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Mechanisms underlying the cortico-basal ganglia network by using neural circuitry analysis

Research Project

Project/Area Number 23300119
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neuroscience in general
Research InstitutionFukushima Medical University

Principal Investigator

KAZUTO Kobayashi  福島県立医科大学, 医学部, 教授 (90211903)

Co-Investigator(Kenkyū-buntansha) 小林 憲太  福島県立医科大学, 医学部, 助教 (70315662)
深堀 良二 (深掘 良二)  福島県立医科大学, 医学部, 助教 (40457784)
Project Period (FY) 2011-04-01 – 2015-03-31
Project Status Completed (Fiscal Year 2014)
Budget Amount *help
¥18,070,000 (Direct Cost: ¥13,900,000、Indirect Cost: ¥4,170,000)
Fiscal Year 2014: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2013: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2012: ¥3,380,000 (Direct Cost: ¥2,600,000、Indirect Cost: ¥780,000)
Fiscal Year 2011: ¥7,930,000 (Direct Cost: ¥6,100,000、Indirect Cost: ¥1,830,000)
Keywords視床線条体路 / 皮質線条体路 / 道具的学習 / 行動柔軟性 / 高頻度逆行性遺伝子導入ベクター / 細胞標的法 / 光遺伝学 / 運動制御 / 逆行性導入ベクター / イムノトキシン / 学習
Outline of Final Research Achievements

In the present study, we aimed to elucidate the neural mechanisms underlying the acquisition, performance, and switching of behaviors by using the technology for genetic manipulation of neural functions we originally developed. First, our results indicated that the thalamostriatal pathways arising from the parafascicular and central lateral nuclei have distinct functions in the acquisition and performance of sensory discrimination learning. The thalamostriatal pathways appear to be partly involved in the process of pavlovian-instrumental transfer. We also developed animal models useful for the analysis of firing activity of thalamostriatal neurons during behavioral paradigm and for the targeting of corticostriatal pathways from different cerebral cortical areas.

Report

(5 results)
  • 2014 Annual Research Report   Final Research Report ( PDF )
  • 2013 Annual Research Report
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (43 results)

All 2014 2013 2012 2011

All Journal Article (14 results) (of which Peer Reviewed: 14 results,  Open Access: 2 results) Presentation (25 results) (of which Invited: 2 results) Book (4 results)

  • [Journal Article] Transcriptional and structural plasticity of tyrosine hydroxylase expressing neurons in both striatum and nucleus accumbens following dopaminergic denervation.2014

    • Author(s)
      Depboylu, C., Klietz, M., Maurer, L., Oertel, W.H., Kobayashi, K., Weihe, E., Höglinger, G.U., and Schäfer, M. K.
    • Journal Title

      J. Chem. Neuroanat.

      Volume: 61/62 Pages: 169-175

    • DOI

      10.1016/j.jchemneu.2014.10.003

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Crucial role of rho-kinase in pressure overload-induced right ventricular hypertrophy and dysfunction in mice2014

    • Author(s)
      Ikeda, S., Satoh, K., Kikuchi, N., Miyata, S., Suzuki, K., Omura, J., Shimizu, T., Kobayashi, K., Kobayashi, K., Fukumoto, Y., Sakata, Y., and Shimokawa, H.
    • Journal Title

      Arterioscler. Thromb. Vasc Biol.

      Volume: 34 Issue: 6 Pages: 1260

    • DOI

      10.1161/atvbaha.114.303320

    • Related Report
      2014 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Dissecting circuit mechanisms by genetic manipulation of specific neural pathways.2013

    • Author(s)
      Kato et al.
    • Journal Title

      Rev. Neurosci.

