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Establishment of Cre-driver mouse lines by using the Exchangeable Gene Trap Ckones.

Research Project

Project/Area Number 23300159
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Laboratory animal science
Research InstitutionKumamoto University

Principal Investigator

ARAKI Masatake  熊本大学, 生命資源研究・支援センター, 准教授 (80271609)

Co-Investigator(Kenkyū-buntansha) ARAKI Kimi  熊本大学, 生命資源研究・支援センター, 准教授 (90211705)
YOSHINOBU Kumiko  熊本大学, 生命資源研究・支援センター, 助教 (20274730)
YOSHIKI Atusi  独立行政法人理化学研究所, 実験動物開発室, 室長 (40212310)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥20,280,000 (Direct Cost: ¥15,600,000、Indirect Cost: ¥4,680,000)
Fiscal Year 2013: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2012: ¥6,500,000 (Direct Cost: ¥5,000,000、Indirect Cost: ¥1,500,000)
Fiscal Year 2011: ¥7,280,000 (Direct Cost: ¥5,600,000、Indirect Cost: ¥1,680,000)
Keywords遺伝子 / バイオリソース / 遺伝子改変マウス / Cre-driver / X-gal染色 / 国際情報交換 / 多国籍 / Cre driver / データベース
Research Abstract

Gene targeting in embryonic stem cells has become the principal technology for manipulation of the mouse genome, most protein coding genes are producing conditional knock out allele. However a variety of Cre driver mouse line, which has an important role about conditional knock out system, is not enough.
We have developed Database for the Exchangeable Gene Trap Clones; EGTC (http://egtc.jp). In our system, reporter beta-geo gene can be exchanged into any other DNA of interest through Cre-mediated recombination.
We have produced more than 300 Cre driver ES cell lines using EGTC ES cells. Among them, about 250 clones were provided to make chimeric mice, and more than 100 mouse lines could be established. Then we did mating of Cre driver mice with ROSA26R mice, and performed X-gal staining of ROSA26R mice with Cre driver allele. Among them, 21-T188SACre mouse line exhibited the cerebellum specific expression pattern.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (84 results)

All 2014 2013 2012 2011 2010 Other

All Journal Article (35 results) (of which Peer Reviewed: 35 results) Presentation (38 results) Remarks (6 results) Patent(Industrial Property Rights) (5 results) (of which Overseas: 4 results)

  • [Journal Article] NRBF2 regulates autophagy and prevents liver injury by modulating Atg14L-linked phosphatidylinositol-3 kinase III activity2014

    • Author(s)
      Lu, J., He, L., Behrends, C., Araki, M., Araki, K., Jun Wang, Q., Catanzaro, J. M., Friedman, S. L., Zong, W. X., Fiel, M. I., Li, M., Yue, Z
    • Journal Title

      Nat. Commun

      Volume: 5 Pages: 3920-3920

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Conformational Change in Transfer RNA Is an Early Indicator of Acute Cellular Damage2014

    • Author(s)
      Mishima, E., Inoue, C., Saigusa, D., Inoue, R., Ito, K., Suzuki, Y., Jinno, D., Tsukui, Y., Akamatsu, Y., Araki, M., Araki, K., Shimizu, R., Shinke, H., Suzuki, T., Takeuchi, Y., Shima, H., Akiyama, Y., Toyohara, T., Suzuki, C., Saiki, Y., Tominaga, T., Miyagi, S., Kawagisihi, N., Soga, T., Ohkubo, T., Yamamura, K., Imai, Y., Masuda, S., Sabbisetti, V., Ichimura, T., Mount, D. B., Bonventre, J. V., Ito, S., Tomioka, Y., Itoh, K., Abe, T
    • Journal Title

      J. Am. Soc. Nephrol

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Database for exchangeable gene trap clones : Pathway and gene ontology analysis of exchangeable gene trap clone mouse lines2014

    • Author(s)
      Araki, M., Nakahara, M., Muta, M., Itou, M., Yanai, C., Yamazoe, F., Miyake, M., Morita, A., Araki, M., Okamoto, Y., Nakagata, N., Yoshinobu, K., Yamamura, K., Araki, K
    • Journal Title

