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Neural control and its impairment of flexible stability during human bipedal standing and walking

Research Project

Project/Area Number 23300166
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionOsaka University

Principal Investigator

NOMURA Taishin  大阪大学, 基礎工学研究科, 教授 (50283734)

Co-Investigator(Kenkyū-buntansha) SAKODA Saburo  国立病院機構刀根山病院, 院長 (00178625)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2013: ¥4,550,000 (Direct Cost: ¥3,500,000、Indirect Cost: ¥1,050,000)
Fiscal Year 2012: ¥6,110,000 (Direct Cost: ¥4,700,000、Indirect Cost: ¥1,410,000)
Fiscal Year 2011: ¥7,670,000 (Direct Cost: ¥5,900,000、Indirect Cost: ¥1,770,000)
Keywords立位姿勢 / 二足歩行 / 静止立位 / 運動制御 / 非線形力学系 / 間欠制御 / 安定性 / パーキンソン病 / 歩行 / すくみ足 / ハイブリッド力学系 / 位相リセット / 運動障害 / 生体システム / フィジオーム / 生体運動制御
Research Abstract

We have proposed recently that human upright standing is stabilized in a flexible and robust manner by an intermittent control. In this study, we provided several evidences that support our hypothesis based on mathematical models of postural control and psychophysical experiments. We discussed possibility that a loss of intermittency in the neural control can be a cause of postural instability in patients with Parkinson's disease (PD). Moreover, we investigated a gait symptom called freezing of gait in PD patients, and suggested that a forceful but noisy neural control of interlimb coordination can be a main cause of the freezing of gait.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report
  • Research Products

    (60 results)

All 2014 2013 2012 2011

All Journal Article (23 results) (of which Peer Reviewed: 12 results) Presentation (37 results) (of which Invited: 6 results)

  • [Journal Article] A theoretical study on a computational algorithm for human posture estimation based on motion capture of a small number of markers2014

    • Author(s)
      N Yoshikawa, Y Suzuki, K Kiyono, T Nomura
    • Journal Title

      Advanced Biomedical Engineering

      Volume: Vol.2 Pages: 107-116

    • NAID

      130003397245

    • Related Report
      2013 Final Research Report
  • [Journal Article] A new protocol for intermittent androgen suppression therapy of prostate cancer with unstable saddle-point dynamics2014

    • Author(s)
      Y Suzuki, D Sakai, T Nomura, Y Hirata, K Aihara
    • Journal Title

      Journal of Theoretical Biology

      Volume: 350 Pages: 1-16

    • Related Report
      2013 Annual Research Report 2013 Final Research Report
  • [Journal Article] Accelerating ODE-based Simulation of General and Heterogeneous Biophysical Models using a GPU2014

    • Author(s)
      Tomohiro Okuyama, Masao Okita, Takeshi Abe, Yoshiyuki Asai, Hiroaki Kitano, Taishin Nomura, and Kenichi Hagihara
    • Journal Title

      IEEE Transactions on Parallel and Distributed Systems

      Volume: 201(印刷中) Issue: 8 Pages: 1966-1975

    • DOI

      10.1109/tpds.2013.198

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noisy interlimb coordination can be a main cause of freezing of gait in patients with little to no parkinsonism2013

    • Author(s)
      T Tanahashi, T Yamamoto, T Endo, H Fujimura, M Yokoe, H Mochizuki, T Nomura, S Sakoda
    • Journal Title

      PLoS ONE

      Volume: Vol.8, No.12

    • Related Report
      2013 Final Research Report
  • [Journal Article] 人・社会のモデル化の最前線ヒトと人の数理モデルシミュレーション2013

    • Author(s)
      野村泰伸
    • Journal Title

      日本バーチャルリアリティ学会誌

      Volume: 18巻・3号 Pages: 160-163

    • Related Report
      2013 Final Research Report
  • [Journal Article] Nomura,Learning an Intermittent Control Strategy for Postural Balancing Using an EMG-Based Human-Computer Interface2013

    • Author(s)
      Y Asai, S Tateyama, T Nomura
    • Journal Title

      PLOS ONE

      Volume: Vol.8, No.5

    • Related Report
      2013 Final Research Report
  • [Journal Article] Modeling human postural sway using an intermittent control and hemodynamic perturbation2013

    • Author(s)
      T Nomura, S Oshikawa, Y Suzuki, K Kiyono, P Morasso
    • Journal Title

