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Molecular basis for the secondary neural circuit formation in the mouse olfactory system

Research Project

Project/Area Number 23300140
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Neurophysiology and muscle physiology
Research InstitutionThe University of Tokyo

Principal Investigator

NISHZIUMI Hirofumi  東京大学, 理学(系)研究科(研究院), 助教 (30292832)

Project Period (FY) 2011-11-18 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥11,050,000 (Direct Cost: ¥8,500,000、Indirect Cost: ¥2,550,000)
Fiscal Year 2013: ¥5,330,000 (Direct Cost: ¥4,100,000、Indirect Cost: ¥1,230,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Keywords嗅覚 / 遺伝子改変マウス / 神経回路形成 / シナプス結合 / 再生 / シナプス形成 / 二光子レーザー顕微鏡
Research Abstract

In the mouse olfactory system, map topography is largely established by axon-axon interactions of olfactory sensory neurons (OSNs). However, to make the map functional, the OSNs must make proper connections to the mitral/tufted (M/T) cells. Then, how do the M/T cell dendrites find their partner glomeruli for synapse formation with OSN axons? Does the odorant receptor (OR) specificity of glomeruli play an instructive role in matching M/T cell dendrites with OSN axons? To address these questions, we analyzed dendrite selection and synapse formation of mitral cells in various mutant mice in which glomerular formation was perturbed. We also studied synapse reconstitution in adult glomeruli. Our present results support the "proximity model", whereby mitral cells tend to connect primary dendrites to the nearest neighboring glomeruli regardless of OR specificity. The map location or address code of glomeruli plays a key role in matching mitral cells with their partner glomeruli.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (15 results)

All 2013 2012 2011 Other

All Journal Article (3 results) (of which Peer Reviewed: 3 results) Presentation (10 results) Remarks (2 results)

  • [Journal Article] Agonist-independent GPCR activity regulates anterior-posterior targeting of olfactory sensory neurons2013

    • Author(s)
      Nakashima A., Takeuchi H., Imai T., Saito H., Kiyonari H., Abe T., Chen A., Weinstein L.S., Yu C.R., Storm D.R., Nishizumi H., and Sakano H
    • Journal Title

      Cell

      Volume: 154 Issue: 6 Pages: 1314-1325

    • DOI

      10.1016/j.cell.2013.08.033

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Possible roles of Robo1^<+> ensheathing cells in guiding dorsal-zone olfactory sensory neurons in mouse2013

    • Author(s)
      Aoki M., Takeuchi H., Nakashima A., Nishizumi H., and Sakano H
    • Journal Title

      Dev. Neurobiol

      Volume: 73 Issue: 11 Pages: 828-840

    • DOI

      10.1002/dneu.22103

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] A major allogenic leukocyte antigen in the agnathan hagfish.2013

    • Author(s)
      Hiroyuki Takaba
    • Journal Title

      Scientific Reports

      Volume: 3 Issue: 1 Pages: 1716-1716

    • DOI

      10.1038/srep01716

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Presentation] Genetic manipulation of aversive olfactory circuits in mouse2013

    • Author(s)
      西住裕文
    • Organizer
      JST Mini-Meeting
    • Place of Presentation
      東京
    • Year and Date
      2013-02-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Formation and maintenance of the mouse olfactory map2013

    • Author(s)
      西住裕文
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] Formation and maintenance of the mouse olfactory map2013

    • Author(s)
      Nishizumi H. and Sakano H.
    • Organizer
      第36回 日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド(兵庫県)
    • Related Report
      2013 Annual Research Report
  • [Presentation] マウス嗅覚神経回路の形成と再生の分子機構2012

    • Author(s)
      西住裕文
    • Organizer
      日本応用酵素協会 第38回研究発表会
    • Place of Presentation
      大阪
    • Year and Date
      2012-11-19
    • Related Report
      2013 Final Research Report
  • [Presentation] Formation and maintenance of the mouse olfactory map2011

    • Author(s)
      西住裕文
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] Formation and maintenance of the mouse olfactory map2011

    • Author(s)
      西住裕文
    • Organizer
      International Conference on Frontiers in Neuroscience : From Brain to Mind
    • Place of Presentation
      京都
    • Related Report
      2013 Final Research Report
  • [Presentation] Formation and maintenance of the mouse olfactory map2011

    • Author(s)
      西住裕文
    • Organizer
      International Conference on Frontiers in Neuroscience: From Brain to Mind
    • Place of Presentation
      国際高等研究所 (京都府)
    • Related Report
      2011 Annual Research Report
  • [Presentation] Formation and maintenance of the mouse olfactory map2011

    • Author(s)
      西住裕文
    • Organizer
      第34回 日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜 (神奈川県)
    • Related Report
      2011 Annual Research Report
  • [Presentation] マウス嗅覚神経回路の形成と再生の分子機構

    • Author(s)
      西住裕文
    • Organizer
      日本応用酵素協会 第38回研究発表会
    • Place of Presentation
      ホテル阪急インターナショナル大阪 (大阪府)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Genetic manipulation of aversive olfactory circuits in mouse

    • Author(s)
      西住裕文
    • Organizer
      JST Mini-Meeting
    • Place of Presentation
      東京大学医学部 (東京都)
    • Related Report
      2012 Annual Research Report
  • [Remarks]

    • URL

      http://www.s.u-tokyo.ac.jp/ja/press/2013/42.html

    • Related Report
      2013 Final Research Report
  • [Remarks] 刺激によらないGPCR基礎活性の機能を初めて解明(嗅覚受容体の基礎活性による嗅神経回路の形成)

    • URL

      http://www.s.u-tokyo.ac.jp/ja/press/2013/42.html

    • Related Report
      2013 Annual Research Report

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Published: 2013-05-15   Modified: 2019-07-29  

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