      Dev. Growth Differ

      Volume: 56 Pages: 161-174

    • NAID

      40019987325

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The intramembrane proteases Signal-peptide-peptidase-like 2a and b (SPPL2a/b) have distinct functions in vivo2014

    • Author(s)
      Schneppenheim, J., Huttl, S., Mentrup, T., Lullmann-Rauch, R., Rothaug, M., Engelke, M., Dittmann, K., Dressel, R., Araki, M., Araki, K., Wienands, J., Fluhrer, R., Saftig, P., Schroder, B
    • Journal Title

      Mol. Cell. Biol

      Volume: 34(8) Pages: 1398-1411

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The intramembrane proteases Signal-peptide-peptidase-like 2a and b (SPPL2a/b) have distinct functions in vivo.2014

    • Author(s)
      Schneppenheim, J., Hutti, S., Mentrup, T., Lullmann-Rauch, R., Rothaug, M., Engeike, M., Dittmann, K., Dressel, R., Araki, M., Araki, K., Wienands, J., Fluhrer, R., Saftig, P. and Schroder, B.
    • Journal Title

      Mol. Cell Biol.

      Volume: 34 (8) Pages: 1398-1411

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Database for exchangeable gene trap clones: pathway and gene ontology analysis of exchangeable gene trap clone mouse lines.2014

    • Author(s)
      Araki, M., Nakahara, M., Muta, M., Itou, M., Yanai, C., Yamazoe, F., Miyake, M., Morita, A., Araki, M., Okamoto, Y., Nakagata, N., Yoshinobu, K., Yamamura, K. and Araki, K.
    • Journal Title

      Dev. Growth Differ.

      Volume: 56 (2) Pages: 161-174

    • NAID

      40019987325

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Autophagy regulation in pancreatic acinar cells is independent of epidermal growth factor receptor signaling.2014

    • Author(s)
      Ozaki, N., Fikuchi, Y., Tomiyoshi, SR., Uehara, H., Ida, S., Wang, J., Araki, K., Sibilia, M., Baba, H., Yamamura, K. and Ohmuraya, M.
    • Journal Title

      Biochem. Biophys. Res. Commun.

      Volume: 446 (1) Pages: 224-230

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The kick-in system: a novel rapid knock-in strategy2014

    • Author(s)
      Tomonoh, Y., Deshimaru, M., Araki, K., Miyazaki, Y., Arasaki, T., Tanaka, Y., Kitamura, H., Mori, F., Wakabayashi, K., Yamashita, S., Aaito, R., Itoh, M., Uchida, T., Yamada, J., Migita, K., Ueno, S., Kitaura, H., Kakita, A., Lossin, C., Takano, Y. and Hirose, S.
    • Journal Title

      PLoS One

      Volume: 9 (2)

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Loss of mTOR complex 1 induces developmental blockage in early T-lymphopoiesis and eradicates T-cell acute lymphoblastic leukemia cells.2014

    • Author(s)
      Hoshii, T., Kasada, A., Hatakeyama, T., Ohtani, M., Tadokoro, Y., Naka, K., Ikenoue, T., Ikawa, T., Kawamoto, H., Fehling, HJ., Araki, K., Yamamura, K., Matsuda, S. and Hirano, A.
    • Journal Title

      Proc. Natl. Acad. Sci. USA

      Volume: 111 (10) Pages: 3805-3810

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Generation and analysis of serine protease inhibitor kazal type 3-cre driver mice2014

    • Author(s)
      Sakata, K., Ohmuraya, M., Araki, K., Suzuki, C., Ida, S., Hashimoto, D., Wang, J., Uchiyama, Y., Baba, H. and Yamamura, K.
    • Journal Title

      Exp. Anim.