      Mathematical Biosciences

      Volume: Vol.245, No.1 Pages: 86-95

    • Related Report
      2013 Final Research Report
  • [Journal Article] Modeling human postural sway using an intermittent control and hemodynamic perturbations2013

    • Author(s)
      Nomura T, Oshikawa S, Suzuki Y, Kiyono K, Morasso P
    • Journal Title

      Mathematical Biosciences

      Volume: 245 Pages: 86-95

    • DOI

      10.1016/j.jtbi.2014.02.004

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Learning an intermittent control strategy for postural balancing using an EMG-based human-computer interface2013

    • Author(s)
      Asai Y, Tateyama S, Nomura T
    • Journal Title

      PLOS ONE

      Volume: 22

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Noisy Interlimb Coordination Can Be a Main Cause of Freezing of Gait in Patients with Little to No Parkinsonism2013

    • Author(s)
      棚橋貴夫, 山本智久, 遠藤卓行, 藤村晴俊, 横江勝, 望月秀樹, 野村泰伸, 佐古田三郎
    • Journal Title

      PLoS ONE

      Volume: 8(12) Issue: 12 Pages: e84423-e84423

    • DOI

      10.1371/journal.pone.0084423

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] A Theoretical Study on a Computational Algorithm for Human Posture Estimation Based on Motion Capture of a Small Number of Markers2013

    • Author(s)
      Yoshikawa N, Suzuki Y, Kiyono K, Nomura T
    • Journal Title

      Advanced Biomedical Engineering

      Volume: 2 Issue: 0 Pages: 107-116

    • DOI

      10.14326/abe.2.107

    • NAID

      130003397245

    • ISSN
      2187-5219
    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Modeling human postural sway using an intermittent control and hemodynamic perturbations2013

    • Author(s)
      Nomura, T
    • Journal Title

      Mathematical Biosciences

      Volume: - Issue: 1 Pages: 86-95

    • DOI

      10.1016/j.mbs.2013.02.002

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intermittent control with ankle, hip, and mixed strategies during quiet standing : A theoretical proposal based on a double inverted pendulum model2012

    • Author(s)
      Y Suzuki, T Nomura, M Casadio, P Morasso
    • Journal Title

      Journal of Theoretical Biology

      Volume: Vol.310 Pages: 55-79

    • Related Report
      2013 Final Research Report
  • [Journal Article] 4D human body posture estimation based on a motion capture system and a multi-rigid link model, Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society2012

    • Author(s)
      N Yoshikawa, Y Suzuki, W Ozaki, T Yamamoto, T Nomura
    • Journal Title

      EMBS, art

      Volume: 6347079 Pages: 4847-4850

    • Related Report
      2013 Final Research Report
  • [Journal Article] 健常者およびパーキンソン病患者の重心動揺のパターン分類に対する統計的検証2012

    • Author(s)
      山本智久
    • Journal Title

      第51回日本生体医工学会大会プログラム・抄録集

      Volume: O1-11-1

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] モーションキャプチャによる 次元姿勢推定に体表面上のマーカ変位が及ぼす影響2012

    • Author(s)
      吉川直也
    • Journal Title

      第51回日本生体医工学会大会プログラム・抄録集

      Volume: O3-05-3

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] 4D human body posture estimation based on a motion capture system and a multi-rigid link model2012

    • Author(s)
      Yoshikawa, N
    • Journal Title

      Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society, EMBS

      Volume: Article number6347079 Pages: 4847-4850

    • DOI

      10.1109/embc.2012.6347079

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Intermittent control with ankle, hip, and mixed strategies during quiet standing: A theoretical proposal based on a double inverted pendulum model2012

    • Author(s)
      Suzuki, Y
    • Journal Title

      Journal of Theoretical Biology

      Volume: 310 Pages: 55-79

    • DOI

      10.1016/j.jtbi.2012.06.019

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stability of double inverted pendulum model during human quiet stance with continuous delay feedback control , Proceedings of the Annual International Conference of the IEEE Engineering in Medicine and Biology Society2011

    • Author(s)
      Y Suzuki, T Nomura, P Morasso
    • Journal Title

      EMBS, art

      Volume: 6091747 Pages: 7450-7453

    • Related Report
      2013 Final Research Report
  • [Journal Article] A classification of postural sway patterns during upright stance in healthy adults and patients with Parkinson's disease2011

    • Author(s)
      T Yamamoto, Y Suzuki, K Nomura, T Nomura, T Tanahashi, K Fukada, T Endo, S Sakoda
    • Journal Title

