Theranostic system for cancer by the combination of supramolecular nanocarriers with optical technology
| Project/Area Number |
23300174
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | National Defense Medical College (2012-2013)
防衛医科大学校 (2011) |
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Principal Investigator |
MORIMOTO YUJI 防衛医科大学校(医学教育部医学科進学課程及び専門課程、動物実験施設、共同利用研究, 医学教育部医学科専門課程, 准教授 (10449069)
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| Co-Investigator(Kenkyū-buntansha) |
NISHIYAMA Nobuhiro 東京工業大学, 資源化学研究所, 教授 (10372385)
KISHIMURA Akihiro 九州大学, 工学(系)研究科(研究院), 准教授 (70422326)
ITO Keiichi 防衛医科大学校, 医学教育部医学科専門課程, 准教授 (90260091)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2012: ¥5,200,000 (Direct Cost: ¥4,000,000、Indirect Cost: ¥1,200,000)
Fiscal Year 2011: ¥8,060,000 (Direct Cost: ¥6,200,000、Indirect Cost: ¥1,860,000)
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| Keywords | 光線力学療法 / ナノメディシン / 標的化診断・治療 / 生体イメージング / 超分子 / トランスレーショナルリサーチ / がん / ドラッグデリバリーシステム / ナノメディスン |
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| Research Abstract |
Enhancing its function and maximizing the accumulation efficiency, we advanced our developed supramolecular drug delivery system (DDS), resulted in the creation of light-activating supramolecular devices. Combining them with state-of-the-art optical technology, we have developed a next-generation theranostic system that can be applied to any sites in the body. Photodynamic therapy using the novel supramolecular DDS-type photosensitizers corresponds to highly selective treatment for tumors, including undetectable micro-lesions without any damage to surrounding normal tissues.
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Report
(4 results)
Research Products
(39 results)
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[Journal Article] Multicompartment Micelles with Adjustable Poly (ethylene glycol) Shell for Efficient In Vivo Photodynamic Therapy2014
Author(s)
Synatschke CV, Nomoto T, Cabral H, Förtsch M, Toh K, Matsumoto Y, Miyazaki K, Hanisch A, Schacher FH, Kishimura A, Nishiyama N, Müller AHE, Kataoka K
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Journal Title
ACS nano
Volume: (in press)
Related Report
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[Journal Article] Polyion Complex Vesicles for Photoinduced Intracellular Delivery of Amphiphilic Photosensitizer2013
Author(s)
Chen H, Xiao L, Anraku Y, Mi P, Liu X, Cabral H, Inoue A, Nomoto T, Kishimura A, Nishiyama N, Kataoka K
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Journal Title
Journal of the American Chemical Society
Volume: 136(1)
Pages: 157-163
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