      Volume: 63 (1) Pages: 45-53

    • NAID

      130003391605

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] VMAT2 identified as a regulator of late-stage beta-cell differentiation2014

    • Author(s)
      Sakano, D., Shiraki, N., Kikawa, K., Yamazoe, T., Kataoka, M., Umeda, K., Araki, K., Mao, D., Matsumoto, S., Nakagata, N., Andersson, O., Stainier, D., Endo, F., Kume, K., Uesugi, M. and Kume, S.
    • Journal Title

      Nat. Chem. Biol.

      Volume: 10 (2) Pages: 141-148

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ectopic Expression of Ptf1a Induces Spinal Defects, Urogenital Defects, and Anorectal Malformations in Danforth's Short Tail Mice2013

    • Author(s)
      Kei Semba, Kimi Araki, Ken-ichirou Matsumoto, Hiroko Suda, Takashi Ando, Akira Sei, Hiroshi Mizuta, Katsumasa Takagi, Mai Nakahara, Mayumi Muta, Gen Yamada, Naomi Nakagata, Aritoshi Iida, Shiro Ikegawa, Yusuke Nakamura, Masatake Araki, Kuniya Abe, Ken-ichi Yamamura
    • Journal Title

      PLoS Genetics

      Volume: 9

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice2013

    • Author(s)
      Nakahara, M., Tateyama, H., Araki, M., Nakagata, N., Yamamura, K., Araki, K
    • Journal Title

      Mamm. Genome

      Volume: 24 Pages: 228-239

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment2013

    • Author(s)
      Kappei, D., Butter, F., Benda, C., Scheibe, M., Draskovic, I., Stevense, M., Novo, C. L., Basquin, C., Araki, M., Araki, K., Krastev, D. B., Kittler, R., Jessberger, R., Londono-Vallejo, J. A., Mann, M., Buchholz, F
    • Journal Title

      EMBO J

      Volume: 32 Pages: 1682-1701

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] TASK-2 : a K2P K(+) channel with complex regulation and diverse physiological functions2013

    • Author(s)
      Cid, L. P., Roa-Rojas, H. A., Niemeyer, M. I., Gonzalez, W., Araki, M., Araki, K., Sepulveda, F. V
    • Journal Title

      Front. Physiol

      Volume: 4 Pages: 198-198

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of CD99 with its paralog CD99L2 positively regulates CD99L2 trafficking to cell surfaces2013

    • Author(s)
      Nam, G., Lee, Y. K., Lee, H. Y., Ma, M. J., Araki, M., Araki, K., Lee, S., Lee, I. S., Choi, E. Y
    • Journal Title

      J. Immunol

      Volume: 191 Pages: 5730-5742

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] Interaction of CD99 with its paralog CD99L2 positively regulates CD99L2 trafficking to cell surfaces.2013

    • Author(s)
      Nam, G., Lee, YK., Lee, HY., Ma, MJ., Araki, M., Araki, K., Lee, S., Lee, IS. and Choi, EY.
    • Journal Title

      J. Immunol.

      Volume: 191 (11) Pages: 5730-5742

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] TASK-2: a K2P K(+) channel with complex regulation and diverse physiological functions.2013

    • Author(s)
      Cid, LP., Roa-Rojs, HA., Niemeyer, MI., Gonzalez, W., Araki, M., Araki, K. and Sepulveda, FV.
    • Journal Title

      Front Physiol.

      Volume: 29 July Pages: 198-198

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] HOT1 is a mammalian direct telomere repeat-binding protein contributing to telomerase recruitment.2013

    • Author(s)
      Kappei, D., Butter, F., Benda, C., Scheibe, M., Draskovic, I., Stevense, M., Novo, CL., Basquin, C., Araki, M., Araki, K., Krastev, DB., Kittler, R., Jessberger, R., Londofio-Vallejo, JA., Mann, M. and Buchholz, F.
    • Journal Title

      EMBO J.