      Journal of Advanced Computational Intelligence and Intelligent Informatics

      Volume: Vol.15, No.8 Pages: 997-1010

    • Related Report
      2013 Final Research Report
  • [Journal Article] ヒト静止立位姿勢の神経制御モデル2011

    • Author(s)
      野村泰伸
    • Journal Title

      日本神経回路学会誌

      Volume: Vol.18, No.2 Pages: 85-98

    • NAID

      10029092920

    • Related Report
      2013 Final Research Report 2011 Annual Research Report
  • [Journal Article] A Classification of Postural Sway Patterns During Upright Stance in Healthy Adults and Patients with Parkinson's Disease2011

    • Author(s)
      Tomohisa Yamamoto
    • Journal Title

      Journal of Advanced Computational Intelligence and Intelligent Informatics

      Volume: Vol.15, No.8 Pages: 997-1010

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Stability of Double Inverted Pendulum Model during Human Quiet Stance with Continuous Delay Feedback Control2011

    • Author(s)
      Yasuyuki Suzuki
    • Journal Title

      33rd Annual International Conference of the IEEE EMBS Boston, Massachusetts USA, August 30-September 3, 2011

      Volume: - Pages: 7450-7453

    • DOI

      10.1109/iembs.2011.6091747

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] ヒト静止立位姿勢の神経制御に関する新しい仮説 : 姿勢ゆらぎ・多関節協調・姿勢障害の視点から2014

    • Author(s)
      野村泰伸
    • Organizer
      第12回姿勢と歩行研究会
    • Place of Presentation
      (pp.58-61)
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト静止立位姿勢の神経制御に関する新しい仮説:姿勢ゆらぎ・多関節協調・姿勢障害の視点から2014

    • Author(s)
      野村泰伸
    • Organizer
      第12回姿勢と歩行研究会
    • Place of Presentation
      興和株式会社本社
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] Bifurcation analysis of an intermittent control model during human quiet stance : A possible mechanism of postural sway2013

    • Author(s)
      T Nomura, Y Suzuki, T Yamamoto, K Kiyono, P Morasso
    • Organizer
      SIAM Conference on Applications of Dynamical Systems 2013
    • Place of Presentation
      (p.188)
    • Related Report
      2013 Final Research Report
  • [Presentation] 生体システムにおける柔らかい制御-ホメオダイナミクスを考える,統計数理研究所共同研究リポート2013

    • Author(s)
      野村泰伸
    • Organizer
      ダイナミカルバイオインフォマティクスの展開
    • Place of Presentation
      (vol.294, pp.77-93)
    • Related Report
      2013 Final Research Report
  • [Presentation] パーキンソン病における固縮・振戦症状を再現する大脳基底核神経回路網モデルの構築,統計数理研究所共同研究リポート2013

    • Author(s)
      尺田博之, 野村泰伸
    • Organizer
      ダイナミカルバイオインフォマティクスの展開
    • Place of Presentation
      (Vol.294, pp.54-63)
    • Related Report
      2013 Final Research Report
  • [Presentation] 間欠的制御によるヒト静止立位二重振子モデルの安定化,統計数理研究所共同研究リポート2013

    • Author(s)
      鈴木康之, Pietro Morasso, 野村泰伸
    • Organizer
      ダイナミカルバイオインフォマティクスの展開
    • Place of Presentation
      (Vol.294, pp.1-15)
    • Related Report
      2013 Final Research Report
  • [Presentation] Bifurcation Analysis of an Intermittent Control Model During Human Quiet Stance: A Possible Mechanism of Postural Sway2013

    • Author(s)
      Taishin Nomura
    • Organizer
      SIAM Conference on Applications of Cynamical Systems 2013
    • Place of Presentation
      Salt Lake, USA
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 生体システムにおける柔らかい制御ーホメオダイナミクスを考える2013

    • Author(s)
      野村泰伸
    • Organizer
      統計数理研究所共同研究集会「ダイナミカルバイオインフォマティクスの展開」
    • Place of Presentation
      統計数理研究所
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 柔軟かつ安定なヒト立位姿勢の神経制御とその崩壊メカニズム2013

    • Author(s)
      野村泰伸
    • Organizer
      第47回京都駅前セミナー
    • Place of Presentation
      キャンパスプラザ京都
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] サドル型平衡点を伴うシステムを含むハイブリッド力学系の安定化制御 ~ ヒト立位姿勢・歩行運動制御および前立腺がんの間欠制御 ~2013