      Volume: 24 Issue: 1 Pages: 1-8

    • DOI

      10.1515/revneuro-2012-0043

    • Related Report
      2013 Annual Research Report 2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Signals through the striatopallidal indirect pathway stop movements by phasic excitation in the substantia nigra.2013

    • Author(s)
      Sano et al.
    • Journal Title

      J. Neurosci.

      Volume: 33 Issue: 17 Pages: 7583-7594

    • DOI

      10.1523/jneurosci.4932-12.2013

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Transcranial direct-current stimulation increases extracellular dopamine levels in the rat striatum.2013

    • Author(s)
      Tanaka T
    • Journal Title

      Frontiers in System Neuroscience

      Volume: 7 Pages: 6-6

    • DOI

      10.3389/fnsys.2013.00006

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed / Open Access
  • [Journal Article] Protocadherin 17 regulates presynaptic assembly in topographic corticobasal ganglia circuits2013

    • Author(s)
      Hoshina N, Tanimura A, Yamasaki M, Inoue T, Fukabori R, Kuroda T, Yokoyama K, Tezuka T, Sagara H, Hirano S, Kiyonari H, Takada M, Kobayashi K, Watanabe M, Kano M, Nakazawa T, Yamamoto T
    • Journal Title

      Neuron

      Volume: 78 Issue: 5 Pages: 839

    • DOI

      10.1016/j.neuron.2013.03.031

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Chronic alterations in monoaminergic cells in the locus coeruleus in orexin neuron-ablated narcoleptic mice2013

    • Author(s)
      Tsujino N, Tsunematsu T,Uchigashima M, Konno K,Yamanaka A, Kobayashi K, Watanabe M, Koyama Y, Sakurai T
    • Journal Title

      PLoS ONE

      Volume: 8 Issue: 7 Pages: e70012-e70012

    • DOI

      10.1371/journal.pone.0070012

    • NAID

      120005328803

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Striatal indirect pathway contributes to selection accuracy of learned motor actions.2012

    • Author(s)
      Nishizawa K
    • Journal Title

      J. Neurosci.

      Volume: 32 Issue: 39 Pages: 13421-13432

    • DOI

      10.1523/jneurosci.1969-12.2012

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Functional properties of dopamine neurons and co-expression of vasoactive-intestinal-polypeptide in the dorsal raphe nucleus and ventro-lateral periaqueductal grey.2012

    • Author(s)
      Dougalis, A.G. et al.
    • Journal Title

      Eur. J. Neurosci.

      Volume: 36 Issue: 10 Pages: 3322-3332

    • DOI

      10.1111/j.1460-9568.2012.08255.x

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Striatal direct pathway modulates response time in execution of visual discrimination.2012

    • Author(s)
      Fukabori R
    • Journal Title

      Eur. J. Neurosci.

      Volume: 35巻 Issue: 5 Pages: 784-797

    • DOI

      10.1111/j.1460-9568.2012.08005.x

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Selective Neural Pathway Targeting Reveals Key Roles of Thalamostriatal Projection in the Control of Visual Discrimination2011

    • Author(s)
      Kato, S.; Kuramochi, M.; Kobayashi, K., et al
    • Journal Title

      Journal of Neuroscience

      Volume: 31(47) Issue: 47 Pages: 17169-17179

    • DOI

      10.1523/jneurosci.4005-11.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Neuron-specific gene transfer through retrograde transport of lentiviral vector pseudotyped with a novel type of fusion envelope glycoprotein2011

    • Author(s)
      Kato S, Kuramochi M, Takasumi K, Kobayashi K, Inoue K, Takahara D, Hitoshi S, Ikenaka K, Shimada T, Takada M, Kobayashi K
    • Journal Title

      Hum Gene Ther

      Volume: 22 Issue: 12 Pages: 1511-1523

    • DOI

      10.1089/hum.2011.111

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Targeting of locus ceruleus noradrenergic neurons expressing human interleukin-2 receptor α-subunit in transgenic mice by a recombinant immunotoxin anti-Tac(Fv)-PE38 : A study for exploring noradrenergic influence upon anxiety-like and depression-like behaviors2011

    • Author(s)
      Itoi, K., et al
    • Journal Title

      J.Neurosci.