      Volume: 32 (12) Pages: 1681-1701

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Gene-trap mutagenesis using Mol/MSM-1 embryonic stem cells from MSM/Ms mice.2013

    • Author(s)
      Nakahara, M., Tateyama, H., Araki, M., Nakagata, N., Yamamura, K. and Araki, K.
    • Journal Title

      Mamm. Genome

      Volume: 24 Pages: 228-239

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Novel ROSA26 Cre-reporter knock-in C57BL/6N mice exhibiting green emission before and red emission after Cre-mediated recombination.2013

    • Author(s)
      Hasegawa, Y., Daitoku, Y., Sekiguchi, K., Tanimoto, Y., Mizuno-Iijima, S., Kajiwara, N., Ema, M., Miwa, Y., Mekada, K., Yoshiki, A., Takahashi, S., Sugiyama, F. and Yagami, K.
    • Journal Title

      Exp. Anim.

      Volume: 62 (4) Pages: 295-304

    • NAID

      130003382716

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] CD99-Dependent Expansion of Myeloid-Derived Suppressor Cells and Attenuation of Graft-Versus-Host Disease2012

    • Author(s)
      Park H. J., Byun D., Lee A. H., Kim J. H., Ban Y. L., Araki, M., Araki, K., Yamamura, K. I., Kim I., Park S. H., Jung, K. C
    • Journal Title

      Molecules and Cells

      Volume: 33 Pages: 259-267

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Ectopic expression of Ptf1a induces spinal defects, urogenital defects and anorectal malformations in Danforth's short tail mice.2012

    • Author(s)
      Semba, K., Araki, K., Matsumoto, K.-I., Suda, H., Ando, T. Sei, A., Mizuta, H., Takagi, K., Nakahara, M., Muta, M., Yamada, G., Nakagata, N., Iida, A., Ikegawa, Y., Araki, M., Abe, K. and Yamamura, K.
    • Journal Title

      PLoS Genet.

      Volume: Vol.9 Issue: 2 Pages: 1-17

    • DOI

      10.1371/journal.pgen.1003204

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Cre Knock-in Mouse Line on the Sickle Tail Locus Induces Recombination in the Notochord and Intervertebral Discs.2012

    • Author(s)
      Abe, K. et al.
    • Journal Title

      Genesis

      Volume: 50 Issue: 10 Pages: 758-765

    • DOI

      10.1002/dvg.22035

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] mTORC1is essential for leukemia propagation but not stem cell self-renewal.2012

    • Author(s)
      Hoshii. T
    • Journal Title

      J Clin Invest.

      Volume: 122 Issue: 6 Pages: 2114-2129

    • DOI

      10.1172/jci62279

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 自然哺乳子ウシから分離されたLactobacillus amylovorus Strain Kumamoto (JCM14931)の整腸剤としての可能性.2012

    • Author(s)
      武井直樹
    • Journal Title

      Animal Behaviour and Management

      Volume: 48 Pages: 125-134

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IGSF4 is a novel TCR zeta-chain-interacting protein that enhances TCR-mediated signaling2011

    • Author(s)
      Kim, H. R., Leon, B. H.,Im S. H., Araki, M., Araki, K., Yamamura, K. I., Choi S. C., Park D. S., Jun, C. D
    • Journal Title

      J. Exp. Med

      Volume: 208 Pages: 2545-2560

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] NSrp70 is a novel nuclear speckle-related protein that modulates alternative pre-mRNA splicing in vivo2011

    • Author(s)
      Kim, Y. D., Lee, J. Y., Oh, K. M., Araki, M., Araki, K., Yamamura, K., Jun, C. D
    • Journal Title

      Nucleic Acids Res

      Volume: 39(10) Pages: 4300-4314

    • Related Report
      2013 Final Research Report
    • Peer Reviewed
  • [Journal Article] The floor plate is sufficient for development of the sclerotome and spine without the notochord2011

    • Author(s)
      Takashi Ando
    • Journal Title

      Mechanism of development

      Volume: 128 Pages: 129-140

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The Skt gene, required for anorectal development, is a candidate for a molecular marker of the cloacal plate2011

    • Author(s)
      Hiroko Suda
    • Journal Title

      Pediatric Surgery International

      Volume: 27 Pages: 269-273

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] NSrp70 is a novel nuclea speckle-related protein that modulates alternative pre-mRNA splicing in vivo2011

