Characterization and classification of cancer cells based on protein distributions and expression timings from cell array
| Project/Area Number |
23300110
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Bioinformatics/Life informatics
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| Research Institution | Yamaguchi University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
GE QI-WEI 山口大学, 教育学部, 教授 (30263750)
FURUYA TOMOKO 山口大学, 大学院医学系研究科, 助教 (30379979)
Faure Adrien 山口大学, 理工学研究科, 助教 (00610627)
KITAKAZE HIRONORI 大島商船高等専門学校, 情報工学科, 准教授 (70342558)
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| Co-Investigator(Renkei-kenkyūsha) |
IKEDA NOBUHIKO 徳山工業高等専門学校, 情報電子工学科, 嘱託教授 (60110235)
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| Project Period (FY) |
2011-04-01 – 2016-03-31
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| Project Status |
Completed (Fiscal Year 2015)
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| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2015: ¥2,990,000 (Direct Cost: ¥2,300,000、Indirect Cost: ¥690,000)
Fiscal Year 2014: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2013: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2012: ¥4,030,000 (Direct Cost: ¥3,100,000、Indirect Cost: ¥930,000)
Fiscal Year 2011: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
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| Keywords | システム生物学 / シグナル伝達経路 / ペトリネット / セルアレイ / がん細胞分類 / サポートベクタマシン / シグナル伝達 / シミュレーション工学 / 機械学習 |
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| Outline of Final Research Achievements |
A method expressing characteristics of cancer cells based on linear differentiation, which maps 5 kinds of dispersion patterns, quantity and aggregation ratio of protein, cell size, and quantity and aggregation ratio of DNA, to a fixed dimensional feature space by using kernel function of a support vector machine was developed.
In addition, some necessary conditions for timed Petri net are shown to make it retention-free. Based on the dependencies of transition delay time and cycle structure in Petri net, a method deciding delay times in partial structures in a Petri net model of a signaling pathway and a condition for cycle structure were formulated.
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Report
(6 results)
Research Products
(28 results)
