Development of research with liposomes toward clinical application for cancer and AIDS

• Project/Area Number: 23300173
• Research Category: Grant-in-Aid for Scientific Research (B)
• Allocation Type: Single-year Grants
• Section: 一般
• Research Field: Biomedical engineering/Biological material science
• Research Institution: Sojo University
• Principal Investigator: MATSUMOTO Yoko 崇城大学, 生物生命学部, 教授 (00133562)
• Co-Investigator(Kenkyū-buntansha): GOTO Koichi 崇城大学, 生物生命学部, 教授 (30279377) ; ICHIHARA Hideaki 崇城大学, 生物生命学部, 准教授 (70369114)
• Project Period (FY): 2011-04-01 – 2014-03-31
• Project Status: Completed (Fiscal Year 2013)
• Budget Amount: ¥17,940,000 (Direct Cost: ¥13,800,000、Indirect Cost: ¥4,140,000); Fiscal Year 2013: ¥5,070,000 (Direct Cost: ¥3,900,000、Indirect Cost: ¥1,170,000); Fiscal Year 2012: ¥5,980,000 (Direct Cost: ¥4,600,000、Indirect Cost: ¥1,380,000); Fiscal Year 2011: ¥6,890,000 (Direct Cost: ¥5,300,000、Indirect Cost: ¥1,590,000)
• Keywords: 癌 / リポソーム / エイズ / アポトーシス / 担がんマウス / トレハロース / シグナル伝達 / トランスレーショナルリサーチ / 脂質 / 細胞・組織

Research Abstract

We have produced hybrid liposomes (HL) which can be prepared by sonication of vesicular and micellar molecules in a buffer solution. We investigated the anticancer and anti-AIDS effects of HL and following results are obtained. (A) The remarkable inhibitory effects of HL on the growth of various tumor cells were attained in vitro. (B) apoptotic induction pathway which targeted tumor cell membranes was observed. (C) Significantly chemotherapeutic effects were obtained using mice model of carcinoma after the treatment with HL in vivo. Long-term selective accumulation of fluorescent labeled HL-25 into tumor was observed in pharmacokinetics test using mice model of carcinoma. (D) therapetutic effects of treatment for the lymphoma with relation to AIDS was obtained. These findings suggest that HL should be a new type of nanomedicinaldrug anti-cancer and anti-AIDS that targets refractory disease cell-membranes to trigger apoptotic cell death for various cancer cells.

Research Products

• [Journal Article] Cell cycle arrest by hybrid liposomes for human lung carcinoma cells (2014)
  • Author(s): Y. Komizu, M. Yukihara, Y. Matsumoto, R. Ueoka
  • Journal Title: J. Carcinog. Mutagen Volume: 5 Issue: 01
  • DOI: 10.4172/2157-2518.1000157
  • Peer Reviewed / Open Access
• [Journal Article] Therapeutic Effects of Cationic Hybrid Liposomes on the Hepatic Metastasis of Colon Carcinoma Along with Apoptosis <i>in Vivo</i> (2014)
  • Author(s): H. Ichihara, M. Hino, R. Ueoka, Y. Matsumoto
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 37 Issue: 3 Pages: 498-503
  • DOI: 10.1248/bpb.b13-00764
  • NAID: 130003390947
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Therapeutic effects of hybrid liposomes without drugs for rheumatoid arthritis (2014)
  • Author(s): Yoko Matsumoto, Hideaki Ichihara, Motoki Hino, Masayo Umebayashi, Ryuichi Ueoka
  • Journal Title: Drug Delivery Volume: 21 Issue: 5 Pages: 619-626
  • DOI: 10.3109/10717544.2013.869635
  • Peer Reviewed / Open Access
• [Journal Article] Novel Liposomes Composed of Dimyristoylphosphatidylcholine and Trehalose Surfactants Inhibit the Growth of Tumor Cells along with Apoptosis (2013)
  • Author(s): Y. Matsumoto, E. Cao, R. Ueoka
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 36 Issue: 8 Pages: 1258-1262
