| Project/Area Number |
23300178
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| Research Category |
Grant-in-Aid for Scientific Research (B)
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| Allocation Type | Single-year Grants |
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| Section | 一般 |
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| Research Field |
Biomedical engineering/Biological material science
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| Research Institution | Tokyo Medical and Dental University |
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Principal Investigator |
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| Co-Investigator(Kenkyū-buntansha) |
NAGAI Akiko 東京医科歯科大学, 生体材料工学研究所, 准教授 (40360599)
NAKAMURA Miho 東京医科歯科大学, 生体材料工学研究所, 准教授 (40401385)
HORIUCHI Naohiro 東京医科歯科大学, 生体材料工学研究所, 助教 (90598195)
NOZAKI Kosuke 東京医科歯科大学, 生体材料工学研究所, 助教 (00507767)
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| Project Period (FY) |
2011-04-01 – 2014-03-31
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| Project Status |
Completed (Fiscal Year 2013)
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| Budget Amount *help |
¥18,460,000 (Direct Cost: ¥14,200,000、Indirect Cost: ¥4,260,000)
Fiscal Year 2013: ¥3,640,000 (Direct Cost: ¥2,800,000、Indirect Cost: ¥840,000)
Fiscal Year 2012: ¥6,240,000 (Direct Cost: ¥4,800,000、Indirect Cost: ¥1,440,000)
Fiscal Year 2011: ¥8,580,000 (Direct Cost: ¥6,600,000、Indirect Cost: ¥1,980,000)
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| Keywords | 分極 / バイオセラミックス / リン酸カルシウム / ハイドロキシアパタイト / 炭酸含有アパタイト / スキャホールド / バイオインターフェイス / 硬組織代替デバイス |
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| Research Abstract |
We studied fundamental researches of ceramic biomaterials for tissue regeneration and clinical applications. The surface characteristics showed that the electrical polarization increased the surface free energy and improved wettability of ceramic biomaterial's surfaces. The functionalized ceramic biomaterials by electrical polarization accelerated the cellular responses such as proliferation, adhesion and differentiation of osteogenic cells and tissue responses of bone, skin and blood vessels. This study showed the efficacy of polarized ceramic biomaterials to enhance the tissue regenerations for control of the interface between materials and tissues.
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