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Physiomic analyses of cardiac hypertrophy and ventricular geometry of in cardiac regulation

Research Project

Project/Area Number 23300171
Research Category

Grant-in-Aid for Scientific Research (B)

Allocation TypeSingle-year Grants
Section一般
Research Field Biomedical engineering/Biological material science
Research InstitutionKawasaki Medical School

Principal Investigator

MOHRI Satoshi  川崎医科大学, 医学部, 教授 (00294413)

Co-Investigator(Kenkyū-buntansha) HASHIMOTO Ken  川崎医科大学, 医学部, 講師 (80341080)
UJIHARA Yoshihiro  川崎医科大学, 医学部, 助教 (80610021)
宮坂 武寛  姫路獨協大学, 公私立大学の部局等, 教授 (60308195)
Co-Investigator(Renkei-kenkyūsha) NARUSE Keiji  岡山大学, 医歯(薬)学総合研究科, 教授 (40252233)
Project Period (FY) 2011-04-01 – 2014-03-31
Project Status Completed (Fiscal Year 2013)
Budget Amount *help
¥17,550,000 (Direct Cost: ¥13,500,000、Indirect Cost: ¥4,050,000)
Fiscal Year 2013: ¥4,810,000 (Direct Cost: ¥3,700,000、Indirect Cost: ¥1,110,000)
Fiscal Year 2012: ¥5,720,000 (Direct Cost: ¥4,400,000、Indirect Cost: ¥1,320,000)
Fiscal Year 2011: ¥7,020,000 (Direct Cost: ¥5,400,000、Indirect Cost: ¥1,620,000)
Keywords心機能 / 心肥大 / 心筋分裂 / 酸素環境 / 機械受容 / 冠循環 / フィジオーム / カルシウム / 心不全
Research Abstract

Cardiac pump function is determined by the quantity and quality of myocardium and ventricular geometry. We investigated the regulatory mechanism of the heart for the change in environment. First, we focused the effects of the change in oxygen tension on the cellular switching from division to hypertrophy during perinatal period. Fetal cardiomyocytes were harvested and cultured at different oxygen tension (low O2: 3%, high O2: 20%) . We firstly succeeded to visualize the division of cardiomyocytes using time-lapse motion picture under low O2 condition. Then, we found that cardiomyocytes stopped cell division under high O2 while they kept dividing under low O2 condition. We also performed micro-allay analysis to reveal the genes regulating cell cycle, which would be useful to make the adult cardiomyocytes to restart cell devision. As for the mechan-osensing in the heart, we show that TRPV2 cation channel is critical for the maintenance of cardiac structure and function.

Report

(4 results)
  • 2013 Annual Research Report   Final Research Report ( PDF )
  • 2012 Annual Research Report
  • 2011 Annual Research Report

Research Products

(15 results)

All 2014 2013 2012 2011 Other

All Journal Article Presentation

  • [Journal Article] TRPV2 is critical for the maintenance of cardiac structure and function in mice2014

    • Author(s)
      Katanosaka Y, Iwasaki K, Ujihara Y, Takatsu S, Nishitsuji K, Kanagawa M, Sudo A, Toda T, Katanosaka K, Mohri S, Naruse K
    • Journal Title

      Nat Commun

      Volume: 5 Pages: 3932-3932

    • NAID

      120005690060

    • Related Report
      2013 Final Research Report
  • [Journal Article] TRPV2 is critical for the maintenance of cardiac structure and function in mice2014

    • Author(s)
      Yuki katanosaka, Keiichiro Iwasaki, Yoshihiro Ujihara, Satomi Takatsu, Koki Nishitsuji, Motoi Kanagawa, Atsushi Sudo, Tatsushi Toda, Kimiaki Katanosaka, Satoshi Mohri, and Keiji Naruse
    • Journal Title

      Nature Communications

      Volume: 未定

    • NAID

      120005690060

    • Related Report
      2013 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of propofol on left ventricular mechanoenergetics in the excised cross-circulated canine heart.2012

    • Author(s)
      Fujinaka W, Shimizu J, Iribe G, Imaoka T, Oshima Y, Kiyooka T, Morita K, Mohri S
    • Journal Title

      Acta Med Okayama

      Volume: 66 Pages: 435-442

    • Related Report
      2012 Annual Research Report
    • Peer Reviewed
  • [Journal Article] Effects of Propofol on Left Ventricular Mechanoenergetics in the Excised Cross-circulated Canine Heart2012