  • DOI: 10.1248/bpb.b13-00266
  • NAID: 130003361509
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Hybrid liposomes inhibit tumor growth and lung metastasis of murine osteosarcoma cells (2013)
  • Author(s): H. Kitajima, Y. Komizu, H. Ichihara, K. Goto, R. Ueoka
  • Journal Title: Cancer Med Volume: (in press) Issue: 3 Pages: 267-278
  • DOI: 10.1002/cam4.67
  • Peer Reviewed
• [Journal Article] Growth inhibition by novel liposomes including trehalose surfactant against hepatocarcinoma cells along with apoptosis (2013)
  • Author(s): Yoko Matsumoto, E. Cao, Ryuichi Ueoka
  • Journal Title: Anticancer Research Volume: 33 Pages: 4727-4740
  • Peer Reviewed
• [Journal Article] Hybrid liposomes inhibit tumor growth and lung metastasis of murine osteosarcoma cells (2013)
  • Author(s): Hideki Kitajima
  • Journal Title: Cancer Medicine
  • Peer Reviewed
• [Journal Article] Therapeutic Effects of autologous lymphocytes activated with Trastuzumab for xenograft mouse models of human breast cancer (2013)
  • Author(s): Sinichirou Nakagawa
  • Journal Title: Biological & Pharmaceutical Bulletin Volume: 36
  • Peer Reviewed
• [Journal Article] Therapeutic effects of hybrid liposomes for mouse models of adult T-cell leukemia/lymphoma in vivo (2012)
  • Author(s): Y. Komizu, M. Yukihara, T. Ueoka, H. Ichihara, Y. Matsumoto, S. Okada, R. Ueoka
  • Journal Title: Nano Bull Volume: 1
  • Peer Reviewed
• [Journal Article] Intravenous injection of hybrid liposomes suppresses the liver metastases in xenograft mouse models of colorectal cancer in vivo (2012)
  • Author(s): H. Ichihara, M. Hino, M. Umebayashi, Y. Matsumoto, R. Ueoka
  • Journal Title: Eur. J. Med. Chem Volume: 57 Pages: 143-148
  • DOI: 10.1016/j.ejmech.2012.08.040
  • Peer Reviewed
• [Journal Article] Anti-tumor Effects of Cationic Hybrid Liposomes against Colon Carcinoma along with Apoptosis <i>in Vitro</i> (2012)
  • Author(s): M. Hino, H. Ichihara, Y. Matsumoto, R. Ueoka
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 35 Issue: 11 Pages: 2097-2101
  • DOI: 10.1248/bpb.b12-00633
  • NAID: 130001872276
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Antimelanogenic and antioxidative effects of residual powders from Shochu distillation remnants (2012)
  • Author(s): Masahiro Ohgidani
  • Journal Title: Food Chemistry Volume: 132 Issue: 4 Pages: 2140-2143
  • DOI: 10.1016/j.foodchem.2011.12.049
  • Peer Reviewed
• [Journal Article] Anticancer Effects of Residual Powder from Barley-<i>Shochu</i> Distillation Remnants against the Orthotopic Xenograft Mouse Models of Hepatocellular Carcinoma <i>in Vivo</i> (2012)
  • Author(s): Masahiro Ohgidani
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 35 Issue: 6 Pages: 984-987
  • DOI: 10.1248/bpb.35.984
  • NAID: 130001872186
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Residual powders from Shochu distillation remnants induce apoptosis in human hepatoma cells via the caspase-independent pathway (2012)
  • Author(s): Masahiro Ohgidani
  • Journal Title: Journal of Bioscience and Bioengineering Volume: 114 Issue: 1 Pages: 104-109
  • DOI: 10.1016/j.jbiosc.2012.02.026
  • Peer Reviewed
• [Journal Article] New Cancer Immunotherapy Using Autologous Lymphocytes Activated with Trastuzumab (2012)
  • Author(s): Sinichirou Nakagawa
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 35 Issue: 8 Pages: 1213-1215
  • DOI: 10.1248/bpb.b12-00378
