Function of spinal neural circuit for generating muscle activities
| Project/Area Number |
23300143
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Neurophysiology and muscle physiology
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| Research Institution | National Center of Neurology and Psychiatry |
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Principal Investigator |
SEKI Kazuhiko 独立行政法人国立精神・神経医療研究センター, 神経研究所 モデル動物開発研究部, 部長 (00226630)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥20,150,000 (Direct Cost: ¥15,500,000、Indirect Cost: ¥4,650,000)
Fiscal Year 2013: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2012: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
Fiscal Year 2011: ¥8,450,000 (Direct Cost: ¥6,500,000、Indirect Cost: ¥1,950,000)
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| Keywords | 脊髄 / 下降路 / 抑制性 / 霊長類 / 反射 / 介在ニューロン / 随意運動 / 上肢 / シナジー / 無麻酔 / 手首運動 / 抑制性ニューロン / シナプス前抑制 / 筋電図 |
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| Research Abstract |
In monkeys performing precision grip task, we recorded activity from the cervical spinal cordsimultaneously with electromyographic (EMG) activity from hand and arm muscles during the task. Most PreM-INs (23/25) displayed movement-related firing rate modulations: 11 had phasic followed by tonic facilitation (p+t+); 4 were pure phasic; 4 were pure tonic; and 4 were deactivated, while their target muscles consistently had p+t+ activity (65/66 muscles). Results indicated that several neural pathway could be mediated by the spinal PreM-INs makes a significant contribution to the control of precision grip in primates. For detecting the descending signal mediated by spinal Ins, we identified 251 M1 and 90 rubrospinal neurons, and extracted muscle synergies using non-negative matrix factorization from the EMG signals. Clustering analysis of the PreM connection patterns of the populations indicate each PreM population can provide a neuronal underpinning of muscle synergies in contrasting ways.
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Report
(4 results)
Research Products
(45 results)
