Role of macrophages in the pathogenesis of HIV-1 infection
| Project/Area Number |
23300156
|
|---|
| Research Category |
Grant-in-Aid for Scientific Research (B)
|
| Allocation Type | Single-year Grants |
|---|
| Section | 一般 |
|---|
| Research Field |
Laboratory animal science
|
|---|
| Research Institution | Kyoto University |
|---|
Principal Investigator |
|
|---|
| Project Period (FY) |
2011-04-01 – 2015-03-31
|
| Project Status |
Completed (Fiscal Year 2014)
|
| Budget Amount *help |
¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
|
|---|
| Keywords | HIV / エイズ / マクロファージ / 多剤併用療法 / 半減期 / SHIV / リザーバー / ウイルス / 疾患モデル / リンパ球 / 抗ウイルス剤 / RNA / 減衰率 / ウイルス量 / 血液 |
|---|
| Outline of Final Research Achievements |
Macrophages have been known to be one of the major target cell types for HIV-1, the causative agent of AIDS. However, there are no available data concerning half-life of infected macrophages in infected individuals. Applying combined anti-retroviral regimen to SHIV-rhesus macaque model for AIDS, we revealed that there were at least three populations of infected macrophages with distinct half-lives and that the most durable population was consisted of M2 type macrophages. It is conceivable that specific intervention of these cells would contribute to the cure for the disease.
|
Report
(4 results)
Research Products
(3 results)