  • NAID: 130001872153
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Therapeutic effects of hybrid liposomes for mouse models of adult T-cell leukemia/lymphoma in vivo (2012)
  • Author(s): Yuji Komizu
  • Journal Title: Nano Bulletin Volume: 1
  • Peer Reviewed
• [Journal Article] Inhibitory effects of hybrid liposomes on the growth of synoviocyte causing rheumatoid arthritis (2011)
  • Author(s): H. Ichihara, M. Hino, T. Makizono, M.Umebayashi, Y. Matsumoto, R. Ueoka
  • Journal Title: Bioorg. Med. Chem. Lett Volume: 21 Issue: 1 Pages: 207-210
  • DOI: 10.1016/j.bmcl.2010.11.035
  • Peer Reviewed
• [Journal Article] Chemotherapy with hybrid liposomes for acute lymphatic leukemia leading to apoptosis in vivo (2011)
  • Author(s): H. Ichihara, J. Ueno, M. Umebayashi, Y. Matsumoto, R. Ueoka
  • Journal Title: Int J Pharm Volume: 406 Issue: 1-2 Pages: 173-178
  • DOI: 10.1016/j.ijpharm.2010.12.041
  • Peer Reviewed
• [Journal Article] Membrane Targeted Chemotherapy with Hybrid Liposomes for Tumor Cells Leading to Apoptosis (2011)
  • Author(s): R. Ueoka, Y. Matsumoto, K. Goto, H. Ichihara, Y. Komizu
  • Journal Title: Curr. Pharm. Des Volume: 17 Issue: 17 Pages: 1709-1719
  • DOI: 10.2174/138161211796355128
  • Peer Reviewed
• [Journal Article] Inhibitory effect of drug-free hybrid liposomes on metastasis of human neuroblastoma (2011)
  • Author(s): Joji Yoshizawa
  • Journal Title: Pediatric Surgery International Volume: 27 Issue: 4 Pages: 379-384
  • DOI: 10.1007/s00383-010-2804-1
  • Peer Reviewed
• [Journal Article] Membrane-targeted nanotherapy with hybrid liposomes for tumor cells leading to apoptosis (2011)
  • Author(s): Yuji Komizu
  • Journal Title: ACS Medicinal Chemistry Letters Volume: 2 Issue: 4 Pages: 275-279
  • DOI: 10.1021/ml100269t
  • Peer Reviewed
• [Journal Article] Effective Drug Delivery System for Duchenne Muscular Dystrophy Using Hybrid Liposomes Including Gentamicin along with Reduced Toxicity (2011)
  • Author(s): Mamiko Yukihara
  • Journal Title: Biological and Pharmaceutical Bulletin Volume: 34 Issue: 5 Pages: 712-716
  • DOI: 10.1248/bpb.34.712
  • NAID: 130000657785
  • ISSN: 0918-6158, 1347-5215
  • Peer Reviewed
• [Journal Article] Experimental Therapeutic Effects of Hybrid Liposomes on the Alzheimer's Disease in Vitro (2011)
  • Author(s): 座古恵子
  • Journal Title: YAKUGAKU ZASSHI Volume: 131 Issue: 5 Pages: 775-782
  • DOI: 10.1248/yakushi.131.775
  • NAID: 130000678860
  • ISSN: 0031-6903, 1347-5231
  • Peer Reviewed
• [Presentation] Growth inhibition by novel liposomes including trehalose surfactants against hepatocarcinoma cells along with apoptosis (2014)
  • Author(s): Yoko Matsumoto
  • Organizer: The 2nd International Symposium on Dynamical Ordering of Biomolecular Systems for Creation of Integrated Functions
  • Place of Presentation: キャンパスプラザ京都（京都市下京区）
• [Presentation] トレハロース含有リポソームのがん細胞に対するアポトーシス誘導 (2014)
  • Author(s): 松本陽子、曹娥
  • Organizer: 日本薬学会第134年会
  • Place of Presentation: 熊本大学工学部（熊本市中央区）
• [Presentation] Anti-tumor effects of cationic liposomes against tumor cells along with apoptosis (2013)
  • Author(s): Y. Matsumoto
  • Organizer: 7th International Symposium on Nanomedicine (ISNM2013)
  • Place of Presentation: 福岡県北九州市九州工業大学
  • Year and Date: 2013-11-08
  • Invited
• [Presentation] Anti-tumor effects of cationic liposomes against tumor cells along with apoptosis (2013)