    • Author(s)
      Waso Fujinaka, Juiohiro Shimizu, Gentaro Iribe, Takeshi Imaoka, Yu Oshima, Takahiko Kiyooka, Kiyoshi Morita, Satoshi Mohri
    • Journal Title

      Acta Medica Okayama

      Volume: (in press)

    • Related Report
      2011 Annual Research Report
    • Peer Reviewed
  • [Presentation] TRPV2 is crucial for cardiac structure and function2014

    • Author(s)
      Katanosaka Y, Ujihara Y, Mohri S
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      NH, USA (Colby-Sawyer College)
    • Year and Date
      2014-06-10
    • Related Report
      2013 Final Research Report
  • [Presentation] TRPV2 maintains the structure and function of intercalated discs2014

    • Author(s)
      Mohri S, Ujihara Y, Katanosaka Y
    • Place of Presentation
      NH, USA (Colby-Sawyer College)
    • Year and Date
      2014-06-10
    • Related Report
      2013 Final Research Report
  • [Presentation] Isolated myocytes from TRPV2-deficient heart are fully functional2014

    • Author(s)
      Ujihara Y, Mohri S, Katanosaka Y
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      NH, USA (Colby-Sawyer College)
    • Year and Date
      2014-06-10
    • Related Report
      2013 Final Research Report
  • [Presentation] 甲状腺機能亢進症モデルマウスにおける心臓リモデリングの評価2013

    • Author(s)
      笹江友美, 橋本謙, 氏原嘉洋, 毛利聡
    • Organizer
      第65回日本生理学会大会中国四国地方会
    • Place of Presentation
      倉敷(川崎医科大学)
    • Year and Date
      2013-11-01
    • Related Report
      2013 Final Research Report
  • [Presentation] T 間膜構造維持におけるNa^<+>/Ca^<2+>交換体の役割2013

    • Author(s)
      氏原嘉洋, 岩崎慶一朗, 高津理美, 西辻光希, 橋本謙, 成瀬恵治, 毛利聡, 片 野坂友紀
    • Organizer
      第65回日本生理学会大会中国四国地方会
    • Place of Presentation
      倉敷(川崎医科大学)
    • Year and Date
      2013-11-01
    • Related Report
      2013 Final Research Report
  • [Presentation] 心不全発症と重篤化におけるNa/Ca交換体の役割2011

    • Author(s)
      岩崎慶一朗、毛利聡、高津理美、氏原嘉洋、橋本謙、成瀬恵治、片野坂友紀
    • Organizer
      日本生理学会中国四国地方会
    • Place of Presentation
      広島大学
    • Year and Date
      2011-10-23
    • Related Report
      2011 Annual Research Report
  • [Presentation] 甲状腺機能亢進症モデルマウスにおける心臓のリモデリングの評価

    • Author(s)
      笹江友美、橋本 謙、氏原嘉洋、毛利 聡
    • Organizer
      第65回日本生理学会大会中国四国地方会
    • Place of Presentation
      倉敷(川崎医科大学)
    • Related Report
      2013 Annual Research Report
  • [Presentation] TRPV2 is crucial for cardiac structure and function

    • Author(s)
      Yuki Katanosaka, Yoshihiro Ujihara, Satoshi Mohri
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      米国 Colby-Sawyer College
    • Related Report
      2013 Annual Research Report
  • [Presentation] TRPV2 maintains the structure and function of intercalated discs

    • Author(s)
      Satoshi Mohri, Yoshihiro Ujihara, Yuki Katanosaka
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      米国 Colby-Sawyer College
    • Related Report
      2013 Annual Research Report
  • [Presentation] Isolated myocytes from TRPV2-deficient hearts are fully functional

    • Author(s)
      Yoshihiro Ujihara, Satoshi Mohri, Yuki Katanosaka
    • Organizer
      Gordon Research Conference
    • Place of Presentation
      米国 Colby-Sawyer College
    • Related Report
      2013 Annual Research Report
  • [Presentation] T管膜構造維持におけるNa+/Ca2+交換体の役割

    • Author(s)
      氏原嘉洋、岩崎慶一朗、高津理美、西辻光希、橋本謙、成瀬恵治、毛利聡、片野坂友紀
    • Organizer
      第65回日本生理学会大会中国四国地方会
    • Place of Presentation
      倉敷(川崎医科大学)
    • Related Report
      2013 Annual Research Report

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Published: 2011-04-05   Modified: 2019-07-29  

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