronary Plaque Boundary Detection in Intravascular Ultrasound Image by Using Hybrid Modified Level Set Method and Fuzzy Inference (2013)
  • Author(s): S. Anam, E. Uchino and N. Suetake
  • Organizer: Second International Conference on Informatics Engineering & Information Science
  • Place of Presentation: Advanced Informatics School, University Technology Malaysia, Kuala Lumpur, Malaysia
• [Presentation] Parameter Tuning by PSO for Fuzzy Inference-Based Coronary Plaque Extraction in IVUS Image (2012)
  • Author(s): S. Anam, H. Misawa, E. Uchinoand N. Suetake
  • Organizer: Proc. of the Joint 6th Int. Conf. on Soft Computing and Intelligent Systems and 13th Int. Symposium on Advanced Intelligent Systems (SCIS & ISIS 2012)
  • Place of Presentation: Kobe Convention Center, Kobe Portopia Hotel, Kobe, Japan
  • Year and Date: 2012-12-23
• [Presentation] Moving Window-Based Similarity Analysis and Its Application to Tissue Characterization of Coronary Arteries (2012)
  • Author(s): G. Vachkov, E. Uchino, and S. Nakao
  • Organizer: Proc. Of the 2012 Int. Conf. on Bioinformatics (ICB 2012), Best Student Paper Award
  • Place of Presentation: The Royal Garden Hotel, Kowloon, Hong Kong, China
  • Year and Date: 2012-03-16
• [Presentation] Tissue Classification of Coronary Plaque Using Intravascular Ultrasound Method by Extended Multiple k-Nearest Neighbor (2012)
  • Author(s): K. Tokunaga, E. Uchino, H. Tanaka and N. Suetake
  • Organizer: Proc. of the 2012 Int. Conf. on Artificial Intelligence and Applications (ICAIA 2012), Merit for the Conference (Conference Award)
  • Place of Presentation: The Royal Garden Hotel, Kowloon, Hong Kong, China
  • Year and Date: 2012-03-16
• [Presentation] Tissue Classification of Coronary Plaque Using Intravascular Ultrasound Method by Extended Multiple k-Nearest Neighbor (2012)
  • Author(s): Kazuhiro Tokunaga
  • Organizer: 2012 International Conference on Artificial Intelligence and Applications (ICAIA 2012)
  • Place of Presentation: Hong Kong, China(功績賞)
  • Year and Date: 2012-03-16
• [Presentation] Moving Window-Based Similarity Analysis and Its Application to Tissue Characterization of Coronary Arteries (2012)
  • Author(s): Gancho Vachkov
  • Organizer: 2012 International Conference on Bioinformatics (TCB 2012)
  • Place of Presentation: Hong Kong, China(最優秀論文賞)
  • Year and Date: 2012-03-16
• [Presentation] Tissue Characterization of Coronary Plaque by Soft Computing for the Diagnosis of Arteriosclerosis (2012)
  • Author(s): E. Uchino, N. Suetake R. Kubota, T. Koga, T. Hiro, and M. Matsuzaki
  • Organizer: Proc. of the 2012 Int. Symposium on Semiconductor Manufacturing Intelligence (ISMI 2012) & Decision Analysis Symposium 2012 (DAS 2012)
  • Place of Presentation: National Tsing Hua University, Hsinchu, Taiwan
  • Year and Date: 2012-01-06
• [Presentation] Tissue Characterization of Coronary Plaque by Soft Computing for the Diagnosis of Arteriosclerosis (2012)
  • Author(s): Eiji Uchino
  • Organizer: 2012 International Symposium on Semiconductor Manufacturing Intelligence (ISMI 2012)
  • Place of Presentation: Hsinchu, Taiwan(招待講演)
  • Year and Date: 2012-01-06
• [Presentation] Characterization of Coronary Plaque by Using 2D Frequency Histogram of RF Signal (2012)
  • Author(s): S. Nakao, K. Tokunaga, N. Suetake and E. Uchino
  • Organizer: Proc. of the 17th Online World Conf. on Soft Computing in Industrial Applications (WSC17)
• [Presentation] Similarity Analysis Based on the Weighted Moving Window for Tissue Characterization of Plaque in Coronary Arteries (2012)
  • Author(s): Gancho Vachkov
  • Organizer: 4th International Conference on Intelligent Decision Technologies
  • Place of Presentation: Nagaragawa Convention Center, Gifu, Japan
• [Presentation] Automatic Allocation of Membership Functions Using Particle Swarm Optimization for Coronary Plaque Boundary Extraction in Intravascular Ultrasound Image (2012)