  • Author(s): Y. Matsumoto
  • Organizer: The 3rd Sojo-UTP Joint Seminar on Nano & Bio
  • Place of Presentation: 熊本県熊本市崇城大学
  • Year and Date: 2013-08-27
  • Invited
• [Presentation] 化学工学会女性賞受賞講演 -リポソームによるがん治療 (2013)
  • Author(s): 松本陽子
  • Organizer: 化学工学会第78年会
  • Place of Presentation: 大阪府大阪市大阪大学
  • Year and Date: 2013-03-18
  • Invited
• [Presentation] ハイブリッドリポソームの肺がん細胞に対する細胞周期停止およびアポトーシス誘導によるがん抑制機構 (2013)
  • Author(s): 古水雄志, 松本陽子, 上岡龍一
  • Organizer: 第18回日本がん分子標的治療学会学術集会
  • Place of Presentation: 国立京都国際会館（京都市左京区）
• [Presentation] 大腸がんに対するカチオン性脂質含有ハイブリットリポソームの制がん効果 (2013)
  • Author(s): 日野元貴, 市原英明, 松本陽子
  • Organizer: 第18回日本がん分子標的治療学会学術集会
  • Place of Presentation: 国立京都国際会館（京都市左京区）
• [Presentation] トレハロース含有リポソームのがん細胞に対するアポトシース誘導 (2013)
  • Author(s): 曹娥, 松本陽子
  • Organizer: 第18回日本がん分子標的治療学会学術集会
  • Place of Presentation: 国立京都国際会館（京都市左京区）
• [Presentation] Research anti-tumor effects of cationic liposomes against tumor cells along with apoptosis (2013)
  • Author(s): Yoko Matsumoto
  • Organizer: The 3rd Sojo-UTP Joint Seminar on Nano & Bio
  • Place of Presentation: 崇城大学（熊本市西区）
  • Invited
• [Presentation] Inhibitory effects of hybrid liposomes on the growth of synoviocyte causing rheumatoid arthritis (2013)
  • Author(s): Motoki Hino, Hideaki Ichihara, Yoko Matsumoto
  • Organizer: The 3rd Sojo-UTP Joint Seminar on Nano & Bio
  • Place of Presentation: 崇城大学（熊本市西区）
• [Presentation] Cell cycle arrest by adding hybrid liposomes for lung tumor (2013)
  • Author(s): Yoko Matsumoto, Yuji Komizu, Mamiko Yukihara, Ryuichi Ueoka
  • Organizer: The 72nd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: パシフィコ横浜（横浜市西区）
• [Presentation] Therapeutic effects of hybrid liposomes for mouse models of adult T-cell leukemia/lymphoma in vitro and in vivo (2013)
  • Author(s): Yuji Komizu, Hideaki Ichihara, Yoko Matsumoto, Ryuichi Ueoka
  • Organizer: The 72nd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: パシフィコ横浜（横浜市西区）
• [Presentation] Chemotherapy with hybrid liposomes for acute lymphatic leukemia leading to apoptosis in vivo (2013)
  • Author(s): Hideaki Ichihara, Yoko Matsumoto, Ryuichi Ueoka
  • Organizer: The 72nd Annual Meeting of the Japanese Cancer Association
  • Place of Presentation: パシフィコ横浜（横浜市西区）
• [Presentation] Anti-tumor effects of cationic liposomes against tumor cells along with apoptosis (2013)
  • Author(s): Yoko Matsumoto
  • Organizer: 7th International Symposium on Nanomedicine (ISNM2013)
  • Place of Presentation: 九州工業大学（北九州市戸畑区）
  • Invited
• [Presentation] 化学工学会女性賞受賞講演 -リポソームによるがん治療 (2013)
  • Author(s): 松本 陽子
  • Organizer: 化学工学会第78年会
  • Place of Presentation: 大阪大学豊中キャンパス（大阪府）
  • Invited
• [Presentation] Membrane-targeted therapy with hybrid liposomes leading to apoptosis (2012)
  • Author(s): Y. Matsumoto
  • Organizer: 5th International Symposium on Nanomedicine
  • Place of Presentation: 愛知県名古屋市名古屋大学
  • Year and Date: 2012-03-16
  • Invited
• [Presentation] Membrane-targeted therapy with hybrid liposomes leading to apoptosis (2012)
  • Author(s): Yoko Matsumoto
  • Organizer: 5th International Symposium on Nanomedicine
  • Place of Presentation: 名古屋大学ES総合館(愛知県)(招待講演)
  • Year and Date: 2012-03-16
• [Presentation] Membrane-targeted nanotherapy with hybrid liposomes for cancer cells leading to apoptosis (2012)
  • Author(s): R. Ueoka, Y. Matsumoto
