Development of the technology for the entire tissue restoration using decellularized tissues
| Project/Area Number |
23300177
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
KISHIDA AKIO 東京医科歯科大学, 生体材料工学研究所, 教授 (60224929)
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| Co-Investigator(Kenkyū-buntansha) |
KIMURA Tsuyoshi 東京医科歯科大学, 生体材料工学研究所, 准教授 (10393216)
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| Project Period (FY) |
2011-04-01 – 2015-03-31
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| Project Status |
Completed (Fiscal Year 2014)
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| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Keywords | 再生医療 / 脱細胞化組織 / コラーゲン / 幹細胞 / 骨 / 血管 / 角膜 |
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| Outline of Final Research Achievements |
Here we tried to develop the technology for the restoration of entire tissue by putting small pieces of the decellularized tissue together. The decellularization technique was brushed up sophisticatedly and the restoration and rebuilding techniques of small pieces was newly developed. By in vitro and in vivo study, we found the core factors which was necessary to scaffold materials. Also, we established the methodology for preparing a slice of an aorta tissue and the skin tissue, for rebuilding bone tissue from small pieces, and for reconstitute hematopoietic system in decellularized bone marrow. All of these reconstructed tissues were confirmed to well function in living body. As conclusion, the feasibility of the basic concept that we proposed in this study were proven successfully.
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Report
(5 results)
Research Products
(19 results)
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[Journal Article] Application of detergents or high hydrostatic pressure as decellularization process in uterine tissues and their subsequent effects on in vivo uterine regeneration in murine models2014
Author(s)
E.G.Santoso, K.Yoshida, Y.Hirota, M.Aizawa,O.Yoshino, A.Kishida, Y.Osuga, S.Saito, T.Ushida, K.S.Furukawa,
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Journal Title
PLoS ONE
Volume: 9
Issue: 7
Pages: 1-13
DOI
Related Report
Peer Reviewed / Open Access
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