Long-lasting synaptic plasticity mediated by yin-yang effect of BDNF and proBDNF
| Project/Area Number |
23300132
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Neurochemistry/Neuropharmacology
|
|---|
| Research Institution | Osaka University |
|---|
Principal Investigator |
OGURA Akihiko 大阪大学, 生命機能研究科, 教授 (30260631)
|
|---|
| Co-Investigator(Kenkyū-buntansha) |
TOMINAGA Keiko (YOSHINO Keiko) 大阪大学, 大学院・生命機能研究科, 准教授 (60256196)
|
|---|
| Co-Investigator(Renkei-kenkyūsha) |
KOJIMA Masami 産業技術総合研究所, 関西センターセルエンジニアリング研究部門, グループ長 (40344171)
|
|---|
| Project Period (FY) |
2011-04-01 – 2014-03-31
|
| Project Status |
Completed (Fiscal Year 2013)
|
| Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2013: ¥4,160,000 (Direct Cost: ¥3,200,000、Indirect Cost: ¥960,000)
Fiscal Year 2012: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2011: ¥9,230,000 (Direct Cost: ¥7,100,000、Indirect Cost: ¥2,130,000)
|
|---|
| Keywords | 記憶 / シナプス新生 / シナプス廃止 / BDNF / proBDNF / 脳切片培養 / 記憶固定 / 構造可塑性 / シナプス可塑性 / 長期記憶 / 恐怖学習 / 遺伝子改変マウス / TrkB / p75 / ゆらぎ |
|---|
| Research Abstract |
Brain memory is established through 2 steps; acquisition and consolidation, the cellular mechanisms of the former step have been well analyzed using LTP (long-term potentiation) and LTD (long-term depression) as model phenomena for analysis, while those of the latter remain unclear. We previously reported in the stable cultures of hippocampal slice that 3 repeated inductions of LTP and LTD lead to the long-lasting strengthening and weakening of neuronal circuit supported by new synapse formation and elimination, respectively. In the present research, we demonstrated that the synapse formation is mediated by a BDNF (brain-derived neurotrophic factor)-TrkB signaling pathway, while the synapse elimination is mediated by a proBDNF (precursor protein of BDNF)-p75 pathway. Since BDNF and proBDNF are the products of a single gene, the apparently opposite cellular events are regulated by epigenetic regulation, this fact may provoke a paradigm shift in memory research.
|
Report
(4 results)
Research Products
(59 results)
-
-
-
-
-
-
-
-
[Journal Article] A simplified method to generate serotonergic neurons from mouse embryonic stem and induced pluripotent stem cells2012
Author(s)
Shimada T,Takai Y, Shinohara K, Yamasaki A, Tominaga-Yoshino K, Ogura A, Toi A, Asano K, Shintani N, Hayata-Takano A, Baba A, Hashimoto H
-
Journal Title
J. Neurochem
Volume: 122
Pages: 81-93
Related Report
Peer Reviewed
-
[Journal Article] A simplified Method to Generate Serotonergic Neurons from mouse Embryonic Stem and Induced Pluripotent stem cells2012
Author(s)
Shimada T, Takai Y, Shinohara K, Yamasaki A, Tominaga-Yoshino K, Ogura A, Toi A, Asano K, Shintani N, Hayata-Takano A, Baba A, Hashimoto H
-
Journal Title
Journal of Neurochemistry
Volume: 122
Issue: 1
Pages: 81-93
DOI
Related Report
Peer Reviewed
-
-
-
-
[Journal Article] Effects of creatine and its analogue, beta-guanidinopropionic acid on the differentiation and nucleoli in myoblasts2011
Author(s)
Ohira, Y., Matsuoka, Y., Kawano, F., Ogura, A., Higo, Y., Ohira, T., Terada, M., Oke, Y., Nakai, N.
-
Journal Title
Biosci.Biotech.Biochem.
Volume: 75
Pages: 1085-1089
Related Report
Peer Reviewed
-
-
[Journal Article] Region-specific responses of adductor longus muscle to gravitational load-dependent activity in Wistar Hannover rats2011
Author(s)
Ohira, T., Wang, X.D., Terada, M., Kawano, E, Nakai, N., Ogura, A., Ohira, Y.
-
Journal Title
Related Report
Peer Reviewed
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
-