  • Organizer: The International Conference on Statistical Mechanics of Liquids : From Water to Biomolecules
  • Place of Presentation: 愛知県岡崎市分子科学研究所
  • Year and Date: 2012-02-14
  • Invited
• [Presentation] Membrane-targeted nanotherapy with hybrid liposomes for cancer cells leading to apoptosis (2012)
  • Author(s): Ryuichi Ueoka
  • Organizer: The International Conference on Statistical Mechanics of Liquids : From Water to Biomolecules
  • Place of Presentation: 岡崎コンファレンスセンター(愛知県)(招待講演)
  • Year and Date: 2012-02-14
• [Presentation] Inhibitory effects of cationic hybrid liposomes against colon carcinoma leading to apoptosis (2012)
  • Author(s): Yoko Matsumoto
  • Organizer: The International Conference on Statistical Mechanics of Liquids : From Water to Biomolecules
  • Place of Presentation: 岡崎コンファレンスセンター(愛知県)
  • Year and Date: 2012-02-13
• [Presentation] Chemotherapy with hybrid liposomes for cancer model mice leading to apoptosis in VIVO (2012)
  • Author(s): Hideaki Ichihara
  • Organizer: The International Conference on Statistical Mechanics of Liquids : From Water to Biomolecules
  • Place of Presentation: 岡崎コンファレンスセンター(愛知県)
  • Year and Date: 2012-02-13
• [Presentation] Membrane-targeted therapy with hybrid liposomes in Relation to fluctuation and apoptosis (2012)
  • Author(s): Y. Matsumoto
  • Organizer: The 5th Open Symposium of "Molecular Science of Fluctuation Toward Biological Functions"
  • Place of Presentation: 奈良県奈良市東大寺総合文化センター
  • Year and Date: 2012-01-08
  • Invited
• [Presentation] Inhibitory effects of cationic hybrid liposomes against colon carcinoma leading to apoptosis (2012)
  • Author(s): Motoki Hino
  • Organizer: The 5th Open Symposium of "Molecular Science of Fluctuation Toward Biological Functions"
  • Place of Presentation: 東大寺総合文化センター(奈良県)
  • Year and Date: 2012-01-08
• [Presentation] Inhibitory effects of hybrid liposomes on the growth of synoviocyte causing rheumatoid arthritis (2012)
  • Author(s): Hideaki Ichihara
  • Organizer: The 5th Open Symposium of "Molecular Science of Fluctuation Toward Biological Functions"
  • Place of Presentation: 東大寺総合文化センター(奈良県)
  • Year and Date: 2012-01-08
• [Presentation] Membrane-targeted therapy with hybrid liposomes in Relation to fluctuation and apoptosis (2012)
  • Author(s): Yoko Matsumoto
  • Organizer: The 5th Open Symposium of "Molecular Science of Fluctuation Toward Biological Functions"
  • Place of Presentation: 東大寺総合文化センター(奈良県)(招待講演)
  • Year and Date: 2012-01-08
• [Presentation] Cell cycle regulation by adding hybrid liposomes for tumor cells (2012)
  • Author(s): Mamiko Yukihara
  • Organizer: The 5th Open Symposium of "Molecular Science of Fluctuation Toward Biological Functions"
  • Place of Presentation: 東大寺総合文化センター(奈良県)
  • Year and Date: 2012-01-07
• [Presentation] ハイブリッドリポソームの肺がん細胞に対する細胞周期制御 (2012)
  • Author(s): 行原 真美子
  • Organizer: 第16回日本がん分子標的治療学会学術集会
  • Place of Presentation: 西日本総合展示場（福岡県）
• [Presentation] アポトーシス誘導による疾患治療と細胞膜の揺らぎ (2012)
  • Author(s): 松本 陽子
  • Organizer: 新学術領域研究「揺らぎが機能を決める生命分子の科学」平成24年度合同班会議
  • Place of Presentation: 作並温泉 ゆづくしSalon一の坊（宮城県）
• [Presentation] アポトーシス誘導による疾患治療と細胞膜の揺らぎ (2012)
  • Author(s): 松本 陽子
  • Organizer: 新学術領域「揺らぎと生体機能」「水和とATP」合同公開シンポジウム 「ゆらぎと水－生命のエネルギーと機能の分子機構を探る」
  • Place of Presentation: 大阪ガーデンパレス（大阪府）
• [Presentation] Anti-invasive effect of hybrid liposomes on osteosarcoma cells (2012)
  • Author(s): 北島 英樹
