Development of a Blood Testing Device Using DNA-templated Nanowires
Project/Area Number |
23300168
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Research Category |
Grant-in-Aid for Scientific Research (B)
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Allocation Type | Single-year Grants |
Section | 一般 |
Research Field |
Biomedical engineering/Biological material science
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Research Institution | Kyushu Institute of Technology |
Principal Investigator |
YASUDA Takashi 九州工業大学, 大学院生命体工学研究科, 教授 (80270883)
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Project Period (FY) |
2011-04-01 – 2015-03-31
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Project Status |
Completed (Fiscal Year 2014)
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Budget Amount *help |
¥18,330,000 (Direct Cost: ¥14,100,000、Indirect Cost: ¥4,230,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
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Keywords | ナノワイヤ / DNA / 金属被覆 / マイクロ流路 / DNA分解酵素 / 血液検査 / 静電配向 / インターカレータ / マイクロデバイス / 血漿抽出 |
Outline of Final Research Achievements |
A novel process of nanowire formation was developed using metallization of DNA molecules, and electrical property of the fabricated nanowires was evaluated. First, a single DNA molecule was stretched and immobilized between two electrodes in a nanochannel, and a single nanowire was formed by DNA metallization. Next, we demonstrated that our technique permits double-stranded DNA molecules to be specifically metallized while not permitting metallization of single-stranded DNA molecules. Moreover, a novel technique for deoxyribonuclease (DNase) detection was developed using partially-metallized DNA nanowires. Also, we succeeded in extracting plasma from whole blood easily and rapidly using capillary force in a microchannel, and developed a method for detecting specific proteins in the extracted plasma.
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Report
(5 results)
Research Products
(32 results)
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[Presentation] 金属被覆DNAナノワイヤのインピーダンス評価とAFM観察2014
Author(s)
氷室貴大, 荒木遼, 池堂英幸, 佐藤しのぶ, 竹中繁織, 安田隆
Organizer
平成26年度電気学会センサ・マイクロマシン部門総合研究会 バイオ・マイクロシステム研究会
Place of Presentation
東京大学生産技術研究所(東京都目黒区)
Year and Date
2014-05-27 – 2014-05-28
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