| Budget Amount *help |
¥20,540,000 (Direct Cost: ¥15,800,000、Indirect Cost: ¥4,740,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥9,100,000 (Direct Cost: ¥7,000,000、Indirect Cost: ¥2,100,000)
Fiscal Year 2011: ¥8,320,000 (Direct Cost: ¥6,400,000、Indirect Cost: ¥1,920,000)
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| Outline of Final Research Achievements |
Macrophages have been known to be one of the major target cell types for HIV-1, the causative agent of AIDS. However, there are no available data concerning half-life of infected macrophages in infected individuals. Applying combined anti-retroviral regimen to SHIV-rhesus macaque model for AIDS, we revealed that there were at least three populations of infected macrophages with distinct half-lives and that the most durable population was consisted of M2 type macrophages. It is conceivable that specific intervention of these cells would contribute to the cure for the disease.
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