    • Author(s)
      野村泰伸
    • Organizer
      電子情報通信学会 CAS, VLD, SIP, MSS研究会
    • Place of Presentation
      熊本大学
    • Related Report
      2013 Annual Research Report
    • Invited
  • [Presentation] 静止立位時重心動揺パターンの個人差とその定量化2013

    • Author(s)
      山本智久, 鈴木康之, 清野健, 野村泰伸
    • Organizer
      生体医工学シンポジウム2013
    • Place of Presentation
      九州大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] Marker - less Motion Capture System with Kinect and Foot Pressure Distribution Measurement2013

    • Author(s)
      Toshiyuki Hatta, Tomohisa Yamamoto, Yasuyuki Suzuki, Ken Kiyono, Taishin Nomura
    • Organizer
      IEEE EMBC 2013
    • Place of Presentation
      Osaka International Convention Center
    • Related Report
      2013 Annual Research Report
  • [Presentation] Notes on stability of human motor control2013

    • Author(s)
      Taishin Nomura
    • Organizer
      計測自動制御学会ライフエンジニアリング部門シンポジウム
    • Place of Presentation
      慶応大学
    • Related Report
      2013 Annual Research Report
  • [Presentation] ヒト静止立位姿勢の神経制御メカニズムと中枢神経疾患による姿勢の不安定化2012

    • Author(s)
      野村泰伸
    • Organizer
      電子情報通信学会2012年総合大会
    • Place of Presentation
      岡山大学津島キャンパス(岡山県)(招待講演)
    • Year and Date
      2012-03-20
    • Related Report
      2011 Annual Research Report
  • [Presentation] 二重振子の間欠制御を用いたヒト静止立位姿勢制御のモデル化2012

    • Author(s)
      鈴木康之
    • Organizer
      日本機械学会第24回バイオエンジニアリング講演会
    • Place of Presentation
      大阪大学豊中キャンパス(大阪府)
    • Year and Date
      2012-01-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 健常者およびパーキンソン病患者の立位姿勢動揺パターンの統計的分類2012

    • Author(s)
      山本智久
    • Organizer
      日本機械学会第24回バイオエンジニアリング講演会
    • Place of Presentation
      大阪大学豊中キャンパス(大阪府)
    • Year and Date
      2012-01-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト全身運動のモーションキャプチャデータに基づく4次元全身姿勢推定2012

    • Author(s)
      吉川直也
    • Organizer
      日本機械学会第24回バイオエンジニアリング講演会
    • Place of Presentation
      大阪大学豊中キャンパス(大阪府)
    • Year and Date
      2012-01-08
    • Related Report
      2011 Annual Research Report
  • [Presentation] 柔軟かつ安定なヒト立位姿勢の神経制御とその崩壊メカニズム2012

    • Author(s)
      野村泰伸
    • Organizer
      第47回京都駅前セミナー
    • Related Report
      2013 Final Research Report
  • [Presentation] Stability examination of biped model by Floquet theory,Proceedings of the 27th Symposium on Biological and Physiological Engineering BPES20122012

    • Author(s)
      Chunjiang Fu, Y Suzuki, K Kiyono, T Nomura
    • Organizer
      第27回生体・生理工学シンポジウム論文集
    • Related Report
      2013 Final Research Report
  • [Presentation] 呼吸・心循環系動態とヒト静止立位姿勢動揺の関係2012

    • Author(s)
      押川翔太, 鈴木康之, 清野健, 野村泰伸
    • Organizer
      生体医工学シンポジウム2012 JBMES2012
    • Related Report
      2013 Final Research Report
  • [Presentation] Intermittent Control and Homoclinic Cycle as Underlying Mechanisms of Stochastic Postural Sway with Long-Term Correlation during Human Quiet Standing2012

    • Author(s)
      T Nomura, T Yamamoto, Y Suzuki
    • Organizer
      BIOCOMP2012 Mathematical Modeling and Computational Topics in Biosciences
    • Place of Presentation
      (p.134)
    • Related Report
      2013 Final Research Report
  • [Presentation] 健常者およびパーキンソン病患者の重心動揺のパターン分類に対する統計的検証2012

    • Author(s)
      山本智久, Smith C.E., 鈴木康之, 棚橋貴夫, 遠藤卓行, 佐古田三郎, 野村泰伸
    • Organizer
      第51回日本生体医工学会大会
    • Related Report
      2013 Final Research Report
  • [Presentation] モーションキャプチャによる次元姿勢推定に体表面上のマーカ変位が及ぼす影響2012

