Effective Production of Disease-Related Oligosaccharides and Preparation of Medical Devices
| Project/Area Number |
23300176
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | The University of Tokyo |
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Principal Investigator |
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| Co-Investigator(Renkei-kenkyūsha) |
NAGATA Kyosuke 筑波大学, 学長 (40180492)
SUZUKI Tetsuro 浜松医科大学, 医学部, 教授 (00250184)
KASUYA Maria Carmelita 東京大学, 生産技術研究所, 助教 (30334361)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥17,680,000 (Direct Cost: ¥13,600,000、Indirect Cost: ¥4,080,000)
Fiscal Year 2013: ¥3,120,000 (Direct Cost: ¥2,400,000、Indirect Cost: ¥720,000)
Fiscal Year 2012: ¥10,140,000 (Direct Cost: ¥7,800,000、Indirect Cost: ¥2,340,000)
Fiscal Year 2011: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
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| Keywords | オリゴ糖 / インフルエンザウイルス / シアリルラクトース / 細胞培養 / ガングリオシド / テトラフェニルエチレン / 診断分子 / クリック反応 / クリックケミストリー |
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| Research Abstract |
A method to produce oligosaccharides, which interact with viruses or pathogenic proteins, by using cellular enzymes and donor substrate was established. The obtained oligosaccharides were used for the trial manufacture of the medical devices. Two kinds of molecules, which can detect human and avian influenza viruses, respectively, were developed by binding the oligosaccharides to the tetraphenylethylene which gives the fluorescence in high concentration. In addition, using the cytology molecules which could monitor intracellular oligosaccharide synthesis, searching the drug which could control oligosaccharide synthesis was attempted.
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Report
(4 results)
Research Products
(43 results)
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[Journal Article] Carbohydrate Immobilized on a Dendrimer-Coated Colloidal Gold Surface for Fabrication of a Lectin-Sensing Device Based on Localized Surface Plasmon Resonance Spectroscopy2013
Author(s)
M. Ogiso, J. Kobayashi, T. Imai, M. Itoh, K. Matsuoka, T. Imamura, T. Okada, H. Miura, T. Nishiyama, K. Hatanaka, N. Minoura
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Journal Title
Biosensors and Bioelectronics
Volume: Vol.41
Pages: 465-470
DOI
Related Report
Peer Reviewed
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[Journal Article] Intricate Recognition of Glycolipid-like Compounds by HIV-1 Envelope Proteins Evaluated with Surface Plasmon Resonance Imaging2012
Author(s)
T. Okada, A. Kimura, H. Miura, T.Nishiyama, M. Mori, J. Suzuki, M. Ogiso, K. Matsuoka, T. Sato, K. Hatanaka, N. Minoura.
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Journal Title
J. Carbohydr. Chem.
Volume: 31(7)
Issue: 7
Pages: 584-597
DOI
Related Report
Peer Reviewed
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