Localization of excitatory and inhibitory astrocytes, and their generation mechanism
| Project/Area Number |
23300136
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurochemistry/Neuropharmacology
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| Research Institution | National Institute for Physiological Sciences |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
FURUYA Kishio 名古屋大学, 工学(系)研究科(研究院), 研究員 (40132740)
NAMIKI Shigeyuki 東京大学, 医学(系)研究科(研究院), 助教 (90452193)
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| Co-Investigator(Renkei-kenkyūsha) |
TANAKA Kenji 生理学研究所, 分子生理研究系, 助教 (30329700)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥19,890,000 (Direct Cost: ¥15,300,000、Indirect Cost: ¥4,590,000)
Fiscal Year 2013: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2011: ¥7,410,000 (Direct Cost: ¥5,700,000、Indirect Cost: ¥1,710,000)
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| Keywords | ＡＴＰ / グルタミン酸 / イメージング / アストロサイト / 神経科学 / 薬理学 / ATP |
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| Research Abstract |
We succeeded in observing ATP release from astrocytes in brain slices. This release occurred in a region specific manner, suggesting that ATP-releasing astrocytes regulate neural circuit activity. Pharmaceutical analysis indicated that this ATP release from astrocytes induced by the glutamate addition does not depend on the exocytosis but more depends on the release through channels.
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Report
(4 results)
Research Products
(16 results)