    • Author(s)
      Young-Dae Kim
    • Journal Title

      Nucleic Acids Research

      Volume: 39 Pages: 4300-4314

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] IGSF4 is a novel TCR zeta-chain-interacting protein that enhances TCR-mediated signaling2011

    • Author(s)
      Hye-Ran Kim
    • Journal Title

      Journal of Experimental Medicine

      Volume: 208 Pages: 2545-2560

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Angiopoietin-like protein 2 is an important facilitator of inflammatory carcinogenesis and metastasis2011

    • Author(s)
      Jun Aoi
    • Journal Title

      Cancer Res

      Volume: 71 Pages: 7502-7512

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Essential roles of androgen signaling in Wolffian duct stabilization and epididymal cell differentiation2011

    • Author(s)
      Aki Murashima
    • Journal Title

      Endocrinology

      Volume: 152 Pages: 1640-1651

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] The cell cycle regulator Cdh1 controls the pool sizes of hematopoietic stem cells and mature lineage progenitors by protecting from genotoxic stress2011

    • Author(s)
      Jo Ishizawa
    • Journal Title

      Cancer Science

      Volume: 102 Pages: 967-974

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] 可変型遺伝子トラップクローンの進展2013

    • Author(s)
      吉信公美子, 來海葉子, 慶田貴子, 古閑成美, 中原舞, 山村研一, 荒木喜美, 荒木正健
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸
    • Related Report
      2013 Final Research Report
  • [Presentation] 可変型遺伝子トラップクローンを利用したCre-driver マウスの作製2013

    • Author(s)
      荒木喜美, 森田彩香, 宮家幹子, 吉信公美子, 來海葉子, 古閑成美, 中潟直己, 村上亜弓, 門田雅世, 目加田和之, 吉木淳, 荒木正健
    • Organizer
      第60回日本実験動物学会総会
    • Place of Presentation
      つくば
    • Related Report
      2013 Final Research Report
  • [Presentation] 可変型遺伝子トラップクローンを利用したCre-driverマウスの作製2013

    • Author(s)
      荒木喜美、森田彩香、宮家幹子、吉信公美子、来海葉子、慶田貴子、古閑成美、中潟直己、村上亜弓、門田雅世、目加田和之、吉木淳、荒木正健
    • Organizer
      第60回日本実験動物学会総会
    • Place of Presentation
      つくば国際会議場
    • Related Report
      2013 Annual Research Report
  • [Presentation] Analysis of gene-trap mouse lines trapping long non-coding RNA genes. (Part 1)2013

    • Author(s)
      柳井千佳、山添史雅、中原舞、宮家幹子、森田彩香、荒木美幸、岡本頼幸、伊東春香、山村研一、吉信公美子、荒木正健、荒木喜美
    • Organizer
      第27回モロシヌス研究会
    • Place of Presentation
      筑波山 江戸家
    • Related Report
      2013 Annual Research Report
  • [Presentation] Analysis of gene-trap mouse lines trapping long non-coding RNA genes. (Part 2)2013

    • Author(s)
      山添史雅、柳井千佳、中原舞、宮家幹子、森田彩香、荒木美幸、岡本頼幸、伊藤春香、山村研一、吉信公美子、荒木正健、荒木喜美
    • Organizer
      第27回モロシヌス研究会
    • Place of Presentation
      筑波山 江戸家
    • Related Report
      2013 Annual Research Report
  • [Presentation] 遺伝子トラップマウスを用いたlincRNAの機能解析2013

    • Author(s)
      中原舞、山添史雅、柳井千佳、吉信公美子、山村研一、荒木正健、荒木喜美
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Annual Research Report
  • [Presentation] 可変型遺伝子トラップクローンの進展2013

    • Author(s)
      吉信公美子,來海葉子,慶田貴子,古閑 美,中原舞,山村研一,荒木喜美,荒木正健
    • Organizer
      第36回日本分子生物学会年会
    • Place of Presentation
      神戸ポートアイランド
    • Related Report
      2013 Annual Research Report
  • [Presentation] 可変型遺伝子トラップ法を用いた骨代謝疾患に関与する新規遺伝子の探索2013