  • Author(s): Syaifu Anam
  • Organizer: 第28回ファジィシステムシンポジウム
  • Place of Presentation: 名古屋工業大学, 名古屋
• [Presentation] Parameter Tuning by PSO for Fuzzy Inference-Based Coronary Plaque Extraction in IVUS Image (2012)
  • Author(s): Syaifu Anam
  • Organizer: Joint 6th International Conference on Soft Computing and Intelligent Systems and 13th International Symposium on Advanced Intelligent Systems
  • Place of Presentation: Kobe Convention Center, Kobe, Japan
• [Presentation] Characterization of Coronary Plaque by Using 2D Frequency Histogram of RF Signal (2012)
  • Author(s): Satoshi Nakao
  • Organizer: 17th Online World Conference on Soft Computing in Industrial Applications
  • Place of Presentation: World Wide Web
• [Presentation] カーネル密度推定を用いた冠動脈プラークの組織性状判別 (2012)
  • Author(s): 田中宏樹
  • Organizer: バイオメディカル・ファジィ・システム学会第25回年次大会
  • Place of Presentation: 東京都市大学, 東京
• [Presentation] モジュラ－ネットワーク型自己組織化マップを用いた冠動脈プラークの組織性状判別 (2012)
  • Author(s): 徳永憲洋
  • Organizer: バイオメディカル・ファジィ・システム学会第25回年次大会
  • Place of Presentation: 東京都市大学, 東京
• [Presentation] 移動窓法を用いた類似度解析による冠動脈プラークの組織性状判別 (2011)
  • Author(s): 中尾吏志
  • Organizer: 2011年日本知能情報ファジィ学会中国・四国研究会
  • Place of Presentation: 山口大学,山口
  • Year and Date: 2011-12-23
• [Presentation] Similarity-Based Method for Tissue Characterization of Coronary Artery Plaque (2011)
  • Author(s): Gancho Vachkov
  • Organizer: バイオメディカル・ファジィ・システム学会第24回年次大会
  • Place of Presentation: 山口大学,山口
  • Year and Date: 2011-10-30
• [Presentation] ニューラルガスを用いた階層型k近隣法による冠動脈組織性状の判別速度および精度の向上 (2011)
  • Author(s): 徳永憲洋
  • Organizer: バイオメディカル・ファジィ・システム学会第24回年次大会
  • Place of Presentation: 山口大学,山口
  • Year and Date: 2011-10-30
• [Presentation] Automated Boundary Extraction and Visualization System for Coronary Plaque in IVUS Image by Using Fuzzy Inference-based Method (2011)
  • Author(s): T. Koga, E. Uchinoand N. Suetake
  • Organizer: Proc. of 2011 IEEE Int. Conf. on Fuzzy Systems (FUZZ-IEEE 2011)
  • Place of Presentation: Grand Hyatt Taipei, Taipei, Taiwan
  • Year and Date: 2011-06-29
• [Presentation] Automated Boundary Extraction and Visualization System for Coronary Plaque in IVUS Image by Using Fuzzy Inference-based Method (2011)
  • Author(s): Takanori Koga
  • Organizer: 2011 IEEE International Conference on Fuzzy Systems (FUZZ-IEEE 2011)
  • Place of Presentation: Taipei, Taiwan
  • Year and Date: 2011-06-29
• [Presentation] Similarity Analysis Based on the Weighted Moving Window for Tissue Characterization of Plaque in Coronary Arteries
  • Author(s): G. Vachkov and E. Uchino
  • Organizer: Proc. Of the 4th Int. Conf. on Intelligent Decision Technologies (IDT 2012)
  • Place of Presentation: Nagaragawa Convention Center, Gifu, Japan
• [Book] Soft Computing in Industrial Applications (2014)
  • Author(s): S. Nakao, K. Tokunaga and E. Uchino
  • Total Pages: 391
  • Publisher: Springer
• [Book] Neural Information Processing, Part III, Lecture Notes in Computer Science, LNCS 8228 (2013)
  • Author(s): S. Anam, E. Uchino and N. Suetake
  • Total Pages: 638
  • Publisher: Springer
• [Remarks]
  • URL: http://www.ic.sci.yamaguchi-u.ac.jp/
• [Remarks] 山口大学理工学研究科システム情報科学研究室ホームページ
  • URL: http://www.ic.sci.yamaguchi-u.ac.jp/
• [Remarks]
  • URL: http://www.ic.sci.yamaguchi-u.ac.jp/
• [Patent(Industrial Property Rights)] スパースコーディングを用いた組織性状判別 (2013)
  • Inventor(s): 内野英治, 末竹規哲, 畔津忠博, 松崎益徳, 廣 高史
  • Industrial Property Rights Holder: 国立大学法人山口大学, 公立大学法人山口県立大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2013-03-08
• [Patent(Industrial Property Rights)] 分離測度を用いた重み付け最小二乗法による境界抽出 (2012)
  • Inventor(s): 内野英治, 末竹規哲, 久保田良輔, 松崎益徳, 廣 高史
  • Industrial Property Rights Holder: 国立大学法人山口大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2012-04-06
• [Patent(Industrial Property Rights)] 超音波診断装置及び組織性状判別のプログラム (2011)
  • Inventor(s): 内野英治, 末竹規哲, 久保田良輔, 松崎益徳, 廣 高史
  • Industrial Property Rights Holder: 国立大学法人山口大学
  • Industrial Property Rights Type: 特許
  • Filing Date: 2011-10-14