| Budget Amount *help |
¥19,500,000 (Direct Cost: ¥15,000,000、Indirect Cost: ¥4,500,000)
Fiscal Year 2014: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Fiscal Year 2013: ¥4,940,000 (Direct Cost: ¥3,800,000、Indirect Cost: ¥1,140,000)
Fiscal Year 2012: ¥4,290,000 (Direct Cost: ¥3,300,000、Indirect Cost: ¥990,000)
Fiscal Year 2011: ¥3,250,000 (Direct Cost: ¥2,500,000、Indirect Cost: ¥750,000)
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| Outline of Final Research Achievements |
It takes more than 20 years to build up Alzheimer-related histological features in the brains of nonhuman primates. Therefore, an artificial primate model would be required to improve it. We planned that Adeno-associated virus vector recombined with a candidate gene (Sweden type APP) for onset of Alzheimer disease inoculated to 3 months old mice. As a result, the inoculated mice increased to secrete A beta 1-40 more than control mice. Since this recombined viral vector possesses an ability of hyper expression of A beta, we attempt now to inoculate the vector and are checking the effect of it using cynomolgus monkeys.
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