    • Author(s)
      関本朝久、黒木修司、舩元太郎、大田智美、中村志保子、濱田浩朗、山村研一、中原舞、荒木喜美、荒木正健、帖佐悦男
    • Organizer
      第86回日本整形外科学会学術総会
    • Place of Presentation
      広島グリーンアリーナ
    • Related Report
      2013 Annual Research Report
  • [Presentation] 可変型遺伝子トラップ法を用いたNedd4の骨代謝における機能解析2013

    • Author(s)
      舩元太郎、関本朝久、黒木修司、大田智美、中村志保子、山村研一、中原舞、荒木喜美、荒木正健、帖佐悦男
    • Organizer
      第86回日本整形外科学会学術総会
    • Place of Presentation
      広島グリーンアリーナ
    • Related Report
      2013 Annual Research Report
  • [Presentation] 可変型遺伝子トラップ法を用いたEPLIN遺伝子の骨代謝における機能解析2013

    • Author(s)
      黒木修司、関本朝久、舩元太郎、大田智美、中村志保子、山村研一、中原舞、荒木喜美、荒木正健、帖佐悦男
    • Organizer
      第86回日本整形外科学会学術総会
    • Place of Presentation
      広島グリーンアリーナ
    • Related Report
      2013 Annual Research Report
  • [Presentation] 可変型遺伝子トラップ法を用いた骨代謝疾患に関与する新規遺伝子の探索2013

    • Author(s)
      大田智美、関本朝久、舩元太郎、黒木修司、中村志保子、山村研一、中原舞、荒木善美、荒木正健、帖佐悦男
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      千葉・幕張メッセ
    • Related Report
      2013 Annual Research Report
  • [Presentation] 可変型遺伝子トラップ法を用いたLima1/EPLINの骨代謝における機能解析2013

    • Author(s)
      黒木修司、関本朝久、舩元太郎、大田智美、中村志保子、山村研一、中原舞、荒木喜美、荒木正健、帖佐悦男
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      千葉・幕張メッセ
    • Related Report
      2013 Annual Research Report
  • [Presentation] 可変型遺伝子トラップ法で作製したNedd4欠損マウスは骨量減少を示す2013

    • Author(s)
      舩元太郎、関本朝久、黒木修司、大田智美、中村志保子、山村研一、中原舞、荒木喜美、荒木正健、帖佐悦男
    • Organizer
      第28回日本整形外科学会基礎学術集会
    • Place of Presentation
      千葉・幕張メッセ
    • Related Report
      2013 Annual Research Report
  • [Presentation] 未知遺伝子をトラップした可変型遺伝子トラップマウスラインの解析2012

    • Author(s)
      吉信公美子, 来海葉子, 慶田貴子, 古閑成美, 中原舞, 荒木喜美, 山村研一, 荒木正健
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] 単独では高寄与率のキメラを得ることが困難なES 細胞からヘルパーES 細胞を用いることにより生殖系列キメラを得る手法の開発2012

    • Author(s)
      荒木喜美, 中原舞, 牟田真由美, 荒木正健, 山村研一
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] 可変型遺伝子トラップクローンデータベース(EGTC)2012

    • Author(s)
      荒木正健, 吉信公美子, 中原舞, 山村研一, 荒木喜美
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      福岡
    • Related Report
      2013 Final Research Report
  • [Presentation] EGTC マウスラインのGene Ontology解析2012

    • Author(s)
      荒木正健, 吉信公美子, 山村研一, 荒木喜美
    • Organizer
      第59回日本実験動物学会総会
    • Place of Presentation
      別府
    • Related Report
      2013 Final Research Report
  • [Presentation] ヘルパーES 細胞を用いることによりキメラ作製困難なES 細胞から生殖系列キメラを得る手法の開発2012