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌（北海道）
• [Presentation] Anti-tumor effects of cationic Hybrid Liposomes against Colon Carcinoma along with Apoptosis in vitro (2012)
  • Author(s): 日野 元貴
  • Organizer: 第71回日本癌学会学術総会
  • Place of Presentation: ロイトン札幌（北海道）
• [Presentation] Membrane-targeted nanotherapy with hybrid liposomes for cancer cells leading to apoptosis (2012)
  • Author(s): 上岡 龍一
  • Organizer: The 6th International Symposium of “Molecular Science of Fluctuation Toward Biological Functions”
  • Place of Presentation: 京都テルサ（京都府）
• [Presentation] Inhibitory effects of hybrid liposomes on the growth of synoviocyte causing rheumatoid arthritis in vivo (2012)
  • Author(s): 市原 英明
  • Organizer: The 6th International Symposium of “Molecular Science of Fluctuation Toward Biological Functions”
  • Place of Presentation: 京都テルサ（京都府）
• [Presentation] Cell-cycle regulation by hybrid liposomes for lung tumor cells (2012)
  • Author(s): 古水 雄志
  • Organizer: The 6th International Symposium of “Molecular Science of Fluctuation Toward Biological Functions”
  • Place of Presentation: 京都テルサ（京都府）
• [Presentation] Anti-tumor effects of Cationic hybrid liposomes Against colon carcinoma along with apoptosis (2012)
  • Author(s): 日野 元貴
  • Organizer: The 6th International Symposium of “Molecular Science of Fluctuation Toward Biological Functions”
  • Place of Presentation: 京都テルサ（京都府）
• [Presentation] New type of hybrid liposomes composed of dimyristoylphosphatidyl- choline and trehalose surfactant for the inhibition of tumor growth (2012)
  • Author(s): 曹 娥
  • Organizer: The 6th International Symposium of “Molecular Science of Fluctuation Toward Biological Functions”
  • Place of Presentation: 京都テルサ（京都府）
• [Presentation] Trastuzumabで刺激した強化免疫細胞治療の可能性 (2012)
  • Author(s): 松岡 裕介
  • Organizer: 第25回 日本バイオセラピィ学会学術集会総会
  • Place of Presentation: 倉敷市芸文館（岡山県）
• [Presentation] アポトーシス誘導による疾患治療と細胞膜の揺らぎ (2011)
  • Author(s): 松本陽子
  • Organizer: 新学術領域研究「揺らぎが機能を決める生命分子の科学」平成23年度A03班班会議
  • Place of Presentation: 休暇村近江八幡(滋賀県)
  • Year and Date: 2011-11-03
• [Presentation] Inhibitory effects of hybrid liposomes for human colon carcinoma along with apoptosis (2011)
  • Author(s): 日野元貴
  • Organizer: 第70回日本癌学会学術総会
  • Place of Presentation: 名古屋国際会議場(愛知県)
  • Year and Date: 2011-10-05
• [Presentation] アポトーシス誘導による疾患治療と細胞膜の揺らぎ (2011)
  • Author(s): 松本陽子
  • Organizer: 新学術領域研究「揺らぎが機能を決める生命分子の科学」平成23年度合同班会議
  • Place of Presentation: ゆうばりホテルシェーパロ(北海道)
  • Year and Date: 2011-06-28
• [Presentation] 大腸がんに対するカチオン性脂質含有ハイブリッドリポソームの制がん効果 (2011)
  • Author(s): 日野元貴
  • Organizer: 第15回日本がん分子標的治療学会学術集会
  • Place of Presentation: ホテル日航東京(東京都)
  • Year and Date: 2011-06-23
• [Presentation] バイオミメティックケミストリーからナノメディシンへ
  • Author(s): 松本陽子
  • Organizer: 化学工学会女性技術者セミナー
  • Place of Presentation: 共立会館（東京都文京区）
  • Invited
• [Presentation] Anti-tumor effects of cationic liposomes against tumor cells along with apoptosis
  • Author(s): Yoko Matsumoto
  • Organizer: Kyushu Seminar
  • Place of Presentation: 熊本市民会館（熊本市中央区）
  • Invited
• [Book] Current Pharmaceutical Designs Membrane targeted chemotherapy with hybrid liposomes for tumor cells leading to apoptosis (2011)
  • Author(s): Eyuichi Ueoka
  • Total Pages: 13
  • Publisher: Bentham Science Publishers
• [Remarks]
  • URL: http://www.life.sojo-u.ac.jp/biomed/index.html
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