role of mechanosensitive response of organelle in dynamic biomechanics of cardiomyocytes
| Project/Area Number |
23300167
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Okayama University |
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Principal Investigator |
IRIBE Gentaro 岡山大学, 医歯(薬)学総合研究科, 講師 (90284885)
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| Co-Investigator(Kenkyū-buntansha) |
WAKIMOTO Shuichi 岡山大学, 大学院・自然科学研究科, 准教授 (40452560)
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| Co-Investigator(Renkei-kenkyūsha) |
NARUSE Keiji 岡山大学, 大学院・医歯薬学総合研究科, 教授 (40252233)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,720,000 (Direct Cost: ¥14,400,000、Indirect Cost: ¥4,320,000)
Fiscal Year 2013: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2012: ¥3,770,000 (Direct Cost: ¥2,900,000、Indirect Cost: ¥870,000)
Fiscal Year 2011: ¥11,180,000 (Direct Cost: ¥8,600,000、Indirect Cost: ¥2,580,000)
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| Keywords | 機械感受性 / ミトコンドリア膜電位 / 活性酸素 / カルシウムスパーク / 心筋細胞 / 機械刺激 / ミトコンドリア / 機械電気帰還現象 |
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| Research Abstract |
Calcium spark is diastolic spontaneous calcium releasing event from ryanodine receptors (RyR) on sarcoplasmic reticulum. We have previously reported that myocardial stretch increases calcium spark rate. It has been regarded that stretch-induced increase in reactive oxygen species (ROS) production from NADPH oxidase stimulates RyR to cause the phenomenon. However, the present study revealed that stretch-induced increase in ROS production is derived from mitochondria.
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Report
(4 results)
Research Products
(20 results)