    • Author(s)
      荒木喜美, 中原舞, 作村由美, 牟田真由美, 山村研一, 荒木正健
    • Organizer
      第59回日本実験動物学会総会
    • Place of Presentation
      別府
    • Related Report
      2013 Final Research Report
  • [Presentation] EGTCマウスラインのGene Ontology解析2012

    • Author(s)
      荒木 正健
    • Organizer
      第59回日本実験動物学会総会
    • Place of Presentation
      別府国際コンベンションセンター、別府
    • Related Report
      2012 Annual Research Report
  • [Presentation] ヘルパーES細胞を用いることによりキメラ作製困難なES細胞から生殖系列キメラを得る手法の開発2012

    • Author(s)
      荒木 喜美
    • Organizer
      第59回日本実験動物学会総会
    • Place of Presentation
      別府国際コンベンションセンター、別府
    • Related Report
      2012 Annual Research Report
  • [Presentation] 可変型遺伝子トラップクローンデータベース(EGTC)2012

    • Author(s)
      荒木 正健
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      九州大学医学部百年講堂・同窓会館、福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 単独では高寄与率のキメラを得ることが困難なES細胞からヘルパーES細胞を用いることにより生殖系列キメラを得る手法の開発2012

    • Author(s)
      荒木 喜美
    • Organizer
      日本遺伝学会第84回大会
    • Place of Presentation
      九州大学医学部百年講堂・同窓会館、福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 可変型遺伝子トラップマウスにおけるプロモーター発現解析2012

    • Author(s)
      吉信 公美子
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場、マリンメッセ福岡、福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Danforth’s short tail (Sd)マウスのゲノム変異と原因遺伝子領域の決定2012

    • Author(s)
      仙波 圭
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場、マリンメッセ福岡、福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] Danforth’s short tail (Sd)変異の原因はPtf1aの異所性発現である。2012

    • Author(s)
      荒木 喜美
    • Organizer
      第35回日本分子生物学会年会
    • Place of Presentation
      福岡国際会議場、マリンメッセ福岡、福岡
    • Related Report
      2012 Annual Research Report
  • [Presentation] 可変型遺伝子トラップ法を用いた骨軟骨代謝に異常をきたす疾患モデルマウスライブラリーの構築2012

    • Author(s)
      関本 朝久
    • Organizer
      第85回日本整形外科学会学術総会
    • Place of Presentation
      国立京都国際会館、グランドプリンスホテル京都、京都
    • Related Report
      2012 Annual Research Report
  • [Presentation] 可変型遺伝子トラップ法を用いた骨代謝疾患に関与する新規遺伝子の探索2012

    • Author(s)
      黒木 修司
    • Organizer
      第30回日本骨代謝学会学術集会
    • Place of Presentation
      京王プラザホテル、東京
    • Related Report
      2012 Annual Research Report
  • [Presentation] 可変型遺伝子トラップ法を用いた骨軟骨代謝に関与する新規遺伝子の探索2012

    • Author(s)
      黒木 修司
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] 可変型遺伝子トラップ法を用いたLima1/EPLINの骨代謝における機能解析2012

    • Author(s)
      舩元 太郎
    • Organizer
      第27回日本整形外科学会基礎学術集会
    • Place of Presentation
      名古屋国際会議場、名古屋
    • Related Report
      2012 Annual Research Report
  • [Presentation] EGTC マウスラインのGene Ontology解析2011

    • Author(s)
      荒木正健, 吉信公美子, 山村研一, 荒木喜美
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 可変型遺伝子トラップマウスにおけるプロモーター発現解析2011

    • Author(s)
      吉信公美子, 来海葉子, 慶田貴子, 古閑成美, 江上稔子, 荒木喜美, 山村研一, 荒木正健
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      横浜
    • Related Report
      2013 Final Research Report
  • [Presentation] 新しい部位特異的組換えシステムDre/rox を用いたES 細胞及び マウス個体での組換え率の検討2011

