| Budget Amount *help |
¥18,200,000 (Direct Cost: ¥14,000,000、Indirect Cost: ¥4,200,000)
Fiscal Year 2014: ¥3,510,000 (Direct Cost: ¥2,700,000、Indirect Cost: ¥810,000)
Fiscal Year 2013: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2012: ¥4,420,000 (Direct Cost: ¥3,400,000、Indirect Cost: ¥1,020,000)
Fiscal Year 2011: ¥5,850,000 (Direct Cost: ¥4,500,000、Indirect Cost: ¥1,350,000)
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| Outline of Final Research Achievements |
Here we tried to develop the technology for the restoration of entire tissue by putting small pieces of the decellularized tissue together. The decellularization technique was brushed up sophisticatedly and the restoration and rebuilding techniques of small pieces was newly developed. By in vitro and in vivo study, we found the core factors which was necessary to scaffold materials. Also, we established the methodology for preparing a slice of an aorta tissue and the skin tissue, for rebuilding bone tissue from small pieces, and for reconstitute hematopoietic system in decellularized bone marrow. All of these reconstructed tissues were confirmed to well function in living body. As conclusion, the feasibility of the basic concept that we proposed in this study were proven successfully.
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