| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥6,760,000 (Direct Cost: ¥5,200,000、Indirect Cost: ¥1,560,000)
Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Outline of Final Research Achievements |
We examined the effects of eliminating sensory inputs on the development of peristaltic movements of Drosophila embryos and larvae. We found that inhibition of chordotonal organs (chos), but not multidendritic (md) neurons, caused a lasting decrease in the speed of larval locomotion. To narrow down the sensitive period, we applied shorter inhibition at various embryonic and larval stages and found that two-hour inhibition during 16-20 h AEL, but not at earlier or later stages, was sufficient to cause the effect. These results suggest that neural activity mediated by specific sensory neurons is involved in the maturation of the sensorimotor circuits and there is a critical period for this plastic change. Consistent with a role in sensory feedback, chos were activated during larval peristalsis and acute inhibition of chos transmission in the larvae decreased the speed of locomotion.
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