    • Author(s)
      荒木喜美, 大村谷昌樹, 荒木正健, 山村研一
    • Organizer
      第25回モロシヌス研究会
    • Place of Presentation
      十日町, 新潟
    • Related Report
      2013 Final Research Report
  • [Presentation] 熊本大学CARDのWebによるCARD ENTRYシステム2011

    • Author(s)
      岩本まり
    • Organizer
      第58回日本実験動物学会総会
    • Place of Presentation
      タワーホール船橋、東京
    • Related Report
      2011 Annual Research Report
  • [Presentation] 新しい部位特異的組換えシステムDre/roxを用いたES細胞及びマウス個体での組換え効率の検討2011

    • Author(s)
      荒木喜美
    • Organizer
      第25回モロシヌス研究会
    • Place of Presentation
      ベルナティオ、十日町、新潟県
    • Related Report
      2011 Annual Research Report
  • [Presentation] MSM/Msマウス由来ES細胞を用いた遺伝子トラップクローンの解析2011

    • Author(s)
      中原舞
    • Organizer
      第25回モロシヌス研究会
    • Place of Presentation
      ベルナティオ、千日町、新潟県
    • Related Report
      2011 Annual Research Report
  • [Presentation] EGTCマウスラインのGene Ontology解析2011

    • Author(s)
      荒木正健
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] 可変型遺伝子トラップマウスにおけるプロモーター発現解析2011

    • Author(s)
      吉信公美子
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2011 Annual Research Report
  • [Presentation] 可変型相同組換え法によるTtrおよびRbp遺伝子座のダブルヒト化マウスの作製2011

    • Author(s)
      李正花
    • Organizer
      第34回日本分子生物学会年会
    • Place of Presentation
      パシフィコ横浜、横浜
    • Related Report
      2011 Annual Research Report
  • [Remarks] EGTC; Database for the Exchangeable Gene Trap Clones

    • URL

      http://egtc.jp

    • Related Report
      2013 Final Research Report
  • [Remarks] J-CRED; Japan Cre Resource and Expression Database

    • URL

      https://database.riken.jp/sw/en/Home/cria429sli/

    • Related Report
      2013 Final Research Report
  • [Remarks] EGTC

    • URL

      http://egtc.jp

    • Related Report
      2013 Annual Research Report
  • [Remarks] J-CRED; Japan Cre Resource and Expression Database

    • URL

      https://database.riken.jp/sw/en/Home/cria429s1i/

    • Related Report
      2013 Annual Research Report
  • [Remarks] Database for the Exchangeable Gene Trap Clones

    • URL

      http://egtc.jp

    • Related Report
      2012 Annual Research Report
  • [Remarks] EGTC

    • URL

      http://egtc.jp

    • Related Report
      2011 Annual Research Report
  • [Patent(Industrial Property Rights)] マウス系統を樹立する方法2013

    • Inventor(s)
      荒木正健, 荒木喜美
    • Industrial Property Rights Holder
      国立大学法人熊本大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-02-25
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] マウス系統を樹立する方法2013

    • Inventor(s)
      荒木正健、 荒木喜美
    • Industrial Property Rights Holder
      国立大学法人熊本大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2013-02-25
    • Related Report
      2012 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] マウス系統を樹立する方法2011

    • Inventor(s)
      荒木正健, 荒木喜美
    • Industrial Property Rights Holder
      国立大学法人熊本大学
    • Industrial Property Rights Type
      特許
    • Filing Date
      2011-08-31
    • Related Report
      2013 Final Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] マウス系統を樹立する方法2011

    • Inventor(s)
      荒木正健、荒木喜美
    • Industrial Property Rights Holder
      国立大学法人熊本大学
    • Industrial Property Number
      2010-194910
    • Filing Date
      2011-08-30
    • Related Report
      2011 Annual Research Report
    • Overseas
  • [Patent(Industrial Property Rights)] マウス系統を樹立する方法2010

    • Inventor(s)
      荒木正健、荒木喜美
    • Industrial Property Rights Holder
      国立大学法人熊本大学
    • Industrial Property Number
      2010-194910
    • Filing Date
      2010-08-31
    • Related Report
      2011 Annual Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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