| Budget Amount *help |
¥20,020,000 (Direct Cost: ¥15,400,000、Indirect Cost: ¥4,620,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2011: ¥7,540,000 (Direct Cost: ¥5,800,000、Indirect Cost: ¥1,740,000)
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| Research Abstract |
During development neural circuits are established not only by molecular cues but also neuronal activity. In the present study, we attempted to reveal the molecular mechanisms that underlie activity-dependent axon branching, focusing on the thalamocortical projection. As a result, we found that netrin-4 is expressed in cortical cells in an activity-dependent fashion and promotes branch formation of thalamocortical axons. Moreover, endocytosis in presynaptic sites, which is regulated by firing activity, promotes axon branching by increasing uptake of neurotrophic factors.
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