    • Author(s)
      吉川直也, 鈴木康之, 尾崎航, 山本智久, 野村泰伸
    • Organizer
      第51回日本生体医工学会大会
    • Related Report
      2013 Final Research Report
  • [Presentation] ヒト静止立位の倒立二重振子間欠制御モデル2012

    • Author(s)
      鈴木康之, Pietro Morasso, 野村泰伸
    • Organizer
      第51回日本生体医工学会大会
    • Related Report
      2013 Final Research Report
  • [Presentation] 健常者およびパーキンソン病患者の重心動揺のパターン分類に対する統計的検証2012

    • Author(s)
      山本智久
    • Organizer
      第51回日本生体医工学会大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] モーションキャプチャによる 次元姿勢推定に体表面上のマーカ変位が及ぼす影響2012

    • Author(s)
      吉川直也
    • Organizer
      第51回日本生体医工学会大会
    • Place of Presentation
      福岡国際会議場(福岡)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Intermittent Control and Homeclinic Cycle as Underlying Mechanisms of Stochastic Postural Sway with Long-Term Correlation during Human Quiet Standing2012

    • Author(s)
      Nomura Taishin
    • Organizer
      BIOCOMP2012 Mathematical Modeling and Computational Topics in Biosciences Vietri sul Mare
    • Place of Presentation
      Hotel Loyd's Baia(Italy)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 4D human body posture estimation based on a motion capture system and a multi-rigid link model2012

    • Author(s)
      Yoshikawa, N
    • Organizer
      34th Annual International Conference of the IEEE Engineering in Medicine and Biology Society
    • Place of Presentation
      Hilton San Diego Bayfront(USA)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Stability examination of biped model by Floquet theory2012

    • Author(s)
      Fu Chunjiang
    • Organizer
      The 27th Symposium on Biological and Physiological Engineering BPES2012
    • Place of Presentation
      北海道大学学術交流会館(北海道)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 柔軟かつ安定なヒト立位姿勢の神経制御とその崩壊メカニズム2012

    • Author(s)
      野村泰伸
    • Organizer
      第47回京都駅前セミナー
    • Place of Presentation
      キャンパスプラザ京都(京都)
    • Related Report
      2012 Annual Research Report
    • Invited
  • [Presentation] 生体システムにおける柔らかい制御ーホメオダイナミクスを考える2012

    • Author(s)
      野村泰伸
    • Organizer
      統計数理研究所共同研究集会
    • Place of Presentation
      統計数理研究所(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] 間欠的制御によるヒト静止立位二重振子モデルの安定化2012

    • Author(s)
      鈴木康之
    • Organizer
      統計数理研究所共同研究集会
    • Place of Presentation
      統計数理研究所(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] パーキンソン病における固縮・振戦症状を再現する大脳基底核神経回路網モデルの構築2012

    • Author(s)
      尺田博之
    • Organizer
      統計数理研究所共同研究集会
    • Place of Presentation
      統計数理研究所(東京)
    • Related Report
      2012 Annual Research Report
  • [Presentation] Slow Fluctuations with long-term correlations in postural sway during human quiet standing2011

    • Author(s)
      Taishin Nomura
    • Organizer
      第26回生体・生理工学シンポジウム
    • Place of Presentation
      立命館大学びわこ・くさつキャンパス(滋賀県)
    • Year and Date
      2011-09-22
    • Related Report
      2011 Annual Research Report
  • [Presentation] ヒト静止立位時の微弱皮膚感覚刺激が重心動揺に与える影響2011

    • Author(s)
      吉田信久, 鈴木康之, 野村泰伸
    • Organizer
      生体医工学シンポジウム2011
    • Related Report
      2013 Final Research Report
  • [Presentation] Slow Fluctuations with long-term correlations in postural sway during human quiet standing2011

    • Author(s)
      T Nomura
    • Organizer
      第26回生体・生理工学シンポジウム論文集, BPES2011
    • Place of Presentation
      (pp.552-553)
    • Related Report
      2013 Final Research Report
  • [Presentation] Dynamics of neuronal network models with a large number of ion-channel-based interneuron models for motor pattern generation2011

    • Author(s)
      K Okawa, T Nomura
    • Organizer
      第26回生体・生理工学シンポジウム論文集, BPES2011
    • Place of Presentation
      (pp.297-298)
    • Related Report
      2013 Final Research Report

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Published: 2011-04-06   Modified: 2019-07-29  

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