|Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
|Outline of Final Research Achievements
In the present study, we aimed to elucidate the neural mechanisms underlying the acquisition, performance, and switching of behaviors by using the technology for genetic manipulation of neural functions we originally developed. First, our results indicated that the thalamostriatal pathways arising from the parafascicular and central lateral nuclei have distinct functions in the acquisition and performance of sensory discrimination learning. The thalamostriatal pathways appear to be partly involved in the process of pavlovian-instrumental transfer. We also developed animal models useful for the analysis of firing activity of thalamostriatal neurons during behavioral paradigm and for the targeting of corticostriatal pathways from different cerebral cortical areas.