      Volume: 31 Issue: 16 Pages: 6132-6139

    • DOI

      10.1523/jneurosci.5188-10.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Compensation of depleted neuronal subsets by new neurons in a local area of the adult olfactory bulb2011

    • Author(s)
      Koshi Murata, Maki Imai, Shigetada Nakanishi, Dai Watanabe, Ira Pastan, Kazuto Kobayashi, Tomoko Nihira, Hideki Mochizuki, Shuichi Yamada, Kensaku Mori, Masahiro Yamaguchi
    • Journal Title

      The Journal of Neuroscience

      Volume: 31 Issue: 29 Pages: 10540-10557

    • DOI

      10.1523/jneurosci.1285-11.2011

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] Dorsal striatal indirect pathway regulates the response selection accuracy in auditory conditional discrimination.2014

    • Author(s)
      Nishizawa, K., Fukabori, R., Okada, K., Uchigashima, M., Watanabe, M., Shiota, A., Ueda, M., Tsutsui, Y., and Kobayashi, K.
    • Organizer
      44th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Washington DC
    • Year and Date
      2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Inhibitory role of cholinergic interneurons in the dorsomedial striatum via muscarinic M4 receptors on reversal and extinction learning.2014

    • Author(s)
      Okada, K., Nishizawa, K., Fukabori, R., Kai, N., Shiota, A., Ueda, M., Tsutsui, Y., Sakata, S., Matsushita, N., and Kobayashi, K.
    • Organizer
      44th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Washington DC
    • Year and Date
      2014-11-19
    • Related Report
      2014 Annual Research Report
  • [Presentation] Improvement of gene transduction efficiency for neuron-specific retrograde gene transfer lentiviral vector with a novel function envelope glycoprotein.2014

    • Author(s)
      Kobayashi, K., Kato, S., and Kobayashi, K.
    • Organizer
      44th Annual Meeting of Society for Neuroscience
    • Place of Presentation
      Washington DC
    • Year and Date
      2014-11-18
    • Related Report
      2014 Annual Research Report
  • [Presentation] 背内側線条体から投射する間接路は固執反応の調節を介して条件付弁別学習の実行を制御2014

    • Author(s)
      西澤佳代、深堀良二、岡田佳奈、内ヶ島基政、渡辺雅彦、塩田 明、上田正次、筒井雄二、小林和人
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 背内側線条体コリン作動性介在ニューロンはムスカリン性M4受容体を介して行動柔軟性を抑制する2014

    • Author(s)
      岡田佳奈、西澤佳代、深堀良二、甲斐信行、塩田 明、上田正次、筒井雄二、坂田省吾、松下夏樹、小林和人
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-12
    • Related Report
      2014 Annual Research Report
  • [Presentation] 大脳皮質-線条体ニューロンの神経生理学的役割2014

    • Author(s)
      佐野裕美、小林憲太、加藤成樹、小林和人、南部 篤
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] 神経細胞特異的な逆行性遺伝子導入を示すレンチウイルスベクターにおける融合糖タンパク質ジャンクションの最適化2014

    • Author(s)
      加藤成樹、小林憲太、小林和人
    • Organizer
      第37回日本神経科学大会
    • Place of Presentation
      横浜
    • Year and Date
      2014-09-11
    • Related Report
      2014 Annual Research Report
  • [Presentation] Behavioral roles of thalamostriatal pathway in sensory discrimination learning.2013

    • Author(s)
      Kobayashi, K.
    • Organizer
      Dopamine 2013
    • Place of Presentation
      Alghero
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Key roles of striatal indirect pathway in response selection accuracy of auditory discrimination.2013

    • Author(s)
      Kobayashi et al.
    • Organizer
      43rd Annual Meeting of Society for Neuroscience
    • Place of Presentation
      San Diego
    • Related Report
      2013 Annual Research Report
  • [Presentation] Distinct behavioral roles of thalamostriatal pathways arising from the central lateral and parafascicular nuclear groups in basal ganglia function.2013

    • Author(s)
      Kato et al.
    • Organizer
      第6回MCCS-Asia シンポジウム
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Behavioral roles of the striatal indirect pathway from the dorsomedial striatum in sensory discrimination task.2013

    • Author(s)
      Nishizawa et al.
    • Organizer
      第6回MCCS-Asia シンポジウム
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 神経回路機能の遺伝子操作と制御に向けたウイルスベクター技術2013

    • Author(s)
      小林和人
    • Organizer
      Neuro2013 第36回日本神経科学大会、第56回日本神経化学会大会、第23回日本神経回路学会大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 聴覚弁別学習の遂行における背内側線条体から投射する線条体投射路の機能解析2013

    • Author(s)
      西澤ら
    • Organizer
      Neuro2013 第36回日本神経科学大会、第56回日本神経化学会大会、第23回日本神経回路学会大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] 視床外側中心核と束傍核から背側線条体へ入力する神経路の行動学的役割に関する比較解析2013

    • Author(s)
      加藤ら
    • Organizer
      Neuro2013 第36回日本神経科学大会、第56回日本神経化学会大会、第23回日本神経回路学会大会
    • Place of Presentation
      京都
    • Related Report
      2013 Annual Research Report
  • [Presentation] Neural circuit mechanism for learning dependent on dopamine transmission.2012

    • Author(s)
      Kazuto Kobayashi
    • Organizer
      10th International Catecholamine Symposium (XICS)
    • Place of Presentation
      California, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Selective ablation of dopamine beta-hydroxylase neurons (subpopulation of TH neurons) in the brain: new insights into brain catecholaminergic circuitry and catecholamine-related diseases.2012

    • Author(s)
      Itoi, K. et al.
    • Organizer
      10th International Catecholamine Symposium (XICS)
    • Place of Presentation
      California, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] Neural pathway–specific targeting reveals essential roles of thalamostriatal pathway in the acquisition and performance of sensory discrimination learning.2012

    • Author(s)
      Kobayashi, K. et al.
    • Organizer
      42nd Annual Meeting of Society for Neuroscience,
    • Place of Presentation
      New Orleans, USA
    • Related Report
      2012 Annual Research Report
  • [Presentation] 学習行動に関わる視床線条体路の機能解析2012

    • Author(s)
      加藤成樹、小林和人
    • Organizer
      第27回日本大脳基底核研究会
    • Place of Presentation
      東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 背内側線条体から投射する線条体黒質路は弁別課題遂行時の反応時間を調整する2012

    • Author(s)
      深堀良二ら
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 背外側線条体から投射する線条体淡蒼球路は聴覚弁別学習の正確な遂行を調節する2012

    • Author(s)
      西澤佳代ら
    • Organizer
      第35回日本神経科学大会
    • Place of Presentation
      名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 高頻度逆行性遺伝子導入ベクターの霊長類脳科学への応用2011

    • Author(s)
      小林和人
    • Organizer
      第34回日本神経科学学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 線条体直接路は弁別課題遂行時の反応速度を調節する2011

    • Author(s)
      深堀良二, 他
    • Organizer
      第34回日本神経科学学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-17
    • Related Report
      2011 Annual Research Report
  • [Presentation] 弁別学習行動における視床-線条体路の機能の研究2011

    • Author(s)
      加藤成樹, 他
    • Organizer
      第34回日本神経科学学会
    • Place of Presentation
      横浜
    • Year and Date
      2011-09-16
    • Related Report
      2011 Annual Research Report
  • [Presentation] Behavioral and physiological roles of straital projection pathways in instrumental learning2011

    • Author(s)
      Kobayashi, K.
    • Organizer
      23^<rd> Biennial meeting of International Society for Neurochemistry (ISN)
    • Place of Presentation
      アテネ
    • Year and Date
      2011-08-31
    • Related Report
      2011 Annual Research Report
  • [Presentation] 分子・細胞標的による脳疾患モデル研究2011

    • Author(s)
      小林和人
    • Organizer
      第6回日本統合失調症学会
    • Place of Presentation
      札幌
    • Year and Date
      2011-07-18
    • Related Report
      2011 Annual Research Report
  • [Book] A New Era of Catecholamines in the Laboratory and Clinic2013

    • Author(s)
      Kobayashi et al.
    • Total Pages
      512
    • Publisher
      Academic Press
    • Related Report
      2013 Annual Research Report
  • [Book] Neuromethods, Controlled Genetic Manipulations2012

    • Author(s)
      Kobayashi, K.
    • Total Pages
      227
    • Publisher
      Humana Press Inc., New York (total page 227)
    • Related Report
      2012 Annual Research Report
  • [Book] Controlled Genetic Manipulations2012

    • Author(s)
      Kobayashi, K., et al
    • Total Pages
      227
    • Publisher
      Neuromethods
    • Related Report
      2011 Annual Research Report
  • [Book] Viral Gene Therapy2011

    • Author(s)
      Kato, S., et al
    • Total Pages
      450
    • Publisher
      InTech
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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